Homoserine dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

homoserine dehydrogenase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4X1_LEIBR

TriTrypDb:

LbrM.07.0270 , LBRM2903_070008100

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4X1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4X1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	6
GO:0006520	amino acid metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0019752	carboxylic acid metabolic process	5	6
GO:0043436	oxoacid metabolic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044281	small molecule metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0000096	sulfur amino acid metabolic process	4	4
GO:0000097	sulfur amino acid biosynthetic process	5	4
GO:0006549	isoleucine metabolic process	5	4
GO:0006555	methionine metabolic process	5	4
GO:0006566	threonine metabolic process	6	4
GO:0006790	sulfur compound metabolic process	3	4
GO:0008652	amino acid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009066	aspartate family amino acid metabolic process	5	4
GO:0009067	aspartate family amino acid biosynthetic process	6	4
GO:0009081	branched-chain amino acid metabolic process	4	4
GO:0009082	branched-chain amino acid biosynthetic process	5	4
GO:0009086	methionine biosynthetic process	6	4
GO:0009088	threonine biosynthetic process	7	4
GO:0009097	isoleucine biosynthetic process	6	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044272	sulfur compound biosynthetic process	4	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:1901566	organonitrogen compound biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4
GO:1901605	alpha-amino acid metabolic process	4	4
GO:1901607	alpha-amino acid biosynthetic process	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004412	homoserine dehydrogenase activity	5	6
GO:0016491	oxidoreductase activity	2	6
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	6
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	6
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0036094	small molecule binding	2	4
GO:0050661	NADP binding	4	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.272
CLV_NRD_NRD_1	83	85	PF00675	0.376
CLV_NRD_NRD_1	95	97	PF00675	0.267
CLV_PCSK_KEX2_1	83	85	PF00082	0.385
CLV_PCSK_SKI1_1	166	170	PF00082	0.247
CLV_PCSK_SKI1_1	197	201	PF00082	0.350
CLV_PCSK_SKI1_1	204	208	PF00082	0.387
CLV_PCSK_SKI1_1	5	9	PF00082	0.499
CLV_Separin_Metazoa	149	153	PF03568	0.247
CLV_Separin_Metazoa	93	97	PF03568	0.247
DEG_SPOP_SBC_1	172	176	PF00917	0.344
DEG_SPOP_SBC_1	178	182	PF00917	0.301
DEG_SPOP_SBC_1	24	28	PF00917	0.446
DOC_CKS1_1	145	150	PF01111	0.247
DOC_MAPK_MEF2A_6	33	42	PF00069	0.371
DOC_PP1_RVXF_1	123	130	PF00149	0.247
DOC_USP7_MATH_1	106	110	PF00917	0.251
DOC_USP7_MATH_1	133	137	PF00917	0.405
DOC_USP7_MATH_1	172	176	PF00917	0.392
DOC_USP7_MATH_1	24	28	PF00917	0.615
DOC_WW_Pin1_4	144	149	PF00397	0.435
DOC_WW_Pin1_4	187	192	PF00397	0.293
DOC_WW_Pin1_4	20	25	PF00397	0.652
DOC_WW_Pin1_4	235	240	PF00397	0.247
LIG_14-3-3_CanoR_1	135	139	PF00244	0.308
LIG_14-3-3_CanoR_1	22	32	PF00244	0.441
LIG_Actin_WH2_2	136	154	PF00022	0.247
LIG_Actin_WH2_2	250	268	PF00022	0.478
LIG_BRCT_BRCA1_1	25	29	PF00533	0.492
LIG_EH1_1	65	73	PF00400	0.247
LIG_FHA_1	135	141	PF00498	0.405
LIG_FHA_1	179	185	PF00498	0.301
LIG_FHA_1	190	196	PF00498	0.366
LIG_FHA_1	198	204	PF00498	0.309
LIG_FHA_1	226	232	PF00498	0.410
LIG_FHA_2	221	227	PF00498	0.247
LIG_IRF3_LxIS_1	231	237	PF10401	0.247
LIG_LIR_Nem_3	226	230	PF02991	0.439
LIG_SH2_NCK_1	103	107	PF00017	0.405
LIG_SH2_SRC	103	106	PF00017	0.405
LIG_SH2_STAT5	230	233	PF00017	0.405
LIG_SH2_STAT5	78	81	PF00017	0.405
LIG_SH3_3	120	126	PF00018	0.247
LIG_SH3_3	185	191	PF00018	0.302
LIG_SH3_3	207	213	PF00018	0.320
LIG_SUMO_SIM_par_1	232	238	PF11976	0.405
LIG_SUMO_SIM_par_1	49	55	PF11976	0.247
LIG_TRAF2_1	90	93	PF00917	0.380
LIG_TYR_ITIM	159	164	PF00017	0.405
LIG_TYR_ITSM	226	233	PF00017	0.405
MOD_CDC14_SPxK_1	190	193	PF00782	0.247
MOD_CDK_SPxK_1	187	193	PF00069	0.247
MOD_CK2_1	220	226	PF00069	0.368
MOD_GlcNHglycan	111	115	PF01048	0.447
MOD_GlcNHglycan	267	270	PF01048	0.568
MOD_GSK3_1	106	113	PF00069	0.356
MOD_GSK3_1	173	180	PF00069	0.290
MOD_GSK3_1	18	25	PF00069	0.629
MOD_GSK3_1	261	268	PF00069	0.510
MOD_GSK3_1	52	59	PF00069	0.247
MOD_N-GLC_1	133	138	PF02516	0.247
MOD_N-GLC_1	72	77	PF02516	0.513
MOD_NEK2_1	18	23	PF00069	0.576
MOD_NEK2_1	199	204	PF00069	0.459
MOD_NEK2_1	234	239	PF00069	0.334
MOD_NEK2_1	265	270	PF00069	0.568
MOD_NEK2_1	42	47	PF00069	0.489
MOD_NEK2_1	56	61	PF00069	0.247
MOD_NEK2_1	72	77	PF00069	0.209
MOD_PKA_2	134	140	PF00069	0.405
MOD_Plk_1	133	139	PF00069	0.247
MOD_ProDKin_1	144	150	PF00069	0.435
MOD_ProDKin_1	187	193	PF00069	0.293
MOD_ProDKin_1	20	26	PF00069	0.659
MOD_ProDKin_1	235	241	PF00069	0.247
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.247
TRG_ENDOCYTIC_2	161	164	PF00928	0.405
TRG_ENDOCYTIC_2	230	233	PF00928	0.435
TRG_ER_diArg_1	83	85	PF00400	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPS1	Leishmania donovani	73%	75%
A4HT44	Leishmania infantum	73%	75%
E9AL36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	74%
Q4QIR8	Leishmania major	71%	100%