EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania braziliensis

UniProt:

A4H4Y6_LEIBR

TriTrypDb:

LbrM.07.0420 , LBRM2903_070010600

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4Y6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.637
CLV_MEL_PAP_1	459	465	PF00089	0.215
CLV_NRD_NRD_1	120	122	PF00675	0.419
CLV_NRD_NRD_1	174	176	PF00675	0.545
CLV_NRD_NRD_1	204	206	PF00675	0.432
CLV_NRD_NRD_1	289	291	PF00675	0.488
CLV_NRD_NRD_1	391	393	PF00675	0.487
CLV_NRD_NRD_1	398	400	PF00675	0.466
CLV_NRD_NRD_1	403	405	PF00675	0.272
CLV_NRD_NRD_1	408	410	PF00675	0.272
CLV_PCSK_FUR_1	118	122	PF00082	0.415
CLV_PCSK_FUR_1	174	178	PF00082	0.455
CLV_PCSK_FUR_1	396	400	PF00082	0.467
CLV_PCSK_FUR_1	401	405	PF00082	0.272
CLV_PCSK_KEX2_1	120	122	PF00082	0.419
CLV_PCSK_KEX2_1	173	175	PF00082	0.568
CLV_PCSK_KEX2_1	176	178	PF00082	0.500
CLV_PCSK_KEX2_1	204	206	PF00082	0.432
CLV_PCSK_KEX2_1	289	291	PF00082	0.488
CLV_PCSK_KEX2_1	390	392	PF00082	0.435
CLV_PCSK_KEX2_1	398	400	PF00082	0.466
CLV_PCSK_KEX2_1	403	405	PF00082	0.272
CLV_PCSK_KEX2_1	408	410	PF00082	0.272
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.453
CLV_PCSK_PC7_1	399	405	PF00082	0.440
CLV_PCSK_SKI1_1	198	202	PF00082	0.515
CLV_PCSK_SKI1_1	297	301	PF00082	0.572
CLV_PCSK_SKI1_1	412	416	PF00082	0.377
CLV_PCSK_SKI1_1	94	98	PF00082	0.472
DEG_APCC_DBOX_1	403	411	PF00400	0.472
DOC_CKS1_1	601	606	PF01111	0.308
DOC_CYCLIN_RxL_1	228	239	PF00134	0.639
DOC_CYCLIN_yClb5_NLxxxL_5	573	582	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	589	595	PF00134	0.308
DOC_CYCLIN_yCln2_LP_2	601	607	PF00134	0.308
DOC_MAPK_gen_1	173	183	PF00069	0.709
DOC_MAPK_gen_1	204	212	PF00069	0.633
DOC_MAPK_gen_1	408	417	PF00069	0.522
DOC_MAPK_MEF2A_6	205	214	PF00069	0.633
DOC_MAPK_MEF2A_6	320	327	PF00069	0.682
DOC_MAPK_MEF2A_6	345	353	PF00069	0.668
DOC_MAPK_MEF2A_6	61	70	PF00069	0.515
DOC_MAPK_NFAT4_5	320	328	PF00069	0.616
DOC_MAPK_RevD_3	190	205	PF00069	0.634
DOC_PP4_FxxP_1	416	419	PF00568	0.228
DOC_PP4_FxxP_1	517	520	PF00568	0.547
DOC_PP4_FxxP_1	557	560	PF00568	0.399
DOC_PP4_FxxP_1	92	95	PF00568	0.399
DOC_USP7_MATH_1	276	280	PF00917	0.699
DOC_USP7_MATH_1	510	514	PF00917	0.308
DOC_USP7_MATH_1	9	13	PF00917	0.699
DOC_WW_Pin1_4	280	285	PF00397	0.704
DOC_WW_Pin1_4	588	593	PF00397	0.308
DOC_WW_Pin1_4	600	605	PF00397	0.308
LIG_14-3-3_CanoR_1	120	125	PF00244	0.609
LIG_14-3-3_CanoR_1	220	229	PF00244	0.694
LIG_14-3-3_CanoR_1	263	273	PF00244	0.657
LIG_14-3-3_CanoR_1	403	408	PF00244	0.492
LIG_14-3-3_CanoR_1	460	469	PF00244	0.420
LIG_14-3-3_CanoR_1	492	496	PF00244	0.220
LIG_BIR_III_4	21	25	PF00653	0.702
LIG_BRCT_BRCA1_1	430	434	PF00533	0.220
LIG_BRCT_BRCA1_1	503	507	PF00533	0.325
LIG_BRCT_BRCA1_1	614	618	PF00533	0.293
LIG_CaM_NSCaTE_8	82	89	PF13499	0.293
LIG_FHA_1	128	134	PF00498	0.714
LIG_FHA_1	444	450	PF00498	0.308
LIG_FHA_1	476	482	PF00498	0.308
LIG_FHA_1	510	516	PF00498	0.336
LIG_FHA_1	588	594	PF00498	0.308
LIG_FHA_1	600	606	PF00498	0.351
LIG_FHA_1	622	628	PF00498	0.315
LIG_FHA_2	120	126	PF00498	0.628
LIG_FHA_2	352	358	PF00498	0.637
LIG_FHA_2	550	556	PF00498	0.423
LIG_GBD_Chelix_1	593	601	PF00786	0.308
LIG_Integrin_isoDGR_2	490	492	PF01839	0.555
LIG_LIR_Apic_2	555	560	PF02991	0.356
LIG_LIR_Apic_2	89	95	PF02991	0.364
LIG_LIR_Gen_1	431	442	PF02991	0.316
LIG_LIR_Gen_1	447	458	PF02991	0.293
LIG_LIR_Gen_1	55	64	PF02991	0.544
LIG_LIR_Gen_1	561	570	PF02991	0.322
LIG_LIR_Nem_3	431	437	PF02991	0.316
LIG_LIR_Nem_3	447	453	PF02991	0.309
LIG_LIR_Nem_3	455	459	PF02991	0.359
LIG_LIR_Nem_3	55	59	PF02991	0.540
LIG_LIR_Nem_3	561	565	PF02991	0.393
LIG_LIR_Nem_3	615	621	PF02991	0.316
LIG_MLH1_MIPbox_1	503	507	PF16413	0.308
LIG_NRBOX	536	542	PF00104	0.235
LIG_PDZ_Class_2	641	646	PF00595	0.591
LIG_Pex14_1	109	113	PF04695	0.308
LIG_Pex14_2	417	421	PF04695	0.308
LIG_Pex14_2	92	96	PF04695	0.362
LIG_Pex14_2	97	101	PF04695	0.286
LIG_PTAP_UEV_1	277	282	PF05743	0.649
LIG_PTB_Apo_2	107	114	PF02174	0.308
LIG_PTB_Apo_2	422	429	PF02174	0.308
LIG_SH2_CRK	511	515	PF00017	0.308
LIG_SH2_GRB2like	100	103	PF00017	0.308
LIG_SH2_PTP2	456	459	PF00017	0.415
LIG_SH2_STAP1	511	515	PF00017	0.308
LIG_SH2_STAT5	100	103	PF00017	0.253
LIG_SH2_STAT5	326	329	PF00017	0.665
LIG_SH2_STAT5	426	429	PF00017	0.327
LIG_SH2_STAT5	456	459	PF00017	0.415
LIG_SH2_STAT5	511	514	PF00017	0.313
LIG_SH2_STAT5	622	625	PF00017	0.377
LIG_SH3_1	275	281	PF00018	0.652
LIG_SH3_2	281	286	PF14604	0.649
LIG_SH3_3	275	281	PF00018	0.714
LIG_SH3_3	633	639	PF00018	0.235
LIG_SUMO_SIM_anti_2	346	357	PF11976	0.659
LIG_SUMO_SIM_par_1	545	550	PF11976	0.377
LIG_TRAF2_1	147	150	PF00917	0.708
LIG_TRAF2_1	156	159	PF00917	0.623
LIG_TRAF2_1	344	347	PF00917	0.674
LIG_TYR_ITIM	454	459	PF00017	0.235
LIG_UBA3_1	479	486	PF00899	0.303
LIG_UBA3_1	86	94	PF00899	0.420
LIG_WRC_WIRS_1	53	58	PF05994	0.419
LIG_WW_1	253	256	PF00397	0.662
LIG_WW_3	387	391	PF00397	0.669
MOD_CDC14_SPxK_1	283	286	PF00782	0.563
MOD_CDK_SPxK_1	280	286	PF00069	0.558
MOD_CK1_1	142	148	PF00069	0.534
MOD_CK1_1	17	23	PF00069	0.490
MOD_CK1_1	208	214	PF00069	0.785
MOD_CK1_1	335	341	PF00069	0.593
MOD_CK1_1	433	439	PF00069	0.308
MOD_CK1_1	444	450	PF00069	0.308
MOD_CK1_1	60	66	PF00069	0.228
MOD_CK1_1	600	606	PF00069	0.308
MOD_CK2_1	120	126	PF00069	0.453
MOD_CK2_1	143	149	PF00069	0.637
MOD_CK2_1	220	226	PF00069	0.635
MOD_CK2_1	340	346	PF00069	0.591
MOD_CK2_1	5	11	PF00069	0.525
MOD_CK2_1	549	555	PF00069	0.439
MOD_CMANNOS	559	562	PF00535	0.489
MOD_GlcNHglycan	11	14	PF01048	0.697
MOD_GlcNHglycan	115	118	PF01048	0.534
MOD_GlcNHglycan	162	166	PF01048	0.620
MOD_GlcNHglycan	168	172	PF01048	0.692
MOD_GlcNHglycan	207	210	PF01048	0.790
MOD_GlcNHglycan	216	219	PF01048	0.646
MOD_GlcNHglycan	244	247	PF01048	0.553
MOD_GlcNHglycan	278	281	PF01048	0.670
MOD_GlcNHglycan	32	35	PF01048	0.481
MOD_GlcNHglycan	320	323	PF01048	0.769
MOD_GlcNHglycan	339	342	PF01048	0.568
MOD_GlcNHglycan	463	466	PF01048	0.270
MOD_GlcNHglycan	475	478	PF01048	0.485
MOD_GlcNHglycan	503	506	PF01048	0.424
MOD_GlcNHglycan	614	617	PF01048	0.479
MOD_GlcNHglycan	618	621	PF01048	0.340
MOD_GlcNHglycan	7	10	PF01048	0.750
MOD_GSK3_1	120	127	PF00069	0.555
MOD_GSK3_1	139	146	PF00069	0.701
MOD_GSK3_1	208	215	PF00069	0.620
MOD_GSK3_1	276	283	PF00069	0.720
MOD_GSK3_1	332	339	PF00069	0.591
MOD_GSK3_1	347	354	PF00069	0.592
MOD_GSK3_1	428	435	PF00069	0.349
MOD_GSK3_1	438	445	PF00069	0.354
MOD_GSK3_1	471	478	PF00069	0.500
MOD_GSK3_1	5	12	PF00069	0.566
MOD_GSK3_1	569	576	PF00069	0.424
MOD_GSK3_1	583	590	PF00069	0.233
MOD_GSK3_1	593	600	PF00069	0.308
MOD_GSK3_1	612	619	PF00069	0.411
MOD_GSK3_1	96	103	PF00069	0.323
MOD_N-GLC_1	101	106	PF02516	0.322
MOD_N-GLC_1	382	387	PF02516	0.655
MOD_N-GLC_1	428	433	PF02516	0.308
MOD_N-GLC_1	576	581	PF02516	0.326
MOD_NEK2_1	108	113	PF00069	0.374
MOD_NEK2_1	212	217	PF00069	0.640
MOD_NEK2_1	235	240	PF00069	0.620
MOD_NEK2_1	248	253	PF00069	0.652
MOD_NEK2_1	264	269	PF00069	0.597
MOD_NEK2_1	336	341	PF00069	0.594
MOD_NEK2_1	428	433	PF00069	0.308
MOD_NEK2_1	443	448	PF00069	0.308
MOD_NEK2_1	452	457	PF00069	0.308
MOD_NEK2_1	473	478	PF00069	0.377
MOD_NEK2_1	549	554	PF00069	0.429
MOD_NEK2_1	569	574	PF00069	0.183
MOD_NEK2_1	57	62	PF00069	0.621
MOD_NEK2_1	597	602	PF00069	0.308
MOD_NEK2_1	70	75	PF00069	0.294
MOD_NEK2_1	96	101	PF00069	0.313
MOD_NEK2_2	236	241	PF00069	0.534
MOD_PIKK_1	125	131	PF00454	0.664
MOD_PIKK_1	248	254	PF00454	0.671
MOD_PIKK_1	27	33	PF00454	0.509
MOD_PKA_1	120	126	PF00069	0.453
MOD_PKA_1	403	409	PF00069	0.377
MOD_PKA_2	119	125	PF00069	0.508
MOD_PKA_2	142	148	PF00069	0.493
MOD_PKA_2	403	409	PF00069	0.308
MOD_PKA_2	461	467	PF00069	0.235
MOD_PKA_2	491	497	PF00069	0.286
MOD_PKA_2	9	15	PF00069	0.598
MOD_PKB_1	118	126	PF00069	0.447
MOD_PKB_1	220	228	PF00069	0.544
MOD_PKB_1	401	409	PF00069	0.377
MOD_Plk_1	184	190	PF00069	0.538
MOD_Plk_1	295	301	PF00069	0.553
MOD_Plk_1	332	338	PF00069	0.591
MOD_Plk_1	428	434	PF00069	0.308
MOD_Plk_2-3	158	164	PF00069	0.538
MOD_Plk_4	22	28	PF00069	0.556
MOD_Plk_4	347	353	PF00069	0.585
MOD_Plk_4	438	444	PF00069	0.308
MOD_Plk_4	445	451	PF00069	0.308
MOD_Plk_4	452	458	PF00069	0.308
MOD_Plk_4	475	481	PF00069	0.344
MOD_Plk_4	510	516	PF00069	0.311
MOD_Plk_4	569	575	PF00069	0.377
MOD_Plk_4	70	76	PF00069	0.338
MOD_Plk_4	77	83	PF00069	0.329
MOD_Plk_4	96	102	PF00069	0.204
MOD_ProDKin_1	280	286	PF00069	0.635
MOD_ProDKin_1	588	594	PF00069	0.308
MOD_ProDKin_1	600	606	PF00069	0.308
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.532
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.308
TRG_ENDOCYTIC_2	456	459	PF00928	0.281
TRG_ENDOCYTIC_2	511	514	PF00928	0.308
TRG_ER_diArg_1	119	121	PF00400	0.501
TRG_ER_diArg_1	173	175	PF00400	0.723
TRG_ER_diArg_1	219	222	PF00400	0.539
TRG_ER_diArg_1	288	290	PF00400	0.592
TRG_ER_diArg_1	389	392	PF00400	0.611
TRG_ER_diArg_1	396	399	PF00400	0.577
TRG_ER_diArg_1	401	404	PF00400	0.530
TRG_ER_diArg_1	407	409	PF00400	0.308
TRG_ER_diArg_1	459	462	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM12	Leptomonas seymouri	55%	99%
A0A3S7WPT7	Leishmania donovani	69%	100%
A4HT28	Leishmania infantum	70%	100%
E9AL51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QIQ3	Leishmania major	69%	95%