Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4U1_LEIBR

TriTrypDb:

LbrM.06.1280 , LBRM2903_060020400

Length:

122

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

A4H4U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0020037	heme binding	4	3
GO:0046906	tetrapyrrole binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.633
CLV_PCSK_SKI1_1	34	38	PF00082	0.261
DEG_Nend_UBRbox_3	1	3	PF02207	0.640
DOC_MAPK_gen_1	15	25	PF00069	0.470
DOC_MAPK_gen_1	97	106	PF00069	0.643
DOC_MAPK_MEF2A_6	18	25	PF00069	0.472
DOC_MAPK_MEF2A_6	99	108	PF00069	0.442
DOC_PP2B_PxIxI_1	7	13	PF00149	0.473
DOC_USP7_UBL2_3	47	51	PF12436	0.470
DOC_USP7_UBL2_3	93	97	PF12436	0.664

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH82	Leptomonas seymouri	38%	100%
A0A3Q8ICI2	Leishmania donovani	42%	100%
A0A3Q8ILC3	Leishmania donovani	78%	99%
A0A3S7WPP2	Leishmania donovani	77%	99%
A0A3S7X4C9	Leishmania donovani	34%	100%
A4HJ97	Leishmania braziliensis	33%	100%
A4HJ98	Leishmania braziliensis	38%	100%
A4HJ99	Leishmania braziliensis	31%	100%
A4HT20	Leishmania infantum	78%	99%
A4I6P2	Leishmania infantum	34%	100%

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