Paraflagellar_rod_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4X6_LEIBR

TriTrypDb:

LbrM.07.0320 , LBRM2903_070009400 , LBRM2903_070009500

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0031514	motile cilium	5	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11

Expansion

Sequence features

A4H4X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005516	calmodulin binding	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.552
CLV_C14_Caspase3-7	552	556	PF00656	0.355
CLV_C14_Caspase3-7	711	715	PF00656	0.631
CLV_C14_Caspase3-7	92	96	PF00656	0.425
CLV_NRD_NRD_1	210	212	PF00675	0.456
CLV_NRD_NRD_1	317	319	PF00675	0.400
CLV_NRD_NRD_1	389	391	PF00675	0.547
CLV_NRD_NRD_1	5	7	PF00675	0.551
CLV_NRD_NRD_1	643	645	PF00675	0.297
CLV_PCSK_FUR_1	581	585	PF00082	0.395
CLV_PCSK_KEX2_1	131	133	PF00082	0.594
CLV_PCSK_KEX2_1	210	212	PF00082	0.454
CLV_PCSK_KEX2_1	317	319	PF00082	0.356
CLV_PCSK_KEX2_1	338	340	PF00082	0.534
CLV_PCSK_KEX2_1	389	391	PF00082	0.560
CLV_PCSK_KEX2_1	5	7	PF00082	0.551
CLV_PCSK_KEX2_1	583	585	PF00082	0.357
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.443
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.598
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.395
CLV_PCSK_SKI1_1	185	189	PF00082	0.476
CLV_PCSK_SKI1_1	210	214	PF00082	0.467
CLV_PCSK_SKI1_1	28	32	PF00082	0.612
CLV_PCSK_SKI1_1	318	322	PF00082	0.548
CLV_PCSK_SKI1_1	374	378	PF00082	0.477
CLV_PCSK_SKI1_1	422	426	PF00082	0.440
CLV_PCSK_SKI1_1	543	547	PF00082	0.322
CLV_PCSK_SKI1_1	653	657	PF00082	0.373
CLV_PCSK_SKI1_1	807	811	PF00082	0.537
DEG_APCC_DBOX_1	209	217	PF00400	0.389
DEG_APCC_DBOX_1	373	381	PF00400	0.380
DEG_APCC_DBOX_1	449	457	PF00400	0.402
DEG_APCC_DBOX_1	630	638	PF00400	0.197
DEG_APCC_DBOX_1	789	797	PF00400	0.548
DEG_ODPH_VHL_1	223	235	PF01847	0.542
DEG_SCF_FBW7_2	187	194	PF00400	0.573
DEG_SPOP_SBC_1	741	745	PF00917	0.763
DOC_CKS1_1	176	181	PF01111	0.540
DOC_CKS1_1	188	193	PF01111	0.572
DOC_CKS1_1	677	682	PF01111	0.676
DOC_CYCLIN_RxL_1	78	89	PF00134	0.614
DOC_CYCLIN_RxL_1	801	814	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.588
DOC_MAPK_DCC_7	189	197	PF00069	0.519
DOC_MAPK_gen_1	372	380	PF00069	0.383
DOC_MAPK_gen_1	386	395	PF00069	0.423
DOC_MAPK_MEF2A_6	189	197	PF00069	0.519
DOC_MAPK_MEF2A_6	625	634	PF00069	0.410
DOC_PP2B_LxvP_1	222	225	PF13499	0.562
DOC_PP2B_LxvP_1	698	701	PF13499	0.502
DOC_PP2B_LxvP_1	99	102	PF13499	0.591
DOC_USP7_MATH_1	148	152	PF00917	0.561
DOC_USP7_MATH_1	376	380	PF00917	0.450
DOC_USP7_MATH_1	413	417	PF00917	0.439
DOC_USP7_MATH_1	445	449	PF00917	0.352
DOC_USP7_MATH_1	51	55	PF00917	0.639
DOC_USP7_MATH_1	65	69	PF00917	0.728
DOC_USP7_MATH_1	694	698	PF00917	0.750
DOC_USP7_MATH_1	699	703	PF00917	0.724
DOC_USP7_MATH_1	726	730	PF00917	0.590
DOC_USP7_MATH_1	734	738	PF00917	0.629
DOC_USP7_MATH_1	759	763	PF00917	0.510
DOC_USP7_MATH_2	102	108	PF00917	0.580
DOC_WW_Pin1_4	175	180	PF00397	0.564
DOC_WW_Pin1_4	187	192	PF00397	0.478
DOC_WW_Pin1_4	216	221	PF00397	0.544
DOC_WW_Pin1_4	676	681	PF00397	0.708
LIG_14-3-3_CanoR_1	132	140	PF00244	0.450
LIG_14-3-3_CanoR_1	170	177	PF00244	0.528
LIG_14-3-3_CanoR_1	333	338	PF00244	0.358
LIG_14-3-3_CanoR_1	584	591	PF00244	0.361
LIG_14-3-3_CanoR_1	596	600	PF00244	0.350
LIG_14-3-3_CanoR_1	604	611	PF00244	0.264
LIG_14-3-3_CanoR_1	619	627	PF00244	0.322
LIG_14-3-3_CanoR_1	658	665	PF00244	0.519
LIG_14-3-3_CanoR_1	88	94	PF00244	0.567
LIG_Actin_WH2_2	772	789	PF00022	0.569
LIG_APCC_ABBA_1	378	383	PF00400	0.451
LIG_APCC_ABBA_1	82	87	PF00400	0.449
LIG_BIR_III_2	693	697	PF00653	0.729
LIG_Clathr_ClatBox_1	809	813	PF01394	0.579
LIG_eIF4E_1	17	23	PF01652	0.554
LIG_FHA_1	154	160	PF00498	0.577
LIG_FHA_1	275	281	PF00498	0.650
LIG_FHA_1	423	429	PF00498	0.355
LIG_FHA_1	622	628	PF00498	0.292
LIG_FHA_1	677	683	PF00498	0.658
LIG_FHA_1	701	707	PF00498	0.551
LIG_FHA_1	750	756	PF00498	0.520
LIG_FHA_2	176	182	PF00498	0.533
LIG_FHA_2	284	290	PF00498	0.724
LIG_FHA_2	584	590	PF00498	0.410
LIG_FHA_2	709	715	PF00498	0.706
LIG_LIR_Gen_1	104	110	PF02991	0.538
LIG_LIR_Nem_3	104	108	PF02991	0.542
LIG_LIR_Nem_3	564	569	PF02991	0.371
LIG_LIR_Nem_3	780	786	PF02991	0.557
LIG_NRBOX	212	218	PF00104	0.406
LIG_NRBOX	238	244	PF00104	0.355
LIG_SH2_CRK	105	109	PF00017	0.419
LIG_SH2_SRC	165	168	PF00017	0.408
LIG_SH2_SRC	536	539	PF00017	0.292
LIG_SH2_STAP1	105	109	PF00017	0.419
LIG_SH2_STAP1	409	413	PF00017	0.410
LIG_SH2_STAP1	570	574	PF00017	0.355
LIG_SH2_STAP1	8	12	PF00017	0.565
LIG_SH2_STAT3	484	487	PF00017	0.292
LIG_SH2_STAT3	569	572	PF00017	0.270
LIG_SH2_STAT3	764	767	PF00017	0.518
LIG_SH2_STAT5	165	168	PF00017	0.483
LIG_SH2_STAT5	221	224	PF00017	0.494
LIG_SH2_STAT5	536	539	PF00017	0.254
LIG_SH2_STAT5	566	569	PF00017	0.279
LIG_SH2_STAT5	63	66	PF00017	0.696
LIG_SH2_STAT5	633	636	PF00017	0.297
LIG_SH2_STAT5	764	767	PF00017	0.573
LIG_SH3_1	18	24	PF00018	0.700
LIG_SH3_3	173	179	PF00018	0.397
LIG_SH3_3	18	24	PF00018	0.568
LIG_SH3_3	199	205	PF00018	0.586
LIG_SH3_3	252	258	PF00018	0.587
LIG_SH3_3	68	74	PF00018	0.592
LIG_SH3_3	743	749	PF00018	0.543
LIG_SH3_4	257	264	PF00018	0.640
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.513
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.392
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.434
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.352
LIG_SUMO_SIM_anti_2	391	399	PF11976	0.475
LIG_SUMO_SIM_par_1	376	385	PF11976	0.461
LIG_SUMO_SIM_par_1	391	399	PF11976	0.504
LIG_TRAF2_1	550	553	PF00917	0.355
LIG_TRAF2_1	576	579	PF00917	0.279
LIG_TRAF2_1	778	781	PF00917	0.454
LIG_TRAF2_1	789	792	PF00917	0.545
LIG_TRAF2_1	89	92	PF00917	0.506
LIG_TRFH_1	221	225	PF08558	0.574
LIG_TYR_ITIM	103	108	PF00017	0.423
LIG_TYR_ITIM	38	43	PF00017	0.688
LIG_UBA3_1	367	372	PF00899	0.276
MOD_CK1_1	142	148	PF00069	0.614
MOD_CK1_1	161	167	PF00069	0.587
MOD_CK1_1	379	385	PF00069	0.456
MOD_CK1_1	54	60	PF00069	0.668
MOD_CK1_1	69	75	PF00069	0.704
MOD_CK1_1	729	735	PF00069	0.540
MOD_CK1_1	763	769	PF00069	0.355
MOD_CK2_1	161	167	PF00069	0.464
MOD_CK2_1	243	249	PF00069	0.643
MOD_CK2_1	283	289	PF00069	0.747
MOD_CK2_1	487	493	PF00069	0.410
MOD_CK2_1	635	641	PF00069	0.440
MOD_CK2_1	664	670	PF00069	0.609
MOD_CK2_1	786	792	PF00069	0.609
MOD_CK2_1	86	92	PF00069	0.469
MOD_GlcNHglycan	133	136	PF01048	0.601
MOD_GlcNHglycan	14	17	PF01048	0.616
MOD_GlcNHglycan	150	153	PF01048	0.642
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GlcNHglycan	465	470	PF01048	0.197
MOD_GlcNHglycan	509	512	PF01048	0.397
MOD_GlcNHglycan	68	71	PF01048	0.581
MOD_GlcNHglycan	714	717	PF01048	0.686
MOD_GlcNHglycan	728	731	PF01048	0.445
MOD_GlcNHglycan	75	78	PF01048	0.493
MOD_GSK3_1	329	336	PF00069	0.322
MOD_GSK3_1	434	441	PF00069	0.301
MOD_GSK3_1	50	57	PF00069	0.654
MOD_GSK3_1	594	601	PF00069	0.223
MOD_GSK3_1	65	72	PF00069	0.502
MOD_GSK3_1	708	715	PF00069	0.646
MOD_GSK3_1	726	733	PF00069	0.665
MOD_GSK3_1	759	766	PF00069	0.538
MOD_GSK3_1	83	90	PF00069	0.478
MOD_LATS_1	129	135	PF00433	0.570
MOD_N-GLC_2	267	269	PF02516	0.502
MOD_NEK2_1	594	599	PF00069	0.299
MOD_NEK2_1	657	662	PF00069	0.419
MOD_NEK2_1	742	747	PF00069	0.583
MOD_NEK2_2	158	163	PF00069	0.522
MOD_NEK2_2	376	381	PF00069	0.445
MOD_NEK2_2	445	450	PF00069	0.197
MOD_NEK2_2	51	56	PF00069	0.472
MOD_PIKK_1	196	202	PF00454	0.573
MOD_PIKK_1	228	234	PF00454	0.402
MOD_PIKK_1	428	434	PF00454	0.333
MOD_PIKK_1	583	589	PF00454	0.428
MOD_PIKK_1	598	604	PF00454	0.459
MOD_PIKK_1	657	663	PF00454	0.493
MOD_PIKK_1	763	769	PF00454	0.512
MOD_PIKK_1	87	93	PF00454	0.676
MOD_PKA_1	131	137	PF00069	0.435
MOD_PKA_1	583	589	PF00069	0.410
MOD_PKA_2	131	137	PF00069	0.442
MOD_PKA_2	169	175	PF00069	0.506
MOD_PKA_2	583	589	PF00069	0.313
MOD_PKA_2	595	601	PF00069	0.378
MOD_PKA_2	603	609	PF00069	0.204
MOD_PKA_2	618	624	PF00069	0.201
MOD_PKA_2	657	663	PF00069	0.605
MOD_PKA_2	688	694	PF00069	0.521
MOD_PKA_2	786	792	PF00069	0.552
MOD_PKA_2	87	93	PF00069	0.724
MOD_Plk_1	445	451	PF00069	0.197
MOD_Plk_1	465	471	PF00069	0.150
MOD_Plk_1	760	766	PF00069	0.353
MOD_Plk_2-3	792	798	PF00069	0.402
MOD_Plk_4	104	110	PF00069	0.673
MOD_Plk_4	139	145	PF00069	0.577
MOD_Plk_4	161	167	PF00069	0.555
MOD_Plk_4	231	237	PF00069	0.522
MOD_Plk_4	595	601	PF00069	0.355
MOD_Plk_4	760	766	PF00069	0.353
MOD_ProDKin_1	175	181	PF00069	0.561
MOD_ProDKin_1	187	193	PF00069	0.482
MOD_ProDKin_1	216	222	PF00069	0.546
MOD_ProDKin_1	676	682	PF00069	0.711
MOD_SUMO_rev_2	314	323	PF00179	0.550
MOD_SUMO_rev_2	638	646	PF00179	0.330
MOD_SUMO_rev_2	775	784	PF00179	0.494
TRG_DiLeu_BaEn_1	104	109	PF01217	0.421
TRG_DiLeu_BaEn_1	391	396	PF01217	0.315
TRG_DiLeu_BaEn_1	466	471	PF01217	0.356
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.410
TRG_DiLeu_BaLyEn_6	751	756	PF01217	0.511
TRG_ENDOCYTIC_2	105	108	PF00928	0.539
TRG_ENDOCYTIC_2	40	43	PF00928	0.697
TRG_ENDOCYTIC_2	570	573	PF00928	0.282
TRG_ER_diArg_1	209	211	PF00400	0.460
TRG_ER_diArg_1	388	390	PF00400	0.368
TRG_ER_diArg_1	481	484	PF00400	0.306
TRG_ER_diArg_1	5	7	PF00400	0.551
TRG_ER_diArg_1	590	593	PF00400	0.410
TRG_NES_CRM1_1	138	150	PF08389	0.652
TRG_NES_CRM1_1	412	426	PF08389	0.228
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCV3	Leptomonas seymouri	54%	100%
A0A1X0NP77	Trypanosomatidae	31%	99%
A0A3R7K8M9	Trypanosoma rangeli	33%	100%
A0A3S7WPT1	Leishmania donovani	79%	100%
A4HT49	Leishmania infantum	79%	100%
C9ZUS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QIR3	Leishmania major	78%	100%
V5ASS7	Trypanosoma cruzi	33%	100%