Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Y5_LEIBR

TriTrypDb:

LbrM.07.0410 , LBRM2903_070010500

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.579
CLV_C14_Caspase3-7	428	432	PF00656	0.670
CLV_C14_Caspase3-7	455	459	PF00656	0.623
CLV_C14_Caspase3-7	598	602	PF00656	0.430
CLV_C14_Caspase3-7	844	848	PF00656	0.570
CLV_C14_Caspase3-7	94	98	PF00656	0.519
CLV_NRD_NRD_1	21	23	PF00675	0.604
CLV_NRD_NRD_1	444	446	PF00675	0.599
CLV_NRD_NRD_1	507	509	PF00675	0.612
CLV_NRD_NRD_1	532	534	PF00675	0.692
CLV_NRD_NRD_1	7	9	PF00675	0.647
CLV_NRD_NRD_1	767	769	PF00675	0.582
CLV_PCSK_KEX2_1	21	23	PF00082	0.604
CLV_PCSK_KEX2_1	444	446	PF00082	0.599
CLV_PCSK_KEX2_1	507	509	PF00082	0.612
CLV_PCSK_KEX2_1	532	534	PF00082	0.692
CLV_PCSK_KEX2_1	7	9	PF00082	0.647
CLV_PCSK_KEX2_1	767	769	PF00082	0.679
CLV_PCSK_SKI1_1	201	205	PF00082	0.487
CLV_PCSK_SKI1_1	247	251	PF00082	0.497
CLV_PCSK_SKI1_1	269	273	PF00082	0.657
CLV_PCSK_SKI1_1	41	45	PF00082	0.743
CLV_PCSK_SKI1_1	643	647	PF00082	0.624
CLV_PCSK_SKI1_1	746	750	PF00082	0.755
CLV_PCSK_SKI1_1	811	815	PF00082	0.501
DEG_APCC_DBOX_1	200	208	PF00400	0.627
DEG_Nend_UBRbox_2	1	3	PF02207	0.571
DEG_SCF_FBW7_2	235	242	PF00400	0.715
DEG_SPOP_SBC_1	175	179	PF00917	0.678
DOC_ANK_TNKS_1	426	433	PF00023	0.480
DOC_ANK_TNKS_1	507	514	PF00023	0.461
DOC_CKS1_1	236	241	PF01111	0.611
DOC_CYCLIN_yCln2_LP_2	320	323	PF00134	0.542
DOC_MAPK_DCC_7	615	625	PF00069	0.688
DOC_MAPK_gen_1	21	27	PF00069	0.455
DOC_MAPK_gen_1	640	648	PF00069	0.627
DOC_MAPK_MEF2A_6	150	159	PF00069	0.433
DOC_MAPK_MEF2A_6	640	648	PF00069	0.627
DOC_MAPK_MEF2A_6	846	853	PF00069	0.460
DOC_MAPK_RevD_3	492	508	PF00069	0.620
DOC_PP1_RVXF_1	104	110	PF00149	0.468
DOC_PP2B_LxvP_1	319	322	PF13499	0.597
DOC_PP2B_LxvP_1	494	497	PF13499	0.732
DOC_PP2B_LxvP_1	623	626	PF13499	0.644
DOC_PP2B_LxvP_1	646	649	PF13499	0.644
DOC_PP2B_LxvP_1	85	88	PF13499	0.535
DOC_USP7_MATH_1	135	139	PF00917	0.744
DOC_USP7_MATH_1	164	168	PF00917	0.684
DOC_USP7_MATH_1	186	190	PF00917	0.641
DOC_USP7_MATH_1	43	47	PF00917	0.670
DOC_USP7_MATH_1	525	529	PF00917	0.695
DOC_USP7_MATH_1	577	581	PF00917	0.722
DOC_USP7_MATH_1	582	586	PF00917	0.518
DOC_USP7_MATH_1	662	666	PF00917	0.589
DOC_USP7_MATH_1	679	683	PF00917	0.602
DOC_USP7_MATH_1	713	717	PF00917	0.426
DOC_USP7_MATH_1	789	793	PF00917	0.648
DOC_USP7_MATH_1	98	102	PF00917	0.651
DOC_WW_Pin1_4	235	240	PF00397	0.613
DOC_WW_Pin1_4	264	269	PF00397	0.710
DOC_WW_Pin1_4	298	303	PF00397	0.517
DOC_WW_Pin1_4	338	343	PF00397	0.530
DOC_WW_Pin1_4	446	451	PF00397	0.491
DOC_WW_Pin1_4	553	558	PF00397	0.390
DOC_WW_Pin1_4	592	597	PF00397	0.611
DOC_WW_Pin1_4	700	705	PF00397	0.673
DOC_WW_Pin1_4	787	792	PF00397	0.524
LIG_14-3-3_CanoR_1	113	119	PF00244	0.659
LIG_14-3-3_CanoR_1	21	26	PF00244	0.597
LIG_14-3-3_CanoR_1	269	275	PF00244	0.541
LIG_14-3-3_CanoR_1	276	280	PF00244	0.524
LIG_14-3-3_CanoR_1	444	450	PF00244	0.667
LIG_14-3-3_CanoR_1	451	460	PF00244	0.448
LIG_14-3-3_CanoR_1	498	503	PF00244	0.522
LIG_14-3-3_CanoR_1	558	567	PF00244	0.671
LIG_14-3-3_CanoR_1	615	620	PF00244	0.491
LIG_14-3-3_CanoR_1	681	685	PF00244	0.553
LIG_14-3-3_CanoR_1	773	777	PF00244	0.676
LIG_14-3-3_CanoR_1	811	817	PF00244	0.604
LIG_APCC_ABBA_1	200	205	PF00400	0.528
LIG_APCC_ABBA_1	832	837	PF00400	0.689
LIG_BIR_III_2	57	61	PF00653	0.633
LIG_BIR_III_4	102	106	PF00653	0.760
LIG_BRCT_BRCA1_1	664	668	PF00533	0.738
LIG_CaM_NSCaTE_8	304	311	PF13499	0.694
LIG_CaM_NSCaTE_8	867	874	PF13499	0.462
LIG_CSL_BTD_1	623	626	PF09270	0.644
LIG_deltaCOP1_diTrp_1	412	422	PF00928	0.622
LIG_FHA_1	12	18	PF00498	0.580
LIG_FHA_1	169	175	PF00498	0.528
LIG_FHA_1	183	189	PF00498	0.466
LIG_FHA_1	22	28	PF00498	0.605
LIG_FHA_1	236	242	PF00498	0.614
LIG_FHA_1	377	383	PF00498	0.442
LIG_FHA_1	498	504	PF00498	0.521
LIG_FHA_1	516	522	PF00498	0.697
LIG_FHA_1	560	566	PF00498	0.608
LIG_FHA_1	592	598	PF00498	0.533
LIG_FHA_1	77	83	PF00498	0.493
LIG_FHA_1	788	794	PF00498	0.564
LIG_FHA_1	807	813	PF00498	0.572
LIG_FHA_1	848	854	PF00498	0.626
LIG_FHA_2	177	183	PF00498	0.651
LIG_FHA_2	218	224	PF00498	0.597
LIG_FHA_2	378	384	PF00498	0.438
LIG_FHA_2	733	739	PF00498	0.660
LIG_FHA_2	860	866	PF00498	0.447
LIG_Integrin_RGD_1	429	431	PF01839	0.488
LIG_Integrin_RGD_1	55	57	PF01839	0.671
LIG_LIR_Apic_2	233	239	PF02991	0.610
LIG_LIR_Apic_2	404	409	PF02991	0.667
LIG_LIR_Gen_1	278	288	PF02991	0.540
LIG_LIR_Gen_1	665	676	PF02991	0.637
LIG_LIR_Gen_1	67	78	PF02991	0.588
LIG_LIR_Gen_1	716	724	PF02991	0.424
LIG_LIR_Gen_1	801	808	PF02991	0.627
LIG_LIR_LC3C_4	562	567	PF02991	0.648
LIG_LIR_Nem_3	244	249	PF02991	0.609
LIG_LIR_Nem_3	278	283	PF02991	0.546
LIG_LIR_Nem_3	404	408	PF02991	0.512
LIG_LIR_Nem_3	652	658	PF02991	0.606
LIG_LIR_Nem_3	665	671	PF02991	0.641
LIG_LIR_Nem_3	716	722	PF02991	0.415
LIG_LIR_Nem_3	801	806	PF02991	0.507
LIG_LRP6_Inhibitor_1	49	55	PF00058	0.536
LIG_NRP_CendR_1	880	881	PF00754	0.808
LIG_SH2_CRK	236	240	PF00017	0.613
LIG_SH2_CRK	406	410	PF00017	0.676
LIG_SH2_CRK	655	659	PF00017	0.653
LIG_SH2_NCK_1	309	313	PF00017	0.609
LIG_SH2_SRC	619	622	PF00017	0.734
LIG_SH2_STAP1	343	347	PF00017	0.568
LIG_SH2_STAP1	378	382	PF00017	0.482
LIG_SH2_STAT3	550	553	PF00017	0.507
LIG_SH2_STAT5	343	346	PF00017	0.697
LIG_SH2_STAT5	378	381	PF00017	0.428
LIG_SH2_STAT5	502	505	PF00017	0.590
LIG_SH2_STAT5	550	553	PF00017	0.460
LIG_SH2_STAT5	619	622	PF00017	0.622
LIG_SH2_STAT5	731	734	PF00017	0.552
LIG_SH2_STAT5	81	84	PF00017	0.536
LIG_SH3_3	283	289	PF00018	0.653
LIG_SH3_3	468	474	PF00018	0.763
LIG_SH3_3	487	493	PF00018	0.423
LIG_SH3_3	701	707	PF00018	0.669
LIG_SUMO_SIM_anti_2	171	180	PF11976	0.529
LIG_SUMO_SIM_anti_2	823	828	PF11976	0.378
LIG_SUMO_SIM_par_1	158	163	PF11976	0.647
LIG_SUMO_SIM_par_1	23	29	PF11976	0.709
LIG_SUMO_SIM_par_1	238	244	PF11976	0.525
LIG_SUMO_SIM_par_1	792	798	PF11976	0.443
LIG_SUMO_SIM_par_1	849	854	PF11976	0.456
LIG_TRAF2_1	691	694	PF00917	0.568
MOD_CDK_SPK_2	264	269	PF00069	0.570
MOD_CDK_SPK_2	446	451	PF00069	0.491
MOD_CDK_SPK_2	553	558	PF00069	0.390
MOD_CDK_SPxxK_3	592	599	PF00069	0.522
MOD_CK1_1	101	107	PF00069	0.668
MOD_CK1_1	134	140	PF00069	0.644
MOD_CK1_1	168	174	PF00069	0.763
MOD_CK1_1	177	183	PF00069	0.652
MOD_CK1_1	215	221	PF00069	0.669
MOD_CK1_1	267	273	PF00069	0.710
MOD_CK1_1	278	284	PF00069	0.698
MOD_CK1_1	307	313	PF00069	0.589
MOD_CK1_1	341	347	PF00069	0.745
MOD_CK1_1	404	410	PF00069	0.573
MOD_CK1_1	585	591	PF00069	0.736
MOD_CK1_1	64	70	PF00069	0.637
MOD_CK1_1	695	701	PF00069	0.693
MOD_CK1_1	703	709	PF00069	0.789
MOD_CK2_1	210	216	PF00069	0.468
MOD_CK2_1	377	383	PF00069	0.442
MOD_CK2_1	436	442	PF00069	0.565
MOD_CK2_1	474	480	PF00069	0.590
MOD_CK2_1	541	547	PF00069	0.649
MOD_CK2_1	69	75	PF00069	0.701
MOD_CK2_1	732	738	PF00069	0.657
MOD_CK2_1	752	758	PF00069	0.460
MOD_CK2_1	854	860	PF00069	0.634
MOD_GlcNHglycan	102	106	PF01048	0.680
MOD_GlcNHglycan	126	129	PF01048	0.588
MOD_GlcNHglycan	133	136	PF01048	0.761
MOD_GlcNHglycan	137	140	PF01048	0.696
MOD_GlcNHglycan	144	147	PF01048	0.587
MOD_GlcNHglycan	168	171	PF01048	0.627
MOD_GlcNHglycan	179	182	PF01048	0.730
MOD_GlcNHglycan	216	220	PF01048	0.682
MOD_GlcNHglycan	251	254	PF01048	0.607
MOD_GlcNHglycan	262	265	PF01048	0.667
MOD_GlcNHglycan	309	312	PF01048	0.666
MOD_GlcNHglycan	327	330	PF01048	0.702
MOD_GlcNHglycan	345	348	PF01048	0.690
MOD_GlcNHglycan	357	360	PF01048	0.576
MOD_GlcNHglycan	434	437	PF01048	0.673
MOD_GlcNHglycan	45	48	PF01048	0.773
MOD_GlcNHglycan	527	530	PF01048	0.605
MOD_GlcNHglycan	610	613	PF01048	0.543
MOD_GlcNHglycan	634	637	PF01048	0.636
MOD_GlcNHglycan	640	643	PF01048	0.618
MOD_GlcNHglycan	715	718	PF01048	0.555
MOD_GlcNHglycan	726	729	PF01048	0.495
MOD_GlcNHglycan	778	781	PF01048	0.677
MOD_GlcNHglycan	782	785	PF01048	0.690
MOD_GlcNHglycan	800	803	PF01048	0.293
MOD_GSK3_1	101	108	PF00069	0.604
MOD_GSK3_1	120	127	PF00069	0.577
MOD_GSK3_1	131	138	PF00069	0.588
MOD_GSK3_1	160	167	PF00069	0.650
MOD_GSK3_1	182	189	PF00069	0.624
MOD_GSK3_1	21	28	PF00069	0.648
MOD_GSK3_1	211	218	PF00069	0.672
MOD_GSK3_1	231	238	PF00069	0.363
MOD_GSK3_1	249	256	PF00069	0.459
MOD_GSK3_1	260	267	PF00069	0.692
MOD_GSK3_1	37	44	PF00069	0.676
MOD_GSK3_1	432	439	PF00069	0.569
MOD_GSK3_1	475	482	PF00069	0.655
MOD_GSK3_1	567	574	PF00069	0.448
MOD_GSK3_1	584	591	PF00069	0.671
MOD_GSK3_1	60	67	PF00069	0.678
MOD_GSK3_1	615	622	PF00069	0.504
MOD_GSK3_1	632	639	PF00069	0.684
MOD_GSK3_1	662	669	PF00069	0.737
MOD_GSK3_1	675	682	PF00069	0.604
MOD_GSK3_1	69	76	PF00069	0.546
MOD_GSK3_1	695	702	PF00069	0.756
MOD_GSK3_1	713	720	PF00069	0.479
MOD_GSK3_1	740	747	PF00069	0.618
MOD_GSK3_1	772	779	PF00069	0.580
MOD_N-GLC_1	182	187	PF02516	0.525
MOD_N-GLC_1	50	55	PF02516	0.730
MOD_N-GLC_1	713	718	PF02516	0.421
MOD_N-GLC_1	776	781	PF02516	0.576
MOD_NEK2_1	114	119	PF00069	0.656
MOD_NEK2_1	249	254	PF00069	0.650
MOD_NEK2_1	25	30	PF00069	0.549
MOD_NEK2_1	377	382	PF00069	0.536
MOD_NEK2_1	61	66	PF00069	0.723
MOD_NEK2_1	73	78	PF00069	0.503
MOD_NEK2_1	732	737	PF00069	0.475
MOD_NEK2_1	740	745	PF00069	0.560
MOD_NEK2_1	776	781	PF00069	0.588
MOD_NEK2_1	812	817	PF00069	0.602
MOD_NEK2_1	853	858	PF00069	0.471
MOD_NEK2_2	304	309	PF00069	0.740
MOD_NEK2_2	50	55	PF00069	0.693
MOD_PIKK_1	11	17	PF00454	0.433
MOD_PIKK_1	126	132	PF00454	0.588
MOD_PIKK_1	278	284	PF00454	0.662
MOD_PIKK_1	541	547	PF00454	0.602
MOD_PIKK_1	680	686	PF00454	0.553
MOD_PIKK_1	752	758	PF00454	0.636
MOD_PK_1	692	698	PF00069	0.558
MOD_PKA_1	21	27	PF00069	0.455
MOD_PKA_1	444	450	PF00069	0.714
MOD_PKA_1	767	773	PF00069	0.609
MOD_PKA_2	114	120	PF00069	0.667
MOD_PKA_2	124	130	PF00069	0.776
MOD_PKA_2	21	27	PF00069	0.669
MOD_PKA_2	275	281	PF00069	0.549
MOD_PKA_2	432	438	PF00069	0.477
MOD_PKA_2	444	450	PF00069	0.714
MOD_PKA_2	497	503	PF00069	0.529
MOD_PKA_2	680	686	PF00069	0.638
MOD_PKA_2	767	773	PF00069	0.619
MOD_PKA_2	840	846	PF00069	0.539
MOD_Plk_1	160	166	PF00069	0.582
MOD_Plk_1	411	417	PF00069	0.362
MOD_Plk_1	479	485	PF00069	0.646
MOD_Plk_1	50	56	PF00069	0.690
MOD_Plk_1	692	698	PF00069	0.633
MOD_Plk_1	713	719	PF00069	0.464
MOD_Plk_1	732	738	PF00069	0.584
MOD_Plk_1	859	865	PF00069	0.445
MOD_Plk_4	114	120	PF00069	0.667
MOD_Plk_4	231	237	PF00069	0.692
MOD_Plk_4	275	281	PF00069	0.699
MOD_Plk_4	304	310	PF00069	0.654
MOD_Plk_4	377	383	PF00069	0.591
MOD_Plk_4	401	407	PF00069	0.608
MOD_Plk_4	498	504	PF00069	0.505
MOD_Plk_4	571	577	PF00069	0.578
MOD_Plk_4	615	621	PF00069	0.565
MOD_Plk_4	670	676	PF00069	0.654
MOD_Plk_4	692	698	PF00069	0.793
MOD_Plk_4	744	750	PF00069	0.755
MOD_Plk_4	76	82	PF00069	0.553
MOD_Plk_4	789	795	PF00069	0.499
MOD_Plk_4	827	833	PF00069	0.537
MOD_ProDKin_1	235	241	PF00069	0.611
MOD_ProDKin_1	264	270	PF00069	0.707
MOD_ProDKin_1	298	304	PF00069	0.515
MOD_ProDKin_1	338	344	PF00069	0.531
MOD_ProDKin_1	446	452	PF00069	0.495
MOD_ProDKin_1	553	559	PF00069	0.402
MOD_ProDKin_1	592	598	PF00069	0.598
MOD_ProDKin_1	700	706	PF00069	0.672
MOD_ProDKin_1	787	793	PF00069	0.522
MOD_SUMO_rev_2	257	264	PF00179	0.560
TRG_DiLeu_BaEn_4	547	553	PF01217	0.623
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.538
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.524
TRG_DiLeu_BaLyEn_6	640	645	PF01217	0.723
TRG_ENDOCYTIC_2	378	381	PF00928	0.428
TRG_ENDOCYTIC_2	655	658	PF00928	0.647
TRG_ER_diArg_1	20	22	PF00400	0.602
TRG_ER_diArg_1	443	445	PF00400	0.593
TRG_ER_diArg_1	506	508	PF00400	0.559
TRG_ER_diArg_1	532	534	PF00400	0.692
TRG_ER_diArg_1	6	8	PF00400	0.646
TRG_ER_diArg_1	766	768	PF00400	0.615
TRG_NLS_MonoExtN_4	767	772	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF8	Leptomonas seymouri	41%	100%
A0A3S5H5X7	Leishmania donovani	73%	95%
A4HT29	Leishmania infantum	73%	95%
E9AL50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4QIQ4	Leishmania major	73%	100%