Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H4T8_LEIBR

TriTrypDb:

LbrM.06.1250 , LBRM2903_060020100

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H4T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	365	367	PF00675	0.399
CLV_PCSK_KEX2_1	132	134	PF00082	0.300
CLV_PCSK_KEX2_1	271	273	PF00082	0.299
CLV_PCSK_KEX2_1	365	367	PF00082	0.399
CLV_PCSK_KEX2_1	485	487	PF00082	0.529
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.300
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.358
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.529
CLV_PCSK_SKI1_1	261	265	PF00082	0.315
CLV_PCSK_SKI1_1	271	275	PF00082	0.276
CLV_PCSK_SKI1_1	366	370	PF00082	0.399
CLV_PCSK_SKI1_1	454	458	PF00082	0.197
CLV_PCSK_SKI1_1	461	465	PF00082	0.250
CLV_PCSK_SKI1_1	62	66	PF00082	0.256
DOC_CDC14_PxL_1	40	48	PF14671	0.536
DOC_CDC14_PxL_1	571	579	PF14671	0.338
DOC_CKS1_1	583	588	PF01111	0.441
DOC_CKS1_1	630	635	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.181
DOC_CYCLIN_yCln2_LP_2	583	589	PF00134	0.389
DOC_MAPK_gen_1	132	138	PF00069	0.507
DOC_MAPK_gen_1	259	267	PF00069	0.559
DOC_MAPK_gen_1	459	467	PF00069	0.442
DOC_MAPK_gen_1	485	493	PF00069	0.330
DOC_MAPK_gen_1	599	608	PF00069	0.591
DOC_MAPK_MEF2A_6	225	233	PF00069	0.331
DOC_MAPK_MEF2A_6	393	400	PF00069	0.473
DOC_MAPK_MEF2A_6	485	493	PF00069	0.363
DOC_MAPK_MEF2A_6	62	69	PF00069	0.543
DOC_MAPK_NFAT4_5	62	70	PF00069	0.611
DOC_PP2B_LxvP_1	406	409	PF13499	0.385
DOC_PP2B_LxvP_1	588	591	PF13499	0.366
DOC_PP2B_LxvP_1	595	598	PF13499	0.329
DOC_PP4_FxxP_1	316	319	PF00568	0.464
DOC_USP7_MATH_1	155	159	PF00917	0.272
DOC_USP7_MATH_1	198	202	PF00917	0.333
DOC_USP7_MATH_1	383	387	PF00917	0.369
DOC_USP7_MATH_1	544	548	PF00917	0.408
DOC_USP7_MATH_1	551	555	PF00917	0.400
DOC_WW_Pin1_4	582	587	PF00397	0.424
DOC_WW_Pin1_4	629	634	PF00397	0.650
LIG_14-3-3_CanoR_1	103	108	PF00244	0.499
LIG_14-3-3_CanoR_1	320	325	PF00244	0.385
LIG_14-3-3_CanoR_1	623	630	PF00244	0.704
LIG_APCC_ABBA_1	247	252	PF00400	0.415
LIG_APCC_ABBA_1	49	54	PF00400	0.637
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BIR_III_3	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	429	433	PF00533	0.325
LIG_CaM_IQ_9	264	279	PF13499	0.381
LIG_DLG_GKlike_1	103	110	PF00625	0.427
LIG_EH1_1	465	473	PF00400	0.352
LIG_FHA_1	312	318	PF00498	0.470
LIG_FHA_1	348	354	PF00498	0.362
LIG_FHA_1	446	452	PF00498	0.431
LIG_FHA_1	467	473	PF00498	0.358
LIG_FHA_1	528	534	PF00498	0.481
LIG_FHA_1	578	584	PF00498	0.425
LIG_FHA_2	630	636	PF00498	0.715
LIG_GBD_Chelix_1	467	475	PF00786	0.481
LIG_GBD_Chelix_1	505	513	PF00786	0.507
LIG_LIR_Apic_2	30	34	PF02991	0.622
LIG_LIR_Apic_2	313	319	PF02991	0.537
LIG_LIR_Gen_1	266	273	PF02991	0.560
LIG_LIR_Gen_1	402	412	PF02991	0.352
LIG_LIR_Gen_1	432	441	PF02991	0.331
LIG_LIR_Gen_1	477	484	PF02991	0.345
LIG_LIR_Gen_1	532	541	PF02991	0.518
LIG_LIR_LC3C_4	585	590	PF02991	0.183
LIG_LIR_Nem_3	227	231	PF02991	0.312
LIG_LIR_Nem_3	241	247	PF02991	0.347
LIG_LIR_Nem_3	266	270	PF02991	0.560
LIG_LIR_Nem_3	402	408	PF02991	0.338
LIG_LIR_Nem_3	430	434	PF02991	0.304
LIG_LIR_Nem_3	477	482	PF02991	0.346
LIG_LIR_Nem_3	532	538	PF02991	0.480
LIG_LIR_Nem_3	558	563	PF02991	0.299
LIG_NRBOX	399	405	PF00104	0.223
LIG_Pex14_1	134	138	PF04695	0.183
LIG_Pex14_1	204	208	PF04695	0.392
LIG_Pex14_2	168	172	PF04695	0.376
LIG_Pex14_2	239	243	PF04695	0.310
LIG_Pex14_2	429	433	PF04695	0.313
LIG_Pex14_2	453	457	PF04695	0.375
LIG_Pex14_2	59	63	PF04695	0.497
LIG_PTB_Apo_2	570	577	PF02174	0.328
LIG_PTB_Phospho_1	570	576	PF10480	0.328
LIG_Rb_pABgroove_1	244	252	PF01858	0.183
LIG_REV1ctd_RIR_1	454	463	PF16727	0.541
LIG_SH2_CRK	101	105	PF00017	0.520
LIG_SH2_CRK	150	154	PF00017	0.332
LIG_SH2_CRK	322	326	PF00017	0.607
LIG_SH2_CRK	345	349	PF00017	0.357
LIG_SH2_CRK	370	374	PF00017	0.368
LIG_SH2_CRK	434	438	PF00017	0.306
LIG_SH2_CRK	462	466	PF00017	0.503
LIG_SH2_GRB2like	399	402	PF00017	0.389
LIG_SH2_NCK_1	31	35	PF00017	0.654
LIG_SH2_NCK_1	370	374	PF00017	0.422
LIG_SH2_PTP2	228	231	PF00017	0.208
LIG_SH2_PTP2	48	51	PF00017	0.643
LIG_SH2_PTP2	490	493	PF00017	0.402
LIG_SH2_SRC	31	34	PF00017	0.637
LIG_SH2_SRC	399	402	PF00017	0.501
LIG_SH2_SRC	576	579	PF00017	0.208
LIG_SH2_STAP1	130	134	PF00017	0.508
LIG_SH2_STAP1	345	349	PF00017	0.404
LIG_SH2_STAP1	370	374	PF00017	0.297
LIG_SH2_STAP1	462	466	PF00017	0.509
LIG_SH2_STAP1	507	511	PF00017	0.415
LIG_SH2_STAT5	130	133	PF00017	0.506
LIG_SH2_STAT5	228	231	PF00017	0.356
LIG_SH2_STAT5	324	327	PF00017	0.547
LIG_SH2_STAT5	399	402	PF00017	0.359
LIG_SH2_STAT5	405	408	PF00017	0.346
LIG_SH2_STAT5	416	419	PF00017	0.274
LIG_SH2_STAT5	431	434	PF00017	0.267
LIG_SH2_STAT5	455	458	PF00017	0.457
LIG_SH2_STAT5	48	51	PF00017	0.604
LIG_SH2_STAT5	490	493	PF00017	0.314
LIG_SH2_STAT5	499	502	PF00017	0.302
LIG_SH2_STAT5	576	579	PF00017	0.343
LIG_SH2_STAT5	71	74	PF00017	0.526
LIG_SH3_3	283	289	PF00018	0.548
LIG_SH3_3	382	388	PF00018	0.202
LIG_SH3_3	421	427	PF00018	0.287
LIG_SH3_3	627	633	PF00018	0.734
LIG_Sin3_3	138	145	PF02671	0.183
LIG_Sin3_3	593	600	PF02671	0.208
LIG_SUMO_SIM_anti_2	480	485	PF11976	0.326
LIG_SUMO_SIM_anti_2	585	591	PF11976	0.433
LIG_TRAF2_1	6	9	PF00917	0.779
LIG_TRFH_1	150	154	PF08558	0.372
LIG_TRFH_1	594	598	PF08558	0.301
LIG_TYR_ITIM	148	153	PF00017	0.388
LIG_TYR_ITIM	226	231	PF00017	0.208
LIG_TYR_ITIM	343	348	PF00017	0.253
LIG_TYR_ITIM	368	373	PF00017	0.385
LIG_TYR_ITIM	403	408	PF00017	0.336
LIG_TYR_ITIM	46	51	PF00017	0.476
LIG_TYR_ITIM	574	579	PF00017	0.396
LIG_TYR_ITSM	430	437	PF00017	0.414
LIG_UBA3_1	217	225	PF00899	0.208
LIG_UBA3_1	246	254	PF00899	0.402
LIG_UBA3_1	478	485	PF00899	0.334
MOD_CK1_1	106	112	PF00069	0.355
MOD_CK2_1	629	635	PF00069	0.728
MOD_GlcNHglycan	13	16	PF01048	0.669
MOD_GlcNHglycan	138	141	PF01048	0.400
MOD_GlcNHglycan	157	161	PF01048	0.362
MOD_GlcNHglycan	2	5	PF01048	0.693
MOD_GlcNHglycan	233	236	PF01048	0.382
MOD_GlcNHglycan	307	310	PF01048	0.285
MOD_GlcNHglycan	542	545	PF01048	0.408
MOD_GlcNHglycan	563	566	PF01048	0.461
MOD_GSK3_1	106	113	PF00069	0.407
MOD_GSK3_1	204	211	PF00069	0.322
MOD_GSK3_1	301	308	PF00069	0.252
MOD_GSK3_1	357	364	PF00069	0.292
MOD_GSK3_1	429	436	PF00069	0.380
MOD_GSK3_1	540	547	PF00069	0.386
MOD_GSK3_1	63	70	PF00069	0.313
MOD_GSK3_1	7	14	PF00069	0.614
MOD_N-GLC_1	11	16	PF02516	0.535
MOD_N-GLC_1	254	259	PF02516	0.390
MOD_N-GLC_1	569	574	PF02516	0.204
MOD_N-GLC_1	82	87	PF02516	0.388
MOD_N-GLC_2	258	260	PF02516	0.183
MOD_NEK2_1	110	115	PF00069	0.387
MOD_NEK2_1	117	122	PF00069	0.364
MOD_NEK2_1	128	133	PF00069	0.292
MOD_NEK2_1	136	141	PF00069	0.349
MOD_NEK2_1	185	190	PF00069	0.379
MOD_NEK2_1	208	213	PF00069	0.336
MOD_NEK2_1	301	306	PF00069	0.336
MOD_NEK2_1	347	352	PF00069	0.361
MOD_NEK2_1	429	434	PF00069	0.366
MOD_NEK2_1	466	471	PF00069	0.378
MOD_NEK2_1	511	516	PF00069	0.377
MOD_NEK2_1	577	582	PF00069	0.464
MOD_NEK2_1	63	68	PF00069	0.441
MOD_NEK2_1	69	74	PF00069	0.451
MOD_NEK2_2	23	28	PF00069	0.476
MOD_PIKK_1	178	184	PF00454	0.337
MOD_PKA_2	527	533	PF00069	0.346
MOD_Plk_4	103	109	PF00069	0.279
MOD_Plk_4	198	204	PF00069	0.349
MOD_Plk_4	208	214	PF00069	0.341
MOD_Plk_4	224	230	PF00069	0.344
MOD_Plk_4	238	244	PF00069	0.201
MOD_Plk_4	320	326	PF00069	0.332
MOD_Plk_4	357	363	PF00069	0.304
MOD_Plk_4	399	405	PF00069	0.365
MOD_Plk_4	429	435	PF00069	0.445
MOD_Plk_4	467	473	PF00069	0.333
MOD_Plk_4	474	480	PF00069	0.331
MOD_Plk_4	511	517	PF00069	0.319
MOD_Plk_4	551	557	PF00069	0.350
MOD_ProDKin_1	582	588	PF00069	0.424
MOD_ProDKin_1	629	635	PF00069	0.562
MOD_SUMO_rev_2	222	227	PF00179	0.419
MOD_SUMO_rev_2	266	273	PF00179	0.235
MOD_SUMO_rev_2	626	630	PF00179	0.591
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.388
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.331
TRG_ENDOCYTIC_2	101	104	PF00928	0.332
TRG_ENDOCYTIC_2	135	138	PF00928	0.357
TRG_ENDOCYTIC_2	150	153	PF00928	0.347
TRG_ENDOCYTIC_2	228	231	PF00928	0.208
TRG_ENDOCYTIC_2	322	325	PF00928	0.443
TRG_ENDOCYTIC_2	345	348	PF00928	0.358
TRG_ENDOCYTIC_2	370	373	PF00928	0.369
TRG_ENDOCYTIC_2	405	408	PF00928	0.355
TRG_ENDOCYTIC_2	434	437	PF00928	0.355
TRG_ENDOCYTIC_2	462	465	PF00928	0.349
TRG_ENDOCYTIC_2	48	51	PF00928	0.484
TRG_ENDOCYTIC_2	490	493	PF00928	0.477
TRG_ENDOCYTIC_2	576	579	PF00928	0.394
TRG_NES_CRM1_1	503	519	PF08389	0.208
TRG_NLS_Bipartite_1	253	275	PF00514	0.183

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	93%
A0A0N1HY49	Leptomonas seymouri	45%	97%
A0A0N1HZ06	Leptomonas seymouri	46%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	91%
A0A0N1PAY4	Leptomonas seymouri	40%	74%
A0A0N1PB77	Leptomonas seymouri	44%	100%
A0A0N1PBZ2	Leptomonas seymouri	41%	97%
A0A0N1PCC1	Leptomonas seymouri	43%	98%
A0A0S4INN8	Bodo saltans	31%	100%
A0A381MBI0	Leishmania infantum	45%	99%
A0A3Q8I8X7	Leishmania donovani	45%	99%
A0A3Q8IAZ0	Leishmania donovani	42%	93%
A0A3Q8IH50	Leishmania donovani	44%	90%
A0A3Q8IVN0	Leishmania donovani	45%	100%
A0A3R7M4J1	Trypanosoma rangeli	46%	100%
A0A3S5H5P4	Leishmania donovani	44%	96%
A0A3S5H5V2	Leishmania donovani	84%	100%
A0A3S5H6F6	Leishmania donovani	43%	94%
A0A3S5H763	Leishmania donovani	45%	97%
A0A3S7WR10	Leishmania donovani	45%	88%
A0A3S7WR14	Leishmania donovani	41%	95%
A0A3S7WR15	Leishmania donovani	41%	77%
A0A3S7WR24	Leishmania donovani	43%	93%
A4H5Y4	Leishmania braziliensis	42%	100%
A4H617	Leishmania braziliensis	43%	94%
A4H618	Leishmania braziliensis	43%	95%
A4H619	Leishmania braziliensis	43%	94%
A4H620	Leishmania braziliensis	44%	92%
A4H6C3	Leishmania braziliensis	42%	100%
A4HNH7	Leishmania braziliensis	43%	100%
A4HSS2	Leishmania infantum	44%	96%
A4HUE4	Leishmania infantum	45%	88%
A4HUE5	Leishmania infantum	41%	95%
A4HUE6	Leishmania infantum	41%	95%
A4HUE7	Leishmania infantum	43%	93%
A4HUE8	Leishmania infantum	44%	93%
A4HUF4	Leishmania infantum	43%	94%
A4HUF5	Leishmania infantum	44%	99%
A4HYA9	Leishmania infantum	45%	97%
A4IC33	Leishmania infantum	45%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	94%
E9AG72	Leishmania infantum	84%	100%
E9AI40	Leishmania braziliensis	42%	96%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	96%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	88%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	92%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	99%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	97%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4QDC4	Leishmania major	47%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	45%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	43%	100%
Q4QHI0	Leishmania major	42%	100%
Q4QHI1	Leishmania major	43%	99%
Q4QHI2	Leishmania major	41%	100%
Q4QIU9	Leishmania major	84%	100%
Q4QJ48	Leishmania major	45%	100%
Q7KIP2	Leishmania major	44%	99%