Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4W0_LEIBR

TriTrypDb:

LbrM.07.0160 , LBRM2903_070007000

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4W0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.368
CLV_NRD_NRD_1	263	265	PF00675	0.600
CLV_NRD_NRD_1	447	449	PF00675	0.683
CLV_NRD_NRD_1	458	460	PF00675	0.744
CLV_NRD_NRD_1	525	527	PF00675	0.570
CLV_NRD_NRD_1	632	634	PF00675	0.653
CLV_NRD_NRD_1	658	660	PF00675	0.717
CLV_NRD_NRD_1	802	804	PF00675	0.591
CLV_PCSK_FUR_1	777	781	PF00082	0.607
CLV_PCSK_KEX2_1	263	265	PF00082	0.600
CLV_PCSK_KEX2_1	34	36	PF00082	0.386
CLV_PCSK_KEX2_1	458	460	PF00082	0.731
CLV_PCSK_KEX2_1	525	527	PF00082	0.570
CLV_PCSK_KEX2_1	545	547	PF00082	0.804
CLV_PCSK_KEX2_1	632	634	PF00082	0.653
CLV_PCSK_KEX2_1	658	660	PF00082	0.715
CLV_PCSK_KEX2_1	779	781	PF00082	0.602
CLV_PCSK_KEX2_1	806	808	PF00082	0.615
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.386
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.719
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.804
CLV_PCSK_PC1ET2_1	779	781	PF00082	0.590
CLV_PCSK_PC1ET2_1	806	808	PF00082	0.615
CLV_PCSK_SKI1_1	123	127	PF00082	0.336
CLV_PCSK_SKI1_1	246	250	PF00082	0.417
CLV_PCSK_SKI1_1	253	257	PF00082	0.448
CLV_PCSK_SKI1_1	545	549	PF00082	0.809
CLV_PCSK_SKI1_1	624	628	PF00082	0.577
CLV_PCSK_SKI1_1	659	663	PF00082	0.576
CLV_PCSK_SKI1_1	803	807	PF00082	0.512
DEG_APCC_DBOX_1	263	271	PF00400	0.540
DEG_SCF_FBW7_1	344	349	PF00400	0.807
DEG_SPOP_SBC_1	381	385	PF00917	0.555
DOC_CKS1_1	520	525	PF01111	0.564
DOC_CKS1_1	676	681	PF01111	0.781
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.386
DOC_MAPK_gen_1	123	132	PF00069	0.386
DOC_MAPK_gen_1	51	60	PF00069	0.349
DOC_MAPK_gen_1	756	763	PF00069	0.738
DOC_MAPK_gen_1	803	813	PF00069	0.712
DOC_MAPK_MEF2A_6	756	763	PF00069	0.541
DOC_MAPK_MEF2A_6	806	815	PF00069	0.667
DOC_PP2B_LxvP_1	378	381	PF13499	0.563
DOC_PP2B_LxvP_1	431	434	PF13499	0.720
DOC_PP2B_LxvP_1	653	656	PF13499	0.557
DOC_PP2B_LxvP_1	677	680	PF13499	0.538
DOC_PP4_FxxP_1	199	202	PF00568	0.386
DOC_PP4_FxxP_1	396	399	PF00568	0.518
DOC_PP4_MxPP_1	582	585	PF00568	0.569
DOC_USP7_MATH_1	280	284	PF00917	0.653
DOC_USP7_MATH_1	346	350	PF00917	0.614
DOC_USP7_MATH_1	371	375	PF00917	0.714
DOC_USP7_MATH_1	521	525	PF00917	0.560
DOC_USP7_MATH_1	589	593	PF00917	0.659
DOC_USP7_MATH_1	639	643	PF00917	0.563
DOC_USP7_MATH_1	759	763	PF00917	0.658
DOC_USP7_UBL2_3	454	458	PF12436	0.728
DOC_USP7_UBL2_3	532	536	PF12436	0.710
DOC_USP7_UBL2_3	788	792	PF12436	0.558
DOC_USP7_UBL2_3	800	804	PF12436	0.480
DOC_WW_Pin1_4	159	164	PF00397	0.386
DOC_WW_Pin1_4	214	219	PF00397	0.486
DOC_WW_Pin1_4	265	270	PF00397	0.537
DOC_WW_Pin1_4	281	286	PF00397	0.551
DOC_WW_Pin1_4	287	292	PF00397	0.750
DOC_WW_Pin1_4	304	309	PF00397	0.518
DOC_WW_Pin1_4	310	315	PF00397	0.569
DOC_WW_Pin1_4	317	322	PF00397	0.744
DOC_WW_Pin1_4	342	347	PF00397	0.800
DOC_WW_Pin1_4	372	377	PF00397	0.764
DOC_WW_Pin1_4	465	470	PF00397	0.563
DOC_WW_Pin1_4	519	524	PF00397	0.565
DOC_WW_Pin1_4	561	566	PF00397	0.698
DOC_WW_Pin1_4	668	673	PF00397	0.786
DOC_WW_Pin1_4	675	680	PF00397	0.747
DOC_WW_Pin1_4	92	97	PF00397	0.374
LIG_14-3-3_CanoR_1	196	202	PF00244	0.368
LIG_14-3-3_CanoR_1	242	249	PF00244	0.386
LIG_14-3-3_CanoR_1	263	268	PF00244	0.418
LIG_14-3-3_CanoR_1	459	463	PF00244	0.622
LIG_14-3-3_CanoR_1	494	503	PF00244	0.736
LIG_14-3-3_CanoR_1	658	662	PF00244	0.574
LIG_14-3-3_CanoR_1	721	726	PF00244	0.773
LIG_14-3-3_CanoR_1	727	732	PF00244	0.687
LIG_14-3-3_CanoR_1	750	759	PF00244	0.675
LIG_14-3-3_CanoR_1	760	764	PF00244	0.695
LIG_14-3-3_CanoR_1	822	829	PF00244	0.536
LIG_Actin_WH2_2	247	265	PF00022	0.355
LIG_BIR_III_2	593	597	PF00653	0.734
LIG_CtBP_PxDLS_1	358	362	PF00389	0.537
LIG_deltaCOP1_diTrp_1	181	189	PF00928	0.386
LIG_FHA_1	134	140	PF00498	0.446
LIG_FHA_1	147	153	PF00498	0.281
LIG_FHA_1	38	44	PF00498	0.434
LIG_FHA_1	529	535	PF00498	0.789
LIG_FHA_1	823	829	PF00498	0.539
LIG_FHA_1	96	102	PF00498	0.386
LIG_FHA_2	242	248	PF00498	0.245
LIG_FHA_2	377	383	PF00498	0.605
LIG_HP1_1	759	763	PF01393	0.527
LIG_Integrin_isoDGR_2	748	750	PF01839	0.716
LIG_IRF3_LxIS_1	437	442	PF10401	0.564
LIG_LIR_Apic_2	162	168	PF02991	0.386
LIG_LIR_Apic_2	310	314	PF02991	0.536
LIG_LIR_Gen_1	203	211	PF02991	0.386
LIG_LIR_Gen_1	384	395	PF02991	0.544
LIG_LIR_Gen_1	4	12	PF02991	0.457
LIG_LIR_Gen_1	69	76	PF02991	0.423
LIG_LIR_LC3C_4	28	32	PF02991	0.368
LIG_LIR_LC3C_4	329	334	PF02991	0.679
LIG_LIR_Nem_3	203	207	PF02991	0.386
LIG_LIR_Nem_3	212	216	PF02991	0.386
LIG_LIR_Nem_3	384	390	PF02991	0.550
LIG_LIR_Nem_3	4	9	PF02991	0.434
LIG_LIR_Nem_3	598	603	PF02991	0.474
LIG_LIR_Nem_3	83	89	PF02991	0.349
LIG_MAD2	532	540	PF02301	0.795
LIG_PALB2_WD40_1	100	108	PF16756	0.386
LIG_Pex14_2	60	64	PF04695	0.386
LIG_REV1ctd_RIR_1	444	453	PF16727	0.551
LIG_SH2_CRK	311	315	PF00017	0.530
LIG_SH2_CRK	6	10	PF00017	0.425
LIG_SH2_NCK_1	190	194	PF00017	0.486
LIG_SH2_NCK_1	311	315	PF00017	0.530
LIG_SH2_SRC	614	617	PF00017	0.438
LIG_SH2_STAP1	176	180	PF00017	0.381
LIG_SH2_STAP1	725	729	PF00017	0.549
LIG_SH2_STAT3	725	728	PF00017	0.717
LIG_SH2_STAT3	88	91	PF00017	0.486
LIG_SH2_STAT5	114	117	PF00017	0.486
LIG_SH2_STAT5	140	143	PF00017	0.336
LIG_SH2_STAT5	6	9	PF00017	0.441
LIG_SH2_STAT5	614	617	PF00017	0.578
LIG_SH2_STAT5	88	91	PF00017	0.382
LIG_SH3_1	578	584	PF00018	0.577
LIG_SH3_2	581	586	PF14604	0.575
LIG_SH3_3	157	163	PF00018	0.374
LIG_SH3_3	215	221	PF00018	0.274
LIG_SH3_3	233	239	PF00018	0.486
LIG_SH3_3	267	273	PF00018	0.605
LIG_SH3_3	282	288	PF00018	0.656
LIG_SH3_3	302	308	PF00018	0.749
LIG_SH3_3	370	376	PF00018	0.643
LIG_SH3_3	391	397	PF00018	0.640
LIG_SH3_3	459	465	PF00018	0.606
LIG_SH3_3	474	480	PF00018	0.748
LIG_SH3_3	555	561	PF00018	0.759
LIG_SH3_3	578	584	PF00018	0.810
LIG_SH3_3	666	672	PF00018	0.714
LIG_SH3_3	687	693	PF00018	0.713
LIG_SH3_4	586	593	PF00018	0.720
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.330
LIG_SUMO_SIM_anti_2	327	335	PF11976	0.675
LIG_SUMO_SIM_par_1	148	153	PF11976	0.245
LIG_SUMO_SIM_par_1	233	238	PF11976	0.352
LIG_SUMO_SIM_par_1	673	678	PF11976	0.560
LIG_TRAF2_1	762	765	PF00917	0.641
LIG_UBA3_1	85	94	PF00899	0.274
LIG_WRC_WIRS_1	61	66	PF05994	0.386
LIG_WW_2	285	288	PF00397	0.514
LIG_WW_3	678	682	PF00397	0.774
MOD_CDC14_SPxK_1	268	271	PF00782	0.677
MOD_CDC14_SPxK_1	272	275	PF00782	0.640
MOD_CDC14_SPxK_1	564	567	PF00782	0.705
MOD_CDK_SPxK_1	265	271	PF00069	0.555
MOD_CDK_SPxK_1	519	525	PF00069	0.567
MOD_CDK_SPxK_1	561	567	PF00069	0.703
MOD_CDK_SPxK_1	675	681	PF00069	0.791
MOD_CDK_SPxxK_3	519	526	PF00069	0.568
MOD_CK1_1	133	139	PF00069	0.331
MOD_CK1_1	146	152	PF00069	0.340
MOD_CK1_1	153	159	PF00069	0.158
MOD_CK1_1	200	206	PF00069	0.386
MOD_CK1_1	307	313	PF00069	0.706
MOD_CK1_1	316	322	PF00069	0.773
MOD_CK1_1	325	331	PF00069	0.635
MOD_CK1_1	349	355	PF00069	0.815
MOD_CK1_1	383	389	PF00069	0.680
MOD_CK1_1	497	503	PF00069	0.781
MOD_CK1_1	524	530	PF00069	0.808
MOD_CK1_1	742	748	PF00069	0.692
MOD_CK1_1	75	81	PF00069	0.446
MOD_CK2_1	241	247	PF00069	0.245
MOD_CK2_1	376	382	PF00069	0.684
MOD_CK2_1	759	765	PF00069	0.660
MOD_GlcNHglycan	145	148	PF01048	0.358
MOD_GlcNHglycan	199	202	PF01048	0.386
MOD_GlcNHglycan	315	318	PF01048	0.765
MOD_GlcNHglycan	324	327	PF01048	0.515
MOD_GlcNHglycan	507	510	PF01048	0.574
MOD_GlcNHglycan	578	581	PF01048	0.585
MOD_GlcNHglycan	641	644	PF01048	0.700
MOD_GlcNHglycan	695	698	PF01048	0.673
MOD_GlcNHglycan	744	747	PF01048	0.566
MOD_GlcNHglycan	768	771	PF01048	0.467
MOD_GlcNHglycan	77	80	PF01048	0.486
MOD_GlcNHglycan	829	832	PF01048	0.659
MOD_GSK3_1	146	153	PF00069	0.386
MOD_GSK3_1	155	162	PF00069	0.386
MOD_GSK3_1	226	233	PF00069	0.486
MOD_GSK3_1	265	272	PF00069	0.506
MOD_GSK3_1	309	316	PF00069	0.743
MOD_GSK3_1	342	349	PF00069	0.809
MOD_GSK3_1	372	379	PF00069	0.712
MOD_GSK3_1	381	388	PF00069	0.667
MOD_GSK3_1	480	487	PF00069	0.707
MOD_GSK3_1	503	510	PF00069	0.666
MOD_GSK3_1	524	531	PF00069	0.773
MOD_GSK3_1	717	724	PF00069	0.533
MOD_GSK3_1	735	742	PF00069	0.696
MOD_LATS_1	657	663	PF00433	0.575
MOD_LATS_1	820	826	PF00433	0.527
MOD_LATS_1	92	98	PF00433	0.245
MOD_N-GLC_1	153	158	PF02516	0.386
MOD_N-GLC_1	46	51	PF02516	0.378
MOD_N-GLC_1	552	557	PF02516	0.562
MOD_NEK2_1	12	17	PF00069	0.543
MOD_NEK2_1	150	155	PF00069	0.361
MOD_NEK2_1	171	176	PF00069	0.346
MOD_NEK2_1	46	51	PF00069	0.344
MOD_NEK2_1	60	65	PF00069	0.386
MOD_NEK2_2	66	71	PF00069	0.486
MOD_PIKK_1	37	43	PF00454	0.378
MOD_PIKK_1	87	93	PF00454	0.386
MOD_PK_1	148	154	PF00069	0.245
MOD_PK_1	458	464	PF00069	0.576
MOD_PK_1	475	481	PF00069	0.799
MOD_PKA_1	263	269	PF00069	0.428
MOD_PKA_1	458	464	PF00069	0.576
MOD_PKA_2	241	247	PF00069	0.386
MOD_PKA_2	263	269	PF00069	0.428
MOD_PKA_2	274	280	PF00069	0.557
MOD_PKA_2	458	464	PF00069	0.576
MOD_PKA_2	503	509	PF00069	0.613
MOD_PKA_2	524	530	PF00069	0.765
MOD_PKA_2	657	663	PF00069	0.575
MOD_PKA_2	759	765	PF00069	0.760
MOD_PKA_2	821	827	PF00069	0.532
MOD_PKB_1	473	481	PF00069	0.798
MOD_Plk_1	116	122	PF00069	0.245
MOD_Plk_1	46	52	PF00069	0.386
MOD_Plk_4	116	122	PF00069	0.292
MOD_Plk_4	155	161	PF00069	0.381
MOD_Plk_4	230	236	PF00069	0.384
MOD_Plk_4	389	395	PF00069	0.583
MOD_Plk_4	497	503	PF00069	0.536
MOD_Plk_4	60	66	PF00069	0.368
MOD_Plk_4	97	103	PF00069	0.329
MOD_ProDKin_1	159	165	PF00069	0.386
MOD_ProDKin_1	214	220	PF00069	0.486
MOD_ProDKin_1	265	271	PF00069	0.545
MOD_ProDKin_1	281	287	PF00069	0.551
MOD_ProDKin_1	304	310	PF00069	0.592
MOD_ProDKin_1	317	323	PF00069	0.737
MOD_ProDKin_1	342	348	PF00069	0.803
MOD_ProDKin_1	372	378	PF00069	0.766
MOD_ProDKin_1	465	471	PF00069	0.556
MOD_ProDKin_1	519	525	PF00069	0.567
MOD_ProDKin_1	561	567	PF00069	0.703
MOD_ProDKin_1	668	674	PF00069	0.788
MOD_ProDKin_1	675	681	PF00069	0.746
MOD_ProDKin_1	92	98	PF00069	0.374
MOD_SUMO_for_1	778	781	PF00179	0.518
MOD_SUMO_rev_2	119	127	PF00179	0.446
MOD_SUMO_rev_2	133	139	PF00179	0.329
MOD_SUMO_rev_2	621	626	PF00179	0.684
TRG_DiLeu_BaEn_2	487	493	PF01217	0.788
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.787
TRG_DiLeu_BaLyEn_6	690	695	PF01217	0.544
TRG_ENDOCYTIC_2	6	9	PF00928	0.427
TRG_ER_diArg_1	262	264	PF00400	0.599
TRG_ER_diArg_1	473	476	PF00400	0.794
TRG_ER_diArg_1	50	53	PF00400	0.386
TRG_ER_diArg_1	603	606	PF00400	0.435
TRG_ER_diArg_1	680	683	PF00400	0.777
TRG_ER_diArg_1	756	759	PF00400	0.739
TRG_ER_diArg_1	784	787	PF00400	0.585
TRG_NLS_Bipartite_1	448	462	PF00514	0.561
TRG_NLS_MonoExtC_3	802	807	PF00514	0.621
TRG_NLS_MonoExtN_4	457	462	PF00514	0.688
TRG_NLS_MonoExtN_4	800	807	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.774

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD87	Leptomonas seymouri	46%	98%
A0A3S7WPQ0	Leishmania donovani	66%	98%
A4HT34	Leishmania infantum	65%	98%
E9AL26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	98%
Q0CLX3	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	86%
Q4QIS8	Leishmania major	66%	98%