MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4Y1_LEIBR

TriTrypDb:

LbrM.07.0370 , LBRM2903_070010100

Length:

645

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4Y1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.538
CLV_NRD_NRD_1	263	265	PF00675	0.667
CLV_NRD_NRD_1	571	573	PF00675	0.729
CLV_NRD_NRD_1	591	593	PF00675	0.538
CLV_PCSK_FUR_1	588	592	PF00082	0.421
CLV_PCSK_KEX2_1	124	126	PF00082	0.538
CLV_PCSK_KEX2_1	247	249	PF00082	0.639
CLV_PCSK_KEX2_1	263	265	PF00082	0.667
CLV_PCSK_KEX2_1	274	276	PF00082	0.545
CLV_PCSK_KEX2_1	279	281	PF00082	0.468
CLV_PCSK_KEX2_1	47	49	PF00082	0.677
CLV_PCSK_KEX2_1	571	573	PF00082	0.729
CLV_PCSK_KEX2_1	590	592	PF00082	0.370
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.639
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.715
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.638
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.677
CLV_PCSK_PC7_1	275	281	PF00082	0.487
CLV_PCSK_SKI1_1	148	152	PF00082	0.607
CLV_PCSK_SKI1_1	194	198	PF00082	0.462
CLV_PCSK_SKI1_1	615	619	PF00082	0.576
DEG_SPOP_SBC_1	308	312	PF00917	0.588
DEG_SPOP_SBC_1	432	436	PF00917	0.578
DEG_SPOP_SBC_1	442	446	PF00917	0.522
DOC_CKS1_1	426	431	PF01111	0.852
DOC_CKS1_1	488	493	PF01111	0.583
DOC_CKS1_1	573	578	PF01111	0.463
DOC_CYCLIN_yCln2_LP_2	468	474	PF00134	0.547
DOC_PP1_RVXF_1	41	47	PF00149	0.666
DOC_PP2B_LxvP_1	468	471	PF13499	0.546
DOC_PP2B_LxvP_1	500	503	PF13499	0.553
DOC_PP4_FxxP_1	573	576	PF00568	0.467
DOC_PP4_FxxP_1	8	11	PF00568	0.658
DOC_USP7_MATH_1	308	312	PF00917	0.716
DOC_USP7_MATH_1	372	376	PF00917	0.700
DOC_USP7_MATH_1	379	383	PF00917	0.729
DOC_USP7_MATH_1	432	436	PF00917	0.666
DOC_USP7_MATH_1	442	446	PF00917	0.588
DOC_USP7_MATH_1	472	476	PF00917	0.552
DOC_USP7_MATH_1	496	500	PF00917	0.789
DOC_USP7_MATH_1	523	527	PF00917	0.523
DOC_USP7_MATH_1	608	612	PF00917	0.732
DOC_USP7_MATH_1	64	68	PF00917	0.631
DOC_USP7_UBL2_3	148	152	PF12436	0.607
DOC_USP7_UBL2_3	188	192	PF12436	0.758
DOC_USP7_UBL2_3	193	197	PF12436	0.622
DOC_USP7_UBL2_3	255	259	PF12436	0.649
DOC_USP7_UBL2_3	43	47	PF12436	0.654
DOC_WW_Pin1_4	328	333	PF00397	0.559
DOC_WW_Pin1_4	350	355	PF00397	0.544
DOC_WW_Pin1_4	414	419	PF00397	0.731
DOC_WW_Pin1_4	425	430	PF00397	0.804
DOC_WW_Pin1_4	433	438	PF00397	0.708
DOC_WW_Pin1_4	487	492	PF00397	0.746
DOC_WW_Pin1_4	530	535	PF00397	0.796
DOC_WW_Pin1_4	572	577	PF00397	0.691
LIG_14-3-3_CanoR_1	381	389	PF00244	0.761
LIG_14-3-3_CanoR_1	431	437	PF00244	0.577
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_4	317	321	PF00653	0.558
LIG_BRCT_BRCA1_1	542	546	PF00533	0.765
LIG_BRCT_BRCA1_1	610	614	PF00533	0.742
LIG_deltaCOP1_diTrp_1	33	39	PF00928	0.629
LIG_FHA_1	199	205	PF00498	0.592
LIG_FHA_1	283	289	PF00498	0.578
LIG_FHA_1	399	405	PF00498	0.579
LIG_FHA_1	407	413	PF00498	0.559
LIG_FHA_1	434	440	PF00498	0.574
LIG_FHA_1	479	485	PF00498	0.579
LIG_FHA_1	504	510	PF00498	0.756
LIG_FHA_1	71	77	PF00498	0.606
LIG_FHA_1	90	96	PF00498	0.337
LIG_FHA_2	334	340	PF00498	0.756
LIG_LIR_Apic_2	60	64	PF02991	0.648
LIG_LIR_Apic_2	7	11	PF02991	0.662
LIG_LIR_Gen_1	141	150	PF02991	0.567
LIG_LIR_Gen_1	577	587	PF02991	0.658
LIG_LIR_Gen_1	67	76	PF02991	0.613
LIG_LIR_Nem_3	141	146	PF02991	0.556
LIG_LIR_Nem_3	512	518	PF02991	0.548
LIG_LIR_Nem_3	577	583	PF02991	0.670
LIG_LIR_Nem_3	67	72	PF02991	0.623
LIG_LYPXL_S_1	514	518	PF13949	0.503
LIG_LYPXL_yS_3	515	518	PF13949	0.503
LIG_PCNA_yPIPBox_3	225	235	PF02747	0.585
LIG_PDZ_Class_1	640	645	PF00595	0.537
LIG_Pex14_1	35	39	PF04695	0.618
LIG_Pex14_2	614	618	PF04695	0.751
LIG_SH2_CRK	132	136	PF00017	0.529
LIG_SH2_CRK	162	166	PF00017	0.564
LIG_SH2_CRK	561	565	PF00017	0.740
LIG_SH2_CRK	580	584	PF00017	0.393
LIG_SH2_PTP2	61	64	PF00017	0.641
LIG_SH2_SRC	61	64	PF00017	0.641
LIG_SH2_STAP1	132	136	PF00017	0.525
LIG_SH2_STAT5	157	160	PF00017	0.524
LIG_SH2_STAT5	517	520	PF00017	0.722
LIG_SH2_STAT5	61	64	PF00017	0.641
LIG_SH3_1	300	306	PF00018	0.613
LIG_SH3_2	426	431	PF14604	0.802
LIG_SH3_3	289	295	PF00018	0.792
LIG_SH3_3	300	306	PF00018	0.593
LIG_SH3_3	423	429	PF00018	0.813
LIG_SH3_3	495	501	PF00018	0.573
LIG_TRAF2_1	336	339	PF00917	0.759
LIG_TYR_ITIM	130	135	PF00017	0.516
LIG_UBA3_1	146	152	PF00899	0.588
LIG_UBA3_1	235	244	PF00899	0.616
LIG_WRC_WIRS_1	5	10	PF05994	0.656
LIG_WRC_WIRS_1	94	99	PF05994	0.584
MOD_CDK_SPK_2	414	419	PF00069	0.731
MOD_CDK_SPxK_1	425	431	PF00069	0.852
MOD_CDK_SPxK_1	572	578	PF00069	0.689
MOD_CK1_1	380	386	PF00069	0.758
MOD_CK1_1	540	546	PF00069	0.762
MOD_CK1_1	637	643	PF00069	0.530
MOD_CK2_1	332	338	PF00069	0.738
MOD_CK2_1	606	612	PF00069	0.729
MOD_GlcNHglycan	119	122	PF01048	0.367
MOD_GlcNHglycan	288	291	PF01048	0.528
MOD_GlcNHglycan	296	299	PF01048	0.531
MOD_GlcNHglycan	311	314	PF01048	0.734
MOD_GlcNHglycan	322	325	PF01048	0.706
MOD_GlcNHglycan	374	377	PF01048	0.556
MOD_GlcNHglycan	382	385	PF01048	0.510
MOD_GlcNHglycan	474	477	PF01048	0.630
MOD_GSK3_1	238	245	PF00069	0.643
MOD_GSK3_1	282	289	PF00069	0.740
MOD_GSK3_1	31	38	PF00069	0.628
MOD_GSK3_1	328	335	PF00069	0.661
MOD_GSK3_1	339	346	PF00069	0.720
MOD_GSK3_1	414	421	PF00069	0.652
MOD_GSK3_1	427	434	PF00069	0.715
MOD_GSK3_1	437	444	PF00069	0.704
MOD_GSK3_1	466	473	PF00069	0.547
MOD_GSK3_1	636	643	PF00069	0.761
MOD_GSK3_1	89	96	PF00069	0.602
MOD_NEK2_1	146	151	PF00069	0.585
MOD_NEK2_1	343	348	PF00069	0.569
MOD_NEK2_1	412	417	PF00069	0.610
MOD_NEK2_1	438	443	PF00069	0.618
MOD_NEK2_1	76	81	PF00069	0.597
MOD_NEK2_1	95	100	PF00069	0.316
MOD_PIKK_1	163	169	PF00454	0.379
MOD_PIKK_1	484	490	PF00454	0.634
MOD_PIKK_1	62	68	PF00454	0.632
MOD_PIKK_1	70	76	PF00454	0.493
MOD_PK_1	169	175	PF00069	0.496
MOD_PKA_1	188	194	PF00069	0.534
MOD_PKA_2	380	386	PF00069	0.758
MOD_Plk_1	338	344	PF00069	0.668
MOD_Plk_1	624	630	PF00069	0.544
MOD_Plk_1	70	76	PF00069	0.607
MOD_Plk_2-3	87	93	PF00069	0.601
MOD_Plk_4	131	137	PF00069	0.313
MOD_Plk_4	200	206	PF00069	0.364
MOD_Plk_4	35	41	PF00069	0.637
MOD_Plk_4	624	630	PF00069	0.544
MOD_ProDKin_1	328	334	PF00069	0.561
MOD_ProDKin_1	350	356	PF00069	0.544
MOD_ProDKin_1	414	420	PF00069	0.732
MOD_ProDKin_1	425	431	PF00069	0.805
MOD_ProDKin_1	433	439	PF00069	0.707
MOD_ProDKin_1	487	493	PF00069	0.747
MOD_ProDKin_1	530	536	PF00069	0.796
MOD_ProDKin_1	572	578	PF00069	0.689
MOD_SUMO_for_1	273	276	PF00179	0.713
MOD_SUMO_for_1	278	281	PF00179	0.635
MOD_SUMO_for_1	299	302	PF00179	0.587
TRG_DiLeu_BaEn_4	338	344	PF01217	0.576
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.608
TRG_ENDOCYTIC_2	132	135	PF00928	0.518
TRG_ENDOCYTIC_2	162	165	PF00928	0.540
TRG_ENDOCYTIC_2	515	518	PF00928	0.503
TRG_ENDOCYTIC_2	561	564	PF00928	0.745
TRG_ENDOCYTIC_2	580	583	PF00928	0.400
TRG_ER_diArg_1	124	126	PF00400	0.538
TRG_ER_diArg_1	263	265	PF00400	0.667
TRG_ER_diArg_1	571	573	PF00400	0.729
TRG_ER_diArg_1	588	591	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.685

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5X4	Leishmania donovani	72%	98%
A4HT32	Leishmania infantum	72%	98%
E9AL46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	98%
Q4QIQ8	Leishmania major	70%	100%