Protoporphyrinogen oxidase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protoporphyrinogen oxidase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H4U0_LEIBR

TriTrypDb:

LbrM.06.1270 , LBRM2903_060020300

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H4U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4U0

Function

Biological processes
Term	Name	Level	Count
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006778	porphyrin-containing compound metabolic process	5	7
GO:0006779	porphyrin-containing compound biosynthetic process	6	7
GO:0006782	protoporphyrinogen IX biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0033013	tetrapyrrole metabolic process	4	7
GO:0033014	tetrapyrrole biosynthetic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0046483	heterocycle metabolic process	3	7
GO:0046501	protoporphyrinogen IX metabolic process	6	7
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006783	heme biosynthetic process	4	1
GO:0042168	heme metabolic process	3	1
GO:0042440	pigment metabolic process	2	1
GO:0046148	pigment biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004729	oxygen-dependent protoporphyrinogen oxidase activity	5	7
GO:0005488	binding	1	7
GO:0010181	FMN binding	4	7
GO:0016491	oxidoreductase activity	2	7
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	7
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	7
GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor	4	7
GO:0032553	ribonucleotide binding	3	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0070818	protoporphyrinogen oxidase activity	4	7
GO:0070819	menaquinone-dependent protoporphyrinogen oxidase activity	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.426
CLV_C14_Caspase3-7	42	46	PF00656	0.477
CLV_NRD_NRD_1	111	113	PF00675	0.226
CLV_NRD_NRD_1	97	99	PF00675	0.242
CLV_PCSK_KEX2_1	229	231	PF00082	0.427
CLV_PCSK_SKI1_1	112	116	PF00082	0.226
CLV_PCSK_SKI1_1	194	198	PF00082	0.567
CLV_PCSK_SKI1_1	207	211	PF00082	0.243
CLV_PCSK_SKI1_1	28	32	PF00082	0.169
CLV_PCSK_SKI1_1	56	60	PF00082	0.247
CLV_PCSK_SKI1_1	74	78	PF00082	0.219
DEG_APCC_DBOX_1	206	214	PF00400	0.236
DOC_CYCLIN_RxL_1	53	62	PF00134	0.477
DOC_MAPK_gen_1	205	212	PF00069	0.251
DOC_MAPK_RevD_3	180	195	PF00069	0.290
DOC_USP7_MATH_1	85	89	PF00917	0.422
DOC_USP7_MATH_1	97	101	PF00917	0.436
DOC_WW_Pin1_4	115	120	PF00397	0.456
DOC_WW_Pin1_4	182	187	PF00397	0.347
LIG_14-3-3_CanoR_1	171	181	PF00244	0.258
LIG_14-3-3_CanoR_1	67	75	PF00244	0.369
LIG_14-3-3_CanoR_1	98	106	PF00244	0.386
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.280
LIG_BRCT_BRCA1_1	68	72	PF00533	0.477
LIG_BRCT_BRCA1_1	87	91	PF00533	0.336
LIG_BRCT_BRCA1_2	68	74	PF00533	0.419
LIG_CSL_BTD_1	119	122	PF09270	0.206
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.265
LIG_FHA_1	157	163	PF00498	0.301
LIG_FHA_1	17	23	PF00498	0.434
LIG_FHA_1	195	201	PF00498	0.386
LIG_FHA_1	204	210	PF00498	0.155
LIG_FHA_2	150	156	PF00498	0.226
LIG_FHA_2	19	25	PF00498	0.426
LIG_GBD_Chelix_1	192	200	PF00786	0.543
LIG_LIR_Gen_1	165	174	PF02991	0.253
LIG_LIR_Gen_1	175	184	PF02991	0.306
LIG_LIR_Gen_1	52	61	PF02991	0.456
LIG_LIR_Nem_3	165	170	PF02991	0.292
LIG_LIR_Nem_3	175	180	PF02991	0.292
LIG_LIR_Nem_3	52	57	PF02991	0.456
LIG_LIR_Nem_3	62	68	PF02991	0.440
LIG_LIR_Nem_3	69	75	PF02991	0.460
LIG_LIR_Nem_3	88	93	PF02991	0.356
LIG_MLH1_MIPbox_1	87	91	PF16413	0.403
LIG_NRP_CendR_1	229	231	PF00754	0.333
LIG_PCNA_yPIPBox_3	98	110	PF02747	0.386
LIG_Pex14_1	133	137	PF04695	0.230
LIG_Pex14_2	173	177	PF04695	0.249
LIG_REV1ctd_RIR_1	137	146	PF16727	0.254
LIG_SH2_CRK	65	69	PF00017	0.369
LIG_SH2_STAP1	110	114	PF00017	0.426
LIG_SH2_STAP1	164	168	PF00017	0.272
LIG_SH2_STAP1	54	58	PF00017	0.426
LIG_SH2_STAT3	75	78	PF00017	0.477
LIG_SH2_STAT5	110	113	PF00017	0.431
LIG_SH2_STAT5	164	167	PF00017	0.273
LIG_SH2_STAT5	75	78	PF00017	0.456
LIG_SH2_STAT5	8	11	PF00017	0.418
LIG_SH3_3	116	122	PF00018	0.413
LIG_SUMO_SIM_par_1	180	185	PF11976	0.239
LIG_SUMO_SIM_par_1	39	45	PF11976	0.477
LIG_TYR_ITIM	63	68	PF00017	0.415
LIG_UBA3_1	22	28	PF00899	0.377
MOD_CDK_SPxxK_3	182	189	PF00069	0.276
MOD_CK1_1	118	124	PF00069	0.322
MOD_CK1_1	199	205	PF00069	0.350
MOD_CK2_1	149	155	PF00069	0.226
MOD_CK2_1	49	55	PF00069	0.369
MOD_GlcNHglycan	201	204	PF01048	0.635
MOD_GlcNHglycan	68	71	PF01048	0.314
MOD_GlcNHglycan	82	86	PF01048	0.240
MOD_GlcNHglycan	87	90	PF01048	0.181
MOD_GSK3_1	104	111	PF00069	0.364
MOD_GSK3_1	118	125	PF00069	0.259
MOD_GSK3_1	12	19	PF00069	0.437
MOD_GSK3_1	149	156	PF00069	0.226
MOD_GSK3_1	194	201	PF00069	0.345
MOD_GSK3_1	45	52	PF00069	0.396
MOD_GSK3_1	81	88	PF00069	0.494
MOD_GSK3_1	93	100	PF00069	0.424
MOD_N-GLC_1	203	208	PF02516	0.539
MOD_N-GLC_1	93	98	PF02516	0.247
MOD_NEK2_1	10	15	PF00069	0.454
MOD_NEK2_1	149	154	PF00069	0.248
MOD_NEK2_1	196	201	PF00069	0.460
MOD_NEK2_1	220	225	PF00069	0.223
MOD_NEK2_1	59	64	PF00069	0.430
MOD_PKA_1	194	200	PF00069	0.347
MOD_PKA_2	66	72	PF00069	0.369
MOD_PKA_2	97	103	PF00069	0.436
MOD_Plk_1	203	209	PF00069	0.338
MOD_Plk_1	81	87	PF00069	0.427
MOD_Plk_4	18	24	PF00069	0.426
MOD_ProDKin_1	115	121	PF00069	0.456
MOD_ProDKin_1	182	188	PF00069	0.355
TRG_ENDOCYTIC_2	137	140	PF00928	0.248
TRG_ENDOCYTIC_2	54	57	PF00928	0.456
TRG_ENDOCYTIC_2	65	68	PF00928	0.443
TRG_ENDOCYTIC_2	8	11	PF00928	0.418
TRG_ER_diArg_1	205	208	PF00400	0.339
TRG_ER_diArg_1	228	231	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9Q7	Leptomonas seymouri	60%	100%
A0A3S5H5V3	Leishmania donovani	78%	100%
A4HT19	Leishmania infantum	77%	100%
E9AL08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P0ACB4	Escherichia coli (strain K12)	47%	100%
P0ACB5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	47%	100%
P0ACB6	Escherichia coli O157:H7	47%	100%
Q4QIU7	Leishmania major	78%	100%
Q9L6L1	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	47%	100%