Putative 3-hydroxyacyl-ACP dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyacyl-ACP dehydratase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Z0_LEIBR

TriTrypDb:

LbrM.07.0460 , LBRM2903_070010900

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Z0

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006633	fatty acid biosynthetic process	5	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0016053	organic acid biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046394	carboxylic acid biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072330	monocarboxylic acid biosynthetic process	6	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0019171	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	5	2
GO:0004312	fatty acid synthase activity	5	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.307
CLV_PCSK_KEX2_1	107	109	PF00082	0.284
DEG_Nend_UBRbox_3	1	3	PF02207	0.542
DEG_ODPH_VHL_1	88	99	PF01847	0.148
DOC_PP1_RVXF_1	141	148	PF00149	0.344
DOC_PP4_FxxP_1	51	54	PF00568	0.304
DOC_PP4_FxxP_1	87	90	PF00568	0.263
DOC_USP7_MATH_1	13	17	PF00917	0.249
DOC_USP7_MATH_1	38	42	PF00917	0.357
DOC_WW_Pin1_4	50	55	PF00397	0.304
LIG_14-3-3_CanoR_1	107	115	PF00244	0.186
LIG_14-3-3_CanoR_1	20	28	PF00244	0.246
LIG_Actin_RPEL_3	100	119	PF02755	0.247
LIG_Clathr_ClatBox_1	144	148	PF01394	0.223
LIG_FHA_1	108	114	PF00498	0.298
LIG_FHA_1	16	22	PF00498	0.325
LIG_FHA_1	76	82	PF00498	0.357
LIG_FHA_2	130	136	PF00498	0.298
LIG_FHA_2	20	26	PF00498	0.308
LIG_GBD_Chelix_1	60	68	PF00786	0.269
LIG_LIR_Apic_2	84	90	PF02991	0.269
LIG_LIR_Nem_3	63	68	PF02991	0.277
LIG_Rb_LxCxE_1	129	148	PF01857	0.308
LIG_SH2_STAT3	80	83	PF00017	0.263
LIG_SH2_STAT5	80	83	PF00017	0.279
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.354
MOD_CK1_1	151	157	PF00069	0.427
MOD_CK1_1	63	69	PF00069	0.263
MOD_CK2_1	129	135	PF00069	0.366
MOD_GlcNHglycan	65	68	PF01048	0.279
MOD_GSK3_1	122	129	PF00069	0.439
MOD_GSK3_1	15	22	PF00069	0.404
MOD_GSK3_1	75	82	PF00069	0.305
MOD_NEK2_1	106	111	PF00069	0.178
MOD_NEK2_1	60	65	PF00069	0.247
MOD_NEK2_1	81	86	PF00069	0.272
MOD_NEK2_2	15	20	PF00069	0.353
MOD_PIKK_1	101	107	PF00454	0.238
MOD_PIKK_1	19	25	PF00454	0.297
MOD_PIKK_1	79	85	PF00454	0.279
MOD_PKA_1	107	113	PF00069	0.323
MOD_PKA_2	106	112	PF00069	0.176
MOD_PKA_2	19	25	PF00069	0.374
MOD_Plk_1	113	119	PF00069	0.337
MOD_Plk_4	114	120	PF00069	0.315
MOD_Plk_4	60	66	PF00069	0.280
MOD_Plk_4	75	81	PF00069	0.263
MOD_ProDKin_1	50	56	PF00069	0.304
TRG_ER_diArg_1	106	108	PF00400	0.266
TRG_PTS1	154	157	PF00515	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R8	Leptomonas seymouri	64%	100%
A0A0N1I7V2	Leptomonas seymouri	69%	100%
A0A0S4J3A3	Bodo saltans	49%	96%
A0A1X0NPA8	Trypanosomatidae	58%	97%
A0A3S5H5X9	Leishmania donovani	61%	100%
A0A3S7WPU4	Leishmania donovani	85%	100%
A0A422NAR2	Trypanosoma rangeli	57%	100%
A4HT65	Leishmania infantum	61%	100%
A4HT66	Leishmania infantum	85%	100%
C9ZUR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	97%
E9AL54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AL55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O32472	Aeromonas caviae	41%	100%
P86397	Homo sapiens	34%	93%
Q4QIP9	Leishmania major	87%	100%
Q4QIQ0	Leishmania major	61%	100%