WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Z9_LEIBR

TriTrypDb:

LbrM.07.0550 , LBRM2903_070011900

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H4Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Z9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.693
CLV_C14_Caspase3-7	179	183	PF00656	0.653
CLV_NRD_NRD_1	100	102	PF00675	0.386
CLV_NRD_NRD_1	103	105	PF00675	0.404
CLV_NRD_NRD_1	147	149	PF00675	0.450
CLV_NRD_NRD_1	211	213	PF00675	0.414
CLV_NRD_NRD_1	299	301	PF00675	0.440
CLV_PCSK_KEX2_1	147	149	PF00082	0.429
CLV_PCSK_KEX2_1	211	213	PF00082	0.406
CLV_PCSK_KEX2_1	224	226	PF00082	0.350
CLV_PCSK_KEX2_1	299	301	PF00082	0.417
CLV_PCSK_KEX2_1	311	313	PF00082	0.369
CLV_PCSK_KEX2_1	99	101	PF00082	0.389
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.435
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.438
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.342
CLV_PCSK_PC7_1	95	101	PF00082	0.389
CLV_PCSK_SKI1_1	113	117	PF00082	0.511
CLV_PCSK_SKI1_1	299	303	PF00082	0.412
CLV_PCSK_SKI1_1	59	63	PF00082	0.585
CLV_PCSK_SKI1_1	88	92	PF00082	0.382
DEG_SPOP_SBC_1	32	36	PF00917	0.477
DEG_SPOP_SBC_1	381	385	PF00917	0.696
DOC_MAPK_DCC_7	59	69	PF00069	0.424
DOC_MAPK_FxFP_2	205	208	PF00069	0.653
DOC_MAPK_gen_1	160	170	PF00069	0.576
DOC_MAPK_gen_1	311	319	PF00069	0.694
DOC_MAPK_MEF2A_6	154	161	PF00069	0.599
DOC_MAPK_RevD_3	85	100	PF00069	0.556
DOC_PP1_RVXF_1	57	63	PF00149	0.419
DOC_PP2B_LxvP_1	67	70	PF13499	0.356
DOC_PP4_FxxP_1	205	208	PF00568	0.562
DOC_USP7_MATH_1	229	233	PF00917	0.684
DOC_USP7_MATH_1	26	30	PF00917	0.567
DOC_USP7_MATH_1	32	36	PF00917	0.535
DOC_USP7_MATH_1	320	324	PF00917	0.719
DOC_USP7_MATH_1	334	338	PF00917	0.732
DOC_USP7_MATH_1	370	374	PF00917	0.767
DOC_WW_Pin1_4	24	29	PF00397	0.414
DOC_WW_Pin1_4	246	251	PF00397	0.764
DOC_WW_Pin1_4	274	279	PF00397	0.775
LIG_14-3-3_CanoR_1	113	119	PF00244	0.655
LIG_14-3-3_CanoR_1	154	158	PF00244	0.583
LIG_14-3-3_CanoR_1	173	181	PF00244	0.533
LIG_14-3-3_CanoR_1	188	196	PF00244	0.479
LIG_14-3-3_CanoR_1	233	239	PF00244	0.716
LIG_14-3-3_CanoR_1	299	305	PF00244	0.699
LIG_14-3-3_CanoR_1	372	378	PF00244	0.725
LIG_14-3-3_CanoR_1	380	387	PF00244	0.654
LIG_14-3-3_CanoR_1	47	54	PF00244	0.417
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_BRCT_BRCA1_1	294	298	PF00533	0.718
LIG_BRCT_BRCA1_1	5	9	PF00533	0.376
LIG_CaM_NSCaTE_8	44	51	PF13499	0.429
LIG_CSL_BTD_1	67	70	PF09270	0.328
LIG_FHA_1	115	121	PF00498	0.666
LIG_FHA_1	199	205	PF00498	0.580
LIG_FHA_1	376	382	PF00498	0.692
LIG_FHA_1	53	59	PF00498	0.469
LIG_FHA_1	78	84	PF00498	0.350
LIG_FHA_2	177	183	PF00498	0.675
LIG_FHA_2	51	57	PF00498	0.351
LIG_LIR_Apic_2	203	209	PF02991	0.567
LIG_LIR_Gen_1	103	112	PF02991	0.637
LIG_LIR_Gen_1	42	51	PF02991	0.434
LIG_LIR_Gen_1	80	90	PF02991	0.440
LIG_LIR_Nem_3	103	109	PF02991	0.603
LIG_LIR_Nem_3	182	187	PF02991	0.554
LIG_LIR_Nem_3	376	382	PF02991	0.694
LIG_LIR_Nem_3	42	48	PF02991	0.437
LIG_LIR_Nem_3	80	85	PF02991	0.440
LIG_Pex14_1	45	49	PF04695	0.426
LIG_Pex14_2	298	302	PF04695	0.611
LIG_Pex14_2	90	94	PF04695	0.551
LIG_SH2_CRK	379	383	PF00017	0.693
LIG_SH2_STAP1	41	45	PF00017	0.309
LIG_SH2_STAT5	304	307	PF00017	0.603
LIG_SH2_STAT5	82	85	PF00017	0.331
LIG_SH3_3	284	290	PF00018	0.597
LIG_WRC_WIRS_1	82	87	PF05994	0.370
MOD_CDC14_SPxK_1	249	252	PF00782	0.797
MOD_CDK_SPxK_1	246	252	PF00069	0.794
MOD_CK1_1	246	252	PF00069	0.750
MOD_CK1_1	261	267	PF00069	0.681
MOD_CK1_1	269	275	PF00069	0.651
MOD_CK1_1	27	33	PF00069	0.523
MOD_CK1_1	3	9	PF00069	0.493
MOD_CK1_1	327	333	PF00069	0.736
MOD_CK1_1	34	40	PF00069	0.457
MOD_CK1_1	373	379	PF00069	0.745
MOD_CK1_1	383	389	PF00069	0.650
MOD_CK1_1	50	56	PF00069	0.292
MOD_CK2_1	261	267	PF00069	0.808
MOD_CK2_1	319	325	PF00069	0.720
MOD_CK2_1	50	56	PF00069	0.395
MOD_GlcNHglycan	10	13	PF01048	0.726
MOD_GlcNHglycan	189	192	PF01048	0.387
MOD_GlcNHglycan	267	271	PF01048	0.557
MOD_GlcNHglycan	3	6	PF01048	0.741
MOD_GlcNHglycan	325	329	PF01048	0.535
MOD_GlcNHglycan	332	335	PF01048	0.554
MOD_GlcNHglycan	336	339	PF01048	0.530
MOD_GlcNHglycan	343	346	PF01048	0.486
MOD_GlcNHglycan	349	352	PF01048	0.428
MOD_GlcNHglycan	357	360	PF01048	0.418
MOD_GlcNHglycan	49	52	PF01048	0.639
MOD_GSK3_1	1	8	PF00069	0.512
MOD_GSK3_1	24	31	PF00069	0.562
MOD_GSK3_1	242	249	PF00069	0.714
MOD_GSK3_1	258	265	PF00069	0.680
MOD_GSK3_1	32	39	PF00069	0.460
MOD_GSK3_1	320	327	PF00069	0.694
MOD_GSK3_1	330	337	PF00069	0.711
MOD_GSK3_1	343	350	PF00069	0.700
MOD_GSK3_1	371	378	PF00069	0.757
MOD_GSK3_1	73	80	PF00069	0.471
MOD_N-GLC_1	234	239	PF02516	0.494
MOD_N-GLC_1	243	248	PF02516	0.497
MOD_N-GLC_1	274	279	PF02516	0.568
MOD_NEK2_1	1	6	PF00069	0.372
MOD_NEK2_1	153	158	PF00069	0.563
MOD_NEK2_1	176	181	PF00069	0.616
MOD_NEK2_1	186	191	PF00069	0.512
MOD_NEK2_1	243	248	PF00069	0.749
MOD_NEK2_1	294	299	PF00069	0.671
MOD_NEK2_1	319	324	PF00069	0.722
MOD_NEK2_1	7	12	PF00069	0.364
MOD_NEK2_2	81	86	PF00069	0.327
MOD_PIKK_1	198	204	PF00454	0.572
MOD_PIKK_1	39	45	PF00454	0.344
MOD_PKA_2	153	159	PF00069	0.573
MOD_PKA_2	187	193	PF00069	0.560
MOD_PKA_2	262	268	PF00069	0.749
MOD_PKA_2	320	326	PF00069	0.692
MOD_PKA_2	371	377	PF00069	0.769
MOD_Plk_1	140	146	PF00069	0.647
MOD_Plk_1	234	240	PF00069	0.714
MOD_Plk_1	243	249	PF00069	0.715
MOD_Plk_4	77	83	PF00069	0.396
MOD_ProDKin_1	24	30	PF00069	0.414
MOD_ProDKin_1	246	252	PF00069	0.767
MOD_ProDKin_1	274	280	PF00069	0.777
MOD_SUMO_rev_2	303	313	PF00179	0.633
TRG_ENDOCYTIC_2	106	109	PF00928	0.621
TRG_ENDOCYTIC_2	379	382	PF00928	0.694
TRG_ENDOCYTIC_2	82	85	PF00928	0.373
TRG_ER_diArg_1	298	300	PF00400	0.640
TRG_ER_diArg_1	85	88	PF00400	0.406
TRG_ER_diArg_1	99	101	PF00400	0.559
TRG_NES_CRM1_1	165	178	PF08389	0.553
TRG_NLS_Bipartite_1	211	227	PF00514	0.637
TRG_NLS_MonoExtC_3	222	227	PF00514	0.668
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	70%	100%
A0A0S4IXL3	Bodo saltans	32%	100%
A0A1X0NPE0	Trypanosomatidae	38%	100%
A0A3R7NBC4	Trypanosoma rangeli	46%	100%
A0A3S7WPV5	Leishmania donovani	86%	99%
A4HT79	Leishmania infantum	88%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AL61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIP3	Leishmania major	87%	100%
V5B859	Trypanosoma cruzi	44%	100%