RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H4Y3_LEIBR

TriTrypDb:

LbrM.07.0390 , LBRM2903_070010300

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H4Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.821
CLV_NRD_NRD_1	317	319	PF00675	0.530
CLV_NRD_NRD_1	33	35	PF00675	0.577
CLV_NRD_NRD_1	618	620	PF00675	0.835
CLV_PCSK_KEX2_1	138	140	PF00082	0.835
CLV_PCSK_KEX2_1	317	319	PF00082	0.530
CLV_PCSK_KEX2_1	32	34	PF00082	0.581
CLV_PCSK_KEX2_1	618	620	PF00082	0.840
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.595
CLV_PCSK_SKI1_1	767	771	PF00082	0.582
CLV_Separin_Metazoa	443	447	PF03568	0.585
CLV_Separin_Metazoa	483	487	PF03568	0.651
DEG_SCF_FBW7_1	646	653	PF00400	0.597
DEG_SCF_FBW7_1	687	694	PF00400	0.555
DEG_SPOP_SBC_1	126	130	PF00917	0.573
DEG_SPOP_SBC_1	21	25	PF00917	0.820
DOC_AGCK_PIF_1	224	229	PF00069	0.537
DOC_ANK_TNKS_1	380	387	PF00023	0.534
DOC_CKS1_1	538	543	PF01111	0.565
DOC_CKS1_1	61	66	PF01111	0.535
DOC_CKS1_1	651	656	PF01111	0.585
DOC_CKS1_1	688	693	PF01111	0.552
DOC_CYCLIN_yCln2_LP_2	143	146	PF00134	0.585
DOC_MAPK_MEF2A_6	336	343	PF00069	0.661
DOC_PP1_RVXF_1	761	767	PF00149	0.613
DOC_PP2B_LxvP_1	143	146	PF13499	0.838
DOC_PP2B_LxvP_1	722	725	PF13499	0.401
DOC_PP2B_PxIxI_1	426	432	PF00149	0.590
DOC_PP2B_PxIxI_1	510	516	PF00149	0.560
DOC_PP4_FxxP_1	110	113	PF00568	0.573
DOC_PP4_FxxP_1	678	681	PF00568	0.575
DOC_USP7_MATH_1	147	151	PF00917	0.825
DOC_USP7_MATH_1	175	179	PF00917	0.590
DOC_USP7_MATH_1	197	201	PF00917	0.610
DOC_USP7_MATH_1	21	25	PF00917	0.607
DOC_USP7_MATH_1	247	251	PF00917	0.761
DOC_USP7_MATH_1	505	509	PF00917	0.751
DOC_USP7_MATH_1	654	658	PF00917	0.627
DOC_USP7_MATH_1	691	695	PF00917	0.589
DOC_USP7_MATH_1	730	734	PF00917	0.370
DOC_USP7_MATH_1	8	12	PF00917	0.645
DOC_WW_Pin1_4	115	120	PF00397	0.612
DOC_WW_Pin1_4	166	171	PF00397	0.695
DOC_WW_Pin1_4	176	181	PF00397	0.797
DOC_WW_Pin1_4	209	214	PF00397	0.819
DOC_WW_Pin1_4	23	28	PF00397	0.742
DOC_WW_Pin1_4	287	292	PF00397	0.556
DOC_WW_Pin1_4	334	339	PF00397	0.639
DOC_WW_Pin1_4	537	542	PF00397	0.611
DOC_WW_Pin1_4	588	593	PF00397	0.561
DOC_WW_Pin1_4	60	65	PF00397	0.578
DOC_WW_Pin1_4	639	644	PF00397	0.686
DOC_WW_Pin1_4	646	651	PF00397	0.749
DOC_WW_Pin1_4	652	657	PF00397	0.777
DOC_WW_Pin1_4	659	664	PF00397	0.653
DOC_WW_Pin1_4	687	692	PF00397	0.552
DOC_WW_Pin1_4	74	79	PF00397	0.656
LIG_14-3-3_CanoR_1	159	164	PF00244	0.814
LIG_14-3-3_CanoR_1	367	373	PF00244	0.565
LIG_14-3-3_CanoR_1	409	413	PF00244	0.586
LIG_14-3-3_CanoR_1	607	614	PF00244	0.684
LIG_14-3-3_CanoR_1	619	628	PF00244	0.782
LIG_14-3-3_CanoR_1	729	739	PF00244	0.630
LIG_14-3-3_CanoR_1	803	807	PF00244	0.631
LIG_Actin_WH2_2	558	576	PF00022	0.557
LIG_APCC_ABBA_1	753	758	PF00400	0.587
LIG_BIR_II_1	1	5	PF00653	0.554
LIG_BRCT_BRCA1_1	106	110	PF00533	0.578
LIG_BRCT_BRCA1_1	590	594	PF00533	0.556
LIG_BRCT_BRCA1_1	727	731	PF00533	0.623
LIG_BRCT_MDC1_1	824	828	PF00533	0.651
LIG_eIF4E_1	456	462	PF01652	0.372
LIG_FHA_1	151	157	PF00498	0.563
LIG_FHA_1	201	207	PF00498	0.594
LIG_FHA_1	238	244	PF00498	0.606
LIG_FHA_1	253	259	PF00498	0.768
LIG_FHA_1	263	269	PF00498	0.660
LIG_FHA_1	510	516	PF00498	0.562
LIG_FHA_1	538	544	PF00498	0.674
LIG_FHA_1	61	67	PF00498	0.576
LIG_FHA_1	629	635	PF00498	0.616
LIG_FHA_1	646	652	PF00498	0.784
LIG_FHA_1	675	681	PF00498	0.783
LIG_FHA_2	252	258	PF00498	0.823
LIG_FHA_2	288	294	PF00498	0.538
LIG_FHA_2	385	391	PF00498	0.693
LIG_FHA_2	395	401	PF00498	0.594
LIG_FHA_2	583	589	PF00498	0.566
LIG_FHA_2	608	614	PF00498	0.580
LIG_FHA_2	619	625	PF00498	0.535
LIG_FHA_2	69	75	PF00498	0.553
LIG_Integrin_RGD_1	398	400	PF01839	0.779
LIG_IRF3_LxIS_1	539	546	PF10401	0.565
LIG_LIR_Apic_2	107	113	PF02991	0.573
LIG_LIR_Apic_2	588	592	PF02991	0.811
LIG_LIR_Apic_2	677	681	PF02991	0.779
LIG_LIR_Gen_1	710	720	PF02991	0.617
LIG_LIR_Nem_3	221	227	PF02991	0.708
LIG_LIR_Nem_3	228	232	PF02991	0.754
LIG_LIR_Nem_3	710	715	PF02991	0.612
LIG_LIR_Nem_3	765	769	PF02991	0.581
LIG_Pex14_1	786	790	PF04695	0.660
LIG_Pex14_2	800	804	PF04695	0.620
LIG_SH2_CRK	727	731	PF00017	0.371
LIG_SH2_GRB2like	771	774	PF00017	0.355
LIG_SH2_NCK_1	727	731	PF00017	0.371
LIG_SH2_STAT5	456	459	PF00017	0.383
LIG_SH2_STAT5	739	742	PF00017	0.589
LIG_SH2_STAT5	754	757	PF00017	0.324
LIG_SH2_STAT5	790	793	PF00017	0.656
LIG_SH3_1	84	90	PF00018	0.547
LIG_SH3_3	219	225	PF00018	0.688
LIG_SH3_3	439	445	PF00018	0.374
LIG_SH3_3	492	498	PF00018	0.625
LIG_SH3_3	535	541	PF00018	0.556
LIG_SH3_3	584	590	PF00018	0.689
LIG_SH3_3	63	69	PF00018	0.539
LIG_SH3_3	648	654	PF00018	0.590
LIG_SH3_3	676	682	PF00018	0.524
LIG_SH3_3	84	90	PF00018	0.547
LIG_SUMO_SIM_anti_2	279	286	PF11976	0.435
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.613
LIG_SUMO_SIM_anti_2	481	486	PF11976	0.643
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.560
LIG_SUMO_SIM_par_1	254	259	PF11976	0.672
LIG_SUMO_SIM_par_1	279	286	PF11976	0.623
LIG_SUMO_SIM_par_1	459	465	PF11976	0.613
LIG_SUMO_SIM_par_1	511	518	PF11976	0.579
LIG_TRAF2_1	387	390	PF00917	0.565
LIG_TRAF2_2	287	292	PF00917	0.653
LIG_TRFH_1	678	682	PF08558	0.520
LIG_WRC_WIRS_1	226	231	PF05994	0.534
LIG_WRC_WIRS_1	52	57	PF05994	0.534
MOD_CDC14_SPxK_1	655	658	PF00782	0.581
MOD_CDK_SPxK_1	646	652	PF00069	0.597
MOD_CK1_1	150	156	PF00069	0.663
MOD_CK1_1	179	185	PF00069	0.610
MOD_CK1_1	2	8	PF00069	0.594
MOD_CK1_1	200	206	PF00069	0.768
MOD_CK1_1	252	258	PF00069	0.645
MOD_CK1_1	261	267	PF00069	0.676
MOD_CK1_1	366	372	PF00069	0.649
MOD_CK1_1	509	515	PF00069	0.694
MOD_CK1_1	546	552	PF00069	0.663
MOD_CK1_1	566	572	PF00069	0.685
MOD_CK1_1	662	668	PF00069	0.545
MOD_CK1_1	694	700	PF00069	0.559
MOD_CK2_1	251	257	PF00069	0.820
MOD_CK2_1	366	372	PF00069	0.396
MOD_CK2_1	384	390	PF00069	0.483
MOD_CK2_1	607	613	PF00069	0.585
MOD_CK2_1	618	624	PF00069	0.539
MOD_GlcNHglycan	109	113	PF01048	0.561
MOD_GlcNHglycan	184	187	PF01048	0.617
MOD_GlcNHglycan	235	238	PF01048	0.707
MOD_GlcNHglycan	249	252	PF01048	0.645
MOD_GlcNHglycan	27	30	PF01048	0.620
MOD_GlcNHglycan	279	282	PF01048	0.534
MOD_GlcNHglycan	377	380	PF01048	0.752
MOD_GlcNHglycan	41	44	PF01048	0.677
MOD_GlcNHglycan	508	511	PF01048	0.618
MOD_GlcNHglycan	550	553	PF01048	0.716
MOD_GlcNHglycan	57	60	PF01048	0.596
MOD_GlcNHglycan	693	696	PF01048	0.813
MOD_GlcNHglycan	824	827	PF01048	0.520
MOD_GlcNHglycan	90	93	PF01048	0.762
MOD_GlcNHglycan	94	97	PF01048	0.801
MOD_GSK3_1	104	111	PF00069	0.615
MOD_GSK3_1	127	134	PF00069	0.693
MOD_GSK3_1	159	166	PF00069	0.675
MOD_GSK3_1	175	182	PF00069	0.570
MOD_GSK3_1	195	202	PF00069	0.500
MOD_GSK3_1	204	211	PF00069	0.572
MOD_GSK3_1	21	28	PF00069	0.575
MOD_GSK3_1	233	240	PF00069	0.741
MOD_GSK3_1	243	250	PF00069	0.661
MOD_GSK3_1	258	265	PF00069	0.578
MOD_GSK3_1	444	451	PF00069	0.372
MOD_GSK3_1	499	506	PF00069	0.684
MOD_GSK3_1	509	516	PF00069	0.530
MOD_GSK3_1	51	58	PF00069	0.581
MOD_GSK3_1	521	528	PF00069	0.540
MOD_GSK3_1	533	540	PF00069	0.725
MOD_GSK3_1	543	550	PF00069	0.678
MOD_GSK3_1	588	595	PF00069	0.588
MOD_GSK3_1	646	653	PF00069	0.849
MOD_GSK3_1	683	690	PF00069	0.559
MOD_GSK3_1	714	721	PF00069	0.621
MOD_GSK3_1	725	732	PF00069	0.443
MOD_GSK3_1	74	81	PF00069	0.726
MOD_GSK3_1	88	95	PF00069	0.621
MOD_LATS_1	605	611	PF00433	0.576
MOD_N-GLC_1	198	203	PF02516	0.581
MOD_N-GLC_1	208	213	PF02516	0.552
MOD_N-GLC_1	546	551	PF02516	0.556
MOD_NEK2_1	124	129	PF00069	0.744
MOD_NEK2_1	204	209	PF00069	0.599
MOD_NEK2_1	258	263	PF00069	0.829
MOD_NEK2_1	462	467	PF00069	0.599
MOD_NEK2_1	543	548	PF00069	0.568
MOD_NEK2_1	55	60	PF00069	0.600
MOD_NEK2_1	594	599	PF00069	0.772
MOD_NEK2_1	628	633	PF00069	0.586
MOD_NEK2_1	742	747	PF00069	0.499
MOD_NEK2_2	225	230	PF00069	0.535
MOD_NEK2_2	27	32	PF00069	0.575
MOD_OFUCOSY	73	80	PF10250	0.555
MOD_PIKK_1	104	110	PF00454	0.575
MOD_PIKK_1	366	372	PF00454	0.649
MOD_PIKK_1	462	468	PF00454	0.619
MOD_PIKK_1	592	598	PF00454	0.758
MOD_PKA_1	618	624	PF00069	0.582
MOD_PKA_2	366	372	PF00069	0.649
MOD_PKA_2	408	414	PF00069	0.591
MOD_PKA_2	606	612	PF00069	0.581
MOD_PKA_2	618	624	PF00069	0.570
MOD_PKA_2	802	808	PF00069	0.635
MOD_Plk_1	468	474	PF00069	0.385
MOD_Plk_1	563	569	PF00069	0.551
MOD_Plk_4	117	123	PF00069	0.565
MOD_Plk_4	269	275	PF00069	0.797
MOD_Plk_4	44	50	PF00069	0.640
MOD_Plk_4	515	521	PF00069	0.671
MOD_Plk_4	568	574	PF00069	0.560
MOD_Plk_4	674	680	PF00069	0.539
MOD_Plk_4	683	689	PF00069	0.512
MOD_ProDKin_1	115	121	PF00069	0.612
MOD_ProDKin_1	166	172	PF00069	0.697
MOD_ProDKin_1	176	182	PF00069	0.795
MOD_ProDKin_1	209	215	PF00069	0.819
MOD_ProDKin_1	23	29	PF00069	0.742
MOD_ProDKin_1	287	293	PF00069	0.552
MOD_ProDKin_1	334	340	PF00069	0.643
MOD_ProDKin_1	537	543	PF00069	0.614
MOD_ProDKin_1	588	594	PF00069	0.561
MOD_ProDKin_1	60	66	PF00069	0.580
MOD_ProDKin_1	639	645	PF00069	0.685
MOD_ProDKin_1	646	652	PF00069	0.751
MOD_ProDKin_1	659	665	PF00069	0.650
MOD_ProDKin_1	687	693	PF00069	0.553
MOD_ProDKin_1	74	80	PF00069	0.658
TRG_DiLeu_BaEn_2	806	812	PF01217	0.620
TRG_ENDOCYTIC_2	601	604	PF00928	0.575
TRG_ENDOCYTIC_2	739	742	PF00928	0.589
TRG_ER_diArg_1	32	34	PF00400	0.581
TRG_ER_diArg_1	485	488	PF00400	0.659
TRG_ER_diArg_1	617	619	PF00400	0.847
TRG_NLS_MonoExtN_4	137	142	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPU3	Leishmania donovani	65%	90%
A4HT31	Leishmania infantum	66%	90%
E9AL48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	90%
Q4QIQ6	Leishmania major	67%	100%