Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3735)/Abscisic acid G-protein coupled receptor, putative

Species:

Leishmania braziliensis

UniProt:

A4H4X8_LEIBR

TriTrypDb:

LbrM.07.0340 , LBRM2903_070009700

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H4X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.464
CLV_C14_Caspase3-7	440	444	PF00656	0.618
CLV_NRD_NRD_1	142	144	PF00675	0.522
CLV_NRD_NRD_1	147	149	PF00675	0.497
CLV_NRD_NRD_1	153	155	PF00675	0.412
CLV_NRD_NRD_1	173	175	PF00675	0.425
CLV_NRD_NRD_1	227	229	PF00675	0.617
CLV_NRD_NRD_1	243	245	PF00675	0.674
CLV_NRD_NRD_1	331	333	PF00675	0.767
CLV_NRD_NRD_1	397	399	PF00675	0.275
CLV_NRD_NRD_1	672	674	PF00675	0.501
CLV_PCSK_FUR_1	225	229	PF00082	0.587
CLV_PCSK_KEX2_1	142	144	PF00082	0.527
CLV_PCSK_KEX2_1	147	149	PF00082	0.507
CLV_PCSK_KEX2_1	153	155	PF00082	0.418
CLV_PCSK_KEX2_1	173	175	PF00082	0.425
CLV_PCSK_KEX2_1	202	204	PF00082	0.406
CLV_PCSK_KEX2_1	227	229	PF00082	0.617
CLV_PCSK_KEX2_1	243	245	PF00082	0.674
CLV_PCSK_KEX2_1	330	332	PF00082	0.778
CLV_PCSK_KEX2_1	671	673	PF00082	0.475
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.341
CLV_PCSK_PC7_1	143	149	PF00082	0.485
CLV_PCSK_PC7_1	169	175	PF00082	0.414
CLV_PCSK_SKI1_1	133	137	PF00082	0.313
CLV_PCSK_SKI1_1	205	209	PF00082	0.364
CLV_PCSK_SKI1_1	359	363	PF00082	0.499
CLV_PCSK_SKI1_1	562	566	PF00082	0.409
CLV_PCSK_SKI1_1	615	619	PF00082	0.329
CLV_PCSK_SKI1_1	710	714	PF00082	0.312
CLV_PCSK_SKI1_1	812	816	PF00082	0.231
DEG_APCC_DBOX_1	204	212	PF00400	0.529
DEG_APCC_DBOX_1	709	717	PF00400	0.312
DOC_ANK_TNKS_1	671	678	PF00023	0.329
DOC_CDC14_PxL_1	515	523	PF14671	0.645
DOC_CYCLIN_RxL_1	590	598	PF00134	0.608
DOC_MAPK_gen_1	202	211	PF00069	0.501
DOC_MAPK_MEF2A_6	205	213	PF00069	0.324
DOC_MAPK_MEF2A_6	359	367	PF00069	0.275
DOC_MAPK_MEF2A_6	622	631	PF00069	0.475
DOC_MAPK_MEF2A_6	730	738	PF00069	0.488
DOC_PP1_RVXF_1	200	207	PF00149	0.648
DOC_PP1_RVXF_1	83	90	PF00149	0.354
DOC_PP2B_LxvP_1	229	232	PF13499	0.394
DOC_PP2B_LxvP_1	256	259	PF13499	0.485
DOC_PP4_FxxP_1	383	386	PF00568	0.312
DOC_PP4_FxxP_1	96	99	PF00568	0.332
DOC_USP7_MATH_1	167	171	PF00917	0.741
DOC_USP7_MATH_1	275	279	PF00917	0.589
DOC_USP7_MATH_1	338	342	PF00917	0.585
DOC_USP7_MATH_1	355	359	PF00917	0.216
DOC_USP7_MATH_1	498	502	PF00917	0.716
DOC_USP7_MATH_1	59	63	PF00917	0.387
DOC_USP7_MATH_2	259	265	PF00917	0.431
DOC_USP7_MATH_2	498	504	PF00917	0.639
DOC_WW_Pin1_4	182	187	PF00397	0.622
DOC_WW_Pin1_4	330	335	PF00397	0.458
DOC_WW_Pin1_4	376	381	PF00397	0.312
DOC_WW_Pin1_4	433	438	PF00397	0.680
DOC_WW_Pin1_4	441	446	PF00397	0.680
DOC_WW_Pin1_4	451	456	PF00397	0.700
DOC_WW_Pin1_4	503	508	PF00397	0.653
DOC_WW_Pin1_4	551	556	PF00397	0.672
DOC_WW_Pin1_4	557	562	PF00397	0.666
DOC_WW_Pin1_4	760	765	PF00397	0.327
DOC_WW_Pin1_4	773	778	PF00397	0.250
LIG_14-3-3_CanoR_1	178	187	PF00244	0.696
LIG_14-3-3_CanoR_1	227	232	PF00244	0.460
LIG_14-3-3_CanoR_1	252	256	PF00244	0.471
LIG_14-3-3_CanoR_1	359	364	PF00244	0.296
LIG_14-3-3_CanoR_1	449	454	PF00244	0.740
LIG_14-3-3_CanoR_1	562	568	PF00244	0.638
LIG_14-3-3_CanoR_1	593	598	PF00244	0.609
LIG_14-3-3_CanoR_1	615	620	PF00244	0.529
LIG_14-3-3_CanoR_1	754	758	PF00244	0.339
LIG_Actin_WH2_2	590	606	PF00022	0.488
LIG_Actin_WH2_2	740	756	PF00022	0.391
LIG_BRCT_BRCA1_1	171	175	PF00533	0.729
LIG_BRCT_BRCA1_1	183	187	PF00533	0.635
LIG_BRCT_BRCA1_1	196	200	PF00533	0.644
LIG_BRCT_BRCA1_1	435	439	PF00533	0.687
LIG_BRCT_BRCA1_2	196	202	PF00533	0.557
LIG_deltaCOP1_diTrp_1	432	439	PF00928	0.635
LIG_deltaCOP1_diTrp_1	797	800	PF00928	0.312
LIG_deltaCOP1_diTrp_1	83	89	PF00928	0.354
LIG_EH1_1	14	22	PF00400	0.231
LIG_EH1_1	744	752	PF00400	0.312
LIG_eIF4E_1	16	22	PF01652	0.316
LIG_eIF4E_1	745	751	PF01652	0.312
LIG_FHA_1	107	113	PF00498	0.320
LIG_FHA_1	116	122	PF00498	0.335
LIG_FHA_1	123	129	PF00498	0.350
LIG_FHA_1	224	230	PF00498	0.410
LIG_FHA_1	251	257	PF00498	0.472
LIG_FHA_1	355	361	PF00498	0.278
LIG_FHA_1	41	47	PF00498	0.312
LIG_FHA_1	527	533	PF00498	0.758
LIG_FHA_1	548	554	PF00498	0.648
LIG_FHA_1	656	662	PF00498	0.275
LIG_FHA_1	665	671	PF00498	0.294
LIG_FHA_1	90	96	PF00498	0.411
LIG_FHA_2	343	349	PF00498	0.351
LIG_FHA_2	682	688	PF00498	0.329
LIG_GBD_Chelix_1	705	713	PF00786	0.231
LIG_LIR_Apic_2	432	437	PF02991	0.624
LIG_LIR_Apic_2	501	507	PF02991	0.642
LIG_LIR_Apic_2	516	520	PF02991	0.620
LIG_LIR_Apic_2	94	99	PF02991	0.331
LIG_LIR_Gen_1	107	116	PF02991	0.461
LIG_LIR_Gen_1	372	382	PF02991	0.388
LIG_LIR_Gen_1	49	59	PF02991	0.312
LIG_LIR_Gen_1	592	601	PF02991	0.571
LIG_LIR_Gen_1	797	802	PF02991	0.309
LIG_LIR_Gen_1	9	17	PF02991	0.307
LIG_LIR_Nem_3	107	113	PF02991	0.437
LIG_LIR_Nem_3	3	8	PF02991	0.362
LIG_LIR_Nem_3	372	377	PF02991	0.388
LIG_LIR_Nem_3	473	478	PF02991	0.641
LIG_LIR_Nem_3	49	54	PF02991	0.312
LIG_LIR_Nem_3	592	597	PF02991	0.574
LIG_LIR_Nem_3	598	603	PF02991	0.517
LIG_LIR_Nem_3	786	792	PF02991	0.324
LIG_LIR_Nem_3	797	801	PF02991	0.256
LIG_LIR_Nem_3	9	14	PF02991	0.300
LIG_NRBOX	111	117	PF00104	0.309
LIG_NRBOX	207	213	PF00104	0.388
LIG_Pex14_1	110	114	PF04695	0.231
LIG_Pex14_2	127	131	PF04695	0.231
LIG_Pex14_2	187	191	PF04695	0.634
LIG_Pex14_2	40	44	PF04695	0.312
LIG_Pex14_2	96	100	PF04695	0.331
LIG_PTAP_UEV_1	276	281	PF05743	0.437
LIG_SH2_CRK	246	250	PF00017	0.483
LIG_SH2_CRK	374	378	PF00017	0.312
LIG_SH2_CRK	427	431	PF00017	0.582
LIG_SH2_CRK	475	479	PF00017	0.720
LIG_SH2_CRK	624	628	PF00017	0.312
LIG_SH2_CRK	634	638	PF00017	0.312
LIG_SH2_CRK	792	796	PF00017	0.275
LIG_SH2_NCK_1	374	378	PF00017	0.312
LIG_SH2_PTP2	517	520	PF00017	0.646
LIG_SH2_SRC	517	520	PF00017	0.646
LIG_SH2_STAP1	11	15	PF00017	0.312
LIG_SH2_STAT3	790	793	PF00017	0.275
LIG_SH2_STAT5	16	19	PF00017	0.340
LIG_SH2_STAT5	246	249	PF00017	0.565
LIG_SH2_STAT5	387	390	PF00017	0.486
LIG_SH2_STAT5	410	413	PF00017	0.565
LIG_SH2_STAT5	517	520	PF00017	0.646
LIG_SH2_STAT5	600	603	PF00017	0.537
LIG_SH2_STAT5	745	748	PF00017	0.312
LIG_SH2_STAT5	824	827	PF00017	0.641
LIG_SH3_2	326	331	PF14604	0.575
LIG_SH3_3	23	29	PF00018	0.458
LIG_SH3_3	274	280	PF00018	0.435
LIG_SH3_3	323	329	PF00018	0.505
LIG_SH3_3	758	764	PF00018	0.217
LIG_SH3_3	765	771	PF00018	0.205
LIG_Sin3_3	51	58	PF02671	0.307
LIG_SUMO_SIM_par_1	749	756	PF11976	0.312
LIG_TYR_ITIM	425	430	PF00017	0.570
LIG_ULM_U2AF65_1	202	207	PF00076	0.538
LIG_WRC_WIRS_1	128	133	PF05994	0.231
LIG_WRC_WIRS_1	302	307	PF05994	0.425
MOD_CDC14_SPxK_1	446	449	PF00782	0.729
MOD_CDC14_SPxK_1	454	457	PF00782	0.692
MOD_CDK_SPK_2	557	562	PF00069	0.616
MOD_CDK_SPxK_1	443	449	PF00069	0.728
MOD_CDK_SPxK_1	451	457	PF00069	0.693
MOD_CK1_1	181	187	PF00069	0.700
MOD_CK1_1	230	236	PF00069	0.436
MOD_CK1_1	251	257	PF00069	0.411
MOD_CK1_1	268	274	PF00069	0.437
MOD_CK1_1	317	323	PF00069	0.462
MOD_CK1_1	341	347	PF00069	0.377
MOD_CK1_1	441	447	PF00069	0.641
MOD_CK1_1	482	488	PF00069	0.631
MOD_CK1_1	49	55	PF00069	0.278
MOD_CK1_1	503	509	PF00069	0.695
MOD_CK1_1	551	557	PF00069	0.684
MOD_CK1_1	566	572	PF00069	0.667
MOD_CK1_1	589	595	PF00069	0.612
MOD_CK1_1	726	732	PF00069	0.466
MOD_CK1_1	88	94	PF00069	0.435
MOD_CK2_1	681	687	PF00069	0.407
MOD_CK2_1	760	766	PF00069	0.255
MOD_CK2_1	824	830	PF00069	0.599
MOD_CMANNOS	86	89	PF00535	0.665
MOD_Cter_Amidation	140	143	PF01082	0.491
MOD_Cter_Amidation	145	148	PF01082	0.498
MOD_DYRK1A_RPxSP_1	451	455	PF00069	0.638
MOD_GlcNHglycan	155	158	PF01048	0.422
MOD_GlcNHglycan	165	168	PF01048	0.468
MOD_GlcNHglycan	267	270	PF01048	0.765
MOD_GlcNHglycan	277	280	PF01048	0.723
MOD_GlcNHglycan	318	322	PF01048	0.660
MOD_GlcNHglycan	371	374	PF01048	0.466
MOD_GlcNHglycan	440	443	PF01048	0.422
MOD_GlcNHglycan	485	488	PF01048	0.488
MOD_GlcNHglycan	51	54	PF01048	0.247
MOD_GlcNHglycan	550	553	PF01048	0.471
MOD_GlcNHglycan	634	637	PF01048	0.272
MOD_GlcNHglycan	65	68	PF01048	0.615
MOD_GlcNHglycan	687	691	PF01048	0.512
MOD_GlcNHglycan	723	726	PF01048	0.281
MOD_GlcNHglycan	826	829	PF01048	0.384
MOD_GSK3_1	149	156	PF00069	0.658
MOD_GSK3_1	163	170	PF00069	0.633
MOD_GSK3_1	174	181	PF00069	0.691
MOD_GSK3_1	223	230	PF00069	0.512
MOD_GSK3_1	244	251	PF00069	0.469
MOD_GSK3_1	261	268	PF00069	0.404
MOD_GSK3_1	338	345	PF00069	0.477
MOD_GSK3_1	355	362	PF00069	0.323
MOD_GSK3_1	40	47	PF00069	0.312
MOD_GSK3_1	433	440	PF00069	0.705
MOD_GSK3_1	470	477	PF00069	0.655
MOD_GSK3_1	479	486	PF00069	0.684
MOD_GSK3_1	547	554	PF00069	0.688
MOD_GSK3_1	562	569	PF00069	0.679
MOD_GSK3_1	589	596	PF00069	0.630
MOD_GSK3_1	59	66	PF00069	0.384
MOD_GSK3_1	677	684	PF00069	0.329
MOD_GSK3_1	717	724	PF00069	0.489
MOD_GSK3_1	753	760	PF00069	0.312
MOD_GSK3_1	818	825	PF00069	0.561
MOD_GSK3_1	85	92	PF00069	0.350
MOD_N-GLC_1	562	567	PF02516	0.439
MOD_N-GLC_1	589	594	PF02516	0.315
MOD_NEK2_1	114	119	PF00069	0.239
MOD_NEK2_1	127	132	PF00069	0.301
MOD_NEK2_1	212	217	PF00069	0.248
MOD_NEK2_1	40	45	PF00069	0.312
MOD_NEK2_1	46	51	PF00069	0.312
MOD_NEK2_1	535	540	PF00069	0.641
MOD_NEK2_1	595	600	PF00069	0.544
MOD_NEK2_1	649	654	PF00069	0.274
MOD_NEK2_1	664	669	PF00069	0.271
MOD_NEK2_1	681	686	PF00069	0.205
MOD_NEK2_1	7	12	PF00069	0.225
MOD_NEK2_1	717	722	PF00069	0.522
MOD_NEK2_1	723	728	PF00069	0.475
MOD_NEK2_1	752	757	PF00069	0.332
MOD_NEK2_1	815	820	PF00069	0.621
MOD_NEK2_2	581	586	PF00069	0.494
MOD_NEK2_2	59	64	PF00069	0.361
MOD_PIKK_1	244	250	PF00454	0.530
MOD_PK_1	227	233	PF00069	0.461
MOD_PKA_1	153	159	PF00069	0.663
MOD_PKA_1	173	179	PF00069	0.608
MOD_PKA_1	227	233	PF00069	0.394
MOD_PKA_2	141	147	PF00069	0.734
MOD_PKA_2	153	159	PF00069	0.592
MOD_PKA_2	173	179	PF00069	0.675
MOD_PKA_2	227	233	PF00069	0.470
MOD_PKA_2	234	240	PF00069	0.479
MOD_PKA_2	251	257	PF00069	0.523
MOD_PKA_2	262	268	PF00069	0.471
MOD_PKA_2	525	531	PF00069	0.676
MOD_PKA_2	753	759	PF00069	0.339
MOD_PKB_1	225	233	PF00069	0.413
MOD_Plk_1	562	568	PF00069	0.615
MOD_Plk_1	589	595	PF00069	0.543
MOD_Plk_1	59	65	PF00069	0.434
MOD_Plk_1	664	670	PF00069	0.359
MOD_Plk_1	677	683	PF00069	0.320
MOD_Plk_4	115	121	PF00069	0.324
MOD_Plk_4	122	128	PF00069	0.327
MOD_Plk_4	212	218	PF00069	0.231
MOD_Plk_4	251	257	PF00069	0.523
MOD_Plk_4	385	391	PF00069	0.529
MOD_Plk_4	46	52	PF00069	0.428
MOD_Plk_4	513	519	PF00069	0.720
MOD_Plk_4	59	65	PF00069	0.380
MOD_Plk_4	595	601	PF00069	0.549
MOD_Plk_4	615	621	PF00069	0.611
MOD_Plk_4	642	648	PF00069	0.288
MOD_Plk_4	664	670	PF00069	0.313
MOD_Plk_4	736	742	PF00069	0.334
MOD_Plk_4	818	824	PF00069	0.552
MOD_Plk_4	85	91	PF00069	0.464
MOD_ProDKin_1	182	188	PF00069	0.622
MOD_ProDKin_1	330	336	PF00069	0.455
MOD_ProDKin_1	376	382	PF00069	0.312
MOD_ProDKin_1	433	439	PF00069	0.686
MOD_ProDKin_1	441	447	PF00069	0.677
MOD_ProDKin_1	451	457	PF00069	0.700
MOD_ProDKin_1	503	509	PF00069	0.655
MOD_ProDKin_1	551	557	PF00069	0.673
MOD_ProDKin_1	760	766	PF00069	0.327
MOD_ProDKin_1	773	779	PF00069	0.250
MOD_SUMO_for_1	308	311	PF00179	0.544
MOD_SUMO_rev_2	190	197	PF00179	0.593
MOD_SUMO_rev_2	77	87	PF00179	0.369
TRG_ENDOCYTIC_2	11	14	PF00928	0.312
TRG_ENDOCYTIC_2	246	249	PF00928	0.446
TRG_ENDOCYTIC_2	374	377	PF00928	0.312
TRG_ENDOCYTIC_2	427	430	PF00928	0.576
TRG_ENDOCYTIC_2	475	478	PF00928	0.711
TRG_ENDOCYTIC_2	600	603	PF00928	0.565
TRG_ENDOCYTIC_2	624	627	PF00928	0.312
TRG_ENDOCYTIC_2	634	637	PF00928	0.312
TRG_ENDOCYTIC_2	792	795	PF00928	0.275
TRG_ER_diArg_1	153	155	PF00400	0.642
TRG_ER_diArg_1	173	175	PF00400	0.600
TRG_ER_diArg_1	203	206	PF00400	0.662
TRG_ER_diArg_1	225	228	PF00400	0.401
TRG_ER_diArg_1	243	245	PF00400	0.472
TRG_ER_diArg_1	329	332	PF00400	0.577
TRG_ER_diArg_1	390	393	PF00400	0.475
TRG_ER_diArg_1	670	673	PF00400	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7R5	Leptomonas seymouri	46%	100%
A0A3S7WPT2	Leishmania donovani	70%	100%
A4HT51	Leishmania infantum	70%	100%
E9AL43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QIR1	Leishmania major	70%	100%