Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4T7_LEIBR

TriTrypDb:

LbrM.06.1240 , LBRM2903_060019900

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H4T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.500
CLV_NRD_NRD_1	20	22	PF00675	0.409
CLV_NRD_NRD_1	24	26	PF00675	0.410
CLV_PCSK_KEX2_1	11	13	PF00082	0.410
CLV_PCSK_KEX2_1	175	177	PF00082	0.547
CLV_PCSK_KEX2_1	19	21	PF00082	0.377
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.462
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.536
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.427
DOC_MAPK_DCC_7	125	135	PF00069	0.421
DOC_MAPK_MEF2A_6	125	134	PF00069	0.444
DOC_MAPK_MEF2A_6	199	208	PF00069	0.539
DOC_PP1_RVXF_1	154	161	PF00149	0.719
DOC_PP1_RVXF_1	197	203	PF00149	0.514
DOC_PP2B_PxIxI_1	55	61	PF00149	0.369
DOC_PP4_FxxP_1	93	96	PF00568	0.662
DOC_USP7_MATH_1	94	98	PF00917	0.519
DOC_WW_Pin1_4	151	156	PF00397	0.639
DOC_WW_Pin1_4	47	52	PF00397	0.675
LIG_14-3-3_CanoR_1	125	133	PF00244	0.393
LIG_14-3-3_CanoR_1	159	165	PF00244	0.717
LIG_Actin_WH2_2	146	161	PF00022	0.630
LIG_APCC_ABBA_1	214	219	PF00400	0.330
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_Clathr_ClatBox_1	215	219	PF01394	0.405
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.292
LIG_eIF4E_1	137	143	PF01652	0.485
LIG_FAT_LD_1	200	208	PF03623	0.561
LIG_FHA_1	37	43	PF00498	0.704
LIG_FHA_1	50	56	PF00498	0.522
LIG_LIR_Apic_2	118	123	PF02991	0.446
LIG_LIR_Gen_1	154	164	PF02991	0.725
LIG_LIR_Gen_1	31	42	PF02991	0.675
LIG_LIR_Gen_1	75	84	PF02991	0.306
LIG_LIR_Gen_1	97	107	PF02991	0.510
LIG_LIR_Nem_3	154	160	PF02991	0.703
LIG_LIR_Nem_3	232	237	PF02991	0.406
LIG_LIR_Nem_3	31	37	PF02991	0.659
LIG_LIR_Nem_3	75	79	PF02991	0.331
LIG_LIR_Nem_3	97	102	PF02991	0.504
LIG_NRBOX	199	205	PF00104	0.561
LIG_NRBOX	58	64	PF00104	0.485
LIG_NRBOX	84	90	PF00104	0.424
LIG_NRP_CendR_1	235	238	PF00754	0.557
LIG_Pex14_2	111	115	PF04695	0.374
LIG_PTB_Apo_2	106	113	PF02174	0.490
LIG_PTB_Apo_2	114	121	PF02174	0.318
LIG_PTB_Phospho_1	114	120	PF10480	0.349
LIG_REV1ctd_RIR_1	108	118	PF16727	0.355
LIG_SH2_CRK	120	124	PF00017	0.485
LIG_SH2_NCK_1	120	124	PF00017	0.455
LIG_SH2_PTP2	137	140	PF00017	0.432
LIG_SH2_PTP2	152	155	PF00017	0.469
LIG_SH2_PTP2	217	220	PF00017	0.272
LIG_SH2_SRC	217	220	PF00017	0.339
LIG_SH2_SRC	34	37	PF00017	0.668
LIG_SH2_STAT5	137	140	PF00017	0.389
LIG_SH2_STAT5	149	152	PF00017	0.311
LIG_SH2_STAT5	157	160	PF00017	0.492
LIG_SH2_STAT5	217	220	PF00017	0.444
LIG_SH2_STAT5	34	37	PF00017	0.666
LIG_SH3_3	62	68	PF00018	0.396
LIG_SUMO_SIM_anti_2	104	109	PF11976	0.473
LIG_SUMO_SIM_anti_2	33	39	PF11976	0.669
LIG_TYR_ITIM	135	140	PF00017	0.420
LIG_TYR_ITIM	215	220	PF00017	0.444
MOD_CDK_SPK_2	151	156	PF00069	0.639
MOD_CK1_1	2	8	PF00069	0.678
MOD_CK2_1	2	8	PF00069	0.646
MOD_GSK3_1	36	43	PF00069	0.645
MOD_GSK3_1	45	52	PF00069	0.672
MOD_GSK3_1	63	70	PF00069	0.195
MOD_NEK2_1	158	163	PF00069	0.711
MOD_NEK2_1	63	68	PF00069	0.401
MOD_PIKK_1	124	130	PF00454	0.359
MOD_PIKK_1	49	55	PF00454	0.532
MOD_PKA_1	40	46	PF00069	0.547
MOD_PKA_2	113	119	PF00069	0.508
MOD_PKA_2	124	130	PF00069	0.414
MOD_PKA_2	158	164	PF00069	0.722
MOD_PKA_2	169	175	PF00069	0.646
MOD_PKA_2	45	51	PF00069	0.732
MOD_Plk_4	101	107	PF00069	0.239
MOD_Plk_4	229	235	PF00069	0.386
MOD_Plk_4	84	90	PF00069	0.389
MOD_ProDKin_1	151	157	PF00069	0.645
MOD_ProDKin_1	47	53	PF00069	0.672
TRG_DiLeu_BaEn_2	197	203	PF01217	0.514
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.481
TRG_ENDOCYTIC_2	137	140	PF00928	0.389
TRG_ENDOCYTIC_2	157	160	PF00928	0.492
TRG_ENDOCYTIC_2	217	220	PF00928	0.412
TRG_ENDOCYTIC_2	34	37	PF00928	0.644
TRG_NLS_MonoExtN_4	175	180	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	40	44	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBC2	Leptomonas seymouri	65%	100%
A0A0S4JA41	Bodo saltans	31%	100%
A0A1X0NGU0	Trypanosomatidae	36%	100%
A0A3S5H5V0	Leishmania donovani	85%	100%
A4HT17	Leishmania infantum	85%	100%
C9ZTQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AL05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QIV0	Leishmania major	84%	100%