Histone-lysine N-methyltransferase, H3 lysine-79 specific

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone-lysine N-methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H4U6_LEIBR

TriTrypDb:

LbrM.07.0030 , LBRM2903_070005400

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	23
GO:0043226	organelle	2	23
GO:0043227	membrane-bounded organelle	3	23
GO:0043229	intracellular organelle	3	23
GO:0043231	intracellular membrane-bounded organelle	4	23
GO:0110165	cellular anatomical entity	1	23
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4H4U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U6

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	23
GO:0006479	protein methylation	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0008213	protein alkylation	5	23
GO:0009987	cellular process	1	23
GO:0016043	cellular component organization	3	23
GO:0016570	histone modification	5	23
GO:0016571	histone methylation	5	23
GO:0018022	peptidyl-lysine methylation	5	23
GO:0018193	peptidyl-amino acid modification	5	23
GO:0018205	peptidyl-lysine modification	6	23
GO:0019538	protein metabolic process	3	23
GO:0032259	methylation	2	23
GO:0034729	histone H3-K79 methylation	7	23
GO:0034968	histone lysine methylation	6	23
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0043414	macromolecule methylation	3	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0044260	obsolete cellular macromolecule metabolic process	3	23
GO:0050789	regulation of biological process	2	23
GO:0050794	regulation of cellular process	3	23
GO:0051726	regulation of cell cycle	4	23
GO:0065007	biological regulation	1	23
GO:0071704	organic substance metabolic process	2	23
GO:0071840	cellular component organization or biogenesis	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0000075	cell cycle checkpoint signaling	4	2
GO:0000077	DNA damage checkpoint signaling	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0007165	signal transduction	2	2
GO:0009605	response to external stimulus	2	1
GO:0009607	response to biotic stimulus	2	1
GO:0010564	regulation of cell cycle process	5	2
GO:0010948	negative regulation of cell cycle process	6	2
GO:0020033	antigenic variation	7	1
GO:0031570	DNA integrity checkpoint signaling	5	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035556	intracellular signal transduction	3	2
GO:0042770	signal transduction in response to DNA damage	4	2
GO:0042783	evasion of host immune response	6	1
GO:0043207	response to external biotic stimulus	3	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0045786	negative regulation of cell cycle	5	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050896	response to stimulus	1	2
GO:0051098	regulation of binding	3	2
GO:0051101	regulation of DNA binding	4	2
GO:0051701	biological process involved in interaction with host	3	1
GO:0051707	response to other organism	2	1
GO:0051716	cellular response to stimulus	2	2
GO:0052173	response to defenses of other organism	3	1
GO:0052200	response to host defenses	4	1
GO:0052572	response to host immune response	5	1
GO:0065009	regulation of molecular function	2	2
GO:0075136	response to host	3	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901988	negative regulation of cell cycle phase transition	7	2
GO:2000677	regulation of transcription regulatory region DNA binding	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0008168	methyltransferase activity	4	23
GO:0008170	N-methyltransferase activity	5	23
GO:0008276	protein methyltransferase activity	3	23
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	23
GO:0016278	lysine N-methyltransferase activity	6	23
GO:0016279	protein-lysine N-methyltransferase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016741	transferase activity, transferring one-carbon groups	3	23
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	23
GO:0031151	histone H3K79 methyltransferase activity	6	23
GO:0042054	histone methyltransferase activity	4	23
GO:0140096	catalytic activity, acting on a protein	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.260
CLV_NRD_NRD_1	297	299	PF00675	0.364
CLV_NRD_NRD_1	64	66	PF00675	0.531
CLV_PCSK_FUR_1	5	9	PF00082	0.519
CLV_PCSK_KEX2_1	100	102	PF00082	0.390
CLV_PCSK_KEX2_1	16	18	PF00082	0.558
CLV_PCSK_KEX2_1	187	189	PF00082	0.374
CLV_PCSK_KEX2_1	7	9	PF00082	0.587
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.394
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.567
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.428
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.586
CLV_PCSK_SKI1_1	114	118	PF00082	0.339
CLV_PCSK_SKI1_1	21	25	PF00082	0.648
CLV_PCSK_SKI1_1	228	232	PF00082	0.274
CLV_PCSK_SKI1_1	44	48	PF00082	0.666
DEG_SCF_FBW7_1	116	122	PF00400	0.264
DEG_SCF_FBW7_1	238	245	PF00400	0.316
DOC_CKS1_1	116	121	PF01111	0.264
DOC_CKS1_1	204	209	PF01111	0.337
DOC_CYCLIN_RxL_1	109	118	PF00134	0.386
DOC_CYCLIN_RxL_1	16	26	PF00134	0.624
DOC_MAPK_gen_1	184	195	PF00069	0.305
DOC_MAPK_gen_1	99	105	PF00069	0.488
DOC_MAPK_MEF2A_6	187	195	PF00069	0.293
DOC_PP1_RVXF_1	244	251	PF00149	0.286
DOC_PP4_FxxP_1	226	229	PF00568	0.426
DOC_USP7_MATH_1	119	123	PF00917	0.316
DOC_USP7_MATH_1	42	46	PF00917	0.666
DOC_USP7_MATH_2	48	54	PF00917	0.571
DOC_WW_Pin1_4	115	120	PF00397	0.426
DOC_WW_Pin1_4	203	208	PF00397	0.395
DOC_WW_Pin1_4	238	243	PF00397	0.316
DOC_WW_Pin1_4	44	49	PF00397	0.535
DOC_WW_Pin1_4	52	57	PF00397	0.418
LIG_14-3-3_CanoR_1	21	29	PF00244	0.614
LIG_14-3-3_CanoR_1	237	242	PF00244	0.402
LIG_14-3-3_CanoR_1	258	264	PF00244	0.222
LIG_BRCT_BRCA1_1	144	148	PF00533	0.286
LIG_deltaCOP1_diTrp_1	276	286	PF00928	0.286
LIG_FHA_1	116	122	PF00498	0.403
LIG_FHA_1	195	201	PF00498	0.316
LIG_FHA_1	215	221	PF00498	0.415
LIG_FHA_1	229	235	PF00498	0.302
LIG_FHA_1	243	249	PF00498	0.321
LIG_FHA_1	290	296	PF00498	0.284
LIG_FHA_1	31	37	PF00498	0.698
LIG_FHA_2	129	135	PF00498	0.291
LIG_FHA_2	206	212	PF00498	0.380
LIG_FHA_2	260	266	PF00498	0.187
LIG_FHA_2	45	51	PF00498	0.498
LIG_LIR_Apic_2	183	189	PF02991	0.264
LIG_LIR_Apic_2	262	266	PF02991	0.222
LIG_LIR_Gen_1	173	182	PF02991	0.299
LIG_LIR_Gen_1	276	284	PF02991	0.340
LIG_LIR_Gen_1	285	294	PF02991	0.261
LIG_LIR_Gen_1	85	94	PF02991	0.404
LIG_LIR_Nem_3	134	139	PF02991	0.288
LIG_LIR_Nem_3	173	178	PF02991	0.299
LIG_LIR_Nem_3	85	89	PF02991	0.388
LIG_LIR_Nem_3	91	97	PF02991	0.386
LIG_PTB_Apo_2	220	227	PF02174	0.318
LIG_SH2_CRK	186	190	PF00017	0.264
LIG_SH2_CRK	94	98	PF00017	0.402
LIG_SH2_STAT3	277	280	PF00017	0.334
LIG_SH2_STAT5	209	212	PF00017	0.426
LIG_SH2_STAT5	277	280	PF00017	0.332
LIG_SH3_3	12	18	PF00018	0.640
LIG_SH3_3	53	59	PF00018	0.400
LIG_SUMO_SIM_par_1	101	106	PF11976	0.362
LIG_UBA3_1	220	228	PF00899	0.302
LIG_UBA3_1	271	275	PF00899	0.364
MOD_CDK_SPK_2	44	49	PF00069	0.620
MOD_CK1_1	115	121	PF00069	0.391
MOD_CK1_1	205	211	PF00069	0.394
MOD_CK1_1	259	265	PF00069	0.399
MOD_CK1_1	37	43	PF00069	0.613
MOD_CK2_1	205	211	PF00069	0.173
MOD_CK2_1	44	50	PF00069	0.584
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.558
MOD_GlcNHglycan	104	108	PF01048	0.530
MOD_GlcNHglycan	35	39	PF01048	0.641
MOD_GlcNHglycan	52	55	PF01048	0.376
MOD_GSK3_1	115	122	PF00069	0.276
MOD_GSK3_1	128	135	PF00069	0.205
MOD_GSK3_1	228	235	PF00069	0.274
MOD_GSK3_1	238	245	PF00069	0.347
MOD_GSK3_1	285	292	PF00069	0.213
MOD_GSK3_1	30	37	PF00069	0.504
MOD_N-GLC_1	142	147	PF02516	0.284
MOD_N-GLC_2	71	73	PF02516	0.379
MOD_NEK2_1	289	294	PF00069	0.374
MOD_NEK2_1	90	95	PF00069	0.311
MOD_Plk_1	280	286	PF00069	0.256
MOD_Plk_2-3	132	138	PF00069	0.299
MOD_Plk_2-3	285	291	PF00069	0.321
MOD_Plk_4	112	118	PF00069	0.335
MOD_Plk_4	132	138	PF00069	0.145
MOD_Plk_4	142	148	PF00069	0.280
MOD_Plk_4	205	211	PF00069	0.315
MOD_Plk_4	289	295	PF00069	0.258
MOD_ProDKin_1	115	121	PF00069	0.426
MOD_ProDKin_1	203	209	PF00069	0.395
MOD_ProDKin_1	238	244	PF00069	0.316
MOD_ProDKin_1	44	50	PF00069	0.525
MOD_ProDKin_1	52	58	PF00069	0.418
TRG_DiLeu_BaEn_2	289	295	PF01217	0.426
TRG_ENDOCYTIC_2	94	97	PF00928	0.409
TRG_ER_diArg_1	8	11	PF00400	0.610
TRG_NES_CRM1_1	273	285	PF08389	0.347
TRG_NLS_MonoExtC_3	6	12	PF00514	0.631
TRG_NLS_MonoExtC_3	98	104	PF00514	0.478
TRG_NLS_MonoExtN_4	5	11	PF00514	0.603
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P397	Leptomonas seymouri	72%	100%
A0A0N0P563	Leptomonas seymouri	51%	100%
A0A0S4IIL9	Bodo saltans	55%	96%
A0A0S4IQV1	Bodo saltans	59%	100%
A0A1X0NK69	Trypanosomatidae	58%	100%
A0A1X0NY45	Trypanosomatidae	49%	100%
A0A3R7LQU8	Trypanosoma rangeli	53%	100%
A0A3S5H5V6	Leishmania donovani	85%	100%
A0A3S7WVS5	Leishmania donovani	53%	100%
A0A422NTB2	Trypanosoma rangeli	61%	100%
A4HBH1	Leishmania braziliensis	49%	100%
A4HT24	Leishmania infantum	84%	100%
A4HYJ5	Leishmania infantum	53%	100%
C9ZHT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZUW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9AL12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9AUE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
Q4QD41	Leishmania major	53%	100%
Q4QIU2	Leishmania major	85%	100%
V5ATA1	Trypanosoma cruzi	62%	100%
V5BVL1	Trypanosoma cruzi	47%	100%