Putative acyl-CoA dehydrogenase, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA dehydrogenase, mitochondrial precursor, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Z2_LEIBR

TriTrypDb:

LbrM.07.0480 , LBRM2903_070011200

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Z2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019605	butyrate metabolic process	6	1
GO:0019626	short-chain fatty acid catabolic process	6	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046359	butyrate catabolic process	7	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0046459	short-chain fatty acid metabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003995	acyl-CoA dehydrogenase activity	5	1
GO:0004085	butyryl-CoA dehydrogenase activity	6	1
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.211
CLV_C14_Caspase3-7	407	411	PF00656	0.437
CLV_C14_Caspase3-7	92	96	PF00656	0.387
CLV_NRD_NRD_1	2	4	PF00675	0.518
CLV_NRD_NRD_1	37	39	PF00675	0.365
CLV_PCSK_KEX2_1	2	4	PF00082	0.518
CLV_PCSK_KEX2_1	261	263	PF00082	0.284
CLV_PCSK_KEX2_1	506	508	PF00082	0.351
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.299
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.366
CLV_PCSK_SKI1_1	118	122	PF00082	0.257
CLV_PCSK_SKI1_1	123	127	PF00082	0.257
CLV_PCSK_SKI1_1	184	188	PF00082	0.385
CLV_PCSK_SKI1_1	2	6	PF00082	0.587
CLV_PCSK_SKI1_1	208	212	PF00082	0.462
CLV_PCSK_SKI1_1	241	245	PF00082	0.428
CLV_PCSK_SKI1_1	348	352	PF00082	0.350
CLV_PCSK_SKI1_1	464	468	PF00082	0.336
CLV_PCSK_SKI1_1	68	72	PF00082	0.329
CLV_Separin_Metazoa	515	519	PF03568	0.384
DEG_APCC_DBOX_1	347	355	PF00400	0.431
DEG_Nend_UBRbox_1	1	4	PF02207	0.566
DEG_SPOP_SBC_1	319	323	PF00917	0.328
DOC_CYCLIN_RxL_1	461	468	PF00134	0.250
DOC_MAPK_FxFP_2	33	36	PF00069	0.323
DOC_PP1_SILK_1	257	262	PF00149	0.295
DOC_PP2B_LxvP_1	301	304	PF13499	0.437
DOC_PP4_FxxP_1	33	36	PF00568	0.323
DOC_USP7_MATH_1	289	293	PF00917	0.261
DOC_USP7_MATH_1	313	317	PF00917	0.373
DOC_USP7_MATH_1	34	38	PF00917	0.449
DOC_USP7_MATH_1	408	412	PF00917	0.400
DOC_USP7_MATH_1	451	455	PF00917	0.259
DOC_USP7_MATH_1	501	505	PF00917	0.486
DOC_WW_Pin1_4	222	227	PF00397	0.345
DOC_WW_Pin1_4	331	336	PF00397	0.445
LIG_14-3-3_CanoR_1	14	19	PF00244	0.307
LIG_14-3-3_CanoR_1	2	12	PF00244	0.522
LIG_14-3-3_CanoR_1	200	204	PF00244	0.330
LIG_14-3-3_CanoR_1	241	246	PF00244	0.428
LIG_14-3-3_CanoR_1	26	35	PF00244	0.337
LIG_14-3-3_CanoR_1	348	354	PF00244	0.400
LIG_14-3-3_CanoR_1	378	383	PF00244	0.437
LIG_14-3-3_CanoR_1	56	64	PF00244	0.306
LIG_14-3-3_CanoR_1	68	76	PF00244	0.120
LIG_Actin_WH2_2	252	270	PF00022	0.431
LIG_APCC_ABBA_1	243	248	PF00400	0.296
LIG_BRCT_BRCA1_1	355	359	PF00533	0.357
LIG_DLG_GKlike_1	14	22	PF00625	0.347
LIG_FHA_1	175	181	PF00498	0.301
LIG_FHA_1	200	206	PF00498	0.399
LIG_FHA_1	296	302	PF00498	0.443
LIG_FHA_1	377	383	PF00498	0.404
LIG_FHA_1	466	472	PF00498	0.306
LIG_FHA_2	187	193	PF00498	0.462
LIG_FHA_2	48	54	PF00498	0.350
LIG_FHA_2	498	504	PF00498	0.399
LIG_FHA_2	90	96	PF00498	0.387
LIG_LIR_Apic_2	30	36	PF02991	0.325
LIG_LIR_Gen_1	177	186	PF02991	0.284
LIG_LIR_Gen_1	323	333	PF02991	0.459
LIG_LIR_Gen_1	477	487	PF02991	0.358
LIG_LIR_Nem_3	177	182	PF02991	0.288
LIG_LIR_Nem_3	202	206	PF02991	0.359
LIG_LIR_Nem_3	323	329	PF02991	0.448
LIG_LIR_Nem_3	370	375	PF02991	0.367
LIG_LIR_Nem_3	502	508	PF02991	0.360
LIG_LIR_Nem_3	71	76	PF02991	0.257
LIG_MAD2	26	34	PF02301	0.382
LIG_PCNA_yPIPBox_3	426	437	PF02747	0.243
LIG_SH2_CRK	372	376	PF00017	0.468
LIG_SH2_CRK	505	509	PF00017	0.384
LIG_SH2_CRK	73	77	PF00017	0.257
LIG_SH2_SRC	250	253	PF00017	0.291
LIG_SH2_STAP1	15	19	PF00017	0.236
LIG_SH2_STAP1	252	256	PF00017	0.262
LIG_SH2_STAP1	295	299	PF00017	0.268
LIG_SH2_STAP1	361	365	PF00017	0.301
LIG_SH2_STAP1	449	453	PF00017	0.254
LIG_SH2_STAT5	110	113	PF00017	0.278
LIG_SH2_STAT5	12	15	PF00017	0.511
LIG_SH2_STAT5	124	127	PF00017	0.189
LIG_SH2_STAT5	162	165	PF00017	0.322
LIG_SH2_STAT5	179	182	PF00017	0.296
LIG_SH2_STAT5	250	253	PF00017	0.272
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.182
LIG_SUMO_SIM_par_1	241	248	PF11976	0.280
LIG_TRAF2_1	138	141	PF00917	0.231
LIG_UBA3_1	256	261	PF00899	0.292
LIG_UBA3_1	51	60	PF00899	0.378
MOD_CK1_1	129	135	PF00069	0.266
MOD_CK1_1	145	151	PF00069	0.487
MOD_CK1_1	199	205	PF00069	0.419
MOD_CK1_1	328	334	PF00069	0.372
MOD_CK1_1	42	48	PF00069	0.458
MOD_CK1_1	491	497	PF00069	0.472
MOD_CK1_1	93	99	PF00069	0.320
MOD_CK2_1	186	192	PF00069	0.489
MOD_CK2_1	267	273	PF00069	0.502
MOD_CK2_1	349	355	PF00069	0.375
MOD_CK2_1	47	53	PF00069	0.296
MOD_CK2_1	55	61	PF00069	0.190
MOD_GlcNHglycan	174	177	PF01048	0.255
MOD_GlcNHglycan	207	211	PF01048	0.392
MOD_GlcNHglycan	291	294	PF01048	0.249
MOD_GlcNHglycan	362	365	PF01048	0.424
MOD_GlcNHglycan	405	409	PF01048	0.471
MOD_GlcNHglycan	410	413	PF01048	0.454
MOD_GlcNHglycan	451	454	PF01048	0.267
MOD_GlcNHglycan	6	9	PF01048	0.599
MOD_GlcNHglycan	92	95	PF01048	0.273
MOD_GSK3_1	106	113	PF00069	0.166
MOD_GSK3_1	148	155	PF00069	0.355
MOD_GSK3_1	182	189	PF00069	0.372
MOD_GSK3_1	325	332	PF00069	0.361
MOD_GSK3_1	349	356	PF00069	0.392
MOD_GSK3_1	404	411	PF00069	0.418
MOD_GSK3_1	449	456	PF00069	0.268
MOD_GSK3_1	497	504	PF00069	0.509
MOD_GSK3_1	89	96	PF00069	0.323
MOD_N-GLC_1	426	431	PF02516	0.382
MOD_NEK2_1	111	116	PF00069	0.225
MOD_NEK2_1	164	169	PF00069	0.304
MOD_NEK2_1	172	177	PF00069	0.279
MOD_NEK2_1	182	187	PF00069	0.283
MOD_NEK2_1	196	201	PF00069	0.419
MOD_NEK2_1	267	272	PF00069	0.375
MOD_NEK2_1	318	323	PF00069	0.341
MOD_NEK2_1	349	354	PF00069	0.369
MOD_NEK2_1	359	364	PF00069	0.264
MOD_NEK2_1	376	381	PF00069	0.329
MOD_NEK2_1	404	409	PF00069	0.446
MOD_NEK2_1	460	465	PF00069	0.371
MOD_NEK2_1	475	480	PF00069	0.260
MOD_NEK2_1	78	83	PF00069	0.242
MOD_NEK2_1	98	103	PF00069	0.282
MOD_NEK2_2	313	318	PF00069	0.432
MOD_PIKK_1	136	142	PF00454	0.448
MOD_PIKK_1	184	190	PF00454	0.358
MOD_PIKK_1	426	432	PF00454	0.359
MOD_PK_1	211	217	PF00069	0.472
MOD_PK_1	325	331	PF00069	0.232
MOD_PKA_2	199	205	PF00069	0.320
MOD_PKA_2	267	273	PF00069	0.502
MOD_PKA_2	377	383	PF00069	0.443
MOD_PKA_2	55	61	PF00069	0.306
MOD_Plk_1	145	151	PF00069	0.361
MOD_Plk_1	305	311	PF00069	0.373
MOD_Plk_1	404	410	PF00069	0.351
MOD_Plk_1	501	507	PF00069	0.456
MOD_Plk_2-3	302	308	PF00069	0.461
MOD_Plk_4	106	112	PF00069	0.331
MOD_Plk_4	129	135	PF00069	0.300
MOD_Plk_4	14	20	PF00069	0.269
MOD_Plk_4	199	205	PF00069	0.307
MOD_Plk_4	252	258	PF00069	0.234
MOD_Plk_4	305	311	PF00069	0.326
MOD_Plk_4	313	319	PF00069	0.259
MOD_Plk_4	325	331	PF00069	0.189
MOD_Plk_4	349	355	PF00069	0.347
MOD_Plk_4	443	449	PF00069	0.293
MOD_Plk_4	47	53	PF00069	0.281
MOD_Plk_4	475	481	PF00069	0.395
MOD_ProDKin_1	222	228	PF00069	0.346
MOD_ProDKin_1	331	337	PF00069	0.441
MOD_SUMO_for_1	469	472	PF00179	0.361
MOD_SUMO_rev_2	89	99	PF00179	0.335
TRG_DiLeu_BaEn_1	370	375	PF01217	0.467
TRG_DiLeu_BaEn_1	443	448	PF01217	0.275
TRG_DiLeu_BaEn_2	354	360	PF01217	0.288
TRG_ENDOCYTIC_2	179	182	PF00928	0.407
TRG_ENDOCYTIC_2	372	375	PF00928	0.373
TRG_ENDOCYTIC_2	505	508	PF00928	0.386
TRG_ENDOCYTIC_2	73	76	PF00928	0.242
TRG_ER_diArg_1	1	3	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I163	Leptomonas seymouri	82%	100%
A0A0S4JAW1	Bodo saltans	38%	81%
A0A1X0NP97	Trypanosomatidae	55%	99%
A0A3S5H5Y0	Leishmania donovani	89%	100%
A0A422NAN1	Trypanosoma rangeli	56%	99%
A4HT68	Leishmania infantum	89%	100%
B1WC61	Rattus norvegicus	28%	83%
C9ZUR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AL57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
P45953	Rattus norvegicus	26%	79%
P48818	Bos taurus	26%	79%
P49748	Homo sapiens	24%	79%
P50544	Mus musculus	26%	79%
Q4QIP7	Leishmania major	89%	100%
Q8HXY7	Macaca fascicularis	24%	79%
Q8JZN5	Mus musculus	28%	83%
Q9H845	Homo sapiens	27%	84%
V5BCS4	Trypanosoma cruzi	55%	99%