Serine/threonine-protein phosphatase 2A activator

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A, regulatory subunit B, putative

Species:

Leishmania braziliensis

UniProt:

A4H4W3_LEIBR

TriTrypDb:

LbrM.07.0190 , LBRM2903_070007300

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000159	protein phosphatase type 2A complex	5	1
GO:0005634	nucleus	5	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

A4H4W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0008047	enzyme activator activity	3	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0019208	phosphatase regulator activity	3	12
GO:0019211	phosphatase activator activity	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0140677	molecular function activator activity	2	12
GO:0008160	protein tyrosine phosphatase activator activity	6	1
GO:0019888	protein phosphatase regulator activity	4	1
GO:0072542	protein phosphatase activator activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.613
CLV_NRD_NRD_1	231	233	PF00675	0.267
CLV_NRD_NRD_1	234	236	PF00675	0.245
CLV_NRD_NRD_1	51	53	PF00675	0.270
CLV_PCSK_FUR_1	121	125	PF00082	0.276
CLV_PCSK_FUR_1	232	236	PF00082	0.320
CLV_PCSK_KEX2_1	123	125	PF00082	0.283
CLV_PCSK_KEX2_1	233	235	PF00082	0.246
CLV_PCSK_KEX2_1	255	257	PF00082	0.244
CLV_PCSK_KEX2_1	51	53	PF00082	0.316
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.296
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.291
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.276
CLV_PCSK_PC7_1	251	257	PF00082	0.276
CLV_PCSK_SKI1_1	123	127	PF00082	0.345
CLV_PCSK_SKI1_1	38	42	PF00082	0.300
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_SPOP_SBC_1	146	150	PF00917	0.514
DOC_MAPK_MEF2A_6	206	215	PF00069	0.523
DOC_MAPK_RevD_3	221	235	PF00069	0.534
DOC_PP1_RVXF_1	174	180	PF00149	0.395
DOC_PP1_RVXF_1	382	389	PF00149	0.356
DOC_PP2B_LxvP_1	215	218	PF13499	0.516
DOC_USP7_MATH_1	17	21	PF00917	0.511
DOC_USP7_MATH_1	261	265	PF00917	0.415
DOC_USP7_MATH_1	69	73	PF00917	0.476
DOC_USP7_UBL2_3	25	29	PF12436	0.393
DOC_WW_Pin1_4	70	75	PF00397	0.458
LIG_14-3-3_CanoR_1	24	33	PF00244	0.569
LIG_14-3-3_CanoR_1	256	260	PF00244	0.535
LIG_14-3-3_CanoR_1	51	59	PF00244	0.426
LIG_14-3-3_CanoR_1	78	84	PF00244	0.476
LIG_APCC_ABBA_1	240	245	PF00400	0.516
LIG_BRCT_BRCA1_1	52	56	PF00533	0.415
LIG_BRCT_BRCA1_2	52	58	PF00533	0.351
LIG_Clathr_ClatBox_1	212	216	PF01394	0.476
LIG_CNOT1_NIM_1	240	249	PF04054	0.356
LIG_EH1_1	186	194	PF00400	0.440
LIG_eIF4E_1	244	250	PF01652	0.436
LIG_FHA_1	208	214	PF00498	0.376
LIG_FHA_2	173	179	PF00498	0.417
LIG_FHA_2	80	86	PF00498	0.482
LIG_LIR_Gen_1	245	253	PF02991	0.444
LIG_LIR_Gen_1	271	280	PF02991	0.415
LIG_LIR_Gen_1	320	329	PF02991	0.440
LIG_LIR_Gen_1	353	363	PF02991	0.458
LIG_LIR_Gen_1	53	63	PF02991	0.415
LIG_LIR_Gen_1	73	83	PF02991	0.319
LIG_LIR_Nem_3	184	190	PF02991	0.415
LIG_LIR_Nem_3	237	243	PF02991	0.431
LIG_LIR_Nem_3	245	249	PF02991	0.400
LIG_LIR_Nem_3	271	276	PF02991	0.415
LIG_LIR_Nem_3	320	325	PF02991	0.415
LIG_LIR_Nem_3	353	358	PF02991	0.426
LIG_LIR_Nem_3	53	59	PF02991	0.415
LIG_Pex14_1	355	359	PF04695	0.426
LIG_SH2_CRK	246	250	PF00017	0.476
LIG_SH2_STAP1	26	30	PF00017	0.379
LIG_SH2_STAT5	166	169	PF00017	0.426
LIG_SH2_STAT5	238	241	PF00017	0.465
LIG_SH2_STAT5	26	29	PF00017	0.454
LIG_SH2_STAT5	278	281	PF00017	0.530
LIG_SH2_STAT5	322	325	PF00017	0.439
LIG_SH2_STAT5	62	65	PF00017	0.415
LIG_SH2_STAT5	92	95	PF00017	0.516
LIG_SH2_STAT5	97	100	PF00017	0.516
LIG_SH3_2	33	38	PF14604	0.422
LIG_SH3_3	208	214	PF00018	0.447
LIG_SH3_3	215	221	PF00018	0.433
LIG_SH3_3	289	295	PF00018	0.516
LIG_SH3_3	30	36	PF00018	0.391
LIG_TRAF2_1	152	155	PF00917	0.436
LIG_TRFH_1	257	261	PF08558	0.415
LIG_UBA3_1	327	335	PF00899	0.516
LIG_WRC_WIRS_1	168	173	PF05994	0.476
MOD_CK2_1	147	153	PF00069	0.418
MOD_CK2_1	178	184	PF00069	0.415
MOD_CK2_1	347	353	PF00069	0.440
MOD_CK2_1	42	48	PF00069	0.514
MOD_GlcNHglycan	180	183	PF01048	0.316
MOD_GlcNHglycan	349	352	PF01048	0.217
MOD_GlcNHglycan	359	362	PF01048	0.215
MOD_GlcNHglycan	52	55	PF01048	0.240
MOD_GSK3_1	141	148	PF00069	0.463
MOD_GSK3_1	154	161	PF00069	0.499
MOD_N-GLC_1	172	177	PF02516	0.267
MOD_N-GLC_1	333	338	PF02516	0.255
MOD_N-GLC_1	347	352	PF02516	0.217
MOD_N-GLC_1	374	379	PF02516	0.316
MOD_N-GLC_2	84	86	PF02516	0.156
MOD_NEK2_1	101	106	PF00069	0.401
MOD_NEK2_1	130	135	PF00069	0.463
MOD_NEK2_1	141	146	PF00069	0.434
MOD_NEK2_1	374	379	PF00069	0.453
MOD_NEK2_1	50	55	PF00069	0.432
MOD_NEK2_1	79	84	PF00069	0.458
MOD_NEK2_2	201	206	PF00069	0.520
MOD_NEK2_2	86	91	PF00069	0.476
MOD_PIKK_1	374	380	PF00454	0.516
MOD_PKA_1	24	30	PF00069	0.616
MOD_PKA_1	255	261	PF00069	0.476
MOD_PKA_2	1	7	PF00069	0.580
MOD_PKA_2	255	261	PF00069	0.476
MOD_PKA_2	50	56	PF00069	0.426
MOD_PKA_2	77	83	PF00069	0.503
MOD_Plk_1	130	136	PF00069	0.499
MOD_Plk_1	154	160	PF00069	0.545
MOD_Plk_1	172	178	PF00069	0.447
MOD_Plk_1	299	305	PF00069	0.491
MOD_Plk_1	42	48	PF00069	0.516
MOD_Plk_1	86	92	PF00069	0.476
MOD_Plk_2-3	42	48	PF00069	0.516
MOD_Plk_4	130	136	PF00069	0.486
MOD_Plk_4	207	213	PF00069	0.377
MOD_Plk_4	299	305	PF00069	0.361
MOD_Plk_4	42	48	PF00069	0.491
MOD_ProDKin_1	70	76	PF00069	0.458
TRG_DiLeu_BaEn_1	42	47	PF01217	0.405
TRG_DiLeu_BaEn_2	183	189	PF01217	0.415
TRG_ENDOCYTIC_2	244	247	PF00928	0.416
TRG_ENDOCYTIC_2	273	276	PF00928	0.415
TRG_ENDOCYTIC_2	322	325	PF00928	0.415
TRG_ENDOCYTIC_2	359	362	PF00928	0.426
TRG_ENDOCYTIC_2	76	79	PF00928	0.356
TRG_ER_diArg_1	231	234	PF00400	0.483
TRG_ER_diArg_1	50	52	PF00400	0.516
TRG_NLS_MonoCore_2	231	236	PF00514	0.476
TRG_NLS_MonoExtC_3	231	237	PF00514	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC2	Leptomonas seymouri	75%	100%
A0A0S4JLT6	Bodo saltans	40%	100%
A0A1X0NL05	Trypanosomatidae	52%	99%
A0A3R7M448	Trypanosoma rangeli	53%	100%
A0A3S5H5W4	Leishmania donovani	84%	100%
A4HT37	Leishmania infantum	84%	100%
C9ZUU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E9AL29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O36016	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
P0C153	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	94%
P0CQ00	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	100%
P0CQ01	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	100%
P0CQ02	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	31%	100%
P0CQ03	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	31%	100%
P40454	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P58389	Mus musculus	33%	100%
Q12461	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q15257	Homo sapiens	37%	100%
Q28717	Oryctolagus cuniculus	32%	100%
Q2KJ44	Bos taurus	36%	100%
Q2UCL6	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	33%	93%
Q2UN27	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	33%	82%
Q4I0M9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	88%
Q4INW6	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	91%
Q4P4W3	Ustilago maydis (strain 521 / FGSC 9021)	35%	81%
Q4PCR0	Ustilago maydis (strain 521 / FGSC 9021)	30%	86%
Q4QIS5	Leishmania major	83%	100%
Q4WMU5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	83%
Q4WSA8	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	93%
Q54WH6	Dictyostelium discoideum	31%	84%
Q55CJ3	Dictyostelium discoideum	34%	100%
Q5ADP9	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	93%
Q5B6C5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	91%
Q6BNW4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	89%
Q6BU97	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	100%
Q6C712	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	100%
Q6CFX5	Yarrowia lipolytica (strain CLIB 122 / E 150)	36%	91%
Q6CKF0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6CYH1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6FK00	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q6FRQ9	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	34%	93%
Q753L9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q75BY1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q7SEF9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	88%
Q9P7H4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5D9E5	Trypanosoma cruzi	55%	100%