Methionine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methionine synthase

Gene product:

cobalamin-dependent methionine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4V2_LEIBR

TriTrypDb:

LbrM.07.0090 , LBRM2903_070006100

Length:

1249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H4V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V2

Function

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Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000097	sulfur amino acid biosynthetic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006555	methionine metabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008652	amino acid biosynthetic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0008168	methyltransferase activity	4	8
GO:0008172	S-methyltransferase activity	5	8
GO:0008270	zinc ion binding	6	8
GO:0008705	methionine synthase activity	6	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0019842	vitamin binding	3	8
GO:0031419	cobalamin binding	4	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.287
CLV_NRD_NRD_1	1229	1231	PF00675	0.287
CLV_NRD_NRD_1	128	130	PF00675	0.325
CLV_NRD_NRD_1	391	393	PF00675	0.228
CLV_NRD_NRD_1	478	480	PF00675	0.321
CLV_NRD_NRD_1	945	947	PF00675	0.546
CLV_PCSK_FUR_1	765	769	PF00082	0.597
CLV_PCSK_KEX2_1	105	107	PF00082	0.287
CLV_PCSK_KEX2_1	128	130	PF00082	0.287
CLV_PCSK_KEX2_1	18	20	PF00082	0.540

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7K4	Leptomonas seymouri	86%	100%
A0A0S4ISL0	Bodo saltans	65%	96%
A0A3S5H5V8	Leishmania donovani	90%	100%
A4HT60	Leishmania infantum	90%	100%
A6H5Y3	Mus musculus	55%	100%
A8XY95	Caenorhabditis briggsae	53%	98%
E9AL19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O33259	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
P13009	Escherichia coli (strain K12)	52%	100%
P37586	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	52%	100%

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