SIN1_PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Y7_LEIBR

TriTrypDb:

LbrM.07.0430 , LBRM2903_070010700

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.623
CLV_NRD_NRD_1	21	23	PF00675	0.586
CLV_NRD_NRD_1	476	478	PF00675	0.393
CLV_NRD_NRD_1	479	481	PF00675	0.393
CLV_PCSK_KEX2_1	155	157	PF00082	0.476
CLV_PCSK_KEX2_1	476	478	PF00082	0.413
CLV_PCSK_KEX2_1	481	483	PF00082	0.417
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.491
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.456
CLV_PCSK_PC7_1	477	483	PF00082	0.469
CLV_PCSK_SKI1_1	236	240	PF00082	0.466
CLV_PCSK_SKI1_1	243	247	PF00082	0.500
CLV_PCSK_SKI1_1	334	338	PF00082	0.374
CLV_PCSK_SKI1_1	424	428	PF00082	0.340
CLV_PCSK_SKI1_1	499	503	PF00082	0.567
CLV_PCSK_SKI1_1	58	62	PF00082	0.653
CLV_Separin_Metazoa	360	364	PF03568	0.667
DOC_MAPK_FxFP_2	238	241	PF00069	0.476
DOC_MAPK_gen_1	155	161	PF00069	0.616
DOC_MAPK_gen_1	424	434	PF00069	0.421
DOC_MAPK_MEF2A_6	155	163	PF00069	0.505
DOC_MAPK_MEF2A_6	252	260	PF00069	0.553
DOC_PP1_RVXF_1	56	63	PF00149	0.437
DOC_PP4_FxxP_1	238	241	PF00568	0.484
DOC_SPAK_OSR1_1	341	345	PF12202	0.357
DOC_USP7_MATH_1	129	133	PF00917	0.689
DOC_USP7_MATH_1	181	185	PF00917	0.416
DOC_USP7_MATH_1	412	416	PF00917	0.447
DOC_USP7_MATH_1	45	49	PF00917	0.683
DOC_USP7_UBL2_3	23	27	PF12436	0.610
DOC_WW_Pin1_4	102	107	PF00397	0.471
DOC_WW_Pin1_4	25	30	PF00397	0.559
LIG_14-3-3_CanoR_1	123	129	PF00244	0.486
LIG_14-3-3_CanoR_1	144	150	PF00244	0.414
LIG_14-3-3_CanoR_1	156	162	PF00244	0.414
LIG_14-3-3_CanoR_1	191	199	PF00244	0.411
LIG_14-3-3_CanoR_1	334	340	PF00244	0.368
LIG_14-3-3_CanoR_1	411	419	PF00244	0.333
LIG_14-3-3_CanoR_1	58	63	PF00244	0.449
LIG_14-3-3_CanoR_1	85	93	PF00244	0.631
LIG_APCC_ABBA_1	432	437	PF00400	0.365
LIG_BRCT_BRCA1_1	448	452	PF00533	0.365
LIG_BRCT_BRCA1_1	505	509	PF00533	0.537
LIG_Clathr_ClatBox_1	399	403	PF01394	0.421
LIG_deltaCOP1_diTrp_1	34	43	PF00928	0.669
LIG_FHA_1	138	144	PF00498	0.582
LIG_FHA_1	156	162	PF00498	0.375
LIG_FHA_1	249	255	PF00498	0.528
LIG_FHA_1	85	91	PF00498	0.610
LIG_FHA_2	125	131	PF00498	0.701
LIG_FHA_2	206	212	PF00498	0.413
LIG_FHA_2	248	254	PF00498	0.515
LIG_FHA_2	37	43	PF00498	0.540
LIG_FHA_2	59	65	PF00498	0.568
LIG_GBD_Chelix_1	365	373	PF00786	0.482
LIG_HCF-1_HBM_1	405	408	PF13415	0.421
LIG_Integrin_isoDGR_2	350	352	PF01839	0.524
LIG_LIR_Gen_1	34	45	PF02991	0.730
LIG_LIR_Gen_1	380	389	PF02991	0.317
LIG_LIR_Gen_1	454	463	PF02991	0.329
LIG_LIR_Gen_1	61	70	PF02991	0.556
LIG_LIR_Gen_1	78	88	PF02991	0.408
LIG_LIR_Nem_3	167	171	PF02991	0.464
LIG_LIR_Nem_3	223	227	PF02991	0.403
LIG_LIR_Nem_3	316	320	PF02991	0.414
LIG_LIR_Nem_3	34	40	PF02991	0.733
LIG_LIR_Nem_3	380	384	PF02991	0.317
LIG_LIR_Nem_3	61	65	PF02991	0.538
LIG_LIR_Nem_3	78	83	PF02991	0.442
LIG_PCNA_yPIPBox_3	191	202	PF02747	0.447
LIG_SH2_CRK	26	30	PF00017	0.643
LIG_SH2_GRB2like	317	320	PF00017	0.411
LIG_SH2_STAT5	207	210	PF00017	0.542
LIG_SH2_STAT5	24	27	PF00017	0.508
LIG_SH2_STAT5	408	411	PF00017	0.315
LIG_SH2_STAT5	446	449	PF00017	0.336
LIG_SH3_3	259	265	PF00018	0.476
LIG_SH3_3	324	330	PF00018	0.573
LIG_TRAF2_1	208	211	PF00917	0.399
LIG_TRAF2_1	353	356	PF00917	0.601
LIG_WRC_WIRS_1	146	151	PF05994	0.416
MOD_CDC14_SPxK_1	105	108	PF00782	0.475
MOD_CDK_SPxK_1	102	108	PF00069	0.473
MOD_CK1_1	48	54	PF00069	0.673
MOD_CK2_1	205	211	PF00069	0.405
MOD_CK2_1	447	453	PF00069	0.287
MOD_CK2_1	58	64	PF00069	0.579
MOD_Cter_Amidation	153	156	PF01082	0.479
MOD_GlcNHglycan	130	134	PF01048	0.495
MOD_GlcNHglycan	29	32	PF01048	0.483
MOD_GlcNHglycan	295	298	PF01048	0.545
MOD_GlcNHglycan	47	50	PF01048	0.675
MOD_GlcNHglycan	99	102	PF01048	0.637
MOD_GSK3_1	119	126	PF00069	0.753
MOD_GSK3_1	129	136	PF00069	0.704
MOD_GSK3_1	157	164	PF00069	0.592
MOD_GSK3_1	186	193	PF00069	0.445
MOD_GSK3_1	281	288	PF00069	0.578
MOD_GSK3_1	44	51	PF00069	0.651
MOD_GSK3_1	499	506	PF00069	0.612
MOD_GSK3_1	93	100	PF00069	0.658
MOD_LATS_1	490	496	PF00433	0.374
MOD_N-GLC_1	123	128	PF02516	0.649
MOD_N-GLC_1	161	166	PF02516	0.598
MOD_N-GLC_1	247	252	PF02516	0.612
MOD_N-GLC_1	254	259	PF02516	0.480
MOD_N-GLC_1	412	417	PF02516	0.421
MOD_N-GLC_1	45	50	PF02516	0.686
MOD_N-GLC_1	492	497	PF02516	0.516
MOD_NEK2_1	161	166	PF00069	0.576
MOD_NEK2_1	246	251	PF00069	0.608
MOD_NEK2_1	285	290	PF00069	0.528
MOD_PIKK_1	161	167	PF00454	0.609
MOD_PIKK_1	186	192	PF00454	0.563
MOD_PKA_1	155	161	PF00069	0.506
MOD_PKA_2	155	161	PF00069	0.558
MOD_PKA_2	190	196	PF00069	0.452
MOD_PKA_2	84	90	PF00069	0.582
MOD_Plk_1	123	129	PF00069	0.676
MOD_Plk_1	254	260	PF00069	0.500
MOD_Plk_1	285	291	PF00069	0.533
MOD_Plk_1	332	338	PF00069	0.363
MOD_Plk_1	492	498	PF00069	0.491
MOD_Plk_4	145	151	PF00069	0.537
MOD_Plk_4	335	341	PF00069	0.394
MOD_ProDKin_1	102	108	PF00069	0.473
MOD_ProDKin_1	25	31	PF00069	0.560
MOD_SUMO_rev_2	147	157	PF00179	0.523
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.421
TRG_ENDOCYTIC_2	168	171	PF00928	0.504
TRG_ENDOCYTIC_2	199	202	PF00928	0.458
TRG_ENDOCYTIC_2	317	320	PF00928	0.456
TRG_ENDOCYTIC_2	441	444	PF00928	0.295
TRG_ER_diArg_1	475	477	PF00400	0.437
TRG_ER_diArg_1	479	482	PF00400	0.458
TRG_ER_diArg_1	504	507	PF00400	0.568
TRG_NES_CRM1_1	364	377	PF08389	0.582
TRG_NES_CRM1_1	423	437	PF08389	0.197
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	398	403	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I2	Leptomonas seymouri	70%	99%
A0A0S4ILP7	Bodo saltans	40%	100%
A0A1X0NPY0	Trypanosomatidae	49%	100%
A0A3R7KA86	Trypanosoma rangeli	49%	100%
A0A3S7WPU9	Leishmania donovani	85%	100%
C9ZUR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AG73	Leishmania infantum	85%	100%
E9AL52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QIQ2	Leishmania major	85%	100%
V5D8S1	Trypanosoma cruzi	48%	100%