LeishMANIAdb
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Putative ubiquitin activating E1 enzyme

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative ubiquitin activating E1 enzyme
Gene product:
Ubiquitin-like modifier-activating enzyme ATG7, putative
Species:
Leishmania braziliensis
UniProt:
A4H4U4_LEIBR
TriTrypDb:
LbrM.07.0010 , LBRM2903_070005000 *
Length:
725

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
TermNameLevelCount
GO:0000407 phagophore assembly site 2 1
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A4H4U4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U4

Function

Biological processes
TermNameLevelCount
GO:0000045 autophagosome assembly 6 1
GO:0000422 autophagy of mitochondrion 4 1
GO:0006497 protein lipidation 5 1
GO:0006501 C-terminal protein lipidation 6 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006914 autophagy 3 1
GO:0006950 response to stress 2 1
GO:0006995 cellular response to nitrogen starvation 5 1
GO:0006996 organelle organization 4 1
GO:0007005 mitochondrion organization 5 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 11
GO:0008641 ubiquitin-like modifier activating enzyme activity 2 11
GO:0016874 ligase activity 2 11
GO:0016877 ligase activity, forming carbon-sulfur bonds 3 11
GO:0019778 Atg12 activating enzyme activity 3 1
GO:0019779 Atg8 activating enzyme activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 11
GO:0140657 ATP-dependent activity 1 11
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 135 139 PF00656 0.556
CLV_C14_Caspase3-7 152 156 PF00656 0.435
CLV_C14_Caspase3-7 445 449 PF00656 0.418
CLV_NRD_NRD_1 343 345 PF00675 0.294
CLV_NRD_NRD_1 490 492 PF00675 0.412
CLV_PCSK_KEX2_1 490 492 PF00082 0.412
CLV_PCSK_SKI1_1 111 115 PF00082 0.263
CLV_PCSK_SKI1_1 28 32 PF00082 0.333
CLV_PCSK_SKI1_1 295 299 PF00082 0.333
CLV_PCSK_SKI1_1 391 395 PF00082 0.356
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P2V7 Leptomonas seymouri 64% 100%
A0A1X0P0S1 Trypanosomatidae 36% 88%
A0A3R7K2D8 Trypanosoma rangeli 42% 95%
A0A3S5H5V4 Leishmania donovani 84% 100%
A3LPA1 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 30% 100%
A4HT22 Leishmania infantum 84% 100%
A5DLC6 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 30% 100%
A6QXC6 Ajellomyces capsulatus (strain NAm1 / WU24) 31% 100%
A6ZT79 Saccharomyces cerevisiae (strain YJM789) 31% 100%
A7EI75 Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) 31% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS