Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4X7_LEIBR

TriTrypDb:

LbrM.07.0330 , LBRM2903_070009600

Length:

1048

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4X7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.629
CLV_C14_Caspase3-7	181	185	PF00656	0.332
CLV_C14_Caspase3-7	616	620	PF00656	0.675
CLV_C14_Caspase3-7	641	645	PF00656	0.505
CLV_C14_Caspase3-7	709	713	PF00656	0.638
CLV_C14_Caspase3-7	975	979	PF00656	0.385
CLV_NRD_NRD_1	1019	1021	PF00675	0.460
CLV_NRD_NRD_1	2	4	PF00675	0.587
CLV_NRD_NRD_1	256	258	PF00675	0.525
CLV_NRD_NRD_1	593	595	PF00675	0.737
CLV_PCSK_KEX2_1	1019	1021	PF00082	0.460
CLV_PCSK_KEX2_1	2	4	PF00082	0.589
CLV_PCSK_KEX2_1	593	595	PF00082	0.644
CLV_PCSK_SKI1_1	1009	1013	PF00082	0.370
CLV_PCSK_SKI1_1	257	261	PF00082	0.450
CLV_PCSK_SKI1_1	422	426	PF00082	0.388
CLV_PCSK_SKI1_1	6	10	PF00082	0.580
CLV_Separin_Metazoa	1022	1026	PF03568	0.297
DEG_APCC_DBOX_1	237	245	PF00400	0.303
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
DEG_SCF_FBW7_1	809	816	PF00400	0.510
DOC_CDC14_PxL_1	958	966	PF14671	0.371
DOC_CKS1_1	264	269	PF01111	0.344
DOC_CKS1_1	308	313	PF01111	0.509
DOC_CKS1_1	810	815	PF01111	0.656
DOC_CYCLIN_RxL_1	255	265	PF00134	0.367
DOC_CYCLIN_RxL_1	558	567	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	924	930	PF00134	0.336
DOC_MAPK_DCC_7	359	367	PF00069	0.394
DOC_MAPK_gen_1	1016	1026	PF00069	0.477
DOC_MAPK_gen_1	2	11	PF00069	0.588
DOC_MAPK_gen_1	417	426	PF00069	0.407
DOC_MAPK_gen_1	492	500	PF00069	0.583
DOC_MAPK_gen_1	559	568	PF00069	0.552
DOC_MAPK_MEF2A_6	1030	1039	PF00069	0.514
DOC_MAPK_MEF2A_6	917	926	PF00069	0.324
DOC_MAPK_RevD_3	580	594	PF00069	0.494
DOC_PP1_RVXF_1	559	566	PF00149	0.547
DOC_PP1_RVXF_1	963	970	PF00149	0.386
DOC_PP2B_LxvP_1	924	927	PF13499	0.330
DOC_PP4_FxxP_1	308	311	PF00568	0.450
DOC_USP7_MATH_1	102	106	PF00917	0.675
DOC_USP7_MATH_1	1043	1047	PF00917	0.432
DOC_USP7_MATH_1	112	116	PF00917	0.699
DOC_USP7_MATH_1	157	161	PF00917	0.459
DOC_USP7_MATH_1	230	234	PF00917	0.251
DOC_USP7_MATH_1	488	492	PF00917	0.689
DOC_USP7_MATH_1	664	668	PF00917	0.692
DOC_USP7_MATH_1	735	739	PF00917	0.642
DOC_USP7_MATH_1	748	752	PF00917	0.649
DOC_USP7_MATH_1	90	94	PF00917	0.755
DOC_WW_Pin1_4	1029	1034	PF00397	0.469
DOC_WW_Pin1_4	20	25	PF00397	0.513
DOC_WW_Pin1_4	263	268	PF00397	0.498
DOC_WW_Pin1_4	307	312	PF00397	0.481
DOC_WW_Pin1_4	319	324	PF00397	0.383
DOC_WW_Pin1_4	360	365	PF00397	0.463
DOC_WW_Pin1_4	527	532	PF00397	0.629
DOC_WW_Pin1_4	700	705	PF00397	0.523
DOC_WW_Pin1_4	737	742	PF00397	0.661
DOC_WW_Pin1_4	809	814	PF00397	0.548
DOC_WW_Pin1_4	850	855	PF00397	0.598
DOC_WW_Pin1_4	97	102	PF00397	0.804
LIG_14-3-3_CanoR_1	1009	1017	PF00244	0.463
LIG_14-3-3_CanoR_1	214	218	PF00244	0.344
LIG_14-3-3_CanoR_1	243	252	PF00244	0.465
LIG_14-3-3_CanoR_1	420	425	PF00244	0.401
LIG_14-3-3_CanoR_1	593	597	PF00244	0.739
LIG_14-3-3_CanoR_1	630	634	PF00244	0.760
LIG_14-3-3_CanoR_1	689	693	PF00244	0.687
LIG_14-3-3_CanoR_1	917	922	PF00244	0.497
LIG_Actin_WH2_2	1010	1027	PF00022	0.307
LIG_Actin_WH2_2	185	201	PF00022	0.525
LIG_Actin_WH2_2	325	340	PF00022	0.504
LIG_Actin_WH2_2	875	893	PF00022	0.428
LIG_Actin_WH2_2	950	967	PF00022	0.386
LIG_APCC_Cbox_2	63	69	PF00515	0.431
LIG_BIR_III_4	838	842	PF00653	0.645
LIG_BRCT_BRCA1_1	644	648	PF00533	0.534
LIG_CaM_IQ_9	189	205	PF13499	0.356
LIG_deltaCOP1_diTrp_1	4	11	PF00928	0.532
LIG_DLG_GKlike_1	917	924	PF00625	0.325
LIG_EH1_1	228	236	PF00400	0.347
LIG_EH1_1	312	320	PF00400	0.362
LIG_eIF4E_1	255	261	PF01652	0.483
LIG_eIF4E_1	313	319	PF01652	0.359
LIG_eIF4E_1	467	473	PF01652	0.440
LIG_FHA_1	1010	1016	PF00498	0.358
LIG_FHA_1	1032	1038	PF00498	0.492
LIG_FHA_1	199	205	PF00498	0.472
LIG_FHA_1	282	288	PF00498	0.519
LIG_FHA_1	324	330	PF00498	0.459
LIG_FHA_1	334	340	PF00498	0.411
LIG_FHA_1	543	549	PF00498	0.469
LIG_FHA_1	619	625	PF00498	0.815
LIG_FHA_1	638	644	PF00498	0.613
LIG_FHA_1	810	816	PF00498	0.798
LIG_FHA_1	821	827	PF00498	0.617
LIG_FHA_1	850	856	PF00498	0.531
LIG_FHA_1	931	937	PF00498	0.415
LIG_FHA_2	129	135	PF00498	0.602
LIG_FHA_2	179	185	PF00498	0.422
LIG_FHA_2	214	220	PF00498	0.469
LIG_FHA_2	245	251	PF00498	0.510
LIG_FHA_2	639	645	PF00498	0.503
LIG_FHA_2	657	663	PF00498	0.578
LIG_FHA_2	989	995	PF00498	0.536
LIG_GBD_Chelix_1	439	447	PF00786	0.480
LIG_LIR_Apic_2	151	157	PF02991	0.486
LIG_LIR_Gen_1	27	38	PF02991	0.592
LIG_LIR_Gen_1	275	286	PF02991	0.520
LIG_LIR_Gen_1	340	350	PF02991	0.448
LIG_LIR_Gen_1	385	396	PF02991	0.389
LIG_LIR_Gen_1	53	61	PF02991	0.523
LIG_LIR_Gen_1	645	655	PF02991	0.503
LIG_LIR_Gen_1	734	744	PF02991	0.497
LIG_LIR_Gen_1	920	928	PF02991	0.327
LIG_LIR_Nem_3	27	33	PF02991	0.531
LIG_LIR_Nem_3	275	281	PF02991	0.687
LIG_LIR_Nem_3	292	297	PF02991	0.344
LIG_LIR_Nem_3	340	345	PF02991	0.422
LIG_LIR_Nem_3	385	391	PF02991	0.409
LIG_LIR_Nem_3	425	431	PF02991	0.406
LIG_LIR_Nem_3	53	59	PF02991	0.635
LIG_LIR_Nem_3	645	651	PF02991	0.510
LIG_LIR_Nem_3	734	739	PF02991	0.493
LIG_LIR_Nem_3	920	924	PF02991	0.328
LIG_LYPXL_yS_3	379	382	PF13949	0.463
LIG_PCNA_yPIPBox_3	446	456	PF02747	0.472
LIG_Pex14_1	26	30	PF04695	0.519
LIG_Pex14_2	7	11	PF04695	0.523
LIG_Rb_LxCxE_1	363	375	PF01857	0.460
LIG_RPA_C_Fungi	487	499	PF08784	0.647
LIG_SH2_CRK	264	268	PF00017	0.510
LIG_SH2_CRK	278	282	PF00017	0.614
LIG_SH2_CRK	875	879	PF00017	0.421
LIG_SH2_GRB2like	278	281	PF00017	0.572
LIG_SH2_GRB2like	509	512	PF00017	0.475
LIG_SH2_GRB2like	968	971	PF00017	0.358
LIG_SH2_NCK_1	264	268	PF00017	0.451
LIG_SH2_SRC	120	123	PF00017	0.565
LIG_SH2_SRC	227	230	PF00017	0.337
LIG_SH2_SRC	299	302	PF00017	0.548
LIG_SH2_STAP1	342	346	PF00017	0.485
LIG_SH2_STAT3	313	316	PF00017	0.337
LIG_SH2_STAT3	467	470	PF00017	0.398
LIG_SH2_STAT3	478	481	PF00017	0.690
LIG_SH2_STAT5	154	157	PF00017	0.488
LIG_SH2_STAT5	215	218	PF00017	0.482
LIG_SH2_STAT5	227	230	PF00017	0.363
LIG_SH2_STAT5	240	243	PF00017	0.345
LIG_SH2_STAT5	255	258	PF00017	0.401
LIG_SH2_STAT5	264	267	PF00017	0.402
LIG_SH2_STAT5	299	302	PF00017	0.455
LIG_SH2_STAT5	453	456	PF00017	0.434
LIG_SH2_STAT5	467	470	PF00017	0.372
LIG_SH2_STAT5	478	481	PF00017	0.671
LIG_SH2_STAT5	61	64	PF00017	0.475
LIG_SH2_STAT5	921	924	PF00017	0.456
LIG_SH2_STAT5	945	948	PF00017	0.386
LIG_SH2_STAT5	968	971	PF00017	0.358
LIG_SH2_STAT5	984	987	PF00017	0.363
LIG_SH3_3	256	262	PF00018	0.471
LIG_SH3_3	308	314	PF00018	0.413
LIG_SH3_3	403	409	PF00018	0.471
LIG_SH3_3	516	522	PF00018	0.631
LIG_SH3_3	578	584	PF00018	0.643
LIG_SH3_3	648	654	PF00018	0.764
LIG_SH3_3	66	72	PF00018	0.657
LIG_SH3_3	924	930	PF00018	0.417
LIG_TRAF2_1	583	586	PF00917	0.568
LIG_TRAF2_1	935	938	PF00917	0.502
LIG_TYR_ITIM	276	281	PF00017	0.579
MOD_CDC14_SPxK_1	322	325	PF00782	0.541
MOD_CDK_SPxK_1	263	269	PF00069	0.515
MOD_CDK_SPxK_1	319	325	PF00069	0.553
MOD_CK1_1	1004	1010	PF00069	0.384
MOD_CK1_1	115	121	PF00069	0.663
MOD_CK1_1	530	536	PF00069	0.654
MOD_CK1_1	632	638	PF00069	0.611
MOD_CK1_1	642	648	PF00069	0.624
MOD_CK1_1	656	662	PF00069	0.540
MOD_CK1_1	683	689	PF00069	0.598
MOD_CK1_1	728	734	PF00069	0.498
MOD_CK1_1	767	773	PF00069	0.795
MOD_CK1_1	786	792	PF00069	0.776
MOD_CK1_1	795	801	PF00069	0.802
MOD_CK1_1	827	833	PF00069	0.572
MOD_CK1_1	93	99	PF00069	0.824
MOD_CK2_1	244	250	PF00069	0.416
MOD_CK2_1	337	343	PF00069	0.467
MOD_CK2_1	664	670	PF00069	0.546
MOD_CK2_1	728	734	PF00069	0.655
MOD_CK2_1	840	846	PF00069	0.516
MOD_CK2_1	932	938	PF00069	0.538
MOD_CK2_1	988	994	PF00069	0.409
MOD_GlcNHglycan	105	108	PF01048	0.777
MOD_GlcNHglycan	457	460	PF01048	0.453
MOD_GlcNHglycan	485	489	PF01048	0.673
MOD_GlcNHglycan	527	530	PF01048	0.715
MOD_GlcNHglycan	596	599	PF01048	0.702
MOD_GlcNHglycan	634	637	PF01048	0.589
MOD_GlcNHglycan	644	647	PF01048	0.576
MOD_GlcNHglycan	655	658	PF01048	0.717
MOD_GlcNHglycan	666	669	PF01048	0.788
MOD_GlcNHglycan	682	685	PF01048	0.545
MOD_GlcNHglycan	700	703	PF01048	0.595
MOD_GlcNHglycan	717	720	PF01048	0.689
MOD_GlcNHglycan	726	730	PF01048	0.626
MOD_GlcNHglycan	748	751	PF01048	0.633
MOD_GlcNHglycan	785	788	PF01048	0.626
MOD_GlcNHglycan	789	792	PF01048	0.635
MOD_GlcNHglycan	798	801	PF01048	0.637
MOD_GlcNHglycan	816	819	PF01048	0.536
MOD_GlcNHglycan	828	832	PF01048	0.587
MOD_GlcNHglycan	940	944	PF01048	0.455
MOD_GSK3_1	112	119	PF00069	0.525
MOD_GSK3_1	123	130	PF00069	0.526
MOD_GSK3_1	281	288	PF00069	0.622
MOD_GSK3_1	319	326	PF00069	0.488
MOD_GSK3_1	333	340	PF00069	0.403
MOD_GSK3_1	382	389	PF00069	0.413
MOD_GSK3_1	484	491	PF00069	0.610
MOD_GSK3_1	50	57	PF00069	0.541
MOD_GSK3_1	525	532	PF00069	0.774
MOD_GSK3_1	538	545	PF00069	0.750
MOD_GSK3_1	594	601	PF00069	0.707
MOD_GSK3_1	628	635	PF00069	0.595
MOD_GSK3_1	638	645	PF00069	0.636
MOD_GSK3_1	679	686	PF00069	0.623
MOD_GSK3_1	698	705	PF00069	0.534
MOD_GSK3_1	742	749	PF00069	0.636
MOD_GSK3_1	755	762	PF00069	0.668
MOD_GSK3_1	783	790	PF00069	0.641
MOD_GSK3_1	792	799	PF00069	0.709
MOD_GSK3_1	809	816	PF00069	0.619
MOD_GSK3_1	820	827	PF00069	0.674
MOD_GSK3_1	93	100	PF00069	0.736
MOD_N-GLC_1	693	698	PF02516	0.599
MOD_N-GLC_1	710	715	PF02516	0.534
MOD_N-GLC_1	988	993	PF02516	0.333
MOD_N-GLC_2	411	413	PF02516	0.353
MOD_NEK2_1	1026	1031	PF00069	0.365
MOD_NEK2_1	198	203	PF00069	0.488
MOD_NEK2_1	213	218	PF00069	0.436
MOD_NEK2_1	223	228	PF00069	0.417
MOD_NEK2_1	337	342	PF00069	0.466
MOD_NEK2_1	346	351	PF00069	0.370
MOD_NEK2_1	438	443	PF00069	0.372
MOD_NEK2_1	447	452	PF00069	0.377
MOD_NEK2_1	484	489	PF00069	0.572
MOD_NEK2_1	634	639	PF00069	0.717
MOD_NEK2_1	680	685	PF00069	0.604
MOD_NEK2_1	698	703	PF00069	0.581
MOD_NEK2_1	81	86	PF00069	0.613
MOD_NEK2_1	814	819	PF00069	0.637
MOD_NEK2_1	878	883	PF00069	0.423
MOD_PIKK_1	123	129	PF00454	0.549
MOD_PKA_2	198	204	PF00069	0.552
MOD_PKA_2	213	219	PF00069	0.414
MOD_PKA_2	244	250	PF00069	0.453
MOD_PKA_2	488	494	PF00069	0.685
MOD_PKA_2	592	598	PF00069	0.783
MOD_PKA_2	613	619	PF00069	0.674
MOD_PKA_2	629	635	PF00069	0.632
MOD_PKA_2	688	694	PF00069	0.660
MOD_PKA_2	93	99	PF00069	0.704
MOD_PKB_1	420	428	PF00069	0.388
MOD_Plk_1	274	280	PF00069	0.625
MOD_Plk_1	346	352	PF00069	0.374
MOD_Plk_1	372	378	PF00069	0.511
MOD_Plk_1	50	56	PF00069	0.508
MOD_Plk_1	693	699	PF00069	0.679
MOD_Plk_1	930	936	PF00069	0.511
MOD_Plk_1	988	994	PF00069	0.488
MOD_Plk_4	1031	1037	PF00069	0.423
MOD_Plk_4	223	229	PF00069	0.401
MOD_Plk_4	230	236	PF00069	0.355
MOD_Plk_4	337	343	PF00069	0.406
MOD_Plk_4	439	445	PF00069	0.402
MOD_Plk_4	542	548	PF00069	0.638
MOD_Plk_4	629	635	PF00069	0.679
MOD_Plk_4	644	650	PF00069	0.685
MOD_Plk_4	894	900	PF00069	0.689
MOD_Plk_4	917	923	PF00069	0.400
MOD_ProDKin_1	1029	1035	PF00069	0.469
MOD_ProDKin_1	20	26	PF00069	0.511
MOD_ProDKin_1	263	269	PF00069	0.507
MOD_ProDKin_1	307	313	PF00069	0.476
MOD_ProDKin_1	319	325	PF00069	0.387
MOD_ProDKin_1	360	366	PF00069	0.461
MOD_ProDKin_1	527	533	PF00069	0.629
MOD_ProDKin_1	700	706	PF00069	0.526
MOD_ProDKin_1	737	743	PF00069	0.663
MOD_ProDKin_1	809	815	PF00069	0.548
MOD_ProDKin_1	850	856	PF00069	0.597
MOD_ProDKin_1	97	103	PF00069	0.804
MOD_SUMO_for_1	1037	1040	PF00179	0.384
MOD_SUMO_rev_2	296	305	PF00179	0.475
MOD_SUMO_rev_2	384	394	PF00179	0.490
MOD_SUMO_rev_2	398	406	PF00179	0.506
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.490
TRG_ENDOCYTIC_2	278	281	PF00928	0.549
TRG_ENDOCYTIC_2	28	31	PF00928	0.608
TRG_ENDOCYTIC_2	342	345	PF00928	0.477
TRG_ENDOCYTIC_2	379	382	PF00928	0.470
TRG_ENDOCYTIC_2	388	391	PF00928	0.384
TRG_ENDOCYTIC_2	428	431	PF00928	0.425
TRG_ENDOCYTIC_2	875	878	PF00928	0.604
TRG_ENDOCYTIC_2	921	924	PF00928	0.321
TRG_ER_diArg_1	1	3	PF00400	0.596
TRG_ER_diArg_1	1019	1021	PF00400	0.460
TRG_ER_diArg_1	242	245	PF00400	0.447
TRG_ER_diArg_1	493	496	PF00400	0.734
TRG_ER_diArg_1	962	965	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7D4	Leptomonas seymouri	55%	91%
A0A3R7MCX5	Trypanosoma rangeli	39%	100%
A0A3S5H5X2	Leishmania donovani	75%	100%
A4HT50	Leishmania infantum	75%	100%
E9AL42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QIR2	Leishmania major	73%	98%
V5D8R0	Trypanosoma cruzi	40%	100%