QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4H502_LEIBR

TriTrypDb:

LbrM.07.0580 , LBRM2903_070012200

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005794	Golgi apparatus	5	1
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0012507	ER to Golgi transport vesicle membrane	6	1
GO:0030658	transport vesicle membrane	5	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031201	SNARE complex	3	1
GO:0031902	late endosome membrane	6	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H502

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H502

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.616
CLV_NRD_NRD_1	18	20	PF00675	0.254
CLV_NRD_NRD_1	60	62	PF00675	0.380
CLV_PCSK_KEX2_1	20	22	PF00082	0.332
CLV_PCSK_KEX2_1	230	232	PF00082	0.546
CLV_PCSK_KEX2_1	60	62	PF00082	0.380
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.332
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.546
CLV_PCSK_PC7_1	56	62	PF00082	0.356
CLV_PCSK_SKI1_1	140	144	PF00082	0.367
CLV_PCSK_SKI1_1	206	210	PF00082	0.334
DEG_APCC_DBOX_1	160	168	PF00400	0.561
DEG_APCC_DBOX_1	48	56	PF00400	0.633
DEG_Nend_UBRbox_2	1	3	PF02207	0.684
DOC_ANK_TNKS_1	18	25	PF00023	0.456
DOC_MAPK_gen_1	19	27	PF00069	0.641
DOC_MAPK_gen_1	204	211	PF00069	0.538
DOC_MAPK_MEF2A_6	60	67	PF00069	0.519
DOC_MAPK_RevD_3	217	231	PF00069	0.309
DOC_PP1_RVXF_1	191	198	PF00149	0.533
DOC_USP7_MATH_1	142	146	PF00917	0.603
DOC_WW_Pin1_4	97	102	PF00397	0.690
LIG_14-3-3_CanoR_1	102	107	PF00244	0.609
LIG_14-3-3_CanoR_1	161	171	PF00244	0.586
LIG_14-3-3_CanoR_1	60	64	PF00244	0.618
LIG_FHA_1	147	153	PF00498	0.644
LIG_FHA_1	60	66	PF00498	0.651
LIG_FHA_1	98	104	PF00498	0.542
LIG_FHA_2	103	109	PF00498	0.586
LIG_FHA_2	161	167	PF00498	0.592
LIG_FHA_2	28	34	PF00498	0.585
LIG_FHA_2	4	10	PF00498	0.541
LIG_LIR_Gen_1	205	216	PF02991	0.435
LIG_LIR_Nem_3	205	211	PF02991	0.435
LIG_LIR_Nem_3	91	97	PF02991	0.535
LIG_LYPXL_S_1	93	97	PF13949	0.320
LIG_LYPXL_yS_3	94	97	PF13949	0.533
LIG_PCNA_yPIPBox_3	161	175	PF02747	0.491
LIG_Pex14_2	224	228	PF04695	0.344
LIG_SH2_CRK	199	203	PF00017	0.562
LIG_SH2_STAP1	85	89	PF00017	0.561
LIG_SH2_STAT3	106	109	PF00017	0.677
LIG_SUMO_SIM_par_1	61	66	PF11976	0.628
LIG_TRAF2_1	105	108	PF00917	0.675
LIG_TRAF2_1	7	10	PF00917	0.459
LIG_UBA3_1	14	20	PF00899	0.450
LIG_WRC_WIRS_1	1	6	PF05994	0.605
MOD_CDK_SPK_2	97	102	PF00069	0.627
MOD_CDK_SPxxK_3	97	104	PF00069	0.623
MOD_CK1_1	226	232	PF00069	0.532
MOD_CK1_1	3	9	PF00069	0.528
MOD_CK1_1	59	65	PF00069	0.607
MOD_CK2_1	102	108	PF00069	0.605
MOD_CK2_1	160	166	PF00069	0.590
MOD_CK2_1	27	33	PF00069	0.564
MOD_CK2_1	3	9	PF00069	0.506
MOD_GlcNHglycan	132	135	PF01048	0.350
MOD_GlcNHglycan	97	100	PF01048	0.485
MOD_GSK3_1	142	149	PF00069	0.606
MOD_GSK3_1	156	163	PF00069	0.523
MOD_N-GLC_1	153	158	PF02516	0.394
MOD_NEK2_1	125	130	PF00069	0.627
MOD_PIKK_1	88	94	PF00454	0.569
MOD_PKA_2	160	166	PF00069	0.541
MOD_PKA_2	59	65	PF00069	0.578
MOD_PKA_2	95	101	PF00069	0.662
MOD_Plk_1	78	84	PF00069	0.643
MOD_Plk_4	207	213	PF00069	0.286
MOD_Plk_4	223	229	PF00069	0.286
MOD_ProDKin_1	97	103	PF00069	0.690
MOD_SUMO_rev_2	111	120	PF00179	0.644
MOD_SUMO_rev_2	86	91	PF00179	0.640
TRG_DiLeu_BaEn_3	9	15	PF01217	0.449
TRG_DiLeu_BaEn_4	179	185	PF01217	0.625
TRG_ENDOCYTIC_2	199	202	PF00928	0.547
TRG_ENDOCYTIC_2	94	97	PF00928	0.533
TRG_ER_diArg_1	18	21	PF00400	0.457
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYF5	Leptomonas seymouri	74%	100%
A0A0S4IUP1	Bodo saltans	46%	100%
A0A1X0NPE9	Trypanosomatidae	62%	100%
A0A3R7MA41	Trypanosoma rangeli	56%	100%
A0A3S7WPV3	Leishmania donovani	83%	100%
A4HT76	Leishmania infantum	83%	100%
C9ZUP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AL64	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIP0	Leishmania major	83%	100%
V5B8J0	Trypanosoma cruzi	54%	100%