Putative 3-hydroxyacyl-ACP dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyacyl-ACP dehydratase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Y9_LEIBR

TriTrypDb:

LbrM.07.0450 , LBRM2903_070010900

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016829	lyase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	106	112	PF00089	0.695
CLV_NRD_NRD_1	205	207	PF00675	0.600
CLV_PCSK_SKI1_1	241	245	PF00082	0.690
DEG_SPOP_SBC_1	80	84	PF00917	0.930
DOC_CKS1_1	37	42	PF01111	0.845
DOC_CYCLIN_RxL_1	238	249	PF00134	0.680
DOC_MAPK_gen_1	206	214	PF00069	0.659
DOC_PP1_RVXF_1	239	246	PF00149	0.679
DOC_PP4_FxxP_1	186	189	PF00568	0.600
DOC_USP7_MATH_1	137	141	PF00917	0.600
DOC_USP7_MATH_1	97	101	PF00917	0.859
DOC_WW_Pin1_4	36	41	PF00397	0.856
DOC_WW_Pin1_4	92	97	PF00397	0.893
LIG_14-3-3_CanoR_1	185	189	PF00244	0.600
LIG_BIR_II_1	1	5	PF00653	0.859
LIG_EVH1_1	52	56	PF00568	0.827
LIG_EVH1_2	53	57	PF00568	0.825
LIG_FHA_1	105	111	PF00498	0.706
LIG_FHA_1	113	119	PF00498	0.459
LIG_FHA_1	175	181	PF00498	0.600
LIG_FHA_1	185	191	PF00498	0.425
LIG_FHA_2	42	48	PF00498	0.823
LIG_FHA_2	9	15	PF00498	0.853
LIG_LIR_Gen_1	6	14	PF02991	0.859
LIG_LIR_Gen_1	60	70	PF02991	0.828
LIG_LIR_Nem_3	126	131	PF02991	0.600
LIG_LIR_Nem_3	153	159	PF02991	0.600
LIG_LIR_Nem_3	162	167	PF02991	0.442
LIG_LIR_Nem_3	6	10	PF02991	0.867
LIG_LIR_Nem_3	60	65	PF02991	0.817
LIG_OCRL_FandH_1	19	31	PF00620	0.867
LIG_SH2_GRB2like	48	51	PF00017	0.827
LIG_SH2_STAT3	119	122	PF00017	0.600
LIG_SH2_STAT3	179	182	PF00017	0.600
LIG_SH2_STAT5	119	122	PF00017	0.600
LIG_SH2_STAT5	179	182	PF00017	0.600
LIG_SH2_STAT5	213	216	PF00017	0.652
LIG_SH2_STAT5	61	64	PF00017	0.818
LIG_SH3_3	50	56	PF00018	0.826
LIG_SUMO_SIM_par_1	198	204	PF11976	0.600
LIG_UBA3_1	163	170	PF00899	0.600
LIG_WRC_WIRS_1	125	130	PF05994	0.600
MOD_CK1_1	112	118	PF00069	0.250
MOD_CK1_1	162	168	PF00069	0.600
MOD_CK1_1	38	44	PF00069	0.827
MOD_CK1_1	64	70	PF00069	0.832
MOD_CK1_1	81	87	PF00069	0.633
MOD_CK1_1	92	98	PF00069	0.697
MOD_CK2_1	137	143	PF00069	0.600
MOD_CK2_1	41	47	PF00069	0.816
MOD_CK2_1	8	14	PF00069	0.854
MOD_CK2_1	81	87	PF00069	0.930
MOD_GlcNHglycan	164	167	PF01048	0.600
MOD_GlcNHglycan	233	237	PF01048	0.644
MOD_GlcNHglycan	74	78	PF01048	0.890
MOD_GSK3_1	114	121	PF00069	0.600
MOD_GSK3_1	174	181	PF00069	0.600
MOD_GSK3_1	218	225	PF00069	0.696
MOD_GSK3_1	57	64	PF00069	0.821
MOD_GSK3_1	65	72	PF00069	0.701
MOD_GSK3_1	79	86	PF00069	0.684
MOD_GSK3_1	8	15	PF00069	0.854
MOD_N-GLC_1	123	128	PF02516	0.600
MOD_NEK2_1	184	189	PF00069	0.600
MOD_NEK2_1	35	40	PF00069	0.873
MOD_NEK2_1	57	62	PF00069	0.818
MOD_NEK2_2	114	119	PF00069	0.600
MOD_NEK2_2	159	164	PF00069	0.600
MOD_NEK2_2	18	23	PF00069	0.880
MOD_PIKK_1	109	115	PF00454	0.692
MOD_PIKK_1	118	124	PF00454	0.442
MOD_PIKK_1	178	184	PF00454	0.600
MOD_PKA_2	184	190	PF00069	0.600
MOD_PKB_1	71	79	PF00069	0.884
MOD_Plk_1	123	129	PF00069	0.600
MOD_Plk_4	114	120	PF00069	0.600
MOD_Plk_4	159	165	PF00069	0.600
MOD_Plk_4	174	180	PF00069	0.337
MOD_Plk_4	225	231	PF00069	0.701
MOD_Plk_4	57	63	PF00069	0.822
MOD_Plk_4	65	71	PF00069	0.700
MOD_ProDKin_1	36	42	PF00069	0.851
MOD_ProDKin_1	92	98	PF00069	0.890
MOD_SUMO_for_1	243	246	PF00179	0.677
TRG_ER_diArg_1	70	73	PF00400	0.859

Homologs


Protein	Taxonomy	Sequence identity	Coverage
C5AZ74	METEA	42%	100%
O32472	AERCA	39%	100%
P86397	HUMAN	34%	100%
P9WNP2	MYCTO	35%	100%
P9WNP3	MYCTU	35%	100%
Q2RQ36	RHORT	36%	100%
Q7U2S5	MYCBO	35%	100%