60S ribosomal protein L7a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7a, putative

Species:

Leishmania braziliensis

UniProt:

A4H500_LEIBR

TriTrypDb:

LbrM.07.0560 , LBRM2903_070012100

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	14
GO:0022625	cytosolic large ribosomal subunit	5	14
GO:0032991	protein-containing complex	1	14
GO:0044391	ribosomal subunit	3	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H500

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H500

Function

Biological processes
Term	Name	Level	Count
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.470
CLV_NRD_NRD_1	106	108	PF00675	0.483
CLV_NRD_NRD_1	121	123	PF00675	0.438
CLV_NRD_NRD_1	192	194	PF00675	0.368
CLV_NRD_NRD_1	231	233	PF00675	0.406
CLV_NRD_NRD_1	247	249	PF00675	0.433
CLV_NRD_NRD_1	60	62	PF00675	0.431
CLV_NRD_NRD_1	68	70	PF00675	0.439
CLV_PCSK_FUR_1	61	65	PF00082	0.436
CLV_PCSK_KEX2_1	106	108	PF00082	0.534
CLV_PCSK_KEX2_1	231	233	PF00082	0.406
CLV_PCSK_KEX2_1	63	65	PF00082	0.438
CLV_PCSK_KEX2_1	68	70	PF00082	0.439
CLV_PCSK_KEX2_1	7	9	PF00082	0.519
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.438
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.509
CLV_PCSK_PC7_1	64	70	PF00082	0.441
CLV_PCSK_SKI1_1	194	198	PF00082	0.312
CLV_PCSK_SKI1_1	4	8	PF00082	0.623
CLV_PCSK_SKI1_1	63	67	PF00082	0.440
CLV_PCSK_SKI1_1	68	72	PF00082	0.430
CLV_PCSK_SKI1_1	93	97	PF00082	0.442
CLV_Separin_Metazoa	90	94	PF03568	0.308
DEG_APCC_DBOX_1	127	135	PF00400	0.411
DOC_MAPK_gen_1	146	154	PF00069	0.479
DOC_MAPK_gen_1	193	201	PF00069	0.579
DOC_MAPK_gen_1	231	239	PF00069	0.415
DOC_MAPK_gen_1	85	94	PF00069	0.399
DOC_MAPK_HePTP_8	229	241	PF00069	0.411
DOC_MAPK_MEF2A_6	232	241	PF00069	0.416
DOC_PP2B_LxvP_1	165	168	PF13499	0.469
DOC_PP2B_LxvP_1	70	73	PF13499	0.423
DOC_USP7_MATH_1	23	27	PF00917	0.640
DOC_USP7_UBL2_3	119	123	PF12436	0.545
DOC_WW_Pin1_4	14	19	PF00397	0.658
LIG_14-3-3_CanoR_1	122	131	PF00244	0.398
LIG_14-3-3_CanoR_1	193	201	PF00244	0.568
LIG_14-3-3_CanoR_1	27	35	PF00244	0.441
LIG_14-3-3_CanoR_1	8	12	PF00244	0.500
LIG_BIR_III_4	189	193	PF00653	0.494
LIG_CaM_IQ_9	134	150	PF13499	0.469
LIG_CSL_BTD_1	165	168	PF09270	0.469
LIG_CtBP_PxDLS_1	160	164	PF00389	0.469
LIG_FHA_1	139	145	PF00498	0.487
LIG_FHA_1	78	84	PF00498	0.429
LIG_FHA_1	8	14	PF00498	0.516
LIG_LIR_Apic_2	17	22	PF02991	0.652
LIG_LRP6_Inhibitor_1	211	217	PF00058	0.328
LIG_SH2_CRK	178	182	PF00017	0.469
LIG_SH2_CRK	19	23	PF00017	0.692
LIG_SH2_SRC	178	181	PF00017	0.469
LIG_SH2_STAP1	43	47	PF00017	0.452
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.469
LIG_SUMO_SIM_par_1	129	135	PF11976	0.325
LIG_TRAF2_1	113	116	PF00917	0.573
LIG_TRAF2_1	206	209	PF00917	0.314
LIG_TYR_ITIM	176	181	PF00017	0.469
MOD_CDC14_SPxK_1	17	20	PF00782	0.652
MOD_CDK_SPxK_1	14	20	PF00069	0.657
MOD_CDK_SPxxK_3	14	21	PF00069	0.622
MOD_CK1_1	240	246	PF00069	0.428
MOD_CK1_1	26	32	PF00069	0.402
MOD_CK2_1	240	246	PF00069	0.445
MOD_CK2_1	84	90	PF00069	0.416
MOD_Cter_Amidation	191	194	PF01082	0.368
MOD_GSK3_1	41	48	PF00069	0.402
MOD_N-GLC_2	169	171	PF02516	0.374
MOD_NEK2_1	215	220	PF00069	0.410
MOD_NEK2_1	237	242	PF00069	0.430
MOD_NEK2_1	83	88	PF00069	0.319
MOD_PIKK_1	7	13	PF00454	0.664
MOD_PKA_1	7	13	PF00069	0.644
MOD_PKA_2	121	127	PF00069	0.423
MOD_PKA_2	192	198	PF00069	0.570
MOD_PKA_2	26	32	PF00069	0.402
MOD_PKA_2	7	13	PF00069	0.537
MOD_PKA_2	84	90	PF00069	0.407
MOD_Plk_1	45	51	PF00069	0.446
MOD_Plk_4	52	58	PF00069	0.428
MOD_ProDKin_1	14	20	PF00069	0.657
MOD_SUMO_rev_2	139	149	PF00179	0.473
TRG_DiLeu_BaEn_1	90	95	PF01217	0.394
TRG_DiLeu_BaEn_4	207	213	PF01217	0.306
TRG_DiLeu_LyEn_5	90	95	PF01217	0.303
TRG_ENDOCYTIC_2	178	181	PF00928	0.469
TRG_ER_diArg_1	230	232	PF00400	0.405
TRG_ER_diArg_1	241	244	PF00400	0.421
TRG_ER_diArg_1	68	70	PF00400	0.439
TRG_NLS_Bipartite_1	231	252	PF00514	0.429
TRG_NLS_MonoCore_2	60	65	PF00514	0.434
TRG_NLS_MonoExtC_3	102	107	PF00514	0.498
TRG_NLS_MonoExtN_4	100	107	PF00514	0.492
TRG_NLS_MonoExtN_4	61	66	PF00514	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HQX1	Leptomonas seymouri	93%	100%
A0A0S4IQB8	Bodo saltans	75%	100%
A0A1D8PF11	Candida albicans (strain SC5314 / ATCC MYA-2876)	43%	100%
A0A1X0NEX8	Trypanosomatidae	86%	100%
A0A1X0NPC4	Trypanosomatidae	86%	98%
A0A3S7WPW6	Leishmania donovani	94%	100%
A4HT77	Leishmania infantum	94%	79%
A4HT78	Leishmania infantum	94%	76%
C9ZUQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	96%
E9AL62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AL63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	88%
O13672	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O57592	Takifugu rubripes	45%	99%
O76732	Anopheles gambiae	44%	97%
P0DJ14	Tetrahymena thermophila	44%	100%
P0DKK7	Oryza sativa subsp. japonica	43%	100%
P12970	Mus musculus	47%	99%
P17076	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P29453	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P32429	Gallus gallus	47%	99%
P35685	Oryza sativa subsp. japonica	43%	100%
P46223	Drosophila melanogaster	47%	97%
P49692	Arabidopsis thaliana	42%	100%
P62424	Homo sapiens	47%	99%
P62425	Rattus norvegicus	47%	99%
Q2TBQ5	Bos taurus	47%	99%
Q4QIP1	Leishmania major	92%	100%
Q4R5C2	Macaca fascicularis	47%	99%
Q54ZD1	Dictyostelium discoideum	43%	93%
Q5ANA1	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	100%
Q8SSG1	Encephalitozoon cuniculi (strain GB-M1)	36%	100%
Q90YW2	Ictalurus punctatus	46%	99%
Q966C6	Caenorhabditis elegans	40%	100%
Q9LZH9	Arabidopsis thaliana	41%	100%
V5DPU1	Trypanosoma cruzi	83%	86%