Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4W9_LEIBR

TriTrypDb:

LbrM.07.0250 , LBRM2903_070007800

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H4W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.329
CLV_NRD_NRD_1	233	235	PF00675	0.619
CLV_NRD_NRD_1	268	270	PF00675	0.546
CLV_NRD_NRD_1	287	289	PF00675	0.437
CLV_NRD_NRD_1	300	302	PF00675	0.576
CLV_NRD_NRD_1	312	314	PF00675	0.510
CLV_NRD_NRD_1	362	364	PF00675	0.647
CLV_NRD_NRD_1	40	42	PF00675	0.365
CLV_NRD_NRD_1	416	418	PF00675	0.742
CLV_PCSK_FUR_1	298	302	PF00082	0.645
CLV_PCSK_FUR_1	434	438	PF00082	0.639
CLV_PCSK_KEX2_1	233	235	PF00082	0.623
CLV_PCSK_KEX2_1	268	270	PF00082	0.546
CLV_PCSK_KEX2_1	287	289	PF00082	0.437
CLV_PCSK_KEX2_1	300	302	PF00082	0.576
CLV_PCSK_KEX2_1	312	314	PF00082	0.537
CLV_PCSK_KEX2_1	362	364	PF00082	0.640
CLV_PCSK_KEX2_1	39	41	PF00082	0.381
CLV_PCSK_KEX2_1	416	418	PF00082	0.742
CLV_PCSK_KEX2_1	436	438	PF00082	0.643
CLV_PCSK_KEX2_1	507	509	PF00082	0.612
CLV_PCSK_KEX2_1	6	8	PF00082	0.435
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.580
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.585
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.438
CLV_PCSK_PC7_1	229	235	PF00082	0.634
CLV_PCSK_PC7_1	36	42	PF00082	0.308
CLV_PCSK_SKI1_1	268	272	PF00082	0.551
CLV_PCSK_SKI1_1	27	31	PF00082	0.344
CLV_PCSK_SKI1_1	444	448	PF00082	0.683
CLV_PCSK_SKI1_1	46	50	PF00082	0.501
CLV_PCSK_SKI1_1	492	496	PF00082	0.744
CLV_PCSK_SKI1_1	504	508	PF00082	0.581
DEG_APCC_DBOX_1	40	48	PF00400	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SCF_FBW7_1	376	381	PF00400	0.452
DEG_SPOP_SBC_1	157	161	PF00917	0.452
DOC_CYCLIN_RxL_1	265	274	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	318	324	PF00134	0.374
DOC_MAPK_gen_1	233	239	PF00069	0.353
DOC_MAPK_gen_1	362	369	PF00069	0.375
DOC_MAPK_gen_1	416	423	PF00069	0.500
DOC_MAPK_gen_1	467	475	PF00069	0.374
DOC_MAPK_MEF2A_6	132	140	PF00069	0.304
DOC_MAPK_RevD_3	349	363	PF00069	0.399
DOC_PP2B_LxvP_1	79	82	PF13499	0.457
DOC_PP4_FxxP_1	125	128	PF00568	0.370
DOC_PP4_FxxP_1	324	327	PF00568	0.458
DOC_USP7_MATH_1	211	215	PF00917	0.448
DOC_USP7_MATH_1	378	382	PF00917	0.481
DOC_USP7_MATH_1	448	452	PF00917	0.525
DOC_USP7_MATH_1	561	565	PF00917	0.457
DOC_WW_Pin1_4	271	276	PF00397	0.389
DOC_WW_Pin1_4	292	297	PF00397	0.376
DOC_WW_Pin1_4	374	379	PF00397	0.439
LIG_14-3-3_CanoR_1	132	140	PF00244	0.304
LIG_14-3-3_CanoR_1	162	170	PF00244	0.472
LIG_14-3-3_CanoR_1	184	189	PF00244	0.428
LIG_14-3-3_CanoR_1	268	274	PF00244	0.361
LIG_14-3-3_CanoR_1	416	422	PF00244	0.458
LIG_14-3-3_CanoR_1	472	478	PF00244	0.430
LIG_14-3-3_CanoR_1	511	515	PF00244	0.376
LIG_Actin_WH2_2	112	129	PF00022	0.362
LIG_Actin_WH2_2	513	528	PF00022	0.532
LIG_APCC_ABBA_1	20	25	PF00400	0.576
LIG_APCC_ABBA_1	351	356	PF00400	0.326
LIG_BRCT_BRCA1_1	188	192	PF00533	0.490
LIG_deltaCOP1_diTrp_1	361	366	PF00928	0.308
LIG_eIF4E_1	258	264	PF01652	0.265
LIG_eIF4E_1	61	67	PF01652	0.314
LIG_FHA_1	258	264	PF00498	0.384
LIG_FHA_1	3	9	PF00498	0.698
LIG_FHA_1	339	345	PF00498	0.411
LIG_FHA_1	371	377	PF00498	0.438
LIG_FHA_1	448	454	PF00498	0.545
LIG_FHA_1	511	517	PF00498	0.388
LIG_FHA_2	406	412	PF00498	0.468
LIG_FHA_2	85	91	PF00498	0.402
LIG_LIR_Apic_2	124	128	PF02991	0.363
LIG_LIR_Gen_1	246	252	PF02991	0.400
LIG_LIR_Gen_1	257	266	PF02991	0.290
LIG_LIR_Gen_1	352	360	PF02991	0.329
LIG_LIR_Nem_3	246	250	PF02991	0.405
LIG_LIR_Nem_3	257	261	PF02991	0.299
LIG_LIR_Nem_3	352	357	PF02991	0.329
LIG_LIR_Nem_3	361	367	PF02991	0.394
LIG_LIR_Nem_3	425	431	PF02991	0.416
LIG_LIR_Nem_3	529	534	PF02991	0.333
LIG_LIR_Nem_3	89	94	PF02991	0.388
LIG_MYND_1	96	100	PF01753	0.352
LIG_PCNA_PIPBox_1	73	82	PF02747	0.380
LIG_PCNA_yPIPBox_3	69	80	PF02747	0.374
LIG_Pex14_2	121	125	PF04695	0.354
LIG_PTAP_UEV_1	207	212	PF05743	0.422
LIG_PTB_Apo_2	241	248	PF02174	0.354
LIG_PTB_Phospho_1	241	247	PF10480	0.349
LIG_REV1ctd_RIR_1	27	36	PF16727	0.609
LIG_SH2_CRK	258	262	PF00017	0.270
LIG_SH2_CRK	424	428	PF00017	0.364
LIG_SH2_NCK_1	133	137	PF00017	0.303
LIG_SH2_NCK_1	247	251	PF00017	0.354
LIG_SH2_NCK_1	258	262	PF00017	0.337
LIG_SH2_PTP2	61	64	PF00017	0.239
LIG_SH2_SRC	424	427	PF00017	0.412
LIG_SH2_SRC	545	548	PF00017	0.454
LIG_SH2_STAP1	133	137	PF00017	0.303
LIG_SH2_STAP1	424	428	PF00017	0.423
LIG_SH2_STAP1	490	494	PF00017	0.409
LIG_SH2_STAT3	539	542	PF00017	0.363
LIG_SH2_STAT5	147	150	PF00017	0.409
LIG_SH2_STAT5	283	286	PF00017	0.333
LIG_SH2_STAT5	426	429	PF00017	0.339
LIG_SH2_STAT5	61	64	PF00017	0.350
LIG_SH2_STAT5	86	89	PF00017	0.386
LIG_SH3_1	205	211	PF00018	0.429
LIG_SH3_1	365	371	PF00018	0.440
LIG_SH3_1	442	448	PF00018	0.485
LIG_SH3_2	208	213	PF14604	0.478
LIG_SH3_3	136	142	PF00018	0.309
LIG_SH3_3	15	21	PF00018	0.704
LIG_SH3_3	195	201	PF00018	0.485
LIG_SH3_3	205	211	PF00018	0.492
LIG_SH3_3	365	371	PF00018	0.452
LIG_SH3_3	397	403	PF00018	0.551
LIG_SH3_3	442	448	PF00018	0.485
LIG_SH3_3	68	74	PF00018	0.328
LIG_SH3_5	82	86	PF00018	0.490
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.318
LIG_SUMO_SIM_anti_2	134	140	PF11976	0.300
LIG_TRAF2_1	592	595	PF00917	0.538
LIG_TYR_ITIM	131	136	PF00017	0.363
LIG_TYR_ITIM	256	261	PF00017	0.318
LIG_UBA3_1	122	127	PF00899	0.354
LIG_UBA3_1	238	245	PF00899	0.364
LIG_ULM_U2AF65_1	362	367	PF00076	0.536
LIG_WRC_WIRS_1	122	127	PF05994	0.440
MOD_CDK_SPxK_1	292	298	PF00069	0.451
MOD_CK1_1	156	162	PF00069	0.641
MOD_CK1_1	173	179	PF00069	0.603
MOD_CK1_1	549	555	PF00069	0.430
MOD_CK2_1	184	190	PF00069	0.440
MOD_CK2_1	211	217	PF00069	0.475
MOD_CK2_1	342	348	PF00069	0.394
MOD_CK2_1	448	454	PF00069	0.597
MOD_Cter_Amidation	310	313	PF01082	0.435
MOD_GlcNHglycan	108	111	PF01048	0.313
MOD_GlcNHglycan	14	17	PF01048	0.560
MOD_GlcNHglycan	175	178	PF01048	0.677
MOD_GlcNHglycan	275	278	PF01048	0.581
MOD_GlcNHglycan	391	394	PF01048	0.731
MOD_GlcNHglycan	395	398	PF01048	0.660
MOD_GlcNHglycan	467	470	PF01048	0.458
MOD_GlcNHglycan	56	59	PF01048	0.323
MOD_GSK3_1	106	113	PF00069	0.528
MOD_GSK3_1	152	159	PF00069	0.625
MOD_GSK3_1	169	176	PF00069	0.602
MOD_GSK3_1	269	276	PF00069	0.595
MOD_GSK3_1	338	345	PF00069	0.564
MOD_GSK3_1	370	377	PF00069	0.551
MOD_GSK3_1	389	396	PF00069	0.630
MOD_GSK3_1	448	455	PF00069	0.505
MOD_GSK3_1	473	480	PF00069	0.416
MOD_GSK3_1	545	552	PF00069	0.553
MOD_N-GLC_1	254	259	PF02516	0.530
MOD_NEK2_1	106	111	PF00069	0.394
MOD_NEK2_1	121	126	PF00069	0.441
MOD_NEK2_1	131	136	PF00069	0.529
MOD_NEK2_1	2	7	PF00069	0.539
MOD_NEK2_1	225	230	PF00069	0.471
MOD_NEK2_1	314	319	PF00069	0.453
MOD_NEK2_2	211	216	PF00069	0.479
MOD_NEK2_2	527	532	PF00069	0.398
MOD_PKA_2	106	112	PF00069	0.401
MOD_PKA_2	131	137	PF00069	0.360
MOD_PKA_2	161	167	PF00069	0.542
MOD_PKA_2	2	8	PF00069	0.557
MOD_PKA_2	415	421	PF00069	0.707
MOD_PKA_2	510	516	PF00069	0.458
MOD_PKA_2	575	581	PF00069	0.372
MOD_Plk_1	153	159	PF00069	0.538
MOD_Plk_1	254	260	PF00069	0.375
MOD_Plk_1	314	320	PF00069	0.544
MOD_Plk_1	371	377	PF00069	0.541
MOD_Plk_1	448	454	PF00069	0.593
MOD_Plk_1	545	551	PF00069	0.509
MOD_Plk_1	84	90	PF00069	0.491
MOD_Plk_2-3	146	152	PF00069	0.474
MOD_Plk_4	121	127	PF00069	0.509
MOD_Plk_4	314	320	PF00069	0.447
MOD_Plk_4	448	454	PF00069	0.593
MOD_Plk_4	46	52	PF00069	0.309
MOD_Plk_4	561	567	PF00069	0.557
MOD_ProDKin_1	271	277	PF00069	0.473
MOD_ProDKin_1	292	298	PF00069	0.451
MOD_ProDKin_1	374	380	PF00069	0.545
MOD_SUMO_rev_2	85	94	PF00179	0.517
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.506
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.702
TRG_ENDOCYTIC_2	133	136	PF00928	0.353
TRG_ENDOCYTIC_2	247	250	PF00928	0.508
TRG_ENDOCYTIC_2	258	261	PF00928	0.339
TRG_ENDOCYTIC_2	281	284	PF00928	0.416
TRG_ENDOCYTIC_2	354	357	PF00928	0.387
TRG_ENDOCYTIC_2	424	427	PF00928	0.506
TRG_ENDOCYTIC_2	428	431	PF00928	0.527
TRG_ENDOCYTIC_2	61	64	PF00928	0.323
TRG_ER_diArg_1	232	234	PF00400	0.561
TRG_ER_diArg_1	268	270	PF00400	0.412
TRG_ER_diArg_1	286	288	PF00400	0.394
TRG_ER_diArg_1	300	302	PF00400	0.454
TRG_ER_diArg_1	31	34	PF00400	0.471
TRG_ER_diArg_1	312	314	PF00400	0.378
TRG_ER_diArg_1	362	364	PF00400	0.534
TRG_ER_diArg_1	38	41	PF00400	0.435
TRG_ER_diArg_1	416	419	PF00400	0.675
TRG_ER_diArg_1	464	467	PF00400	0.551
TRG_ER_diArg_1	470	473	PF00400	0.526
TRG_NES_CRM1_1	348	361	PF08389	0.286
TRG_NES_CRM1_1	563	577	PF08389	0.362
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE68	Leptomonas seymouri	53%	100%
A0A3S5H5W8	Leishmania donovani	80%	98%
A4HT42	Leishmania infantum	80%	98%
E9AL34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QIS0	Leishmania major	78%	100%