Protein POLLEN DEFECTIVE IN GUIDANCE 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic membrane protein family, putative

Species:

Leishmania braziliensis

UniProt:

A4H4V9_LEIBR

TriTrypDb:

LbrM.07.0150 , LBRM2903_070006700

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H4V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0032507	maintenance of protein location in cell	3	1
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	1
GO:0045185	maintenance of protein location	3	1
GO:0051179	localization	1	1
GO:0051235	maintenance of location	2	1
GO:0051651	maintenance of location in cell	2	1
GO:0072595	maintenance of protein localization in organelle	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.219
CLV_C14_Caspase3-7	58	62	PF00656	0.654
CLV_NRD_NRD_1	129	131	PF00675	0.502
CLV_NRD_NRD_1	168	170	PF00675	0.223
CLV_NRD_NRD_1	215	217	PF00675	0.292
CLV_NRD_NRD_1	52	54	PF00675	0.385
CLV_NRD_NRD_1	85	87	PF00675	0.391
CLV_NRD_NRD_1	9	11	PF00675	0.476
CLV_PCSK_KEX2_1	129	131	PF00082	0.516
CLV_PCSK_KEX2_1	168	170	PF00082	0.223
CLV_PCSK_KEX2_1	214	216	PF00082	0.292
CLV_PCSK_KEX2_1	228	230	PF00082	0.308
CLV_PCSK_KEX2_1	443	445	PF00082	0.220
CLV_PCSK_KEX2_1	52	54	PF00082	0.385
CLV_PCSK_KEX2_1	613	615	PF00082	0.474
CLV_PCSK_KEX2_1	9	11	PF00082	0.522
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.349
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.276
CLV_PCSK_PC1ET2_1	613	615	PF00082	0.474
CLV_PCSK_SKI1_1	123	127	PF00082	0.515
CLV_PCSK_SKI1_1	216	220	PF00082	0.190
CLV_PCSK_SKI1_1	255	259	PF00082	0.353
CLV_PCSK_SKI1_1	307	311	PF00082	0.502
CLV_PCSK_SKI1_1	371	375	PF00082	0.223
CLV_PCSK_SKI1_1	440	444	PF00082	0.294
CLV_PCSK_SKI1_1	486	490	PF00082	0.358
DEG_APCC_DBOX_1	129	137	PF00400	0.308
DEG_APCC_DBOX_1	498	506	PF00400	0.581
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SCF_FBW7_1	552	559	PF00400	0.663
DOC_CDC14_PxL_1	403	411	PF14671	0.456
DOC_CKS1_1	249	254	PF01111	0.456
DOC_CKS1_1	430	435	PF01111	0.456
DOC_CKS1_1	553	558	PF01111	0.582
DOC_CKS1_1	591	596	PF01111	0.459
DOC_CYCLIN_RxL_1	250	261	PF00134	0.505
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.375
DOC_MAPK_DCC_7	587	597	PF00069	0.524
DOC_MAPK_gen_1	168	175	PF00069	0.423
DOC_MAPK_gen_1	9	17	PF00069	0.710
DOC_MAPK_MEF2A_6	134	141	PF00069	0.256
DOC_MAPK_MEF2A_6	168	177	PF00069	0.410
DOC_MAPK_MEF2A_6	405	413	PF00069	0.424
DOC_MAPK_MEF2A_6	9	17	PF00069	0.520
DOC_MAPK_MEF2A_6	91	99	PF00069	0.473
DOC_MAPK_NFAT4_5	10	18	PF00069	0.520
DOC_MAPK_NFAT4_5	134	142	PF00069	0.256
DOC_PP1_RVXF_1	305	312	PF00149	0.244
DOC_PP2B_LxvP_1	118	121	PF13499	0.263
DOC_PP2B_LxvP_1	469	472	PF13499	0.183
DOC_USP7_MATH_1	221	225	PF00917	0.386
DOC_USP7_MATH_1	245	249	PF00917	0.448
DOC_USP7_MATH_1	383	387	PF00917	0.355
DOC_USP7_MATH_1	416	420	PF00917	0.401
DOC_USP7_MATH_1	51	55	PF00917	0.684
DOC_USP7_MATH_1	514	518	PF00917	0.748
DOC_USP7_MATH_1	539	543	PF00917	0.529
DOC_USP7_MATH_1	576	580	PF00917	0.592
DOC_USP7_MATH_1	612	616	PF00917	0.575
DOC_WW_Pin1_4	222	227	PF00397	0.545
DOC_WW_Pin1_4	248	253	PF00397	0.456
DOC_WW_Pin1_4	312	317	PF00397	0.256
DOC_WW_Pin1_4	429	434	PF00397	0.466
DOC_WW_Pin1_4	512	517	PF00397	0.699
DOC_WW_Pin1_4	535	540	PF00397	0.630
DOC_WW_Pin1_4	548	553	PF00397	0.558
DOC_WW_Pin1_4	556	561	PF00397	0.616
DOC_WW_Pin1_4	56	61	PF00397	0.780
DOC_WW_Pin1_4	590	595	PF00397	0.523
LIG_14-3-3_CanoR_1	168	173	PF00244	0.442
LIG_14-3-3_CanoR_1	348	354	PF00244	0.256
LIG_14-3-3_CanoR_1	387	395	PF00244	0.441
LIG_14-3-3_CanoR_1	499	503	PF00244	0.521
LIG_14-3-3_CanoR_1	531	537	PF00244	0.640
LIG_Actin_RPEL_3	127	146	PF02755	0.155
LIG_Actin_RPEL_3	341	360	PF02755	0.155
LIG_Actin_WH2_2	118	136	PF00022	0.439
LIG_Actin_WH2_2	291	309	PF00022	0.305
LIG_BRCT_BRCA1_1	563	567	PF00533	0.546
LIG_CtBP_PxDLS_1	382	386	PF00389	0.355
LIG_EH1_1	112	120	PF00400	0.309
LIG_eIF4E_1	389	395	PF01652	0.505
LIG_FHA_1	10	16	PF00498	0.666
LIG_FHA_1	141	147	PF00498	0.296
LIG_FHA_1	154	160	PF00498	0.161
LIG_FHA_1	168	174	PF00498	0.373
LIG_FHA_1	280	286	PF00498	0.223
LIG_FHA_1	535	541	PF00498	0.725
LIG_FHA_1	591	597	PF00498	0.543
LIG_FHA_1	65	71	PF00498	0.609
LIG_FHA_2	200	206	PF00498	0.469
LIG_FHA_2	420	426	PF00498	0.534
LIG_LIR_Apic_2	401	407	PF02991	0.409
LIG_LIR_Gen_1	157	167	PF02991	0.447
LIG_LIR_Gen_1	170	179	PF02991	0.402
LIG_LIR_Gen_1	198	208	PF02991	0.456
LIG_LIR_Gen_1	347	357	PF02991	0.231
LIG_LIR_Gen_1	38	48	PF02991	0.714
LIG_LIR_Gen_1	386	397	PF02991	0.360
LIG_LIR_Gen_1	81	89	PF02991	0.537
LIG_LIR_LC3C_4	504	507	PF02991	0.538
LIG_LIR_Nem_3	100	105	PF02991	0.286
LIG_LIR_Nem_3	157	163	PF02991	0.466
LIG_LIR_Nem_3	170	175	PF02991	0.419
LIG_LIR_Nem_3	198	204	PF02991	0.505
LIG_LIR_Nem_3	205	211	PF02991	0.505
LIG_LIR_Nem_3	347	352	PF02991	0.223
LIG_LIR_Nem_3	386	392	PF02991	0.460
LIG_LIR_Nem_3	4	8	PF02991	0.676
LIG_LIR_Nem_3	81	85	PF02991	0.552
LIG_MYND_3	406	410	PF01753	0.456
LIG_NRBOX	113	119	PF00104	0.265
LIG_NRBOX	273	279	PF00104	0.309
LIG_NRBOX	293	299	PF00104	0.256
LIG_NRBOX	595	601	PF00104	0.526
LIG_Pex14_2	374	378	PF04695	0.410
LIG_PTB_Apo_2	95	102	PF02174	0.390
LIG_Rb_LxCxE_1	356	368	PF01857	0.309
LIG_SH2_CRK	160	164	PF00017	0.448
LIG_SH2_CRK	389	393	PF00017	0.423
LIG_SH2_CRK	452	456	PF00017	0.287
LIG_SH2_CRK	82	86	PF00017	0.616
LIG_SH2_NCK_1	201	205	PF00017	0.456
LIG_SH2_SRC	162	165	PF00017	0.423
LIG_SH2_STAP1	160	164	PF00017	0.414
LIG_SH2_STAP1	37	41	PF00017	0.606
LIG_SH2_STAP1	389	393	PF00017	0.490
LIG_SH2_STAP1	452	456	PF00017	0.287
LIG_SH2_STAT5	102	105	PF00017	0.269
LIG_SH2_STAT5	162	165	PF00017	0.492
LIG_SH2_STAT5	201	204	PF00017	0.355
LIG_SH2_STAT5	211	214	PF00017	0.339
LIG_SH2_STAT5	333	336	PF00017	0.333
LIG_SH2_STAT5	466	469	PF00017	0.324
LIG_SH3_3	410	416	PF00018	0.388
LIG_SH3_3	503	509	PF00018	0.614
LIG_SH3_3	510	516	PF00018	0.685
LIG_SH3_3	518	524	PF00018	0.699
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.628
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.252
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.441
LIG_SUMO_SIM_anti_2	273	278	PF11976	0.383
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.305
LIG_SUMO_SIM_anti_2	390	396	PF11976	0.441
LIG_SUMO_SIM_anti_2	408	414	PF11976	0.441
LIG_SUMO_SIM_anti_2	504	509	PF11976	0.468
LIG_SUMO_SIM_par_1	138	143	PF11976	0.281
LIG_SUMO_SIM_par_1	180	186	PF11976	0.393
LIG_SUMO_SIM_par_1	393	398	PF11976	0.522
LIG_TYR_ITIM	199	204	PF00017	0.456
LIG_TYR_ITIM	450	455	PF00017	0.263
LIG_UBA3_1	114	123	PF00899	0.253
LIG_UBA3_1	178	187	PF00899	0.456
LIG_UBA3_1	477	486	PF00899	0.392
LIG_UBA3_1	595	601	PF00899	0.542
LIG_WRC_WIRS_1	189	194	PF05994	0.394
LIG_WRC_WIRS_1	37	42	PF05994	0.506
MOD_CDK_SPxK_1	222	228	PF00069	0.401
MOD_CDK_SPxxK_3	222	229	PF00069	0.440
MOD_CDK_SPxxK_3	248	255	PF00069	0.456
MOD_CK1_1	190	196	PF00069	0.411
MOD_CK1_1	224	230	PF00069	0.355
MOD_CK1_1	248	254	PF00069	0.419
MOD_CK1_1	270	276	PF00069	0.289
MOD_CK1_1	398	404	PF00069	0.433
MOD_CK1_1	414	420	PF00069	0.542
MOD_CK1_1	46	52	PF00069	0.685
MOD_CK1_1	517	523	PF00069	0.685
MOD_CK1_1	529	535	PF00069	0.623
MOD_CK1_1	54	60	PF00069	0.757
MOD_CK2_1	419	425	PF00069	0.515
MOD_CK2_1	578	584	PF00069	0.545
MOD_CMANNOS	2	5	PF00535	0.324
MOD_GlcNHglycan	231	234	PF01048	0.336
MOD_GlcNHglycan	260	263	PF01048	0.257
MOD_GlcNHglycan	413	416	PF01048	0.313
MOD_GlcNHglycan	43	46	PF01048	0.489
MOD_GlcNHglycan	53	56	PF01048	0.584
MOD_GlcNHglycan	541	544	PF01048	0.421
MOD_GlcNHglycan	580	583	PF01048	0.383
MOD_GlcNHglycan	71	74	PF01048	0.481
MOD_GSK3_1	154	161	PF00069	0.269
MOD_GSK3_1	241	248	PF00069	0.429
MOD_GSK3_1	266	273	PF00069	0.307
MOD_GSK3_1	383	390	PF00069	0.414
MOD_GSK3_1	39	46	PF00069	0.666
MOD_GSK3_1	411	418	PF00069	0.509
MOD_GSK3_1	508	515	PF00069	0.688
MOD_GSK3_1	526	533	PF00069	0.755
MOD_GSK3_1	535	542	PF00069	0.572
MOD_GSK3_1	548	555	PF00069	0.505
MOD_GSK3_1	56	63	PF00069	0.708
MOD_N-GLC_1	301	306	PF02516	0.408
MOD_NEK2_1	103	108	PF00069	0.263
MOD_NEK2_1	140	145	PF00069	0.361
MOD_NEK2_1	154	159	PF00069	0.190
MOD_NEK2_1	258	263	PF00069	0.315
MOD_NEK2_1	267	272	PF00069	0.287
MOD_NEK2_1	41	46	PF00069	0.683
MOD_NEK2_1	488	493	PF00069	0.288
MOD_NEK2_2	498	503	PF00069	0.598
MOD_OFUCOSY	266	271	PF10250	0.309
MOD_PIKK_1	154	160	PF00454	0.323
MOD_PIKK_1	190	196	PF00454	0.441
MOD_PIKK_1	245	251	PF00454	0.355
MOD_PIKK_1	387	393	PF00454	0.441
MOD_PIKK_1	514	520	PF00454	0.570
MOD_PIKK_1	526	532	PF00454	0.604
MOD_PKA_1	168	174	PF00069	0.423
MOD_PKA_1	9	15	PF00069	0.576
MOD_PKA_2	167	173	PF00069	0.423
MOD_PKA_2	347	353	PF00069	0.256
MOD_PKA_2	498	504	PF00069	0.520
MOD_PKA_2	51	57	PF00069	0.584
MOD_PKA_2	530	536	PF00069	0.728
MOD_PKA_2	9	15	PF00069	0.645
MOD_Plk_1	206	212	PF00069	0.355
MOD_Plk_4	123	129	PF00069	0.273
MOD_Plk_4	140	146	PF00069	0.272
MOD_Plk_4	158	164	PF00069	0.377
MOD_Plk_4	168	174	PF00069	0.450
MOD_Plk_4	206	212	PF00069	0.355
MOD_Plk_4	272	278	PF00069	0.274
MOD_Plk_4	290	296	PF00069	0.271
MOD_Plk_4	36	42	PF00069	0.506
MOD_Plk_4	398	404	PF00069	0.415
MOD_Plk_4	488	494	PF00069	0.358
MOD_Plk_4	570	576	PF00069	0.558
MOD_ProDKin_1	222	228	PF00069	0.545
MOD_ProDKin_1	248	254	PF00069	0.456
MOD_ProDKin_1	312	318	PF00069	0.256
MOD_ProDKin_1	429	435	PF00069	0.466
MOD_ProDKin_1	512	518	PF00069	0.703
MOD_ProDKin_1	535	541	PF00069	0.630
MOD_ProDKin_1	548	554	PF00069	0.559
MOD_ProDKin_1	556	562	PF00069	0.617
MOD_ProDKin_1	56	62	PF00069	0.781
MOD_ProDKin_1	590	596	PF00069	0.517
TRG_DiLeu_BaEn_1	290	295	PF01217	0.223
TRG_DiLeu_BaEn_1	426	431	PF01217	0.456
TRG_DiLeu_BaLyEn_6	591	596	PF01217	0.561
TRG_ENDOCYTIC_2	102	105	PF00928	0.306
TRG_ENDOCYTIC_2	160	163	PF00928	0.476
TRG_ENDOCYTIC_2	164	167	PF00928	0.489
TRG_ENDOCYTIC_2	201	204	PF00928	0.456
TRG_ENDOCYTIC_2	333	336	PF00928	0.256
TRG_ENDOCYTIC_2	37	40	PF00928	0.607
TRG_ENDOCYTIC_2	389	392	PF00928	0.412
TRG_ENDOCYTIC_2	452	455	PF00928	0.249
TRG_ENDOCYTIC_2	466	469	PF00928	0.221
TRG_ENDOCYTIC_2	82	85	PF00928	0.615
TRG_ER_diArg_1	128	130	PF00400	0.347
TRG_ER_diArg_1	167	169	PF00400	0.423
TRG_ER_diArg_1	214	216	PF00400	0.489
TRG_ER_diArg_1	51	53	PF00400	0.578
TRG_ER_diArg_1	8	10	PF00400	0.565
TRG_ER_diLys_1	611	616	PF00400	0.674
TRG_NES_CRM1_1	329	343	PF08389	0.166
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JBJ3	Bodo saltans	35%	100%
A0A1X0NLV9	Trypanosomatidae	40%	100%
A0A3S7WPS5	Leishmania donovani	78%	100%
A0A422NTF0	Trypanosoma rangeli	40%	100%
A4HT53	Leishmania infantum	78%	100%
C9ZUV5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AL25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QIS9	Leishmania major	79%	99%
Q4VBD2	Mus musculus	27%	100%
Q6NXT6	Homo sapiens	26%	100%
V5D9E0	Trypanosoma cruzi	40%	100%