Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4W6_LEIBR

TriTrypDb:

LbrM.07.0220 , LBRM2903_070007600

Length:

617

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.411
CLV_C14_Caspase3-7	339	343	PF00656	0.709
CLV_C14_Caspase3-7	377	381	PF00656	0.346
CLV_C14_Caspase3-7	586	590	PF00656	0.381
CLV_NRD_NRD_1	105	107	PF00675	0.509
CLV_NRD_NRD_1	19	21	PF00675	0.561
CLV_NRD_NRD_1	286	288	PF00675	0.459
CLV_NRD_NRD_1	564	566	PF00675	0.350
CLV_NRD_NRD_1	582	584	PF00675	0.459
CLV_NRD_NRD_1	9	11	PF00675	0.515
CLV_PCSK_KEX2_1	19	21	PF00082	0.571
CLV_PCSK_KEX2_1	564	566	PF00082	0.350
CLV_PCSK_SKI1_1	213	217	PF00082	0.529
CLV_PCSK_SKI1_1	418	422	PF00082	0.419
CLV_PCSK_SKI1_1	576	580	PF00082	0.439
CLV_PCSK_SKI1_1	604	608	PF00082	0.613
CLV_Separin_Metazoa	384	388	PF03568	0.495
DEG_APCC_DBOX_1	19	27	PF00400	0.527
DEG_Nend_UBRbox_1	1	4	PF02207	0.454
DEG_SPOP_SBC_1	173	177	PF00917	0.369
DOC_CKS1_1	200	205	PF01111	0.442
DOC_CYCLIN_RxL_1	487	495	PF00134	0.519
DOC_MAPK_FxFP_2	435	438	PF00069	0.297
DOC_MAPK_gen_1	10	16	PF00069	0.592
DOC_MAPK_gen_1	210	218	PF00069	0.598
DOC_MAPK_MEF2A_6	210	218	PF00069	0.531
DOC_MAPK_MEF2A_6	387	395	PF00069	0.519
DOC_MAPK_MEF2A_6	477	485	PF00069	0.453
DOC_PP2B_LxvP_1	357	360	PF13499	0.518
DOC_PP2B_LxvP_1	478	481	PF13499	0.445
DOC_PP4_FxxP_1	353	356	PF00568	0.411
DOC_PP4_FxxP_1	414	417	PF00568	0.309
DOC_PP4_FxxP_1	435	438	PF00568	0.512
DOC_USP7_MATH_1	173	177	PF00917	0.444
DOC_USP7_MATH_1	185	189	PF00917	0.452
DOC_USP7_MATH_1	349	353	PF00917	0.597
DOC_USP7_MATH_1	396	400	PF00917	0.373
DOC_USP7_MATH_1	429	433	PF00917	0.562
DOC_USP7_MATH_1	450	454	PF00917	0.661
DOC_USP7_MATH_1	577	581	PF00917	0.603
DOC_USP7_MATH_1	606	610	PF00917	0.608
DOC_USP7_MATH_1	79	83	PF00917	0.565
DOC_USP7_UBL2_3	107	111	PF12436	0.492
DOC_USP7_UBL2_3	70	74	PF12436	0.788
DOC_WW_Pin1_4	199	204	PF00397	0.514
DOC_WW_Pin1_4	413	418	PF00397	0.306
DOC_WW_Pin1_4	50	55	PF00397	0.767
DOC_WW_Pin1_4	599	604	PF00397	0.664
LIG_14-3-3_CanoR_1	534	541	PF00244	0.413
LIG_14-3-3_CanoR_1	583	589	PF00244	0.473
LIG_APCC_ABBA_1	32	37	PF00400	0.406
LIG_APCC_ABBA_1	367	372	PF00400	0.433
LIG_BRCT_BRCA1_1	143	147	PF00533	0.437
LIG_BRCT_BRCA1_1	431	435	PF00533	0.310
LIG_deltaCOP1_diTrp_1	140	147	PF00928	0.472
LIG_deltaCOP1_diTrp_1	550	557	PF00928	0.374
LIG_DLG_GKlike_1	387	395	PF00625	0.311
LIG_eIF4E_1	370	376	PF01652	0.440
LIG_FHA_1	296	302	PF00498	0.381
LIG_FHA_1	329	335	PF00498	0.432
LIG_FHA_1	387	393	PF00498	0.421
LIG_FHA_1	400	406	PF00498	0.402
LIG_FHA_1	489	495	PF00498	0.443
LIG_FHA_1	534	540	PF00498	0.376
LIG_FHA_1	577	583	PF00498	0.460
LIG_FHA_1	591	597	PF00498	0.435
LIG_FHA_2	339	345	PF00498	0.561
LIG_FHA_2	425	431	PF00498	0.417
LIG_GBD_Chelix_1	518	526	PF00786	0.355
LIG_LIR_Apic_2	198	203	PF02991	0.447
LIG_LIR_Apic_2	351	356	PF02991	0.427
LIG_LIR_Apic_2	412	417	PF02991	0.299
LIG_LIR_Apic_2	432	438	PF02991	0.282
LIG_LIR_Gen_1	144	154	PF02991	0.419
LIG_LIR_Gen_1	175	186	PF02991	0.396
LIG_LIR_Gen_1	271	281	PF02991	0.489
LIG_LIR_Gen_1	348	357	PF02991	0.636
LIG_LIR_Gen_1	380	391	PF02991	0.451
LIG_LIR_LC3C_4	388	393	PF02991	0.312
LIG_LIR_Nem_3	140	146	PF02991	0.420
LIG_LIR_Nem_3	175	181	PF02991	0.376
LIG_LIR_Nem_3	271	276	PF02991	0.504
LIG_LIR_Nem_3	279	285	PF02991	0.401
LIG_LIR_Nem_3	300	306	PF02991	0.321
LIG_LIR_Nem_3	348	353	PF02991	0.663
LIG_LIR_Nem_3	380	386	PF02991	0.432
LIG_LIR_Nem_3	406	410	PF02991	0.441
LIG_LYPXL_S_1	436	440	PF13949	0.290
LIG_LYPXL_yS_3	407	410	PF13949	0.453
LIG_LYPXL_yS_3	437	440	PF13949	0.296
LIG_MLH1_MIPbox_1	143	147	PF16413	0.342
LIG_PCNA_yPIPBox_3	243	253	PF02747	0.326
LIG_PCNA_yPIPBox_3	564	573	PF02747	0.429
LIG_Pex14_1	143	147	PF04695	0.555
LIG_SH2_CRK	178	182	PF00017	0.381
LIG_SH2_CRK	200	204	PF00017	0.443
LIG_SH2_CRK	282	286	PF00017	0.415
LIG_SH2_CRK	303	307	PF00017	0.414
LIG_SH2_CRK	473	477	PF00017	0.574
LIG_SH2_NCK_1	178	182	PF00017	0.381
LIG_SH2_NCK_1	200	204	PF00017	0.443
LIG_SH2_SRC	273	276	PF00017	0.471
LIG_SH2_STAP1	178	182	PF00017	0.381
LIG_SH2_STAP1	282	286	PF00017	0.400
LIG_SH2_STAP1	370	374	PF00017	0.464
LIG_SH2_STAT5	146	149	PF00017	0.519
LIG_SH2_STAT5	228	231	PF00017	0.523
LIG_SH2_STAT5	3	6	PF00017	0.464
LIG_SH2_STAT5	333	336	PF00017	0.509
LIG_SH2_STAT5	409	412	PF00017	0.391
LIG_SH2_STAT5	419	422	PF00017	0.406
LIG_SH2_STAT5	521	524	PF00017	0.375
LIG_SH2_STAT5	572	575	PF00017	0.297
LIG_SH3_3	332	338	PF00018	0.479
LIG_SH3_3	390	396	PF00018	0.311
LIG_SUMO_SIM_par_1	490	495	PF11976	0.409
LIG_TRAF2_1	61	64	PF00917	0.533
LIG_TYR_ITIM	280	285	PF00017	0.204
LIG_TYR_ITIM	301	306	PF00017	0.472
LIG_TYR_ITIM	405	410	PF00017	0.455
LIG_TYR_ITSM	269	276	PF00017	0.494
LIG_UBA3_1	499	507	PF00899	0.452
LIG_WRC_WIRS_1	350	355	PF05994	0.656
MOD_CDK_SPK_2	413	418	PF00069	0.304
MOD_CDK_SPK_2	599	604	PF00069	0.555
MOD_CK1_1	145	151	PF00069	0.518
MOD_CK1_1	351	357	PF00069	0.648
MOD_CK1_1	399	405	PF00069	0.281
MOD_CK1_1	41	47	PF00069	0.676
MOD_CK1_1	424	430	PF00069	0.404
MOD_CK1_1	445	451	PF00069	0.536
MOD_CK1_1	58	64	PF00069	0.653
MOD_CK2_1	349	355	PF00069	0.620
MOD_CK2_1	424	430	PF00069	0.482
MOD_CK2_1	49	55	PF00069	0.732
MOD_CK2_1	58	64	PF00069	0.510
MOD_GlcNHglycan	137	140	PF01048	0.485
MOD_GlcNHglycan	167	170	PF01048	0.562
MOD_GlcNHglycan	282	285	PF01048	0.311
MOD_GlcNHglycan	39	43	PF01048	0.583
MOD_GlcNHglycan	445	448	PF01048	0.613
MOD_GlcNHglycan	55	58	PF01048	0.597
MOD_GlcNHglycan	560	563	PF01048	0.389
MOD_GlcNHglycan	579	582	PF01048	0.306
MOD_GlcNHglycan	60	63	PF01048	0.656
MOD_GSK3_1	141	148	PF00069	0.519
MOD_GSK3_1	165	172	PF00069	0.457
MOD_GSK3_1	195	202	PF00069	0.604
MOD_GSK3_1	276	283	PF00069	0.327
MOD_GSK3_1	420	427	PF00069	0.441
MOD_GSK3_1	49	56	PF00069	0.715
MOD_GSK3_1	58	65	PF00069	0.590
MOD_GSK3_1	79	86	PF00069	0.680
MOD_N-GLC_1	268	273	PF02516	0.401
MOD_N-GLC_1	424	429	PF02516	0.432
MOD_N-GLC_1	483	488	PF02516	0.357
MOD_N-GLC_1	589	594	PF02516	0.620
MOD_N-GLC_1	599	604	PF02516	0.656
MOD_NEK2_1	165	170	PF00069	0.551
MOD_NEK2_1	295	300	PF00069	0.259
MOD_NEK2_1	361	366	PF00069	0.355
MOD_NEK2_1	420	425	PF00069	0.405
MOD_NEK2_1	514	519	PF00069	0.406
MOD_NEK2_1	557	562	PF00069	0.303
MOD_NEK2_2	297	302	PF00069	0.384
MOD_NEK2_2	62	67	PF00069	0.524
MOD_PKA_1	583	589	PF00069	0.432
MOD_PKA_2	386	392	PF00069	0.394
MOD_PKA_2	533	539	PF00069	0.371
MOD_PKA_2	582	588	PF00069	0.530
MOD_Plk_1	268	274	PF00069	0.361
MOD_Plk_1	387	393	PF00069	0.526
MOD_Plk_1	429	435	PF00069	0.556
MOD_Plk_1	62	68	PF00069	0.538
MOD_Plk_2-3	263	269	PF00069	0.429
MOD_Plk_4	142	148	PF00069	0.558
MOD_Plk_4	361	367	PF00069	0.477
MOD_Plk_4	387	393	PF00069	0.314
MOD_ProDKin_1	199	205	PF00069	0.513
MOD_ProDKin_1	413	419	PF00069	0.316
MOD_ProDKin_1	50	56	PF00069	0.769
MOD_ProDKin_1	599	605	PF00069	0.670
MOD_SUMO_rev_2	135	144	PF00179	0.361
MOD_SUMO_rev_2	82	87	PF00179	0.439
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.371
TRG_ENDOCYTIC_2	178	181	PF00928	0.380
TRG_ENDOCYTIC_2	273	276	PF00928	0.471
TRG_ENDOCYTIC_2	282	285	PF00928	0.425
TRG_ENDOCYTIC_2	303	306	PF00928	0.429
TRG_ENDOCYTIC_2	407	410	PF00928	0.453
TRG_ENDOCYTIC_2	437	440	PF00928	0.296
TRG_ENDOCYTIC_2	473	476	PF00928	0.568
TRG_ER_diArg_1	18	20	PF00400	0.579
TRG_ER_diArg_1	563	565	PF00400	0.383
TRG_NES_CRM1_1	243	258	PF08389	0.316
TRG_NES_CRM1_1	25	37	PF08389	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7J6	Leptomonas seymouri	63%	96%
A0A1X0NKC6	Trypanosomatidae	37%	100%
A0A3R7NMJ1	Trypanosoma rangeli	33%	100%
A0A3S5H5W7	Leishmania donovani	74%	97%
A4HT40	Leishmania infantum	74%	97%
C9ZUU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AL32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	97%
Q4QIS2	Leishmania major	73%	100%
V5B8V4	Trypanosoma cruzi	33%	100%