Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4V7_LEIBR

TriTrypDb:

LbrM.07.0140 , LBRM2903_070006600

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H4V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	8
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	8
GO:0016192	vesicle-mediated transport	4	8
GO:0048193	Golgi vesicle transport	5	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	322	324	PF00675	0.482
CLV_PCSK_KEX2_1	322	324	PF00082	0.482
CLV_PCSK_SKI1_1	218	222	PF00082	0.499
CLV_PCSK_SKI1_1	260	264	PF00082	0.497
CLV_PCSK_SKI1_1	317	321	PF00082	0.470
CLV_PCSK_SKI1_1	50	54	PF00082	0.518
CLV_Separin_Metazoa	237	241	PF03568	0.564
DEG_SCF_FBW7_1	275	282	PF00400	0.788
DOC_CDC14_PxL_1	1	9	PF14671	0.543
DOC_CKS1_1	276	281	PF01111	0.796
DOC_CYCLIN_RxL_1	257	266	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	262	265	PF00134	0.773
DOC_MAPK_FxFP_2	233	236	PF00069	0.678
DOC_MAPK_gen_1	249	259	PF00069	0.555
DOC_PP2B_LxvP_1	262	265	PF13499	0.773
DOC_PP4_FxxP_1	233	236	PF00568	0.678
DOC_USP7_MATH_1	223	227	PF00917	0.726
DOC_USP7_MATH_1	291	295	PF00917	0.687
DOC_USP7_MATH_1	333	337	PF00917	0.787
DOC_USP7_MATH_1	341	345	PF00917	0.649
DOC_USP7_MATH_1	75	79	PF00917	0.455
DOC_WW_Pin1_4	11	16	PF00397	0.541
DOC_WW_Pin1_4	275	280	PF00397	0.797
DOC_WW_Pin1_4	329	334	PF00397	0.715
LIG_14-3-3_CanoR_1	115	119	PF00244	0.413
LIG_14-3-3_CanoR_1	149	157	PF00244	0.647
LIG_14-3-3_CanoR_1	50	55	PF00244	0.383
LIG_Actin_WH2_2	101	117	PF00022	0.501
LIG_Actin_WH2_2	227	242	PF00022	0.741
LIG_BRCT_BRCA1_1	224	228	PF00533	0.546
LIG_deltaCOP1_diTrp_1	196	201	PF00928	0.303
LIG_eIF4E_1	88	94	PF01652	0.549
LIG_FHA_1	15	21	PF00498	0.411
LIG_FHA_1	296	302	PF00498	0.815
LIG_FHA_1	51	57	PF00498	0.380
LIG_FHA_1	68	74	PF00498	0.220
LIG_FHA_1	97	103	PF00498	0.359
LIG_FHA_2	302	308	PF00498	0.707
LIG_FHA_2	40	46	PF00498	0.308
LIG_FHA_2	57	63	PF00498	0.179
LIG_GBD_Chelix_1	137	145	PF00786	0.311
LIG_LIR_Apic_2	122	128	PF02991	0.332
LIG_LIR_Apic_2	231	236	PF02991	0.732
LIG_LIR_Gen_1	85	94	PF02991	0.556
LIG_LIR_Nem_3	42	47	PF02991	0.455
LIG_LIR_Nem_3	62	67	PF02991	0.171
LIG_LIR_Nem_3	85	91	PF02991	0.556
LIG_NRBOX	249	255	PF00104	0.548
LIG_RPA_C_Fungi	308	320	PF08784	0.605
LIG_SH2_CRK	125	129	PF00017	0.367
LIG_SH2_NCK_1	125	129	PF00017	0.367
LIG_SH2_NCK_1	54	58	PF00017	0.249
LIG_SH2_STAP1	216	220	PF00017	0.522
LIG_SH2_STAP1	54	58	PF00017	0.249
LIG_SH2_STAP1	88	92	PF00017	0.430
LIG_SH2_STAT5	131	134	PF00017	0.380
LIG_SH3_3	271	277	PF00018	0.596
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.501
LIG_SUMO_SIM_anti_2	99	105	PF11976	0.372
LIG_SUMO_SIM_par_1	101	107	PF11976	0.391
LIG_SUMO_SIM_par_1	25	31	PF11976	0.459
LIG_TRAF2_1	305	308	PF00917	0.578
LIG_TRFH_1	44	48	PF08558	0.468
MOD_CK1_1	226	232	PF00069	0.506
MOD_CK1_1	245	251	PF00069	0.348
MOD_CK1_1	332	338	PF00069	0.752
MOD_CK2_1	279	285	PF00069	0.514
MOD_CK2_1	301	307	PF00069	0.618
MOD_CK2_1	39	45	PF00069	0.352
MOD_CK2_1	56	62	PF00069	0.182
MOD_CMANNOS	198	201	PF00535	0.343
MOD_GlcNHglycan	151	154	PF01048	0.557
MOD_GlcNHglycan	225	228	PF01048	0.594
MOD_GlcNHglycan	269	272	PF01048	0.515
MOD_GlcNHglycan	343	346	PF01048	0.594
MOD_GlcNHglycan	77	80	PF01048	0.501
MOD_GSK3_1	218	225	PF00069	0.394
MOD_GSK3_1	275	282	PF00069	0.767
MOD_GSK3_1	285	292	PF00069	0.701
MOD_GSK3_1	30	37	PF00069	0.590
MOD_GSK3_1	329	336	PF00069	0.693
MOD_GSK3_1	341	348	PF00069	0.702
MOD_GSK3_1	52	59	PF00069	0.320
MOD_GSK3_1	75	82	PF00069	0.481
MOD_GSK3_1	92	99	PF00069	0.279
MOD_NEK2_1	114	119	PF00069	0.617
MOD_NEK2_1	210	215	PF00069	0.414
MOD_NEK2_1	39	44	PF00069	0.410
MOD_NEK2_1	56	61	PF00069	0.474
MOD_NEK2_1	92	97	PF00069	0.440
MOD_PKA_2	114	120	PF00069	0.437
MOD_PKB_1	147	155	PF00069	0.544
MOD_Plk_1	121	127	PF00069	0.413
MOD_Plk_1	34	40	PF00069	0.584
MOD_Plk_4	181	187	PF00069	0.482
MOD_Plk_4	19	25	PF00069	0.191
MOD_Plk_4	210	216	PF00069	0.503
MOD_Plk_4	285	291	PF00069	0.581
MOD_Plk_4	3	9	PF00069	0.469
MOD_Plk_4	39	45	PF00069	0.472
MOD_ProDKin_1	11	17	PF00069	0.319
MOD_ProDKin_1	275	281	PF00069	0.767
MOD_ProDKin_1	329	335	PF00069	0.656
TRG_DiLeu_BaEn_1	310	315	PF01217	0.589
TRG_DiLeu_BaEn_2	86	92	PF01217	0.501
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.412
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.419
TRG_DiLeu_LyEn_5	310	315	PF01217	0.589
TRG_ENDOCYTIC_2	131	134	PF00928	0.376
TRG_ENDOCYTIC_2	88	91	PF00928	0.501
TRG_ER_diArg_1	311	314	PF00400	0.660
TRG_ER_diArg_1	322	324	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEF2	Leptomonas seymouri	36%	93%
A0A1X0NKP0	Trypanosomatidae	27%	100%
A0A3S5H5W2	Leishmania donovani	70%	99%
A4HT54	Leishmania infantum	70%	99%
E9AL24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
Q4QIT0	Leishmania major	70%	100%