Mitochondrial calcium uptake 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial calcium uptake 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H4V4_LEIBR

TriTrypDb:

LbrM.07.0110 , LBRM2903_070006300

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	4
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1
GO:0016020	membrane	2	3

Expansion

Sequence features

A4H4V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006816	calcium ion transport	7	12
GO:0006851	mitochondrial calcium ion transmembrane transport	4	12
GO:0009987	cellular process	1	12
GO:0030001	metal ion transport	6	12
GO:0034220	monoatomic ion transmembrane transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0070588	calcium ion transmembrane transport	6	12
GO:0098655	monoatomic cation transmembrane transport	4	12
GO:0098660	inorganic ion transmembrane transport	4	12
GO:0098662	inorganic cation transmembrane transport	5	12
GO:1990542	mitochondrial transmembrane transport	3	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051560	mitochondrial calcium ion homeostasis	8	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005509	calcium ion binding	5	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.305
CLV_NRD_NRD_1	162	164	PF00675	0.429
CLV_NRD_NRD_1	177	179	PF00675	0.320
CLV_NRD_NRD_1	340	342	PF00675	0.595
CLV_NRD_NRD_1	346	348	PF00675	0.567
CLV_NRD_NRD_1	49	51	PF00675	0.359
CLV_PCSK_KEX2_1	162	164	PF00082	0.413
CLV_PCSK_KEX2_1	282	284	PF00082	0.285
CLV_PCSK_KEX2_1	346	348	PF00082	0.567
CLV_PCSK_KEX2_1	51	53	PF00082	0.435
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.339
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.420
CLV_PCSK_SKI1_1	144	148	PF00082	0.486
CLV_PCSK_SKI1_1	154	158	PF00082	0.431
CLV_PCSK_SKI1_1	168	172	PF00082	0.291
CLV_PCSK_SKI1_1	223	227	PF00082	0.465
CLV_PCSK_SKI1_1	346	350	PF00082	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.401
DOC_CKS1_1	25	30	PF01111	0.387
DOC_CYCLIN_RxL_1	148	161	PF00134	0.455
DOC_CYCLIN_RxL_1	162	174	PF00134	0.302
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.255
DOC_WW_Pin1_4	24	29	PF00397	0.409
DOC_WW_Pin1_4	68	73	PF00397	0.458
LIG_14-3-3_CanoR_1	106	112	PF00244	0.391
LIG_14-3-3_CanoR_1	178	183	PF00244	0.329
LIG_14-3-3_CanoR_1	287	292	PF00244	0.389
LIG_14-3-3_CanoR_1	331	337	PF00244	0.473
LIG_14-3-3_CanoR_1	339	345	PF00244	0.574
LIG_BIR_III_4	93	97	PF00653	0.261
LIG_deltaCOP1_diTrp_1	195	201	PF00928	0.293
LIG_DLG_GKlike_1	178	185	PF00625	0.469
LIG_FHA_1	131	137	PF00498	0.404
LIG_FHA_1	15	21	PF00498	0.560
LIG_FHA_1	299	305	PF00498	0.391
LIG_FHA_2	145	151	PF00498	0.472
LIG_FHA_2	211	217	PF00498	0.456
LIG_FHA_2	279	285	PF00498	0.423
LIG_FHA_2	298	304	PF00498	0.133
LIG_FHA_2	58	64	PF00498	0.289
LIG_LIR_Apic_2	24	28	PF02991	0.423
LIG_LIR_Gen_1	137	146	PF02991	0.361
LIG_LIR_Gen_1	215	225	PF02991	0.420
LIG_LIR_Gen_1	284	291	PF02991	0.279
LIG_LIR_Gen_1	303	310	PF02991	0.351
LIG_LIR_Gen_1	320	330	PF02991	0.275
LIG_LIR_Gen_1	97	107	PF02991	0.259
LIG_LIR_Nem_3	104	108	PF02991	0.230
LIG_LIR_Nem_3	120	126	PF02991	0.353
LIG_LIR_Nem_3	137	142	PF02991	0.154
LIG_LIR_Nem_3	200	204	PF02991	0.286
LIG_LIR_Nem_3	215	220	PF02991	0.312
LIG_LIR_Nem_3	284	288	PF02991	0.339
LIG_LIR_Nem_3	303	309	PF02991	0.328
LIG_LIR_Nem_3	320	325	PF02991	0.257
LIG_LIR_Nem_3	41	46	PF02991	0.300
LIG_LIR_Nem_3	97	102	PF02991	0.259
LIG_MYND_1	29	33	PF01753	0.258
LIG_MYND_2	28	32	PF01753	0.259
LIG_NRBOX	107	113	PF00104	0.245
LIG_PCNA_yPIPBox_3	158	171	PF02747	0.421
LIG_Pex14_1	197	201	PF04695	0.291
LIG_Rb_pABgroove_1	303	311	PF01858	0.170
LIG_SH2_CRK	25	29	PF00017	0.322
LIG_SH2_CRK	334	338	PF00017	0.600
LIG_SH2_CRK	46	50	PF00017	0.364
LIG_SH2_NCK_1	25	29	PF00017	0.464
LIG_SH2_NCK_1	334	338	PF00017	0.600
LIG_SH2_SRC	30	33	PF00017	0.354
LIG_SH2_STAP1	262	266	PF00017	0.452
LIG_SH2_STAT3	262	265	PF00017	0.364
LIG_SH2_STAT5	233	236	PF00017	0.377
LIG_SH2_STAT5	30	33	PF00017	0.307
LIG_SH2_STAT5	35	38	PF00017	0.319
LIG_SH2_STAT5	99	102	PF00017	0.320
LIG_SUMO_SIM_anti_2	300	306	PF11976	0.236
LIG_SUMO_SIM_par_1	131	138	PF11976	0.391
LIG_TRAF2_1	135	138	PF00917	0.310
LIG_TRAF2_1	213	216	PF00917	0.462
LIG_TYR_ITIM	230	235	PF00017	0.472
LIG_TYR_ITIM	44	49	PF00017	0.371
LIG_UBA3_1	122	130	PF00899	0.277
LIG_UBA3_1	304	311	PF00899	0.168
LIG_UBA3_1	323	329	PF00899	0.329
LIG_WW_3	336	340	PF00397	0.550
MOD_CDC14_SPxK_1	71	74	PF00782	0.492
MOD_CDK_SPxK_1	68	74	PF00069	0.464
MOD_CK1_1	110	116	PF00069	0.474
MOD_CK1_1	191	197	PF00069	0.489
MOD_CK1_1	24	30	PF00069	0.579
MOD_CK1_1	276	282	PF00069	0.341
MOD_CK2_1	132	138	PF00069	0.334
MOD_CK2_1	144	150	PF00069	0.388
MOD_CK2_1	178	184	PF00069	0.374
MOD_CK2_1	210	216	PF00069	0.467
MOD_CK2_1	287	293	PF00069	0.319
MOD_CK2_1	98	104	PF00069	0.261
MOD_GlcNHglycan	129	133	PF01048	0.402
MOD_GlcNHglycan	243	246	PF01048	0.399
MOD_GlcNHglycan	275	278	PF01048	0.377
MOD_GlcNHglycan	293	297	PF01048	0.361
MOD_GSK3_1	107	114	PF00069	0.378
MOD_GSK3_1	128	135	PF00069	0.356
MOD_GSK3_1	272	279	PF00069	0.501
MOD_N-GLC_1	298	303	PF02516	0.168
MOD_NEK2_1	107	112	PF00069	0.327
MOD_NEK2_1	272	277	PF00069	0.410
MOD_NEK2_1	278	283	PF00069	0.261
MOD_NEK2_1	340	345	PF00069	0.488
MOD_PKA_1	178	184	PF00069	0.422
MOD_PKA_2	340	346	PF00069	0.586
MOD_Plk_1	292	298	PF00069	0.319
MOD_Plk_4	107	113	PF00069	0.332
MOD_Plk_4	118	124	PF00069	0.459
MOD_Plk_4	15	21	PF00069	0.503
MOD_ProDKin_1	24	30	PF00069	0.396
MOD_ProDKin_1	68	74	PF00069	0.464
TRG_DiLeu_BaEn_1	104	109	PF01217	0.245
TRG_DiLeu_BaEn_1	216	221	PF01217	0.388
TRG_DiLeu_BaEn_2	317	323	PF01217	0.250
TRG_ENDOCYTIC_2	232	235	PF00928	0.496
TRG_ENDOCYTIC_2	46	49	PF00928	0.326
TRG_ENDOCYTIC_2	58	61	PF00928	0.245
TRG_ENDOCYTIC_2	99	102	PF00928	0.275
TRG_ER_diArg_1	338	341	PF00400	0.571
TRG_ER_diArg_1	345	347	PF00400	0.560
TRG_ER_diArg_1	39	42	PF00400	0.430
TRG_ER_diArg_1	49	52	PF00400	0.380
TRG_NLS_MonoCore_2	49	54	PF00514	0.494
TRG_NLS_MonoExtN_4	50	55	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P773	Leptomonas seymouri	73%	83%
A0A0S4IPF8	Bodo saltans	44%	91%
A0A1X0NK53	Trypanosomatidae	50%	90%
A0A3S5H5W0	Leishmania donovani	87%	100%
A0A422NT64	Trypanosoma rangeli	47%	90%
A2VEI2	Drosophila melanogaster	22%	69%
A4HT58	Leishmania infantum	87%	100%
A4IG32	Danio rerio	22%	74%
B1H2N3	Xenopus tropicalis	21%	76%
C9ZUW0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	76%
D2HZB0	Ailuropoda melanoleuca	21%	75%
E9AL21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	81%
Q0IIL1	Bos taurus	21%	76%
Q4QIT3	Leishmania major	86%	100%
Q4R518	Macaca fascicularis	22%	76%
Q8CD10	Mus musculus	21%	84%
Q8IYU8	Homo sapiens	21%	83%
Q99P63	Rattus norvegicus	21%	84%
Q9BPX6	Homo sapiens	22%	76%
Q9SZ45	Arabidopsis thaliana	26%	72%
V5B8U7	Trypanosoma cruzi	48%	78%
V5BRA1	Trypanosoma cruzi	20%	78%