MPN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0172), putative

Species:

Leishmania braziliensis

UniProt:

A4H4X4_LEIBR

TriTrypDb:

LbrM.07.0300 , LBRM2903_070009000 , LBRM2903_070009100

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	10
GO:0072546	EMC complex	3	10
GO:0098796	membrane protein complex	2	10
GO:0140534	endoplasmic reticulum protein-containing complex	2	10
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.626
CLV_PCSK_KEX2_1	37	39	PF00082	0.282
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.282
CLV_PCSK_SKI1_1	130	134	PF00082	0.398
CLV_PCSK_SKI1_1	17	21	PF00082	0.282
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.398
DOC_MAPK_RevD_3	238	254	PF00069	0.388
DOC_PP1_RVXF_1	143	150	PF00149	0.398
DOC_USP7_MATH_1	182	186	PF00917	0.340
DOC_USP7_MATH_1	46	50	PF00917	0.355
DOC_USP7_MATH_1	66	70	PF00917	0.308
DOC_WW_Pin1_4	1	6	PF00397	0.598
DOC_WW_Pin1_4	123	128	PF00397	0.306
DOC_WW_Pin1_4	155	160	PF00397	0.351
DOC_WW_Pin1_4	49	54	PF00397	0.428
DOC_WW_Pin1_4	8	13	PF00397	0.398
LIG_14-3-3_CanoR_1	172	179	PF00244	0.406
LIG_14-3-3_CanoR_1	195	203	PF00244	0.398
LIG_14-3-3_CanoR_1	227	235	PF00244	0.193
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BIR_III_2	75	79	PF00653	0.282
LIG_eIF4E_1	242	248	PF01652	0.355
LIG_FHA_1	14	20	PF00498	0.379
LIG_FHA_1	142	148	PF00498	0.353
LIG_FHA_2	129	135	PF00498	0.277
LIG_FHA_2	204	210	PF00498	0.228
LIG_FHA_2	227	233	PF00498	0.257
LIG_FHA_2	239	245	PF00498	0.333
LIG_LIR_Gen_1	93	102	PF02991	0.288
LIG_LIR_Nem_3	221	226	PF02991	0.361
LIG_LIR_Nem_3	93	99	PF02991	0.290
LIG_PCNA_yPIPBox_3	177	191	PF02747	0.193
LIG_SH2_CRK	23	27	PF00017	0.398
LIG_SH2_NCK_1	96	100	PF00017	0.282
LIG_SH2_SRC	96	99	PF00017	0.355
LIG_SH2_STAP1	15	19	PF00017	0.342
LIG_SH2_STAT3	242	245	PF00017	0.282
LIG_SH2_STAT3	25	28	PF00017	0.282
LIG_SH2_STAT5	114	117	PF00017	0.282
LIG_SH2_STAT5	15	18	PF00017	0.340
LIG_SH2_STAT5	155	158	PF00017	0.193
LIG_SH2_STAT5	242	245	PF00017	0.282
LIG_SH2_STAT5	72	75	PF00017	0.355
LIG_SH3_1	23	29	PF00018	0.398
LIG_SH3_3	23	29	PF00018	0.398
LIG_SH3_3	6	12	PF00018	0.398
LIG_TYR_ITIM	94	99	PF00017	0.282
LIG_UBA3_1	247	254	PF00899	0.527
LIG_WRC_WIRS_1	190	195	PF05994	0.260
MOD_CDK_SPxxK_3	123	130	PF00069	0.398
MOD_CK1_1	103	109	PF00069	0.211
MOD_CK1_1	123	129	PF00069	0.295
MOD_CK1_1	180	186	PF00069	0.377
MOD_CK1_1	4	10	PF00069	0.324
MOD_CK1_1	49	55	PF00069	0.360
MOD_CK1_1	64	70	PF00069	0.455
MOD_CK2_1	128	134	PF00069	0.229
MOD_CK2_1	183	189	PF00069	0.428
MOD_CK2_1	203	209	PF00069	0.411
MOD_CK2_1	226	232	PF00069	0.257
MOD_CK2_1	238	244	PF00069	0.364
MOD_Cter_Amidation	35	38	PF01082	0.282
MOD_GlcNHglycan	63	66	PF01048	0.420
MOD_GSK3_1	102	109	PF00069	0.296
MOD_GSK3_1	4	11	PF00069	0.440
MOD_GSK3_1	49	56	PF00069	0.390
MOD_GSK3_1	61	68	PF00069	0.373
MOD_GSK3_1	79	86	PF00069	0.264
MOD_N-GLC_1	53	58	PF02516	0.253
MOD_NEK2_1	120	125	PF00069	0.376
MOD_NEK2_1	163	168	PF00069	0.453
MOD_NEK2_1	79	84	PF00069	0.323
MOD_PIKK_1	180	186	PF00454	0.369
MOD_PKA_2	171	177	PF00069	0.372
MOD_PKA_2	226	232	PF00069	0.193
MOD_Plk_1	203	209	PF00069	0.355
MOD_Plk_4	106	112	PF00069	0.398
MOD_Plk_4	128	134	PF00069	0.193
MOD_Plk_4	4	10	PF00069	0.414
MOD_ProDKin_1	1	7	PF00069	0.584
MOD_ProDKin_1	123	129	PF00069	0.306
MOD_ProDKin_1	155	161	PF00069	0.351
MOD_ProDKin_1	49	55	PF00069	0.428
MOD_ProDKin_1	8	14	PF00069	0.398
TRG_ENDOCYTIC_2	96	99	PF00928	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7U5	Leptomonas seymouri	73%	100%
A0A1X0NP88	Trypanosomatidae	39%	95%
A0A3S7WPT3	Leishmania donovani	85%	100%
A0A422NDI1	Trypanosoma rangeli	44%	100%
A4HT47	Leishmania infantum	85%	100%
C9ZUT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	93%
E9AL39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QIR5	Leishmania major	85%	100%