DHC_N2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein heavy chain, N-terminal region 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Z8_LEIBR

TriTrypDb:

LbrM.07.0540 , LBRM2903_070011800

Length:

4544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005875	microtubule associated complex	2	7
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	7

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Expansion

Sequence features

A4H4Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0007018	microtubule-based movement	3	7
GO:0009987	cellular process	1	7

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Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	7
GO:0003777	microtubule motor activity	2	7
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0008569	minus-end-directed microtubule motor activity	3	7
GO:0045505	dynein intermediate chain binding	3	7
GO:0051959	dynein light intermediate chain binding	3	7
GO:0140657	ATP-dependent activity	1	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1230	1234	PF00656	0.484
CLV_C14_Caspase3-7	1264	1268	PF00656	0.287
CLV_C14_Caspase3-7	1474	1478	PF00656	0.476
CLV_C14_Caspase3-7	2000	2004	PF00656	0.504
CLV_C14_Caspase3-7	2395	2399	PF00656	0.633
CLV_C14_Caspase3-7	2554	2558	PF00656	0.488
CLV_C14_Caspase3-7	2730	2734	PF00656	0.403
CLV_C14_Caspase3-7	2905	2909	PF00656	0.277
CLV_C14_Caspase3-7	3254	3258	PF00656	0.311
CLV_C14_Caspase3-7	3592	3596	PF00656	0.268

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK1	Leptomonas seymouri	42%	100%
A0A3S5H5Y2	Leishmania donovani	76%	94%
A4HT80	Leishmania infantum	76%	94%
E9AL60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%
Q4QIP4	Leishmania major	75%	100%

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