Leucine-rich repeat-containing protein 51

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4X5_LEIBR

TriTrypDb:

LbrM.07.0310 , LBRM2903_070009200 , LBRM2903_070009300

Length:

836

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H4X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	162	166	PF00656	0.687
CLV_C14_Caspase3-7	321	325	PF00656	0.441
CLV_C14_Caspase3-7	493	497	PF00656	0.745
CLV_C14_Caspase3-7	624	628	PF00656	0.540
CLV_NRD_NRD_1	10	12	PF00675	0.515
CLV_NRD_NRD_1	116	118	PF00675	0.681
CLV_NRD_NRD_1	123	125	PF00675	0.671
CLV_NRD_NRD_1	139	141	PF00675	0.681
CLV_NRD_NRD_1	142	144	PF00675	0.691
CLV_NRD_NRD_1	342	344	PF00675	0.575
CLV_NRD_NRD_1	410	412	PF00675	0.607
CLV_NRD_NRD_1	465	467	PF00675	0.826
CLV_PCSK_FUR_1	140	144	PF00082	0.524
CLV_PCSK_KEX2_1	10	12	PF00082	0.515
CLV_PCSK_KEX2_1	115	117	PF00082	0.689
CLV_PCSK_KEX2_1	123	125	PF00082	0.671
CLV_PCSK_KEX2_1	141	143	PF00082	0.545
CLV_PCSK_KEX2_1	410	412	PF00082	0.607
CLV_PCSK_KEX2_1	467	469	PF00082	0.835
CLV_PCSK_KEX2_1	770	772	PF00082	0.648
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.689
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.569
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.802
CLV_PCSK_PC1ET2_1	770	772	PF00082	0.606
CLV_PCSK_PC7_1	112	118	PF00082	0.786
CLV_PCSK_PC7_1	119	125	PF00082	0.653
CLV_PCSK_SKI1_1	11	15	PF00082	0.503
CLV_PCSK_SKI1_1	119	123	PF00082	0.680
CLV_PCSK_SKI1_1	344	348	PF00082	0.632
CLV_PCSK_SKI1_1	410	414	PF00082	0.454
CLV_PCSK_SKI1_1	770	774	PF00082	0.488
CLV_Separin_Metazoa	120	124	PF03568	0.497
DEG_Nend_UBRbox_2	1	3	PF02207	0.562
DOC_ANK_TNKS_1	147	154	PF00023	0.543
DOC_ANK_TNKS_1	180	187	PF00023	0.552
DOC_CDC14_PxL_1	679	687	PF14671	0.523
DOC_CKS1_1	352	357	PF01111	0.486
DOC_CYCLIN_RxL_1	115	126	PF00134	0.670
DOC_CYCLIN_yClb1_LxF_4	585	591	PF00134	0.511
DOC_MAPK_FxFP_2	39	42	PF00069	0.581
DOC_MAPK_gen_1	582	590	PF00069	0.502
DOC_MAPK_gen_1	770	777	PF00069	0.544
DOC_MAPK_HePTP_8	418	430	PF00069	0.451
DOC_MAPK_MEF2A_6	421	430	PF00069	0.472
DOC_MAPK_MEF2A_6	770	777	PF00069	0.544
DOC_MAPK_NFAT4_5	770	778	PF00069	0.550
DOC_PP1_RVXF_1	382	388	PF00149	0.485
DOC_PP1_RVXF_1	785	792	PF00149	0.589
DOC_PP2B_LxvP_1	353	356	PF13499	0.652
DOC_PP2B_LxvP_1	413	416	PF13499	0.510
DOC_PP4_FxxP_1	39	42	PF00568	0.581
DOC_USP7_MATH_1	161	165	PF00917	0.649
DOC_USP7_MATH_1	176	180	PF00917	0.688
DOC_USP7_MATH_1	198	202	PF00917	0.575
DOC_USP7_MATH_1	40	44	PF00917	0.622
DOC_USP7_MATH_1	513	517	PF00917	0.394
DOC_USP7_MATH_1	599	603	PF00917	0.539
DOC_USP7_MATH_1	689	693	PF00917	0.500
DOC_USP7_MATH_1	736	740	PF00917	0.697
DOC_USP7_UBL2_3	568	572	PF12436	0.650
DOC_USP7_UBL2_3	92	96	PF12436	0.558
DOC_WW_Pin1_4	27	32	PF00397	0.528
DOC_WW_Pin1_4	351	356	PF00397	0.488
DOC_WW_Pin1_4	420	425	PF00397	0.635
DOC_WW_Pin1_4	519	524	PF00397	0.580
DOC_WW_Pin1_4	557	562	PF00397	0.569
LIG_14-3-3_CanoR_1	129	136	PF00244	0.739
LIG_14-3-3_CanoR_1	181	185	PF00244	0.545
LIG_14-3-3_CanoR_1	371	380	PF00244	0.425
LIG_14-3-3_CanoR_1	410	416	PF00244	0.634
LIG_14-3-3_CanoR_1	535	540	PF00244	0.641
LIG_14-3-3_CanoR_1	58	62	PF00244	0.484
LIG_BRCT_BRCA1_1	309	313	PF00533	0.594
LIG_eIF4E_1	311	317	PF01652	0.598
LIG_FHA_1	12	18	PF00498	0.495
LIG_FHA_1	227	233	PF00498	0.541
LIG_FHA_1	395	401	PF00498	0.457
LIG_FHA_1	421	427	PF00498	0.462
LIG_FHA_1	71	77	PF00498	0.478
LIG_FHA_2	198	204	PF00498	0.840
LIG_FHA_2	359	365	PF00498	0.661
LIG_FHA_2	412	418	PF00498	0.646
LIG_FHA_2	491	497	PF00498	0.759
LIG_FHA_2	631	637	PF00498	0.397
LIG_FHA_2	793	799	PF00498	0.588
LIG_Integrin_RGD_1	761	763	PF01839	0.512
LIG_LIR_Apic_2	37	42	PF02991	0.563
LIG_LIR_Gen_1	2	8	PF02991	0.520
LIG_LIR_Gen_1	24	34	PF02991	0.521
LIG_LIR_Gen_1	390	399	PF02991	0.318
LIG_LIR_Gen_1	478	488	PF02991	0.708
LIG_LIR_Gen_1	506	515	PF02991	0.529
LIG_LIR_Gen_1	790	799	PF02991	0.587
LIG_LIR_Nem_3	2	6	PF02991	0.526
LIG_LIR_Nem_3	24	29	PF02991	0.511
LIG_LIR_Nem_3	310	316	PF02991	0.578
LIG_LIR_Nem_3	364	369	PF02991	0.641
LIG_LIR_Nem_3	390	394	PF02991	0.376
LIG_LIR_Nem_3	478	484	PF02991	0.714
LIG_LIR_Nem_3	485	490	PF02991	0.671
LIG_LIR_Nem_3	499	505	PF02991	0.542
LIG_LIR_Nem_3	506	510	PF02991	0.515
LIG_LIR_Nem_3	702	706	PF02991	0.516
LIG_LIR_Nem_3	766	772	PF02991	0.545
LIG_LIR_Nem_3	790	794	PF02991	0.595
LIG_MAD2	704	712	PF02301	0.507
LIG_NRBOX	771	777	PF00104	0.539
LIG_PCNA_PIPBox_1	32	41	PF02747	0.636
LIG_PCNA_yPIPBox_3	641	655	PF02747	0.516
LIG_Pex14_1	387	391	PF04695	0.369
LIG_SH2_CRK	26	30	PF00017	0.605
LIG_SH2_CRK	366	370	PF00017	0.731
LIG_SH2_GRB2like	25	28	PF00017	0.341
LIG_SH2_GRB2like	86	89	PF00017	0.551
LIG_SH2_NCK_1	296	300	PF00017	0.475
LIG_SH2_NCK_1	3	7	PF00017	0.516
LIG_SH2_SRC	296	299	PF00017	0.754
LIG_SH2_SRC	591	594	PF00017	0.800
LIG_SH2_STAP1	296	300	PF00017	0.743
LIG_SH2_STAT5	391	394	PF00017	0.542
LIG_SH2_STAT5	715	718	PF00017	0.616
LIG_SH2_STAT5	8	11	PF00017	0.388
LIG_SH3_1	421	427	PF00018	0.542
LIG_SH3_3	187	193	PF00018	0.801
LIG_SH3_3	349	355	PF00018	0.675
LIG_SH3_3	421	427	PF00018	0.598
LIG_SH3_3	551	557	PF00018	0.769
LIG_SUMO_SIM_par_1	32	37	PF11976	0.513
LIG_SUMO_SIM_par_1	334	339	PF11976	0.658
LIG_SUMO_SIM_par_1	411	417	PF11976	0.544
LIG_SUMO_SIM_par_1	665	671	PF11976	0.510
LIG_TRAF2_1	361	364	PF00917	0.761
LIG_TYR_ITIM	713	718	PF00017	0.608
LIG_WRC_WIRS_1	136	141	PF05994	0.754
LIG_WW_3	532	536	PF00397	0.520
MOD_CDK_SPxxK_3	557	564	PF00069	0.548
MOD_CK1_1	224	230	PF00069	0.692
MOD_CK1_1	269	275	PF00069	0.716
MOD_CK1_1	45	51	PF00069	0.639
MOD_CK1_1	562	568	PF00069	0.627
MOD_CK1_1	717	723	PF00069	0.382
MOD_CK1_1	821	827	PF00069	0.552
MOD_CK2_1	358	364	PF00069	0.664
MOD_CK2_1	411	417	PF00069	0.544
MOD_CK2_1	505	511	PF00069	0.361
MOD_CK2_1	586	592	PF00069	0.682
MOD_GlcNHglycan	159	162	PF01048	0.633
MOD_GlcNHglycan	178	181	PF01048	0.493
MOD_GlcNHglycan	200	203	PF01048	0.620
MOD_GlcNHglycan	215	218	PF01048	0.747
MOD_GlcNHglycan	223	226	PF01048	0.688
MOD_GlcNHglycan	262	265	PF01048	0.768
MOD_GlcNHglycan	44	47	PF01048	0.768
MOD_GlcNHglycan	471	475	PF01048	0.577
MOD_GlcNHglycan	524	527	PF01048	0.647
MOD_GlcNHglycan	595	598	PF01048	0.718
MOD_GlcNHglycan	624	627	PF01048	0.688
MOD_GlcNHglycan	642	645	PF01048	0.478
MOD_GlcNHglycan	738	741	PF01048	0.710
MOD_GlcNHglycan	76	79	PF01048	0.703
MOD_GlcNHglycan	765	768	PF01048	0.441
MOD_GSK3_1	157	164	PF00069	0.641
MOD_GSK3_1	176	183	PF00069	0.488
MOD_GSK3_1	207	214	PF00069	0.639
MOD_GSK3_1	265	272	PF00069	0.697
MOD_GSK3_1	320	327	PF00069	0.670
MOD_GSK3_1	40	47	PF00069	0.497
MOD_GSK3_1	426	433	PF00069	0.735
MOD_GSK3_1	439	446	PF00069	0.793
MOD_GSK3_1	668	675	PF00069	0.438
MOD_GSK3_1	70	77	PF00069	0.591
MOD_LATS_1	205	211	PF00433	0.572
MOD_LATS_1	409	415	PF00433	0.618
MOD_N-GLC_1	269	274	PF02516	0.543
MOD_N-GLC_1	562	567	PF02516	0.664
MOD_N-GLC_1	622	627	PF02516	0.563
MOD_N-GLC_1	824	829	PF02516	0.523
MOD_NEK2_1	265	270	PF00069	0.561
MOD_NEK2_1	307	312	PF00069	0.518
MOD_NEK2_1	34	39	PF00069	0.515
MOD_NEK2_1	394	399	PF00069	0.460
MOD_NEK2_1	404	409	PF00069	0.465
MOD_NEK2_1	430	435	PF00069	0.527
MOD_NEK2_1	490	495	PF00069	0.630
MOD_NEK2_1	505	510	PF00069	0.563
MOD_NEK2_1	542	547	PF00069	0.528
MOD_NEK2_1	672	677	PF00069	0.491
MOD_NEK2_1	74	79	PF00069	0.482
MOD_NEK2_1	807	812	PF00069	0.510
MOD_NEK2_2	665	670	PF00069	0.614
MOD_NEK2_2	689	694	PF00069	0.603
MOD_PIKK_1	110	116	PF00454	0.786
MOD_PIKK_1	128	134	PF00454	0.434
MOD_PIKK_1	16	22	PF00454	0.616
MOD_PIKK_1	251	257	PF00454	0.765
MOD_PIKK_1	364	370	PF00454	0.695
MOD_PIKK_1	439	445	PF00454	0.613
MOD_PIKK_1	580	586	PF00454	0.692
MOD_PIKK_1	672	678	PF00454	0.499
MOD_PIKK_1	793	799	PF00454	0.422
MOD_PIKK_1	824	830	PF00454	0.756
MOD_PK_1	207	213	PF00069	0.568
MOD_PKA_2	128	134	PF00069	0.731
MOD_PKA_2	180	186	PF00069	0.547
MOD_PKA_2	446	452	PF00069	0.863
MOD_PKA_2	57	63	PF00069	0.483
MOD_PKA_2	640	646	PF00069	0.502
MOD_Plk_1	505	511	PF00069	0.560
MOD_Plk_1	562	568	PF00069	0.520
MOD_Plk_1	635	641	PF00069	0.508
MOD_Plk_1	677	683	PF00069	0.617
MOD_Plk_1	824	830	PF00069	0.529
MOD_Plk_2-3	678	684	PF00069	0.356
MOD_Plk_4	394	400	PF00069	0.289
MOD_Plk_4	513	519	PF00069	0.611
MOD_Plk_4	542	548	PF00069	0.521
MOD_Plk_4	586	592	PF00069	0.517
MOD_Plk_4	714	720	PF00069	0.369
MOD_ProDKin_1	27	33	PF00069	0.522
MOD_ProDKin_1	351	357	PF00069	0.487
MOD_ProDKin_1	420	426	PF00069	0.642
MOD_ProDKin_1	519	525	PF00069	0.583
MOD_ProDKin_1	557	563	PF00069	0.569
MOD_SUMO_rev_2	298	308	PF00179	0.671
MOD_SUMO_rev_2	321	328	PF00179	0.632
MOD_SUMO_rev_2	728	732	PF00179	0.486
TRG_AP2beta_CARGO_1	485	494	PF09066	0.501
TRG_DiLeu_BaEn_1	304	309	PF01217	0.536
TRG_DiLeu_BaEn_1	514	519	PF01217	0.527
TRG_DiLeu_BaLyEn_6	768	773	PF01217	0.649
TRG_ENDOCYTIC_2	136	139	PF00928	0.652
TRG_ENDOCYTIC_2	25	28	PF00928	0.534
TRG_ENDOCYTIC_2	3	6	PF00928	0.525
TRG_ENDOCYTIC_2	311	314	PF00928	0.592
TRG_ENDOCYTIC_2	366	369	PF00928	0.637
TRG_ENDOCYTIC_2	391	394	PF00928	0.361
TRG_ENDOCYTIC_2	481	484	PF00928	0.706
TRG_ENDOCYTIC_2	715	718	PF00928	0.616
TRG_ENDOCYTIC_2	805	808	PF00928	0.691
TRG_ER_diArg_1	10	12	PF00400	0.515
TRG_ER_diArg_1	116	119	PF00400	0.777
TRG_ER_diArg_1	122	124	PF00400	0.702
TRG_ER_diArg_1	139	142	PF00400	0.542
TRG_ER_diArg_1	410	412	PF00400	0.607
TRG_NLS_MonoExtC_3	114	119	PF00514	0.683
TRG_NLS_MonoExtC_3	465	470	PF00514	0.576
TRG_NLS_MonoExtN_4	112	119	PF00514	0.786
TRG_NLS_MonoExtN_4	464	470	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	686	691	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	755	759	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I156	Leptomonas seymouri	47%	100%
A0A3S7WPS7	Leishmania donovani	70%	99%
A4HT48	Leishmania infantum	69%	98%
E9AL40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	97%
Q4QIR4	Leishmania major	68%	100%