Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4U1_LEIBR

TriTrypDb:

LbrM.06.1280 , LBRM2903_060020400

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

A4H4U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.633
CLV_PCSK_SKI1_1	34	38	PF00082	0.261
DEG_Nend_UBRbox_3	1	3	PF02207	0.640
DOC_MAPK_gen_1	15	25	PF00069	0.470
DOC_MAPK_gen_1	97	106	PF00069	0.643
DOC_MAPK_MEF2A_6	18	25	PF00069	0.472
DOC_MAPK_MEF2A_6	99	108	PF00069	0.442
DOC_PP2B_PxIxI_1	7	13	PF00149	0.473
DOC_USP7_UBL2_3	47	51	PF12436	0.470
DOC_USP7_UBL2_3	93	97	PF12436	0.664
DOC_WW_Pin1_4	4	9	PF00397	0.557
LIG_deltaCOP1_diTrp_1	64	72	PF00928	0.611
LIG_EH1_1	107	115	PF00400	0.271
LIG_FHA_1	54	60	PF00498	0.425
LIG_SH2_CRK	19	23	PF00017	0.470
LIG_SH2_STAT5	3	6	PF00017	0.636
LIG_SUMO_SIM_par_1	55	64	PF11976	0.408
MOD_CDK_SPxxK_3	4	11	PF00069	0.505
MOD_CK1_1	78	84	PF00069	0.669
MOD_GSK3_1	72	79	PF00069	0.642
MOD_N-GLC_1	52	57	PF02516	0.274
MOD_NEK2_1	72	77	PF00069	0.585
MOD_PKA_1	92	98	PF00069	0.648
MOD_Plk_4	109	115	PF00069	0.271
MOD_Plk_4	32	38	PF00069	0.510
MOD_ProDKin_1	4	10	PF00069	0.545
MOD_SUMO_rev_2	64	72	PF00179	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH82	Leptomonas seymouri	38%	100%
A0A3Q8ICI2	Leishmania donovani	42%	100%
A0A3Q8ILC3	Leishmania donovani	78%	99%
A0A3S7WPP2	Leishmania donovani	77%	99%
A0A3S7X4C9	Leishmania donovani	34%	100%
A4HJ97	Leishmania braziliensis	33%	100%
A4HJ98	Leishmania braziliensis	38%	100%
A4HJ99	Leishmania braziliensis	31%	100%
A4HT20	Leishmania infantum	78%	99%
A4I6P2	Leishmania infantum	34%	100%
A4I6P3	Leishmania infantum	42%	100%
E9ACS1	Leishmania major	77%	100%
E9AGY1	Leishmania infantum	78%	99%
E9AL09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
E9AVI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
E9B1R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q4Q6E6	Leishmania major	41%	99%
Q4QIU6	Leishmania major	76%	100%