Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX family hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4X9_LEIBR

TriTrypDb:

LbrM.07.0350 , LBRM2903_070009800

Length:

829

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H4X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006195	purine nucleotide catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009154	purine ribonucleotide catabolic process	6	1
GO:0009166	nucleotide catabolic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009261	ribonucleotide catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015938	coenzyme A catabolic process	7	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033869	nucleoside bisphosphate catabolic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034031	ribonucleoside bisphosphate catabolic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034034	purine nucleoside bisphosphate catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901292	nucleoside phosphate catabolic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0010945	CoA pyrophosphatase activity	6	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0003986	acetyl-CoA hydrolase activity	6	1
GO:0016289	CoA hydrolase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016790	thiolester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.455
CLV_NRD_NRD_1	173	175	PF00675	0.443
CLV_NRD_NRD_1	265	267	PF00675	0.535
CLV_NRD_NRD_1	425	427	PF00675	0.409
CLV_NRD_NRD_1	482	484	PF00675	0.372
CLV_NRD_NRD_1	551	553	PF00675	0.439
CLV_NRD_NRD_1	64	66	PF00675	0.617
CLV_PCSK_FUR_1	422	426	PF00082	0.336
CLV_PCSK_KEX2_1	154	156	PF00082	0.469
CLV_PCSK_KEX2_1	173	175	PF00082	0.543
CLV_PCSK_KEX2_1	265	267	PF00082	0.535
CLV_PCSK_KEX2_1	424	426	PF00082	0.422
CLV_PCSK_KEX2_1	482	484	PF00082	0.372
CLV_PCSK_KEX2_1	550	552	PF00082	0.436
CLV_PCSK_KEX2_1	64	66	PF00082	0.617
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.456
CLV_PCSK_PC7_1	547	553	PF00082	0.352
CLV_PCSK_SKI1_1	109	113	PF00082	0.616
CLV_PCSK_SKI1_1	201	205	PF00082	0.478
CLV_PCSK_SKI1_1	228	232	PF00082	0.475
CLV_PCSK_SKI1_1	257	261	PF00082	0.577
CLV_PCSK_SKI1_1	285	289	PF00082	0.531
CLV_PCSK_SKI1_1	49	53	PF00082	0.559
CLV_PCSK_SKI1_1	59	63	PF00082	0.555
CLV_PCSK_SKI1_1	728	732	PF00082	0.439
DEG_APCC_DBOX_1	284	292	PF00400	0.300
DEG_COP1_1	607	616	PF00400	0.637
DEG_SCF_FBW7_1	304	311	PF00400	0.377
DEG_SCF_FBW7_1	689	695	PF00400	0.653
DEG_SCF_FBW7_2	498	505	PF00400	0.485
DEG_SPOP_SBC_1	309	313	PF00917	0.570
DEG_SPOP_SBC_1	80	84	PF00917	0.428
DOC_CKS1_1	305	310	PF01111	0.383
DOC_CKS1_1	499	504	PF01111	0.495
DOC_CKS1_1	689	694	PF01111	0.653
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	457	463	PF00134	0.583
DOC_MAPK_DCC_7	722	732	PF00069	0.640
DOC_MAPK_gen_1	796	803	PF00069	0.631
DOC_MAPK_MEF2A_6	34	43	PF00069	0.318
DOC_MAPK_MEF2A_6	728	736	PF00069	0.636
DOC_PP1_RVXF_1	190	196	PF00149	0.217
DOC_PP2B_LxvP_1	3	6	PF13499	0.304
DOC_PP4_FxxP_1	276	279	PF00568	0.432
DOC_PP4_FxxP_1	380	383	PF00568	0.384
DOC_PP4_FxxP_1	496	499	PF00568	0.225
DOC_USP7_MATH_1	272	276	PF00917	0.430
DOC_USP7_MATH_1	436	440	PF00917	0.624
DOC_USP7_MATH_1	447	451	PF00917	0.607
DOC_USP7_MATH_1	567	571	PF00917	0.651
DOC_USP7_MATH_1	572	576	PF00917	0.617
DOC_USP7_MATH_1	668	672	PF00917	0.726
DOC_USP7_MATH_1	768	772	PF00917	0.624
DOC_USP7_MATH_1	80	84	PF00917	0.488
DOC_USP7_MATH_1	804	808	PF00917	0.637
DOC_USP7_MATH_1	97	101	PF00917	0.415
DOC_WW_Pin1_4	235	240	PF00397	0.275
DOC_WW_Pin1_4	304	309	PF00397	0.355
DOC_WW_Pin1_4	316	321	PF00397	0.432
DOC_WW_Pin1_4	349	354	PF00397	0.508
DOC_WW_Pin1_4	459	464	PF00397	0.571
DOC_WW_Pin1_4	498	503	PF00397	0.489
DOC_WW_Pin1_4	559	564	PF00397	0.610
DOC_WW_Pin1_4	666	671	PF00397	0.722
DOC_WW_Pin1_4	680	685	PF00397	0.732
DOC_WW_Pin1_4	688	693	PF00397	0.693
DOC_WW_Pin1_4	809	814	PF00397	0.635
LIG_14-3-3_CanoR_1	257	264	PF00244	0.271
LIG_14-3-3_CanoR_1	377	381	PF00244	0.400
LIG_14-3-3_CanoR_1	446	452	PF00244	0.693
LIG_14-3-3_CanoR_1	619	625	PF00244	0.688
LIG_14-3-3_CanoR_1	728	733	PF00244	0.649
LIG_BIR_III_2	579	583	PF00653	0.607
LIG_BRCT_BRCA1_1	220	224	PF00533	0.312
LIG_BRCT_BRCA1_1	774	778	PF00533	0.623
LIG_BRCT_BRCA1_1	89	93	PF00533	0.515
LIG_CtBP_PxDLS_1	638	642	PF00389	0.611
LIG_deltaCOP1_diTrp_1	159	169	PF00928	0.217
LIG_EH1_1	521	529	PF00400	0.231
LIG_eIF4E_1	522	528	PF01652	0.231
LIG_FHA_1	106	112	PF00498	0.478
LIG_FHA_1	115	121	PF00498	0.404
LIG_FHA_1	15	21	PF00498	0.371
LIG_FHA_1	236	242	PF00498	0.275
LIG_FHA_1	243	249	PF00498	0.287
LIG_FHA_1	305	311	PF00498	0.374
LIG_FHA_1	413	419	PF00498	0.597
LIG_FHA_1	50	56	PF00498	0.362
LIG_FHA_1	502	508	PF00498	0.297
LIG_FHA_1	620	626	PF00498	0.742
LIG_FHA_1	677	683	PF00498	0.695
LIG_FHA_1	689	695	PF00498	0.714
LIG_FHA_1	700	706	PF00498	0.670
LIG_FHA_1	729	735	PF00498	0.647
LIG_FHA_2	321	327	PF00498	0.453
LIG_FHA_2	342	348	PF00498	0.562
LIG_FHA_2	365	371	PF00498	0.372
LIG_FHA_2	436	442	PF00498	0.621
LIG_FHA_2	605	611	PF00498	0.696
LIG_FHA_2	660	666	PF00498	0.655
LIG_FHA_2	667	673	PF00498	0.751
LIG_FHA_2	705	711	PF00498	0.651
LIG_FHA_2	718	724	PF00498	0.645
LIG_FXI_DFP_1	179	183	PF00024	0.529
LIG_Integrin_RGD_1	426	428	PF01839	0.354
LIG_IRF3_LxIS_1	582	589	PF10401	0.603
LIG_LIR_Apic_2	275	279	PF02991	0.433
LIG_LIR_Apic_2	379	383	PF02991	0.365
LIG_LIR_Gen_1	180	190	PF02991	0.275
LIG_LIR_Gen_1	202	210	PF02991	0.283
LIG_LIR_Gen_1	295	304	PF02991	0.352
LIG_LIR_Gen_1	481	491	PF02991	0.475
LIG_LIR_Gen_1	509	518	PF02991	0.229
LIG_LIR_Gen_1	643	652	PF02991	0.626
LIG_LIR_Nem_3	121	126	PF02991	0.369
LIG_LIR_Nem_3	180	185	PF02991	0.275
LIG_LIR_Nem_3	189	193	PF02991	0.275
LIG_LIR_Nem_3	202	206	PF02991	0.228
LIG_LIR_Nem_3	250	256	PF02991	0.275
LIG_LIR_Nem_3	295	299	PF02991	0.419
LIG_LIR_Nem_3	379	385	PF02991	0.465
LIG_LIR_Nem_3	405	411	PF02991	0.312
LIG_LIR_Nem_3	481	487	PF02991	0.475
LIG_LIR_Nem_3	509	513	PF02991	0.276
LIG_LIR_Nem_3	643	647	PF02991	0.624
LIG_MLH1_MIPbox_1	90	94	PF16413	0.454
LIG_Pex14_2	292	296	PF04695	0.304
LIG_REV1ctd_RIR_1	120	128	PF16727	0.280
LIG_RPA_C_Fungi	641	653	PF08784	0.523
LIG_RPA_C_Fungi	793	805	PF08784	0.531
LIG_SH2_CRK	394	398	PF00017	0.327
LIG_SH2_CRK	484	488	PF00017	0.388
LIG_SH2_NCK_1	190	194	PF00017	0.388
LIG_SH2_NCK_1	522	526	PF00017	0.388
LIG_SH2_SRC	125	128	PF00017	0.323
LIG_SH2_STAP1	404	408	PF00017	0.312
LIG_SH2_STAP1	476	480	PF00017	0.354
LIG_SH2_STAP1	522	526	PF00017	0.388
LIG_SH2_STAP1	755	759	PF00017	0.474
LIG_SH2_STAT5	125	128	PF00017	0.480
LIG_SH2_STAT5	522	525	PF00017	0.388
LIG_SH3_3	266	272	PF00018	0.441
LIG_SH3_3	302	308	PF00018	0.427
LIG_SH3_3	350	356	PF00018	0.588
LIG_SH3_3	457	463	PF00018	0.462
LIG_SH3_3	496	502	PF00018	0.312
LIG_SH3_3	731	737	PF00018	0.675
LIG_SUMO_SIM_anti_2	515	521	PF11976	0.231
LIG_SUMO_SIM_anti_2	9	14	PF11976	0.462
LIG_SUMO_SIM_par_1	517	523	PF11976	0.231
LIG_TRAF2_1	608	611	PF00917	0.544
LIG_TRAF2_1	822	825	PF00917	0.551
LIG_TYR_ITIM	392	397	PF00017	0.403
LIG_UBA3_1	150	154	PF00899	0.312
LIG_WRC_WIRS_1	273	278	PF05994	0.527
LIG_WRC_WIRS_1	507	512	PF05994	0.326
LIG_WRC_WIRS_1	55	60	PF05994	0.392
LIG_WRC_WIRS_1	694	699	PF05994	0.573
MOD_CDK_SPxxK_3	459	466	PF00069	0.433
MOD_CK1_1	100	106	PF00069	0.560
MOD_CK1_1	220	226	PF00069	0.279
MOD_CK1_1	298	304	PF00069	0.534
MOD_CK1_1	311	317	PF00069	0.541
MOD_CK1_1	318	324	PF00069	0.646
MOD_CK1_1	32	38	PF00069	0.472
MOD_CK1_1	349	355	PF00069	0.616
MOD_CK1_1	450	456	PF00069	0.703
MOD_CK1_1	462	468	PF00069	0.458
MOD_CK1_1	571	577	PF00069	0.552
MOD_CK1_1	685	691	PF00069	0.715
MOD_CK1_1	698	704	PF00069	0.574
MOD_CK1_1	70	76	PF00069	0.503
MOD_CK1_1	751	757	PF00069	0.482
MOD_CK1_1	790	796	PF00069	0.528
MOD_CK1_1	809	815	PF00069	0.491
MOD_CK1_1	84	90	PF00069	0.706
MOD_CK1_1	92	98	PF00069	0.580
MOD_CK2_1	364	370	PF00069	0.373
MOD_CK2_1	435	441	PF00069	0.514
MOD_CK2_1	475	481	PF00069	0.440
MOD_CK2_1	604	610	PF00069	0.620
MOD_CK2_1	617	623	PF00069	0.618
MOD_CK2_1	659	665	PF00069	0.560
MOD_CK2_1	704	710	PF00069	0.615
MOD_CK2_1	717	723	PF00069	0.550
MOD_CK2_1	751	757	PF00069	0.484
MOD_CK2_1	794	800	PF00069	0.526
MOD_CK2_1	819	825	PF00069	0.557
MOD_CMANNOS	358	361	PF00535	0.437
MOD_CMANNOS	413	416	PF00535	0.402
MOD_CMANNOS	593	596	PF00535	0.526
MOD_Cter_Amidation	171	174	PF01082	0.302
MOD_GlcNHglycan	103	106	PF01048	0.488
MOD_GlcNHglycan	163	166	PF01048	0.388
MOD_GlcNHglycan	249	252	PF01048	0.318
MOD_GlcNHglycan	34	37	PF01048	0.373
MOD_GlcNHglycan	349	352	PF01048	0.584
MOD_GlcNHglycan	430	433	PF01048	0.522
MOD_GlcNHglycan	489	492	PF01048	0.312
MOD_GlcNHglycan	529	532	PF01048	0.300
MOD_GlcNHglycan	554	557	PF01048	0.573
MOD_GlcNHglycan	570	573	PF01048	0.646
MOD_GlcNHglycan	574	577	PF01048	0.617
MOD_GlcNHglycan	614	617	PF01048	0.686
MOD_GlcNHglycan	634	637	PF01048	0.496
MOD_GlcNHglycan	697	700	PF01048	0.824
MOD_GlcNHglycan	748	753	PF01048	0.559
MOD_GlcNHglycan	769	773	PF01048	0.636
MOD_GlcNHglycan	77	80	PF01048	0.657
MOD_GlcNHglycan	86	89	PF01048	0.776
MOD_GlcNHglycan	95	98	PF01048	0.503
MOD_GlcNHglycan	99	102	PF01048	0.528
MOD_GSK3_1	101	108	PF00069	0.471
MOD_GSK3_1	139	146	PF00069	0.398
MOD_GSK3_1	295	302	PF00069	0.394
MOD_GSK3_1	304	311	PF00069	0.642
MOD_GSK3_1	312	319	PF00069	0.653
MOD_GSK3_1	321	328	PF00069	0.562
MOD_GSK3_1	455	462	PF00069	0.596
MOD_GSK3_1	49	56	PF00069	0.452
MOD_GSK3_1	567	574	PF00069	0.587
MOD_GSK3_1	676	683	PF00069	0.710
MOD_GSK3_1	688	695	PF00069	0.664
MOD_GSK3_1	697	704	PF00069	0.656
MOD_GSK3_1	75	82	PF00069	0.657
MOD_GSK3_1	768	775	PF00069	0.602
MOD_GSK3_1	790	797	PF00069	0.526
MOD_GSK3_1	804	811	PF00069	0.504
MOD_GSK3_1	84	91	PF00069	0.773
MOD_GSK3_1	92	99	PF00069	0.656
MOD_LATS_1	215	221	PF00433	0.231
MOD_N-GLC_2	333	335	PF02516	0.557
MOD_NEK2_1	218	223	PF00069	0.234
MOD_NEK2_1	310	315	PF00069	0.533
MOD_NEK2_1	384	389	PF00069	0.428
MOD_NEK2_1	527	532	PF00069	0.234
MOD_NEK2_1	586	591	PF00069	0.550
MOD_NEK2_1	697	702	PF00069	0.805
MOD_NEK2_1	794	799	PF00069	0.558
MOD_NEK2_1	89	94	PF00069	0.507
MOD_NEK2_2	361	366	PF00069	0.469
MOD_NEK2_2	447	452	PF00069	0.507
MOD_PIKK_1	14	20	PF00454	0.441
MOD_PIKK_1	44	50	PF00454	0.489
MOD_PIKK_1	682	688	PF00454	0.554
MOD_PIKK_1	770	776	PF00454	0.515
MOD_PK_1	426	432	PF00069	0.447
MOD_PKA_1	154	160	PF00069	0.333
MOD_PKA_2	154	160	PF00069	0.322
MOD_PKA_2	186	192	PF00069	0.388
MOD_PKA_2	376	382	PF00069	0.485
MOD_PKA_2	618	624	PF00069	0.607
MOD_PKA_2	710	716	PF00069	0.623
MOD_PKA_2	84	90	PF00069	0.644
MOD_PKB_1	339	347	PF00069	0.597
MOD_PKB_1	424	432	PF00069	0.439
MOD_PKB_1	550	558	PF00069	0.437
MOD_Plk_1	476	482	PF00069	0.363
MOD_Plk_1	53	59	PF00069	0.364
MOD_Plk_1	748	754	PF00069	0.504
MOD_Plk_2-3	710	716	PF00069	0.550
MOD_Plk_4	272	278	PF00069	0.461
MOD_Plk_4	292	298	PF00069	0.394
MOD_Plk_4	299	305	PF00069	0.418
MOD_Plk_4	452	458	PF00069	0.569
MOD_Plk_4	512	518	PF00069	0.231
MOD_Plk_4	790	796	PF00069	0.582
MOD_Plk_4	89	95	PF00069	0.507
MOD_ProDKin_1	235	241	PF00069	0.312
MOD_ProDKin_1	304	310	PF00069	0.442
MOD_ProDKin_1	316	322	PF00069	0.530
MOD_ProDKin_1	349	355	PF00069	0.621
MOD_ProDKin_1	459	465	PF00069	0.435
MOD_ProDKin_1	498	504	PF00069	0.492
MOD_ProDKin_1	559	565	PF00069	0.503
MOD_ProDKin_1	666	672	PF00069	0.659
MOD_ProDKin_1	680	686	PF00069	0.670
MOD_ProDKin_1	688	694	PF00069	0.618
MOD_ProDKin_1	809	815	PF00069	0.537
MOD_SUMO_rev_2	70	78	PF00179	0.560
TRG_DiLeu_BaEn_3	757	763	PF01217	0.608
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.398
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.482
TRG_ENDOCYTIC_2	190	193	PF00928	0.388
TRG_ENDOCYTIC_2	394	397	PF00928	0.371
TRG_ENDOCYTIC_2	403	406	PF00928	0.262
TRG_ENDOCYTIC_2	484	487	PF00928	0.312
TRG_ENDOCYTIC_2	583	586	PF00928	0.502
TRG_ER_diArg_1	264	266	PF00400	0.498
TRG_ER_diArg_1	421	424	PF00400	0.553
TRG_ER_diArg_1	482	484	PF00400	0.402
TRG_ER_diArg_1	550	552	PF00400	0.539
TRG_ER_diArg_1	795	798	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	49	54	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	595	599	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E0	Leptomonas seymouri	42%	100%
A0A3S7WPU2	Leishmania donovani	64%	100%
A4HT52	Leishmania infantum	64%	90%
E9AL44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QIR0	Leishmania major	61%	99%