FAD_binding_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FAD binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H4T6_LEIBR

TriTrypDb:

LbrM.06.1230 , LBRM2903_060019700

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H4T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T6

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	8
GO:0004497	monooxygenase activity	3	8
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	4
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.513
CLV_C14_Caspase3-7	244	248	PF00656	0.169
CLV_C14_Caspase3-7	353	357	PF00656	0.311
CLV_NRD_NRD_1	160	162	PF00675	0.532
CLV_NRD_NRD_1	333	335	PF00675	0.325
CLV_NRD_NRD_1	360	362	PF00675	0.169
CLV_NRD_NRD_1	497	499	PF00675	0.373
CLV_PCSK_KEX2_1	333	335	PF00082	0.265
CLV_PCSK_KEX2_1	360	362	PF00082	0.260
CLV_PCSK_KEX2_1	497	499	PF00082	0.373
CLV_PCSK_KEX2_1	74	76	PF00082	0.484
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.461
CLV_PCSK_SKI1_1	251	255	PF00082	0.265
CLV_PCSK_SKI1_1	317	321	PF00082	0.380
CLV_PCSK_SKI1_1	380	384	PF00082	0.247
CLV_PCSK_SKI1_1	452	456	PF00082	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.563
DEG_SCF_FBW7_1	90	97	PF00400	0.304
DEG_SPOP_SBC_1	308	312	PF00917	0.333
DEG_SPOP_SBC_1	350	354	PF00917	0.311
DOC_CKS1_1	254	259	PF01111	0.380
DOC_CKS1_1	456	461	PF01111	0.436
DOC_CYCLIN_RxL_1	314	323	PF00134	0.380
DOC_CYCLIN_yCln2_LP_2	160	166	PF00134	0.342
DOC_MAPK_gen_1	161	169	PF00069	0.377
DOC_PP1_RVXF_1	160	167	PF00149	0.352
DOC_PP2B_LxvP_1	347	350	PF13499	0.209
DOC_USP7_MATH_1	220	224	PF00917	0.458
DOC_USP7_MATH_1	337	341	PF00917	0.365
DOC_USP7_MATH_1	350	354	PF00917	0.324
DOC_USP7_MATH_1	362	366	PF00917	0.321
DOC_USP7_MATH_1	387	391	PF00917	0.235
DOC_USP7_MATH_1	408	412	PF00917	0.296
DOC_USP7_MATH_1	416	420	PF00917	0.233
DOC_USP7_MATH_1	468	472	PF00917	0.480
DOC_USP7_MATH_1	473	477	PF00917	0.457
DOC_USP7_MATH_1	94	98	PF00917	0.359
DOC_WW_Pin1_4	124	129	PF00397	0.432
DOC_WW_Pin1_4	245	250	PF00397	0.352
DOC_WW_Pin1_4	253	258	PF00397	0.406
DOC_WW_Pin1_4	309	314	PF00397	0.299
DOC_WW_Pin1_4	372	377	PF00397	0.198
DOC_WW_Pin1_4	455	460	PF00397	0.542
DOC_WW_Pin1_4	9	14	PF00397	0.607
DOC_WW_Pin1_4	90	95	PF00397	0.350
LIG_14-3-3_CanoR_1	108	116	PF00244	0.341
LIG_14-3-3_CanoR_1	135	140	PF00244	0.486
LIG_14-3-3_CanoR_1	4	9	PF00244	0.557
LIG_14-3-3_CanoR_1	497	501	PF00244	0.266
LIG_14-3-3_CanoR_1	86	91	PF00244	0.353
LIG_BRCT_BRCA1_1	135	139	PF00533	0.481
LIG_FHA_1	140	146	PF00498	0.644
LIG_FHA_1	230	236	PF00498	0.245
LIG_FHA_1	254	260	PF00498	0.287
LIG_FHA_1	269	275	PF00498	0.237
LIG_FHA_1	408	414	PF00498	0.325
LIG_FHA_1	439	445	PF00498	0.534
LIG_FHA_1	456	462	PF00498	0.396
LIG_FHA_1	59	65	PF00498	0.281
LIG_FHA_1	87	93	PF00498	0.351
LIG_FHA_2	147	153	PF00498	0.572
LIG_FHA_2	189	195	PF00498	0.557
LIG_FHA_2	229	235	PF00498	0.292
LIG_FHA_2	298	304	PF00498	0.314
LIG_FHA_2	321	327	PF00498	0.354
LIG_FHA_2	444	450	PF00498	0.371
LIG_GBD_Chelix_1	327	335	PF00786	0.237
LIG_LIR_Apic_2	455	459	PF02991	0.550
LIG_LIR_Gen_1	156	164	PF02991	0.379
LIG_LIR_Nem_3	156	160	PF02991	0.417
LIG_LIR_Nem_3	234	240	PF02991	0.338
LIG_MLH1_MIPbox_1	136	140	PF16413	0.603
LIG_Pex14_2	285	289	PF04695	0.247
LIG_PTB_Apo_2	303	310	PF02174	0.169
LIG_REV1ctd_RIR_1	286	294	PF16727	0.380
LIG_SH2_NCK_1	263	267	PF00017	0.169
LIG_SH2_NCK_1	78	82	PF00017	0.512
LIG_SH2_STAP1	263	267	PF00017	0.265
LIG_SH2_STAP1	404	408	PF00017	0.247
LIG_SH2_STAT3	500	503	PF00017	0.233
LIG_SH2_STAT5	129	132	PF00017	0.505
LIG_SH2_STAT5	500	503	PF00017	0.233
LIG_SH3_3	206	212	PF00018	0.388
LIG_SH3_3	373	379	PF00018	0.254
LIG_SUMO_SIM_anti_2	65	72	PF11976	0.325
LIG_SUMO_SIM_par_1	88	93	PF11976	0.298
LIG_TRAF2_1	322	325	PF00917	0.295
MOD_CDC14_SPxK_1	248	251	PF00782	0.260
MOD_CDK_SPxK_1	245	251	PF00069	0.260
MOD_CK1_1	134	140	PF00069	0.583
MOD_CK1_1	148	154	PF00069	0.387
MOD_CK1_1	213	219	PF00069	0.502
MOD_CK1_1	352	358	PF00069	0.169
MOD_CK1_1	58	64	PF00069	0.426
MOD_CK2_1	146	152	PF00069	0.608
MOD_CK2_1	319	325	PF00069	0.352
MOD_CK2_1	408	414	PF00069	0.380
MOD_CK2_1	443	449	PF00069	0.366
MOD_Cter_Amidation	72	75	PF01082	0.426
MOD_DYRK1A_RPxSP_1	9	13	PF00069	0.574
MOD_GlcNHglycan	222	225	PF01048	0.411
MOD_GlcNHglycan	23	26	PF01048	0.351
MOD_GlcNHglycan	418	421	PF01048	0.415
MOD_GlcNHglycan	47	50	PF01048	0.615
MOD_GlcNHglycan	487	490	PF01048	0.308
MOD_GlcNHglycan	71	74	PF01048	0.419
MOD_GSK3_1	131	138	PF00069	0.462
MOD_GSK3_1	168	175	PF00069	0.372
MOD_GSK3_1	229	236	PF00069	0.308
MOD_GSK3_1	39	46	PF00069	0.358
MOD_GSK3_1	55	62	PF00069	0.426
MOD_GSK3_1	86	93	PF00069	0.376
MOD_N-GLC_1	146	151	PF02516	0.612
MOD_N-GLC_2	174	176	PF02516	0.400
MOD_N-GLC_2	281	283	PF02516	0.247
MOD_NEK2_1	139	144	PF00069	0.591
MOD_NEK2_1	145	150	PF00069	0.529
MOD_NEK2_1	188	193	PF00069	0.333
MOD_NEK2_1	2	7	PF00069	0.581
MOD_NEK2_1	268	273	PF00069	0.341
MOD_NEK2_1	319	324	PF00069	0.258
MOD_NEK2_1	33	38	PF00069	0.357
MOD_NEK2_1	438	443	PF00069	0.326
MOD_NEK2_1	44	49	PF00069	0.454
MOD_NEK2_1	484	489	PF00069	0.366
MOD_NEK2_1	59	64	PF00069	0.484
MOD_NEK2_1	69	74	PF00069	0.375
MOD_NEK2_2	387	392	PF00069	0.235
MOD_PIKK_1	210	216	PF00454	0.498
MOD_PIKK_1	320	326	PF00454	0.283
MOD_PIKK_1	59	65	PF00454	0.338
MOD_PK_1	88	94	PF00069	0.435
MOD_PKA_1	452	458	PF00069	0.527
MOD_PKA_2	107	113	PF00069	0.346
MOD_PKA_2	134	140	PF00069	0.601
MOD_PKA_2	496	502	PF00069	0.241
MOD_PKB_1	86	94	PF00069	0.248
MOD_Plk_1	233	239	PF00069	0.177
MOD_Plk_4	135	141	PF00069	0.493
MOD_Plk_4	408	414	PF00069	0.360
MOD_Plk_4	452	458	PF00069	0.358
MOD_Plk_4	55	61	PF00069	0.387
MOD_ProDKin_1	124	130	PF00069	0.433
MOD_ProDKin_1	245	251	PF00069	0.352
MOD_ProDKin_1	253	259	PF00069	0.406
MOD_ProDKin_1	309	315	PF00069	0.299
MOD_ProDKin_1	372	378	PF00069	0.198
MOD_ProDKin_1	455	461	PF00069	0.547
MOD_ProDKin_1	9	15	PF00069	0.601
MOD_ProDKin_1	90	96	PF00069	0.346
MOD_SUMO_rev_2	352	359	PF00179	0.190
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.454
TRG_ENDOCYTIC_2	115	118	PF00928	0.338
TRG_ER_diArg_1	333	335	PF00400	0.325
TRG_ER_diArg_1	359	361	PF00400	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4M2	Leptomonas seymouri	75%	99%
A0A1X0NI75	Trypanosomatidae	55%	97%
A0A3R7KEW4	Trypanosoma rangeli	56%	100%
A0A3S7WPP5	Leishmania donovani	83%	100%
A4HT15	Leishmania infantum	83%	100%
C9ZTQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AL03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
F1RAX8	Danio rerio	28%	100%
O01884	Caenorhabditis elegans	27%	100%
P25535	Escherichia coli (strain K12)	26%	100%
P53318	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P75728	Escherichia coli (strain K12)	24%	100%
Q2KIL4	Bos taurus	26%	100%
Q4QIV2	Leishmania major	82%	98%
Q68FU7	Rattus norvegicus	27%	100%
Q6DF46	Xenopus tropicalis	28%	100%
Q8R1S0	Mus musculus	27%	100%
Q9Y2Z9	Homo sapiens	26%	100%
Q9Y7Z9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
V5B825	Trypanosoma cruzi	54%	100%