WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Z9_LEIBR

TriTrypDb:

LbrM.07.0550 , LBRM2903_070011900

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A4H4Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Z9

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.693
CLV_C14_Caspase3-7	179	183	PF00656	0.653
CLV_NRD_NRD_1	100	102	PF00675	0.386
CLV_NRD_NRD_1	103	105	PF00675	0.404
CLV_NRD_NRD_1	147	149	PF00675	0.450
CLV_NRD_NRD_1	211	213	PF00675	0.414
CLV_NRD_NRD_1	299	301	PF00675	0.440
CLV_PCSK_KEX2_1	147	149	PF00082	0.429
CLV_PCSK_KEX2_1	211	213	PF00082	0.406
CLV_PCSK_KEX2_1	224	226	PF00082	0.350

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSU4	Leptomonas seymouri	70%	100%
A0A0S4IXL3	Bodo saltans	32%	100%
A0A1X0NPE0	Trypanosomatidae	38%	100%
A0A3R7NBC4	Trypanosoma rangeli	46%	100%
A0A3S7WPV5	Leishmania donovani	86%	99%
A4HT79	Leishmania infantum	88%	100%
C9ZUQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AL61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIP3	Leishmania major	87%	100%
V5B859	Trypanosoma cruzi	44%	100%

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