C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H4U3_LEIBR

TriTrypDb:

LbrM.06.1300 , LBRM2903_060012800

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.493
CLV_NRD_NRD_1	584	586	PF00675	0.632
CLV_PCSK_KEX2_1	583	585	PF00082	0.637
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.536
DEG_SCF_FBW7_1	424	431	PF00400	0.480
DEG_SPOP_SBC_1	487	491	PF00917	0.560
DEG_SPOP_SBC_1	527	531	PF00917	0.509
DEG_SPOP_SBC_1	95	99	PF00917	0.466
DOC_CKS1_1	165	170	PF01111	0.469
DOC_CKS1_1	38	43	PF01111	0.377
DOC_MAPK_gen_1	583	595	PF00069	0.522
DOC_MAPK_MEF2A_6	588	595	PF00069	0.503
DOC_PP2B_LxvP_1	258	261	PF13499	0.622
DOC_PP2B_LxvP_1	418	421	PF13499	0.587
DOC_PP2B_LxvP_1	468	471	PF13499	0.434
DOC_PP2B_LxvP_1	484	487	PF13499	0.458
DOC_PP4_FxxP_1	274	277	PF00568	0.497
DOC_USP7_MATH_1	142	146	PF00917	0.481
DOC_USP7_MATH_1	186	190	PF00917	0.607
DOC_USP7_MATH_1	269	273	PF00917	0.494
DOC_USP7_MATH_1	328	332	PF00917	0.565
DOC_USP7_MATH_1	355	359	PF00917	0.606
DOC_USP7_MATH_1	365	369	PF00917	0.475
DOC_USP7_MATH_1	394	398	PF00917	0.600
DOC_USP7_MATH_1	428	432	PF00917	0.573
DOC_USP7_MATH_1	453	457	PF00917	0.576
DOC_USP7_MATH_1	487	491	PF00917	0.585
DOC_USP7_MATH_1	521	525	PF00917	0.607
DOC_USP7_MATH_1	526	530	PF00917	0.749
DOC_USP7_MATH_1	569	573	PF00917	0.506
DOC_WW_Pin1_4	164	169	PF00397	0.466
DOC_WW_Pin1_4	242	247	PF00397	0.675
DOC_WW_Pin1_4	256	261	PF00397	0.579
DOC_WW_Pin1_4	37	42	PF00397	0.377
DOC_WW_Pin1_4	424	429	PF00397	0.570
DOC_WW_Pin1_4	482	487	PF00397	0.670
DOC_WW_Pin1_4	496	501	PF00397	0.542
DOC_WW_Pin1_4	514	519	PF00397	0.587
DOC_WW_Pin1_4	578	583	PF00397	0.621
LIG_14-3-3_CanoR_1	375	380	PF00244	0.576
LIG_14-3-3_CanoR_1	437	443	PF00244	0.510
LIG_14-3-3_CanoR_1	507	513	PF00244	0.656
LIG_14-3-3_CanoR_1	534	544	PF00244	0.505
LIG_14-3-3_CanoR_1	585	595	PF00244	0.688
LIG_BIR_III_2	466	470	PF00653	0.460
LIG_BRCT_BRCA1_1	24	28	PF00533	0.377
LIG_BRCT_BRCA1_1	240	244	PF00533	0.510
LIG_BRCT_BRCA1_1	271	275	PF00533	0.502
LIG_BRCT_BRCA1_1	330	334	PF00533	0.470
LIG_BRCT_BRCA1_1	510	514	PF00533	0.495
LIG_CtBP_PxDLS_1	260	264	PF00389	0.658
LIG_DLG_GKlike_1	375	383	PF00625	0.573
LIG_EH_1	25	29	PF12763	0.377
LIG_EVH1_1	468	472	PF00568	0.429
LIG_FHA_1	222	228	PF00498	0.627
LIG_FHA_1	232	238	PF00498	0.598
LIG_FHA_1	243	249	PF00498	0.481
LIG_FHA_1	271	277	PF00498	0.599
LIG_FHA_1	28	34	PF00498	0.308
LIG_FHA_1	37	43	PF00498	0.308
LIG_FHA_1	413	419	PF00498	0.559
LIG_FHA_1	491	497	PF00498	0.769
LIG_FHA_1	5	11	PF00498	0.326
LIG_FHA_1	83	89	PF00498	0.308
LIG_FHA_1	96	102	PF00498	0.411
LIG_FHA_2	138	144	PF00498	0.473
LIG_FHA_2	54	60	PF00498	0.277
LIG_FHA_2	563	569	PF00498	0.471
LIG_FHA_2	87	93	PF00498	0.308
LIG_LIR_Apic_2	272	277	PF02991	0.593
LIG_MLH1_MIPbox_1	271	275	PF16413	0.502
LIG_MYND_1	261	265	PF01753	0.612
LIG_MYND_1	482	486	PF01753	0.465
LIG_PDZ_Class_2	590	595	PF00595	0.498
LIG_Pex14_2	51	55	PF04695	0.308
LIG_PTB_Apo_2	23	30	PF02174	0.377
LIG_PTB_Apo_2	45	52	PF02174	0.308
LIG_SH2_GRB2like	336	339	PF00017	0.579
LIG_SH2_NCK_1	127	131	PF00017	0.444
LIG_SH2_NCK_1	402	406	PF00017	0.590
LIG_SH2_PTP2	76	79	PF00017	0.207
LIG_SH2_SRC	76	79	PF00017	0.207
LIG_SH2_STAP1	301	305	PF00017	0.585
LIG_SH2_STAP1	402	406	PF00017	0.590
LIG_SH2_STAT5	402	405	PF00017	0.594
LIG_SH2_STAT5	76	79	PF00017	0.207
LIG_SH3_3	162	168	PF00018	0.475
LIG_SH3_3	262	268	PF00018	0.605
LIG_SH3_3	276	282	PF00018	0.576
LIG_SH3_3	306	312	PF00018	0.587
LIG_SH3_3	322	328	PF00018	0.633
LIG_SH3_3	342	348	PF00018	0.461
LIG_SH3_3	35	41	PF00018	0.377
LIG_SH3_3	359	365	PF00018	0.566
LIG_SH3_3	416	422	PF00018	0.588
LIG_SH3_3	466	472	PF00018	0.534
LIG_SH3_3	476	482	PF00018	0.576
LIG_SH3_3	512	518	PF00018	0.571
LIG_SH3_3	522	528	PF00018	0.661
LIG_SH3_3	76	82	PF00018	0.209
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.474
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.494
LIG_SUMO_SIM_par_1	161	167	PF11976	0.474
LIG_SUMO_SIM_par_1	4	9	PF11976	0.377
LIG_SUMO_SIM_par_1	85	92	PF11976	0.308
LIG_TRAF2_1	378	381	PF00917	0.575
LIG_TYR_ITIM	74	79	PF00017	0.207
LIG_WRC_WIRS_1	460	465	PF05994	0.478
MOD_CDC14_SPxK_1	504	507	PF00782	0.486
MOD_CDC14_SPxK_1	581	584	PF00782	0.627
MOD_CDK_SPK_2	578	583	PF00069	0.621
MOD_CDK_SPxK_1	261	267	PF00069	0.608
MOD_CDK_SPxK_1	501	507	PF00069	0.499
MOD_CDK_SPxK_1	578	584	PF00069	0.622
MOD_CDK_SPxxK_3	578	585	PF00069	0.625
MOD_CK1_1	147	153	PF00069	0.661
MOD_CK1_1	206	212	PF00069	0.676
MOD_CK1_1	213	219	PF00069	0.663
MOD_CK1_1	357	363	PF00069	0.562
MOD_CK1_1	388	394	PF00069	0.684
MOD_CK1_1	396	402	PF00069	0.537
MOD_CK1_1	436	442	PF00069	0.646
MOD_CK1_1	489	495	PF00069	0.608
MOD_CK1_1	529	535	PF00069	0.681
MOD_CK1_1	574	580	PF00069	0.629
MOD_CK2_1	137	143	PF00069	0.468
MOD_CK2_1	375	381	PF00069	0.576
MOD_CK2_1	436	442	PF00069	0.601
MOD_GlcNHglycan	143	147	PF01048	0.551
MOD_GlcNHglycan	215	218	PF01048	0.733
MOD_GlcNHglycan	330	333	PF01048	0.592
MOD_GlcNHglycan	349	352	PF01048	0.586
MOD_GlcNHglycan	357	360	PF01048	0.693
MOD_GlcNHglycan	367	370	PF01048	0.481
MOD_GlcNHglycan	383	386	PF01048	0.703
MOD_GlcNHglycan	396	399	PF01048	0.484
MOD_GlcNHglycan	403	406	PF01048	0.600
MOD_GlcNHglycan	410	413	PF01048	0.619
MOD_GlcNHglycan	455	458	PF01048	0.574
MOD_GlcNHglycan	463	466	PF01048	0.601
MOD_GlcNHglycan	562	565	PF01048	0.520
MOD_GlcNHglycan	576	579	PF01048	0.628
MOD_GSK3_1	121	128	PF00069	0.423
MOD_GSK3_1	144	151	PF00069	0.585
MOD_GSK3_1	206	213	PF00069	0.594
MOD_GSK3_1	238	245	PF00069	0.522
MOD_GSK3_1	375	382	PF00069	0.611
MOD_GSK3_1	388	395	PF00069	0.540
MOD_GSK3_1	396	403	PF00069	0.476
MOD_GSK3_1	408	415	PF00069	0.605
MOD_GSK3_1	424	431	PF00069	0.616
MOD_GSK3_1	432	439	PF00069	0.574
MOD_GSK3_1	441	448	PF00069	0.512
MOD_GSK3_1	482	489	PF00069	0.563
MOD_GSK3_1	492	499	PF00069	0.585
MOD_GSK3_1	526	533	PF00069	0.574
MOD_GSK3_1	570	577	PF00069	0.632
MOD_GSK3_1	82	89	PF00069	0.308
MOD_N-GLC_1	206	211	PF02516	0.526
MOD_N-GLC_1	261	266	PF02516	0.513
MOD_N-GLC_1	270	275	PF02516	0.638
MOD_N-GLC_1	289	294	PF02516	0.482
MOD_N-GLC_1	337	342	PF02516	0.574
MOD_N-GLC_1	424	429	PF02516	0.547
MOD_N-GLC_1	43	48	PF02516	0.276
MOD_N-GLC_1	51	56	PF02516	0.346
MOD_N-GLC_2	118	120	PF02516	0.395
MOD_NEK2_1	210	215	PF00069	0.516
MOD_NEK2_1	29	34	PF00069	0.377
MOD_NEK2_1	379	384	PF00069	0.571
MOD_NEK2_1	401	406	PF00069	0.591
MOD_NEK2_1	432	437	PF00069	0.674
MOD_NEK2_1	459	464	PF00069	0.488
MOD_NEK2_1	488	493	PF00069	0.611
MOD_NEK2_1	51	56	PF00069	0.308
MOD_NEK2_1	546	551	PF00069	0.560
MOD_NEK2_2	270	275	PF00069	0.499
MOD_NEK2_2	53	58	PF00069	0.284
MOD_NEK2_2	64	69	PF00069	0.363
MOD_NEK2_2	86	91	PF00069	0.308
MOD_PIKK_1	144	150	PF00454	0.489
MOD_PIKK_1	388	394	PF00454	0.633
MOD_PIKK_1	410	416	PF00454	0.660
MOD_PK_1	445	451	PF00069	0.502
MOD_PKA_2	436	442	PF00069	0.510
MOD_PKA_2	506	512	PF00069	0.551
MOD_Plk_1	206	212	PF00069	0.513
MOD_Plk_1	270	276	PF00069	0.685
MOD_Plk_1	289	295	PF00069	0.480
MOD_Plk_1	43	49	PF00069	0.276
MOD_Plk_1	51	57	PF00069	0.346
MOD_Plk_1	521	527	PF00069	0.501
MOD_Plk_4	158	164	PF00069	0.520
MOD_Plk_4	206	212	PF00069	0.532
MOD_Plk_4	270	276	PF00069	0.598
MOD_Plk_4	397	403	PF00069	0.591
MOD_Plk_4	428	434	PF00069	0.707
MOD_Plk_4	86	92	PF00069	0.308
MOD_ProDKin_1	164	170	PF00069	0.468
MOD_ProDKin_1	242	248	PF00069	0.677
MOD_ProDKin_1	256	262	PF00069	0.581
MOD_ProDKin_1	37	43	PF00069	0.377
MOD_ProDKin_1	424	430	PF00069	0.570
MOD_ProDKin_1	482	488	PF00069	0.676
MOD_ProDKin_1	496	502	PF00069	0.542
MOD_ProDKin_1	514	520	PF00069	0.579
MOD_ProDKin_1	578	584	PF00069	0.622
TRG_ENDOCYTIC_2	76	79	PF00928	0.207
TRG_NLS_MonoExtC_3	582	587	PF00514	0.529
TRG_NLS_MonoExtN_4	582	587	PF00514	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C1	Leptomonas seymouri	52%	79%
A0A3S7WPJ8	Leishmania donovani	70%	81%
A4HSW2	Leishmania infantum	70%	81%
E9AKV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	81%
Q4QJ07	Leishmania major	70%	100%