Putative Golgi/lysosome glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi/lysosome glycoprotein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H4V1_LEIBR

TriTrypDb:

LbrM.07.0080 , LBRM2903_070006000

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005765	lysosomal membrane	7	1
GO:0005773	vacuole	5	1
GO:0005774	vacuolar membrane	5	1
GO:0005794	Golgi apparatus	5	1
GO:0031090	organelle membrane	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098852	lytic vacuole membrane	6	1

Expansion

Sequence features

A4H4V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V1

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006952	defense response	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.288
CLV_C14_Caspase3-7	222	226	PF00656	0.419
CLV_C14_Caspase3-7	292	296	PF00656	0.383
CLV_NRD_NRD_1	320	322	PF00675	0.631
CLV_NRD_NRD_1	381	383	PF00675	0.580
CLV_NRD_NRD_1	514	516	PF00675	0.495
CLV_NRD_NRD_1	570	572	PF00675	0.482
CLV_PCSK_KEX2_1	31	33	PF00082	0.721
CLV_PCSK_KEX2_1	381	383	PF00082	0.565
CLV_PCSK_KEX2_1	465	467	PF00082	0.677
CLV_PCSK_KEX2_1	570	572	PF00082	0.482
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.721
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.565
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.673
CLV_PCSK_PC7_1	566	572	PF00082	0.474
CLV_PCSK_SKI1_1	119	123	PF00082	0.569
CLV_PCSK_SKI1_1	157	161	PF00082	0.644
CLV_PCSK_SKI1_1	192	196	PF00082	0.572
CLV_PCSK_SKI1_1	466	470	PF00082	0.591
CLV_PCSK_SKI1_1	5	9	PF00082	0.639
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DOC_MAPK_gen_1	437	445	PF00069	0.407
DOC_MAPK_gen_1	539	549	PF00069	0.269
DOC_MAPK_gen_1	570	577	PF00069	0.633
DOC_MAPK_MEF2A_6	3	11	PF00069	0.596
DOC_MAPK_MEF2A_6	300	307	PF00069	0.389
DOC_MAPK_MEF2A_6	437	445	PF00069	0.397
DOC_MAPK_MEF2A_6	481	488	PF00069	0.366
DOC_MAPK_MEF2A_6	539	548	PF00069	0.310
DOC_PP1_RVXF_1	326	333	PF00149	0.453
DOC_PP1_RVXF_1	479	486	PF00149	0.438
DOC_PP4_FxxP_1	257	260	PF00568	0.454
DOC_USP7_MATH_1	134	138	PF00917	0.357
DOC_USP7_MATH_1	190	194	PF00917	0.442
DOC_USP7_MATH_1	269	273	PF00917	0.469
DOC_USP7_MATH_1	555	559	PF00917	0.227
DOC_USP7_UBL2_3	308	312	PF12436	0.343
DOC_USP7_UBL2_3	377	381	PF12436	0.327
DOC_WW_Pin1_4	337	342	PF00397	0.413
LIG_14-3-3_CanoR_1	157	163	PF00244	0.347
LIG_14-3-3_CanoR_1	247	257	PF00244	0.433
LIG_14-3-3_CanoR_1	268	278	PF00244	0.421
LIG_14-3-3_CanoR_1	3	8	PF00244	0.640
LIG_14-3-3_CanoR_1	32	39	PF00244	0.425
LIG_14-3-3_CanoR_1	367	376	PF00244	0.359
LIG_14-3-3_CanoR_1	466	472	PF00244	0.454
LIG_14-3-3_CanoR_1	60	65	PF00244	0.395
LIG_Actin_WH2_2	451	467	PF00022	0.442
LIG_BRCT_BRCA1_1	139	143	PF00533	0.307
LIG_Clathr_ClatBox_1	617	621	PF01394	0.602
LIG_deltaCOP1_diTrp_1	432	438	PF00928	0.503
LIG_DLG_GKlike_1	3	10	PF00625	0.663
LIG_FHA_1	165	171	PF00498	0.498
LIG_FHA_1	206	212	PF00498	0.441
LIG_FHA_1	238	244	PF00498	0.446
LIG_FHA_1	260	266	PF00498	0.376
LIG_FHA_1	360	366	PF00498	0.384
LIG_FHA_1	528	534	PF00498	0.473
LIG_FHA_1	59	65	PF00498	0.358
LIG_FHA_1	90	96	PF00498	0.360
LIG_FHA_2	254	260	PF00498	0.456
LIG_FHA_2	367	373	PF00498	0.446
LIG_FHA_2	396	402	PF00498	0.483
LIG_FHA_2	495	501	PF00498	0.447
LIG_FHA_2	79	85	PF00498	0.428
LIG_LIR_Apic_2	169	175	PF02991	0.310
LIG_LIR_Apic_2	255	260	PF02991	0.442
LIG_LIR_Gen_1	137	147	PF02991	0.366
LIG_LIR_Gen_1	232	241	PF02991	0.445
LIG_LIR_Gen_1	326	333	PF02991	0.476
LIG_LIR_Gen_1	82	89	PF02991	0.472
LIG_LIR_Nem_3	137	142	PF02991	0.357
LIG_LIR_Nem_3	227	233	PF02991	0.422
LIG_LIR_Nem_3	310	316	PF02991	0.332
LIG_LIR_Nem_3	326	332	PF02991	0.420
LIG_LIR_Nem_3	432	438	PF02991	0.403
LIG_LIR_Nem_3	82	88	PF02991	0.439
LIG_NRBOX	457	463	PF00104	0.425
LIG_PCNA_yPIPBox_3	151	160	PF02747	0.413
LIG_Pex14_2	139	143	PF04695	0.359
LIG_PTB_Apo_2	284	291	PF02174	0.364
LIG_PTB_Phospho_1	284	290	PF10480	0.365
LIG_Rb_pABgroove_1	582	590	PF01858	0.722
LIG_SH2_CRK	172	176	PF00017	0.374
LIG_SH2_CRK	234	238	PF00017	0.309
LIG_SH2_CRK	602	606	PF00017	0.664
LIG_SH2_CRK	85	89	PF00017	0.425
LIG_SH2_GRB2like	186	189	PF00017	0.293
LIG_SH2_NCK_1	162	166	PF00017	0.450
LIG_SH2_NCK_1	172	176	PF00017	0.390
LIG_SH2_NCK_1	291	295	PF00017	0.440
LIG_SH2_NCK_1	602	606	PF00017	0.761
LIG_SH2_NCK_1	71	75	PF00017	0.424
LIG_SH2_SRC	291	294	PF00017	0.364
LIG_SH2_SRC	94	97	PF00017	0.305
LIG_SH2_STAP1	186	190	PF00017	0.457
LIG_SH2_STAP1	588	592	PF00017	0.722
LIG_SH2_STAP1	96	100	PF00017	0.391
LIG_SH2_STAT5	104	107	PF00017	0.255
LIG_SH2_STAT5	234	237	PF00017	0.428
LIG_SH2_STAT5	509	512	PF00017	0.340
LIG_SH2_STAT5	567	570	PF00017	0.541
LIG_SH2_STAT5	85	88	PF00017	0.423
LIG_SH2_STAT5	94	97	PF00017	0.341
LIG_SH3_3	15	21	PF00018	0.532
LIG_SH3_3	400	406	PF00018	0.529
LIG_SH3_3	412	418	PF00018	0.399
LIG_Sin3_3	15	22	PF02671	0.407
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.408
LIG_SUMO_SIM_anti_2	206	215	PF11976	0.292
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.255
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.379
LIG_SUMO_SIM_anti_2	6	11	PF11976	0.554
LIG_SUMO_SIM_par_1	176	181	PF11976	0.365
LIG_SUMO_SIM_par_1	193	198	PF11976	0.336
LIG_SUMO_SIM_par_1	206	215	PF11976	0.396
LIG_SUMO_SIM_par_1	616	622	PF11976	0.693
LIG_SUMO_SIM_par_1	72	79	PF11976	0.378
LIG_TYR_ITIM	69	74	PF00017	0.421
LIG_UBA3_1	1	5	PF00899	0.692
LIG_UBA3_1	461	465	PF00899	0.390
LIG_UBA3_1	468	475	PF00899	0.395
MOD_CK1_1	137	143	PF00069	0.323
MOD_CK1_1	217	223	PF00069	0.485
MOD_CK1_1	419	425	PF00069	0.424
MOD_CK1_1	456	462	PF00069	0.398
MOD_CK1_1	467	473	PF00069	0.378
MOD_CK1_1	47	53	PF00069	0.428
MOD_CK1_1	58	64	PF00069	0.283
MOD_CK1_1	75	81	PF00069	0.290
MOD_CK2_1	122	128	PF00069	0.440
MOD_CK2_1	253	259	PF00069	0.440
MOD_CK2_1	366	372	PF00069	0.435
MOD_CK2_1	494	500	PF00069	0.519
MOD_GlcNHglycan	250	253	PF01048	0.636
MOD_GlcNHglycan	34	37	PF01048	0.689
MOD_GlcNHglycan	44	47	PF01048	0.607
MOD_GlcNHglycan	49	52	PF01048	0.618
MOD_GlcNHglycan	57	60	PF01048	0.626
MOD_GlcNHglycan	595	598	PF01048	0.544
MOD_GSK3_1	103	110	PF00069	0.344
MOD_GSK3_1	137	144	PF00069	0.401
MOD_GSK3_1	205	212	PF00069	0.448
MOD_GSK3_1	233	240	PF00069	0.359
MOD_GSK3_1	248	255	PF00069	0.231
MOD_GSK3_1	269	276	PF00069	0.404
MOD_GSK3_1	368	375	PF00069	0.432
MOD_GSK3_1	40	47	PF00069	0.409
MOD_GSK3_1	522	529	PF00069	0.403
MOD_GSK3_1	58	65	PF00069	0.266
MOD_LATS_1	473	479	PF00433	0.287
MOD_N-GLC_1	107	112	PF02516	0.649
MOD_N-GLC_1	114	119	PF02516	0.629
MOD_N-GLC_1	245	250	PF02516	0.628
MOD_N-GLC_1	269	274	PF02516	0.582
MOD_N-GLC_1	359	364	PF02516	0.695
MOD_N-GLC_1	494	499	PF02516	0.566
MOD_N-GLC_1	537	542	PF02516	0.559
MOD_N-GLC_1	55	60	PF02516	0.537
MOD_NEK2_1	195	200	PF00069	0.336
MOD_NEK2_1	454	459	PF00069	0.367
MOD_NEK2_1	464	469	PF00069	0.347
MOD_NEK2_1	549	554	PF00069	0.419
MOD_NEK2_2	279	284	PF00069	0.407
MOD_NEK2_2	522	527	PF00069	0.364
MOD_PIKK_1	134	140	PF00454	0.334
MOD_PIKK_1	273	279	PF00454	0.435
MOD_PIKK_1	425	431	PF00454	0.458
MOD_PIKK_1	58	64	PF00454	0.417
MOD_PK_1	114	120	PF00069	0.427
MOD_PK_1	437	443	PF00069	0.362
MOD_PKA_2	217	223	PF00069	0.293
MOD_PKA_2	252	258	PF00069	0.382
MOD_PKA_2	366	372	PF00069	0.344
MOD_Plk_1	114	120	PF00069	0.416
MOD_Plk_1	245	251	PF00069	0.364
MOD_Plk_1	359	365	PF00069	0.467
MOD_Plk_1	395	401	PF00069	0.381
MOD_Plk_1	40	46	PF00069	0.311
MOD_Plk_1	499	505	PF00069	0.469
MOD_Plk_2-3	209	215	PF00069	0.446
MOD_Plk_2-3	395	401	PF00069	0.388
MOD_Plk_2-3	500	506	PF00069	0.454
MOD_Plk_4	173	179	PF00069	0.347
MOD_Plk_4	209	215	PF00069	0.444
MOD_Plk_4	361	367	PF00069	0.363
MOD_Plk_4	5	11	PF00069	0.526
MOD_Plk_4	50	56	PF00069	0.342
MOD_Plk_4	549	555	PF00069	0.356
MOD_ProDKin_1	337	343	PF00069	0.412
MOD_SUMO_for_1	351	354	PF00179	0.312
MOD_SUMO_rev_2	325	330	PF00179	0.432
MOD_SUMO_rev_2	348	353	PF00179	0.308
MOD_SUMO_rev_2	478	483	PF00179	0.450
MOD_SUMO_rev_2	536	541	PF00179	0.464
TRG_DiLeu_BaEn_1	209	214	PF01217	0.341
TRG_ENDOCYTIC_2	234	237	PF00928	0.314
TRG_ENDOCYTIC_2	290	293	PF00928	0.335
TRG_ENDOCYTIC_2	602	605	PF00928	0.610
TRG_ENDOCYTIC_2	71	74	PF00928	0.428
TRG_ENDOCYTIC_2	85	88	PF00928	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P769	Leptomonas seymouri	49%	98%
A0A1X0NKD5	Trypanosomatidae	36%	100%
A0A3R7KSB6	Trypanosoma rangeli	37%	100%
A0A3S7WPQ4	Leishmania donovani	74%	100%
A4HT61	Leishmania infantum	74%	100%
C9ZUW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QIT6	Leishmania major	72%	100%
V5BDE1	Trypanosoma cruzi	34%	100%