CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylglycerolphosphate synthase, mitochondrial, putative

Species:

Leishmania braziliensis

UniProt:

A4H4W4_LEIBR

TriTrypDb:

LbrM.07.0200 , LBRM2903_070007400

Length:

756

Annotations

LeishMANIAdb annotations

Overall very similar to animal mitochondrial PGS1 enzymes, with one key difference: instead a a transit signal, the Kinetoplastid variant has membrane anchor.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H4W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006650	glycerophospholipid metabolic process	5	11
GO:0006655	phosphatidylglycerol biosynthetic process	6	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0032048	cardiolipin metabolic process	7	11
GO:0032049	cardiolipin biosynthetic process	7	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0045017	glycerolipid biosynthetic process	4	11
GO:0046471	phosphatidylglycerol metabolic process	6	11
GO:0046474	glycerophospholipid biosynthetic process	5	11
GO:0046486	glycerolipid metabolic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008444	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.605
CLV_NRD_NRD_1	196	198	PF00675	0.438
CLV_NRD_NRD_1	371	373	PF00675	0.451
CLV_NRD_NRD_1	456	458	PF00675	0.468
CLV_NRD_NRD_1	611	613	PF00675	0.423
CLV_NRD_NRD_1	635	637	PF00675	0.502
CLV_PCSK_KEX2_1	140	142	PF00082	0.342
CLV_PCSK_KEX2_1	611	613	PF00082	0.423
CLV_PCSK_KEX2_1	635	637	PF00082	0.497
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.342
CLV_PCSK_SKI1_1	284	288	PF00082	0.360
CLV_PCSK_SKI1_1	305	309	PF00082	0.351
CLV_PCSK_SKI1_1	353	357	PF00082	0.394
CLV_PCSK_SKI1_1	531	535	PF00082	0.361
CLV_PCSK_SKI1_1	621	625	PF00082	0.416
CLV_PCSK_SKI1_1	92	96	PF00082	0.404
DEG_APCC_DBOX_1	196	204	PF00400	0.571
DEG_APCC_DBOX_1	587	595	PF00400	0.608
DEG_APCC_DBOX_1	714	722	PF00400	0.516
DEG_SPOP_SBC_1	235	239	PF00917	0.702
DEG_SPOP_SBC_1	268	272	PF00917	0.769
DEG_SPOP_SBC_1	414	418	PF00917	0.607
DEG_SPOP_SBC_1	44	48	PF00917	0.778
DOC_CYCLIN_RxL_1	525	538	PF00134	0.588
DOC_MAPK_FxFP_2	511	514	PF00069	0.519
DOC_MAPK_gen_1	197	203	PF00069	0.587
DOC_MAPK_gen_1	303	310	PF00069	0.555
DOC_MAPK_gen_1	457	464	PF00069	0.581
DOC_MAPK_MEF2A_6	740	747	PF00069	0.602
DOC_PP1_RVXF_1	170	176	PF00149	0.598
DOC_PP1_RVXF_1	619	626	PF00149	0.562
DOC_PP2B_LxvP_1	297	300	PF13499	0.608
DOC_PP4_FxxP_1	511	514	PF00568	0.519
DOC_USP7_MATH_1	119	123	PF00917	0.587
DOC_USP7_MATH_1	145	149	PF00917	0.572
DOC_USP7_MATH_1	228	232	PF00917	0.761
DOC_USP7_MATH_1	235	239	PF00917	0.762
DOC_USP7_MATH_1	275	279	PF00917	0.741
DOC_USP7_MATH_1	385	389	PF00917	0.776
DOC_USP7_MATH_1	403	407	PF00917	0.761
DOC_USP7_MATH_1	413	417	PF00917	0.752
DOC_USP7_MATH_1	44	48	PF00917	0.750
DOC_USP7_MATH_1	682	686	PF00917	0.504
DOC_USP7_MATH_1	83	87	PF00917	0.662
DOC_WW_Pin1_4	387	392	PF00397	0.789
DOC_WW_Pin1_4	40	45	PF00397	0.734
DOC_WW_Pin1_4	422	427	PF00397	0.732
DOC_WW_Pin1_4	436	441	PF00397	0.683
DOC_WW_Pin1_4	449	454	PF00397	0.626
DOC_WW_Pin1_4	544	549	PF00397	0.498
DOC_WW_Pin1_4	56	61	PF00397	0.731
DOC_WW_Pin1_4	78	83	PF00397	0.681
LIG_14-3-3_CanoR_1	126	131	PF00244	0.531
LIG_14-3-3_CanoR_1	357	363	PF00244	0.542
LIG_14-3-3_CanoR_1	364	368	PF00244	0.559
LIG_14-3-3_CanoR_1	457	464	PF00244	0.556
LIG_14-3-3_CanoR_1	482	487	PF00244	0.586
LIG_14-3-3_CanoR_1	535	544	PF00244	0.528
LIG_14-3-3_CanoR_1	635	645	PF00244	0.593
LIG_14-3-3_CanoR_1	727	734	PF00244	0.543
LIG_Actin_WH2_2	596	613	PF00022	0.627
LIG_APCC_ABBA_1	19	24	PF00400	0.625
LIG_APCC_ABBAyCdc20_2	520	526	PF00400	0.517
LIG_BRCT_BRCA1_1	161	165	PF00533	0.569
LIG_BRCT_BRCA1_1	243	247	PF00533	0.705
LIG_deltaCOP1_diTrp_1	504	511	PF00928	0.602
LIG_EH1_1	182	190	PF00400	0.561
LIG_eIF4E_1	507	513	PF01652	0.415
LIG_FHA_1	122	128	PF00498	0.572
LIG_FHA_1	16	22	PF00498	0.345
LIG_FHA_1	184	190	PF00498	0.574
LIG_FHA_1	214	220	PF00498	0.738
LIG_FHA_1	31	37	PF00498	0.633
LIG_FHA_1	354	360	PF00498	0.606
LIG_FHA_1	441	447	PF00498	0.758
LIG_FHA_1	481	487	PF00498	0.515
LIG_FHA_1	49	55	PF00498	0.701
LIG_FHA_1	513	519	PF00498	0.502
LIG_FHA_1	562	568	PF00498	0.544
LIG_FHA_1	569	575	PF00498	0.499
LIG_FHA_1	729	735	PF00498	0.528
LIG_FHA_2	203	209	PF00498	0.567
LIG_FHA_2	335	341	PF00498	0.516
LIG_FHA_2	536	542	PF00498	0.599
LIG_FHA_2	703	709	PF00498	0.584
LIG_FHA_2	79	85	PF00498	0.702
LIG_LIR_Apic_2	509	514	PF02991	0.524
LIG_LIR_Gen_1	132	143	PF02991	0.543
LIG_LIR_Gen_1	18	26	PF02991	0.606
LIG_LIR_Gen_1	190	196	PF02991	0.548
LIG_LIR_Gen_1	292	301	PF02991	0.610
LIG_LIR_Gen_1	340	350	PF02991	0.510
LIG_LIR_Gen_1	439	447	PF02991	0.596
LIG_LIR_Gen_1	506	516	PF02991	0.499
LIG_LIR_Gen_1	546	557	PF02991	0.509
LIG_LIR_Nem_3	132	138	PF02991	0.542
LIG_LIR_Nem_3	18	22	PF02991	0.378
LIG_LIR_Nem_3	292	297	PF02991	0.616
LIG_LIR_Nem_3	340	345	PF02991	0.500
LIG_LIR_Nem_3	439	445	PF02991	0.596
LIG_LIR_Nem_3	504	508	PF02991	0.545
LIG_LIR_Nem_3	510	516	PF02991	0.474
LIG_LIR_Nem_3	597	603	PF02991	0.526
LIG_NRBOX	717	723	PF00104	0.533
LIG_OCRL_FandH_1	317	329	PF00620	0.562
LIG_PALB2_WD40_1	350	358	PF16756	0.524
LIG_PCNA_PIPBox_1	104	113	PF02747	0.529
LIG_PCNA_yPIPBox_3	341	355	PF02747	0.545
LIG_PCNA_yPIPBox_3	97	111	PF02747	0.622
LIG_PDZ_Class_3	751	756	PF00595	0.616
LIG_Pex14_1	294	298	PF04695	0.603
LIG_SH2_CRK	288	292	PF00017	0.587
LIG_SH2_CRK	607	611	PF00017	0.615
LIG_SH2_CRK	690	694	PF00017	0.558
LIG_SH2_GRB2like	288	291	PF00017	0.586
LIG_SH2_GRB2like	549	552	PF00017	0.515
LIG_SH2_SRC	288	291	PF00017	0.586
LIG_SH2_STAP1	508	512	PF00017	0.530
LIG_SH2_STAP1	553	557	PF00017	0.550
LIG_SH2_STAT5	155	158	PF00017	0.514
LIG_SH2_STAT5	334	337	PF00017	0.518
LIG_SH2_STAT5	549	552	PF00017	0.521
LIG_SH2_STAT5	566	569	PF00017	0.500
LIG_SH2_STAT5	593	596	PF00017	0.518
LIG_SH2_STAT5	602	605	PF00017	0.543
LIG_SH2_STAT5	679	682	PF00017	0.503
LIG_SH2_STAT5	7	10	PF00017	0.397
LIG_SH3_3	362	368	PF00018	0.443
LIG_SH3_3	666	672	PF00018	0.649
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.556
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.545
LIG_SUMO_SIM_par_1	184	190	PF11976	0.584
LIG_SUMO_SIM_par_1	199	205	PF11976	0.626
LIG_SUMO_SIM_par_1	459	465	PF11976	0.454
LIG_TRAF2_1	538	541	PF00917	0.451
LIG_TYR_ITIM	133	138	PF00017	0.555
LIG_TYR_ITIM	5	10	PF00017	0.378
LIG_TYR_ITIM	591	596	PF00017	0.536
LIG_UBA3_1	206	212	PF00899	0.581
LIG_UBA3_1	297	305	PF00899	0.522
LIG_UBA3_1	718	724	PF00899	0.523
LIG_WRC_WIRS_1	107	112	PF05994	0.535
LIG_WRC_WIRS_1	508	513	PF05994	0.550
LIG_WRC_WIRS_1	553	558	PF05994	0.513
MOD_CDK_SPxK_1	387	393	PF00069	0.796
MOD_CK1_1	129	135	PF00069	0.580
MOD_CK1_1	202	208	PF00069	0.624
MOD_CK1_1	215	221	PF00069	0.657
MOD_CK1_1	231	237	PF00069	0.761
MOD_CK1_1	240	246	PF00069	0.761
MOD_CK1_1	267	273	PF00069	0.799
MOD_CK1_1	40	46	PF00069	0.756
MOD_CK1_1	405	411	PF00069	0.772
MOD_CK1_1	47	53	PF00069	0.790
MOD_CK1_1	473	479	PF00069	0.572
MOD_CK1_1	55	61	PF00069	0.675
MOD_CK1_1	573	579	PF00069	0.546
MOD_CK1_1	78	84	PF00069	0.588
MOD_CK1_1	86	92	PF00069	0.460
MOD_CK2_1	202	208	PF00069	0.588
MOD_CK2_1	534	540	PF00069	0.603
MOD_CK2_1	706	712	PF00069	0.505
MOD_CK2_1	71	77	PF00069	0.735
MOD_Cter_Amidation	633	636	PF01082	0.447
MOD_DYRK1A_RPxSP_1	436	440	PF00069	0.754
MOD_GlcNHglycan	151	154	PF01048	0.308
MOD_GlcNHglycan	224	227	PF01048	0.533
MOD_GlcNHglycan	266	269	PF01048	0.600
MOD_GlcNHglycan	273	276	PF01048	0.547
MOD_GlcNHglycan	39	42	PF01048	0.433
MOD_GlcNHglycan	407	410	PF01048	0.591
MOD_GlcNHglycan	417	420	PF01048	0.520
MOD_GlcNHglycan	471	475	PF01048	0.320
MOD_GlcNHglycan	526	529	PF01048	0.362
MOD_GlcNHglycan	54	57	PF01048	0.570
MOD_GlcNHglycan	638	641	PF01048	0.530
MOD_GlcNHglycan	724	727	PF01048	0.345
MOD_GlcNHglycan	84	88	PF01048	0.454
MOD_GSK3_1	145	152	PF00069	0.565
MOD_GSK3_1	231	238	PF00069	0.754
MOD_GSK3_1	260	267	PF00069	0.796
MOD_GSK3_1	271	278	PF00069	0.711
MOD_GSK3_1	398	405	PF00069	0.718
MOD_GSK3_1	40	47	PF00069	0.724
MOD_GSK3_1	432	439	PF00069	0.703
MOD_GSK3_1	48	55	PF00069	0.773
MOD_GSK3_1	503	510	PF00069	0.499
MOD_GSK3_1	636	643	PF00069	0.629
MOD_GSK3_1	702	709	PF00069	0.554
MOD_GSK3_1	71	78	PF00069	0.677
MOD_GSK3_1	722	729	PF00069	0.547
MOD_LATS_1	614	620	PF00433	0.558
MOD_N-GLC_1	228	233	PF02516	0.425
MOD_N-GLC_1	328	333	PF02516	0.282
MOD_N-GLC_1	44	49	PF02516	0.524
MOD_N-GLC_1	706	711	PF02516	0.347
MOD_NEK2_1	183	188	PF00069	0.583
MOD_NEK2_1	236	241	PF00069	0.766
MOD_NEK2_1	358	363	PF00069	0.532
MOD_NEK2_1	441	446	PF00069	0.698
MOD_NEK2_1	534	539	PF00069	0.558
MOD_NEK2_1	552	557	PF00069	0.444
MOD_NEK2_1	561	566	PF00069	0.539
MOD_NEK2_1	596	601	PF00069	0.565
MOD_NEK2_1	702	707	PF00069	0.519
MOD_NEK2_1	710	715	PF00069	0.520
MOD_NEK2_1	722	727	PF00069	0.512
MOD_NEK2_1	733	738	PF00069	0.640
MOD_NEK2_2	242	247	PF00069	0.691
MOD_NEK2_2	689	694	PF00069	0.525
MOD_PIKK_1	728	734	PF00454	0.619
MOD_PK_1	616	622	PF00069	0.578
MOD_PKA_2	320	326	PF00069	0.562
MOD_PKA_2	363	369	PF00069	0.553
MOD_PKA_2	432	438	PF00069	0.692
MOD_PKA_2	456	462	PF00069	0.624
MOD_PKA_2	534	540	PF00069	0.580
MOD_PKA_2	710	716	PF00069	0.639
MOD_PKA_2	726	732	PF00069	0.530
MOD_Plk_1	228	234	PF00069	0.597
MOD_Plk_1	346	352	PF00069	0.586
MOD_Plk_1	503	509	PF00069	0.581
MOD_Plk_1	596	602	PF00069	0.569
MOD_Plk_1	616	622	PF00069	0.393
MOD_Plk_1	706	712	PF00069	0.614
MOD_Plk_1	71	77	PF00069	0.611
MOD_Plk_4	106	112	PF00069	0.450
MOD_Plk_4	129	135	PF00069	0.454
MOD_Plk_4	202	208	PF00069	0.614
MOD_Plk_4	242	248	PF00069	0.760
MOD_Plk_4	320	326	PF00069	0.482
MOD_Plk_4	346	352	PF00069	0.438
MOD_Plk_4	441	447	PF00069	0.790
MOD_Plk_4	482	488	PF00069	0.444
MOD_Plk_4	507	513	PF00069	0.506
MOD_Plk_4	552	558	PF00069	0.598
MOD_Plk_4	562	568	PF00069	0.598
MOD_ProDKin_1	387	393	PF00069	0.789
MOD_ProDKin_1	40	46	PF00069	0.738
MOD_ProDKin_1	422	428	PF00069	0.730
MOD_ProDKin_1	436	442	PF00069	0.686
MOD_ProDKin_1	449	455	PF00069	0.621
MOD_ProDKin_1	544	550	PF00069	0.500
MOD_ProDKin_1	56	62	PF00069	0.731
MOD_ProDKin_1	78	84	PF00069	0.668
MOD_SUMO_rev_2	190	200	PF00179	0.622
TRG_DiLeu_BaEn_1	346	351	PF01217	0.524
TRG_DiLeu_BaEn_1	717	722	PF01217	0.544
TRG_DiLeu_BaEn_2	105	111	PF01217	0.525
TRG_DiLeu_BaEn_2	539	545	PF01217	0.589
TRG_DiLeu_BaEn_2	697	703	PF01217	0.508
TRG_DiLeu_BaEn_4	540	546	PF01217	0.425
TRG_ENDOCYTIC_2	135	138	PF00928	0.572
TRG_ENDOCYTIC_2	191	194	PF00928	0.533
TRG_ENDOCYTIC_2	342	345	PF00928	0.498
TRG_ENDOCYTIC_2	508	511	PF00928	0.533
TRG_ENDOCYTIC_2	549	552	PF00928	0.515
TRG_ENDOCYTIC_2	553	556	PF00928	0.520
TRG_ENDOCYTIC_2	593	596	PF00928	0.509
TRG_ENDOCYTIC_2	601	604	PF00928	0.516
TRG_ENDOCYTIC_2	607	610	PF00928	0.533
TRG_ENDOCYTIC_2	690	693	PF00928	0.541
TRG_ENDOCYTIC_2	7	10	PF00928	0.360
TRG_ER_diArg_1	172	175	PF00400	0.589
TRG_ER_diArg_1	281	284	PF00400	0.581
TRG_ER_diArg_1	610	612	PF00400	0.561
TRG_ER_FFAT_2	34	43	PF00635	0.506
TRG_NES_CRM1_1	460	471	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX1	Leptomonas seymouri	61%	100%
A0A0S4JQL9	Bodo saltans	35%	100%
A0A3R7KSA0	Trypanosoma rangeli	46%	100%
A0A3S5H5W5	Leishmania donovani	79%	100%
A4HT38	Leishmania infantum	78%	100%
C9ZUU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AL30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QIS4	Leishmania major	78%	99%
V5ATE0	Trypanosoma cruzi	48%	100%