LeishMANIAdb
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Succinate dehydrogenase assembly factor 4, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Succinate dehydrogenase assembly factor 4, mitochondrial
Gene product:
Protein of unknown function (DUF1674), putative
Species:
Leishmania braziliensis
UniProt:
A4H4Y2_LEIBR
TriTrypDb:
LbrM.07.0380 , LBRM2903_070010200
Length:
107

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Y2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 3 5 PF00675 0.496
CLV_NRD_NRD_1 52 54 PF00675 0.463
CLV_PCSK_KEX2_1 3 5 PF00082 0.496
CLV_PCSK_KEX2_1 52 54 PF00082 0.503
CLV_PCSK_SKI1_1 52 56 PF00082 0.492
DEG_Nend_Nbox_1 1 3 PF02207 0.520
LIG_14-3-3_CanoR_1 45 51 PF00244 0.511
LIG_14-3-3_CanoR_1 53 59 PF00244 0.415
LIG_FHA_1 53 59 PF00498 0.485
LIG_FHA_1 72 78 PF00498 0.359
LIG_FHA_1 79 85 PF00498 0.448
LIG_FHA_2 86 92 PF00498 0.467
LIG_Integrin_isoDGR_2 101 103 PF01839 0.211
LIG_PDZ_Class_2 102 107 PF00595 0.467
LIG_SH2_STAT5 26 29 PF00017 0.432
MOD_CK1_1 57 63 PF00069 0.543
MOD_GlcNHglycan 18 21 PF01048 0.428
MOD_GSK3_1 53 60 PF00069 0.500
MOD_NEK2_1 54 59 PF00069 0.492
MOD_PIKK_1 85 91 PF00454 0.424
MOD_PKA_1 52 58 PF00069 0.547
MOD_PKA_2 44 50 PF00069 0.514
MOD_PKA_2 52 58 PF00069 0.395
MOD_Plk_4 13 19 PF00069 0.570
MOD_Plk_4 60 66 PF00069 0.445
TRG_DiLeu_BaEn_2 12 18 PF01217 0.547
TRG_ER_diArg_1 2 4 PF00400 0.504
TRG_ER_diArg_1 51 53 PF00400 0.457

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZK6 Leptomonas seymouri 80% 100%
A0A0S4IQ64 Bodo saltans 74% 100%
A0A1X0NPS9 Trypanosomatidae 67% 100%
A0A3R7NGX7 Trypanosoma rangeli 64% 100%
C9ZUR8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 100%
E9AL47 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS