Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4W5_LEIBR

TriTrypDb:

LbrM.07.0210 , LBRM2903_070007500

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.715
CLV_NRD_NRD_1	24	26	PF00675	0.715
CLV_PCSK_KEX2_1	159	161	PF00082	0.715
CLV_PCSK_KEX2_1	23	25	PF00082	0.724
DOC_PP2B_LxvP_1	185	188	PF13499	0.622
DOC_PP4_FxxP_1	4	7	PF00568	0.683
DOC_USP7_MATH_1	173	177	PF00917	0.509
DOC_USP7_MATH_1	198	202	PF00917	0.650
DOC_USP7_MATH_1	210	214	PF00917	0.507
DOC_USP7_MATH_1	232	236	PF00917	0.567
DOC_WW_Pin1_4	204	209	PF00397	0.674
LIG_14-3-3_CanoR_1	36	43	PF00244	0.540
LIG_APCC_ABBA_1	114	119	PF00400	0.655
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BIR_III_2	82	86	PF00653	0.515
LIG_FHA_1	136	142	PF00498	0.658
LIG_FHA_1	214	220	PF00498	0.507
LIG_FHA_1	85	91	PF00498	0.612
LIG_FHA_1	9	15	PF00498	0.536
LIG_FHA_2	178	184	PF00498	0.511
LIG_FHA_2	24	30	PF00498	0.664
LIG_FHA_2	36	42	PF00498	0.545
LIG_LIR_Apic_2	2	7	PF02991	0.515
LIG_LIR_Gen_1	112	120	PF02991	0.658
LIG_LIR_Nem_3	112	118	PF02991	0.659
LIG_PDZ_Class_1	240	245	PF00595	0.626
LIG_SH2_NCK_1	161	165	PF00017	0.636
LIG_SH2_STAP1	161	165	PF00017	0.555
LIG_SH2_STAP1	233	237	PF00017	0.551
LIG_SH2_STAP1	54	58	PF00017	0.510
LIG_SH2_STAT5	161	164	PF00017	0.517
LIG_TRAF2_1	197	200	PF00917	0.506
LIG_TRAF2_1	39	42	PF00917	0.544
LIG_TRFH_1	4	8	PF08558	0.517
LIG_UBA3_1	3	10	PF00899	0.518
MOD_CDK_SPxxK_3	204	211	PF00069	0.522
MOD_CK1_1	2	8	PF00069	0.548
MOD_CK1_1	201	207	PF00069	0.591
MOD_CK1_1	213	219	PF00069	0.653
MOD_CK1_1	74	80	PF00069	0.539
MOD_CK2_1	160	166	PF00069	0.569
MOD_CK2_1	177	183	PF00069	0.563
MOD_CK2_1	23	29	PF00069	0.615
MOD_CK2_1	35	41	PF00069	0.618
MOD_CK2_1	53	59	PF00069	0.564
MOD_CK2_1	88	94	PF00069	0.726
MOD_GlcNHglycan	121	124	PF01048	0.491
MOD_GlcNHglycan	162	165	PF01048	0.678
MOD_GlcNHglycan	59	63	PF01048	0.509
MOD_GlcNHglycan	99	102	PF01048	0.690
MOD_GSK3_1	105	112	PF00069	0.613
MOD_GSK3_1	173	180	PF00069	0.466
MOD_GSK3_1	49	56	PF00069	0.556
MOD_GSK3_1	71	78	PF00069	0.593
MOD_GSK3_1	84	91	PF00069	0.661
MOD_N-GLC_1	213	218	PF02516	0.598
MOD_NEK2_1	177	182	PF00069	0.518
MOD_NEK2_1	239	244	PF00069	0.614
MOD_NEK2_1	53	58	PF00069	0.547
MOD_NEK2_2	121	126	PF00069	0.512
MOD_PIKK_1	213	219	PF00454	0.495
MOD_PKA_1	159	165	PF00069	0.548
MOD_PKA_1	23	29	PF00069	0.647
MOD_PKA_2	159	165	PF00069	0.528
MOD_PKA_2	210	216	PF00069	0.533
MOD_PKA_2	23	29	PF00069	0.699
MOD_PKA_2	35	41	PF00069	0.526
MOD_PKB_1	23	31	PF00069	0.536
MOD_Plk_1	222	228	PF00069	0.615
MOD_Plk_1	58	64	PF00069	0.566
MOD_Plk_4	109	115	PF00069	0.580
MOD_Plk_4	136	142	PF00069	0.496
MOD_Plk_4	232	238	PF00069	0.544
MOD_Plk_4	49	55	PF00069	0.449
MOD_ProDKin_1	204	210	PF00069	0.669
TRG_ENDOCYTIC_2	233	236	PF00928	0.552
TRG_ER_diArg_1	159	161	PF00400	0.719
TRG_ER_diArg_1	23	25	PF00400	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I988	Leptomonas seymouri	34%	100%
A0A3S5H5W6	Leishmania donovani	62%	97%
A4HT39	Leishmania infantum	62%	97%
E9AL31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	97%
Q4QIS3	Leishmania major	60%	100%