LeishMANIAdb
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60S ribosomal protein L7a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosomal protein L7a
Gene product:
60S ribosomal protein L7a, putative
Species:
Leishmania braziliensis
UniProt:
A4H500_LEIBR
TriTrypDb:
LbrM.07.0560 , LBRM2903_070012100
Length:
264

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 12
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0015934 large ribosomal subunit 4 14
GO:0022625 cytosolic large ribosomal subunit 5 14
GO:0032991 protein-containing complex 1 14
GO:0044391 ribosomal subunit 3 14
GO:1990904 ribonucleoprotein complex 2 14
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4H500
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H500

Function

Biological processes
Term Name Level Count
GO:0000470 maturation of LSU-rRNA 9 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 14
GO:0003723 RNA binding 4 14
GO:0005488 binding 1 14
GO:0097159 organic cyclic compound binding 2 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 102 104 PF00675 0.470
CLV_NRD_NRD_1 106 108 PF00675 0.483
CLV_NRD_NRD_1 121 123 PF00675 0.438
CLV_NRD_NRD_1 192 194 PF00675 0.368
CLV_NRD_NRD_1 231 233 PF00675 0.406
CLV_NRD_NRD_1 247 249 PF00675 0.433
CLV_NRD_NRD_1 60 62 PF00675 0.431
CLV_NRD_NRD_1 68 70 PF00675 0.439
CLV_PCSK_FUR_1 61 65 PF00082 0.436
CLV_PCSK_KEX2_1 106 108 PF00082 0.534
CLV_PCSK_KEX2_1 231 233 PF00082 0.406
CLV_PCSK_KEX2_1 63 65 PF00082 0.438
CLV_PCSK_KEX2_1 68 70 PF00082 0.439
CLV_PCSK_KEX2_1 7 9 PF00082 0.519
CLV_PCSK_PC1ET2_1 63 65 PF00082 0.438
CLV_PCSK_PC1ET2_1 7 9 PF00082 0.509
CLV_PCSK_PC7_1 64 70 PF00082 0.441
CLV_PCSK_SKI1_1 194 198 PF00082 0.312
CLV_PCSK_SKI1_1 4 8 PF00082 0.623
CLV_PCSK_SKI1_1 63 67 PF00082 0.440
CLV_PCSK_SKI1_1 68 72 PF00082 0.430
CLV_PCSK_SKI1_1 93 97 PF00082 0.442
CLV_Separin_Metazoa 90 94 PF03568 0.308
DEG_APCC_DBOX_1 127 135 PF00400 0.411
DOC_MAPK_gen_1 146 154 PF00069 0.479
DOC_MAPK_gen_1 193 201 PF00069 0.579
DOC_MAPK_gen_1 231 239 PF00069 0.415
DOC_MAPK_gen_1 85 94 PF00069 0.399
DOC_MAPK_HePTP_8 229 241 PF00069 0.411
DOC_MAPK_MEF2A_6 232 241 PF00069 0.416
DOC_PP2B_LxvP_1 165 168 PF13499 0.469
DOC_PP2B_LxvP_1 70 73 PF13499 0.423
DOC_USP7_MATH_1 23 27 PF00917 0.640
DOC_USP7_UBL2_3 119 123 PF12436 0.545
DOC_WW_Pin1_4 14 19 PF00397 0.658
LIG_14-3-3_CanoR_1 122 131 PF00244 0.398
LIG_14-3-3_CanoR_1 193 201 PF00244 0.568
LIG_14-3-3_CanoR_1 27 35 PF00244 0.441
LIG_14-3-3_CanoR_1 8 12 PF00244 0.500
LIG_BIR_III_4 189 193 PF00653 0.494
LIG_CaM_IQ_9 134 150 PF13499 0.469
LIG_CSL_BTD_1 165 168 PF09270 0.469
LIG_CtBP_PxDLS_1 160 164 PF00389 0.469
LIG_FHA_1 139 145 PF00498 0.487
LIG_FHA_1 78 84 PF00498 0.429
LIG_FHA_1 8 14 PF00498 0.516
LIG_LIR_Apic_2 17 22 PF02991 0.652
LIG_LRP6_Inhibitor_1 211 217 PF00058 0.328
LIG_SH2_CRK 178 182 PF00017 0.469
LIG_SH2_CRK 19 23 PF00017 0.692
LIG_SH2_SRC 178 181 PF00017 0.469
LIG_SH2_STAP1 43 47 PF00017 0.452
LIG_SUMO_SIM_anti_2 159 165 PF11976 0.469
LIG_SUMO_SIM_par_1 129 135 PF11976 0.325
LIG_TRAF2_1 113 116 PF00917 0.573
LIG_TRAF2_1 206 209 PF00917 0.314
LIG_TYR_ITIM 176 181 PF00017 0.469
MOD_CDC14_SPxK_1 17 20 PF00782 0.652
MOD_CDK_SPxK_1 14 20 PF00069 0.657
MOD_CDK_SPxxK_3 14 21 PF00069 0.622
MOD_CK1_1 240 246 PF00069 0.428
MOD_CK1_1 26 32 PF00069 0.402
MOD_CK2_1 240 246 PF00069 0.445
MOD_CK2_1 84 90 PF00069 0.416
MOD_Cter_Amidation 191 194 PF01082 0.368
MOD_GSK3_1 41 48 PF00069 0.402
MOD_N-GLC_2 169 171 PF02516 0.374
MOD_NEK2_1 215 220 PF00069 0.410
MOD_NEK2_1 237 242 PF00069 0.430
MOD_NEK2_1 83 88 PF00069 0.319
MOD_PIKK_1 7 13 PF00454 0.664
MOD_PKA_1 7 13 PF00069 0.644
MOD_PKA_2 121 127 PF00069 0.423
MOD_PKA_2 192 198 PF00069 0.570
MOD_PKA_2 26 32 PF00069 0.402
MOD_PKA_2 7 13 PF00069 0.537
MOD_PKA_2 84 90 PF00069 0.407
MOD_Plk_1 45 51 PF00069 0.446
MOD_Plk_4 52 58 PF00069 0.428
MOD_ProDKin_1 14 20 PF00069 0.657
MOD_SUMO_rev_2 139 149 PF00179 0.473
TRG_DiLeu_BaEn_1 90 95 PF01217 0.394
TRG_DiLeu_BaEn_4 207 213 PF01217 0.306
TRG_DiLeu_LyEn_5 90 95 PF01217 0.303
TRG_ENDOCYTIC_2 178 181 PF00928 0.469
TRG_ER_diArg_1 230 232 PF00400 0.405
TRG_ER_diArg_1 241 244 PF00400 0.421
TRG_ER_diArg_1 68 70 PF00400 0.439
TRG_NLS_Bipartite_1 231 252 PF00514 0.429
TRG_NLS_MonoCore_2 60 65 PF00514 0.434
TRG_NLS_MonoExtC_3 102 107 PF00514 0.498
TRG_NLS_MonoExtN_4 100 107 PF00514 0.492
TRG_NLS_MonoExtN_4 61 66 PF00514 0.437

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HQX1 Leptomonas seymouri 93% 100%
A0A0S4IQB8 Bodo saltans 75% 100%
A0A1D8PF11 Candida albicans (strain SC5314 / ATCC MYA-2876) 43% 100%
A0A1X0NEX8 Trypanosomatidae 86% 100%
A0A1X0NPC4 Trypanosomatidae 86% 98%
A0A3S7WPW6 Leishmania donovani 94% 100%
A4HT77 Leishmania infantum 94% 79%
A4HT78 Leishmania infantum 94% 76%
C9ZUQ0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 79% 96%
E9AL62 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AL63 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 88%
O13672 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 100%
O57592 Takifugu rubripes 45% 99%
O76732 Anopheles gambiae 44% 97%
P0DJ14 Tetrahymena thermophila 44% 100%
P0DKK7 Oryza sativa subsp. japonica 43% 100%
P12970 Mus musculus 47% 99%
P17076 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 44% 100%
P29453 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 100%
P32429 Gallus gallus 47% 99%
P35685 Oryza sativa subsp. japonica 43% 100%
P46223 Drosophila melanogaster 47% 97%
P49692 Arabidopsis thaliana 42% 100%
P62424 Homo sapiens 47% 99%
P62425 Rattus norvegicus 47% 99%
Q2TBQ5 Bos taurus 47% 99%
Q4QIP1 Leishmania major 92% 100%
Q4R5C2 Macaca fascicularis 47% 99%
Q54ZD1 Dictyostelium discoideum 43% 93%
Q5ANA1 Candida albicans (strain SC5314 / ATCC MYA-2876) 45% 100%
Q8SSG1 Encephalitozoon cuniculi (strain GB-M1) 36% 100%
Q90YW2 Ictalurus punctatus 46% 99%
Q966C6 Caenorhabditis elegans 40% 100%
Q9LZH9 Arabidopsis thaliana 41% 100%
V5DPU1 Trypanosoma cruzi 83% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS