Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Z1_LEIBR

TriTrypDb:

LbrM.07.0470 , LBRM2903_070011100

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Z1

PDB structure(s): 7ane_h

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.515
CLV_NRD_NRD_1	68	70	PF00675	0.355
CLV_PCSK_KEX2_1	19	21	PF00082	0.401
CLV_PCSK_SKI1_1	158	162	PF00082	0.401
CLV_PCSK_SKI1_1	5	9	PF00082	0.512
CLV_PCSK_SKI1_1	69	73	PF00082	0.380
DEG_MDM2_SWIB_1	36	44	PF02201	0.358
DEG_Nend_Nbox_1	1	3	PF02207	0.503
DOC_MAPK_gen_1	120	129	PF00069	0.356
DOC_PP4_FxxP_1	82	85	PF00568	0.360
LIG_14-3-3_CanoR_1	19	26	PF00244	0.429
LIG_14-3-3_CanoR_1	69	76	PF00244	0.389
LIG_eIF4E_1	76	82	PF01652	0.365
LIG_FHA_1	20	26	PF00498	0.421
LIG_LIR_Gen_1	75	84	PF02991	0.460
LIG_LIR_Gen_1	93	102	PF02991	0.253
LIG_LIR_Nem_3	104	110	PF02991	0.399
LIG_LIR_Nem_3	75	79	PF02991	0.409
LIG_LIR_Nem_3	93	98	PF02991	0.252
LIG_Pex14_2	36	40	PF04695	0.363
LIG_PTB_Apo_2	109	116	PF02174	0.266
LIG_PTB_Phospho_1	109	115	PF10480	0.266
LIG_SH2_CRK	110	114	PF00017	0.453
LIG_SH2_CRK	86	90	PF00017	0.292
LIG_SH2_CRK	95	99	PF00017	0.295
LIG_SH2_GRB2like	110	113	PF00017	0.364
LIG_SH2_NCK_1	110	114	PF00017	0.377
LIG_SH2_SRC	110	113	PF00017	0.360
LIG_SH2_STAP1	32	36	PF00017	0.352
LIG_SH3_3	48	54	PF00018	0.442
LIG_TYR_ITIM	108	113	PF00017	0.363
LIG_TYR_ITIM	161	166	PF00017	0.395
LIG_TYR_ITIM	84	89	PF00017	0.393
MOD_CK1_1	114	120	PF00069	0.374
MOD_GlcNHglycan	123	126	PF01048	0.389
MOD_GlcNHglycan	59	62	PF01048	0.457
MOD_N-GLC_1	111	116	PF02516	0.329
MOD_NEK2_1	121	126	PF00069	0.397
MOD_NEK2_1	55	60	PF00069	0.432
MOD_NEK2_2	32	37	PF00069	0.356
MOD_PKA_1	19	25	PF00069	0.381
MOD_PKA_1	69	75	PF00069	0.420
MOD_PKA_2	19	25	PF00069	0.449
MOD_Plk_1	111	117	PF00069	0.323
MOD_Plk_1	139	145	PF00069	0.445
MOD_Plk_1	32	38	PF00069	0.357
TRG_ENDOCYTIC_2	110	113	PF00928	0.364
TRG_ENDOCYTIC_2	115	118	PF00928	0.203
TRG_ENDOCYTIC_2	163	166	PF00928	0.404
TRG_ENDOCYTIC_2	76	79	PF00928	0.394
TRG_ENDOCYTIC_2	86	89	PF00928	0.351
TRG_ENDOCYTIC_2	95	98	PF00928	0.279
TRG_ER_diArg_1	18	20	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E2	Leptomonas seymouri	88%	100%
A0A0S4JA27	Bodo saltans	63%	100%
A0A1X0NPB0	Trypanosomatidae	77%	100%
A0A3S7WPU0	Leishmania donovani	95%	100%
A0A422NAP1	Trypanosoma rangeli	76%	100%
A4HT67	Leishmania infantum	95%	100%
C9ZUR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AL56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QIP8	Leishmania major	94%	100%