Cysteine dioxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1637), putative

Species:

Leishmania braziliensis

UniProt:

A4H4T5_LEIBR

TriTrypDb:

LbrM.06.1220 , LBRM2903_060019600

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	12
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	12
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051213	dioxygenase activity	3	12
GO:0047800	cysteamine dioxygenase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.514
CLV_PCSK_KEX2_1	2	4	PF00082	0.383
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.408
CLV_PCSK_SKI1_1	136	140	PF00082	0.212
CLV_PCSK_SKI1_1	3	7	PF00082	0.384
DEG_Nend_UBRbox_1	1	4	PF02207	0.451
DEG_SCF_FBW7_1	174	181	PF00400	0.354
DEG_SPOP_SBC_1	179	183	PF00917	0.354
DOC_CYCLIN_RxL_1	105	114	PF00134	0.466
DOC_PP2B_LxvP_1	147	150	PF13499	0.354
DOC_PP4_FxxP_1	102	105	PF00568	0.422
DOC_USP7_MATH_1	13	17	PF00917	0.470
DOC_USP7_MATH_1	137	141	PF00917	0.430
DOC_USP7_MATH_1	142	146	PF00917	0.399
DOC_USP7_MATH_1	178	182	PF00917	0.354
DOC_USP7_MATH_1	77	81	PF00917	0.526
DOC_USP7_UBL2_3	2	6	PF12436	0.511
DOC_USP7_UBL2_3	246	250	PF12436	0.466
DOC_WW_Pin1_4	174	179	PF00397	0.535
DOC_WW_Pin1_4	202	207	PF00397	0.435
DOC_WW_Pin1_4	71	76	PF00397	0.520
DOC_WW_Pin1_4	9	14	PF00397	0.339
LIG_14-3-3_CanoR_1	3	9	PF00244	0.486
LIG_14-3-3_CanoR_1	65	73	PF00244	0.556
LIG_Actin_WH2_2	161	177	PF00022	0.354
LIG_FHA_1	226	232	PF00498	0.474
LIG_FHA_1	45	51	PF00498	0.354
LIG_FHA_1	68	74	PF00498	0.466
LIG_FHA_2	12	18	PF00498	0.507
LIG_FHA_2	24	30	PF00498	0.381
LIG_LIR_Apic_2	257	262	PF02991	0.425
LIG_LIR_Gen_1	20	30	PF02991	0.392
LIG_LIR_Nem_3	265	270	PF02991	0.388
LIG_LIR_Nem_3	29	33	PF02991	0.503
LIG_LIR_Nem_3	98	104	PF02991	0.498
LIG_SH2_CRK	259	263	PF00017	0.454
LIG_SH2_NCK_1	208	212	PF00017	0.454
LIG_SH2_STAT5	220	223	PF00017	0.473
LIG_SH2_STAT5	33	36	PF00017	0.441
LIG_SH3_3	100	106	PF00018	0.454
LIG_WRC_WIRS_1	8	13	PF05994	0.274
MOD_CK1_1	23	29	PF00069	0.273
MOD_CK1_1	257	263	PF00069	0.449
MOD_CK1_1	67	73	PF00069	0.394
MOD_CK1_1	7	13	PF00069	0.478
MOD_CK2_1	11	17	PF00069	0.454
MOD_CK2_1	231	237	PF00069	0.311
MOD_GlcNHglycan	144	147	PF01048	0.167
MOD_GlcNHglycan	182	185	PF01048	0.315
MOD_GlcNHglycan	259	262	PF01048	0.325
MOD_GSK3_1	174	181	PF00069	0.202
MOD_GSK3_1	227	234	PF00069	0.202
MOD_GSK3_1	64	71	PF00069	0.364
MOD_GSK3_1	7	14	PF00069	0.407
MOD_N-GLC_1	151	156	PF02516	0.325
MOD_N-GLC_1	257	262	PF02516	0.464
MOD_NEK2_1	225	230	PF00069	0.336
MOD_NEK2_1	4	9	PF00069	0.470
MOD_NEK2_2	87	92	PF00069	0.264
MOD_PIKK_1	137	143	PF00454	0.331
MOD_PIKK_1	68	74	PF00454	0.167
MOD_PKA_2	64	70	PF00069	0.439
MOD_Plk_4	116	122	PF00069	0.260
MOD_Plk_4	151	157	PF00069	0.363
MOD_Plk_4	227	233	PF00069	0.348
MOD_Plk_4	87	93	PF00069	0.297
MOD_ProDKin_1	174	180	PF00069	0.422
MOD_ProDKin_1	202	208	PF00069	0.281
MOD_ProDKin_1	71	77	PF00069	0.400
MOD_ProDKin_1	9	15	PF00069	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C5	Leptomonas seymouri	56%	100%
A0A0S4IQ52	Bodo saltans	30%	100%
A0A1X0NH28	Trypanosomatidae	40%	100%
A0A3S5H5U9	Leishmania donovani	81%	92%
A0A422NM88	Trypanosoma rangeli	33%	100%
A4HT14	Leishmania infantum	80%	92%
C9ZTQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AL02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	92%
Q1G3U6	Arabidopsis thaliana	26%	96%
Q4QIV3	Leishmania major	78%	100%
V5BT74	Trypanosoma cruzi	42%	100%