Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4V0_LEIBR

TriTrypDb:

LbrM.07.0070 , LBRM2903_070005900

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4V0

PDB structure(s): 7aih_Av , 7am2_Av , 7ane_Av

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.474
CLV_NRD_NRD_1	50	52	PF00675	0.464
CLV_NRD_NRD_1	63	65	PF00675	0.467
CLV_PCSK_FUR_1	48	52	PF00082	0.525
CLV_PCSK_KEX2_1	146	148	PF00082	0.476
CLV_PCSK_KEX2_1	175	177	PF00082	0.615
CLV_PCSK_KEX2_1	19	21	PF00082	0.506
CLV_PCSK_KEX2_1	50	52	PF00082	0.503
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.476
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.639
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.525
CLV_PCSK_PC7_1	171	177	PF00082	0.579
CLV_PCSK_SKI1_1	138	142	PF00082	0.470
CLV_PCSK_SKI1_1	9	13	PF00082	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.606
DOC_MAPK_MEF2A_6	81	90	PF00069	0.424
DOC_PP1_RVXF_1	149	155	PF00149	0.465
DOC_PP4_FxxP_1	132	135	PF00568	0.446
DOC_USP7_UBL2_3	19	23	PF12436	0.505
DOC_WW_Pin1_4	131	136	PF00397	0.451
LIG_14-3-3_CanoR_1	155	159	PF00244	0.545
LIG_14-3-3_CanoR_1	4	11	PF00244	0.566
LIG_APCC_ABBA_1	88	93	PF00400	0.472
LIG_BRCT_BRCA1_1	128	132	PF00533	0.601
LIG_deltaCOP1_diTrp_1	102	109	PF00928	0.580
LIG_FHA_1	12	18	PF00498	0.555
LIG_FHA_1	161	167	PF00498	0.596
LIG_FHA_1	93	99	PF00498	0.450
LIG_FHA_2	40	46	PF00498	0.446
LIG_LIR_Apic_2	102	106	PF02991	0.445
LIG_LIR_Apic_2	129	135	PF02991	0.458
LIG_LIR_Nem_3	102	108	PF02991	0.435
LIG_LYPXL_yS_3	105	108	PF13949	0.432
LIG_Pex14_2	132	136	PF04695	0.449
LIG_Rb_pABgroove_1	118	126	PF01858	0.524
LIG_SH2_NCK_1	37	41	PF00017	0.451
LIG_SH2_SRC	37	40	PF00017	0.353
LIG_SH2_STAT5	34	37	PF00017	0.433
LIG_SH2_STAT5	77	80	PF00017	0.467
LIG_SH3_3	179	185	PF00018	0.738
LIG_SUMO_SIM_par_1	65	71	PF11976	0.486
LIG_UBA3_1	158	162	PF00899	0.564
MOD_CDK_SPxxK_3	131	138	PF00069	0.467
MOD_CK1_1	5	11	PF00069	0.431
MOD_CK2_1	39	45	PF00069	0.455
MOD_GlcNHglycan	20	23	PF01048	0.577
MOD_GlcNHglycan	57	60	PF01048	0.585
MOD_GSK3_1	5	12	PF00069	0.429
MOD_GSK3_1	82	89	PF00069	0.487
MOD_NEK2_1	11	16	PF00069	0.558
MOD_NEK2_1	18	23	PF00069	0.507
MOD_NEK2_1	2	7	PF00069	0.617
MOD_OFUCOSY	6	13	PF10250	0.426
MOD_PIKK_1	112	118	PF00454	0.304
MOD_PKA_2	154	160	PF00069	0.527
MOD_Plk_1	101	107	PF00069	0.435
MOD_Plk_4	154	160	PF00069	0.552
MOD_ProDKin_1	131	137	PF00069	0.444
MOD_SUMO_rev_2	26	33	PF00179	0.470
MOD_SUMO_rev_2	62	72	PF00179	0.500
TRG_DiLeu_BaEn_2	48	54	PF01217	0.564
TRG_ENDOCYTIC_2	105	108	PF00928	0.432
TRG_ER_diArg_1	147	149	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW8	Leptomonas seymouri	84%	97%
A0A0S4IMH9	Bodo saltans	63%	100%
A0A1X0NKH3	Trypanosomatidae	69%	100%
A0A3R7MVH7	Trypanosoma rangeli	66%	98%
A0A3S5H5V7	Leishmania donovani	91%	99%
A4HT62	Leishmania infantum	91%	99%
C9ZUW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AL17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
Q4QIT7	Leishmania major	91%	100%