Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4T4_LEIBR

TriTrypDb:

LbrM.06.1210 , LBRM2903_060019500

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	219	221	PF00675	0.432
CLV_NRD_NRD_1	401	403	PF00675	0.611
CLV_NRD_NRD_1	525	527	PF00675	0.597
CLV_NRD_NRD_1	545	547	PF00675	0.720
CLV_NRD_NRD_1	611	613	PF00675	0.718
CLV_NRD_NRD_1	705	707	PF00675	0.662
CLV_PCSK_KEX2_1	219	221	PF00082	0.432
CLV_PCSK_KEX2_1	411	413	PF00082	0.653
CLV_PCSK_KEX2_1	525	527	PF00082	0.661
CLV_PCSK_KEX2_1	545	547	PF00082	0.720
CLV_PCSK_KEX2_1	611	613	PF00082	0.720
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.594
CLV_PCSK_SKI1_1	155	159	PF00082	0.612
CLV_PCSK_SKI1_1	163	167	PF00082	0.457
CLV_PCSK_SKI1_1	2	6	PF00082	0.655
CLV_PCSK_SKI1_1	290	294	PF00082	0.558
CLV_PCSK_SKI1_1	460	464	PF00082	0.683
CLV_PCSK_SKI1_1	477	481	PF00082	0.675
CLV_PCSK_SKI1_1	564	568	PF00082	0.718
CLV_PCSK_SKI1_1	58	62	PF00082	0.574
CLV_PCSK_SKI1_1	706	710	PF00082	0.540
CLV_PCSK_SKI1_1	742	746	PF00082	0.725
CLV_PCSK_SKI1_1	750	754	PF00082	0.645
DEG_APCC_DBOX_1	1	9	PF00400	0.508
DEG_APCC_DBOX_1	315	323	PF00400	0.680
DEG_APCC_DBOX_1	57	65	PF00400	0.433
DEG_COP1_1	386	395	PF00400	0.592
DEG_Nend_UBRbox_1	1	4	PF02207	0.666
DEG_SCF_FBW7_1	531	538	PF00400	0.690
DEG_SIAH_1	96	104	PF03145	0.538
DEG_SPOP_SBC_1	535	539	PF00917	0.786
DOC_CKS1_1	104	109	PF01111	0.645
DOC_CKS1_1	187	192	PF01111	0.603
DOC_CKS1_1	512	517	PF01111	0.591
DOC_CKS1_1	532	537	PF01111	0.691
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.569
DOC_MAPK_gen_1	270	277	PF00069	0.684
DOC_MAPK_gen_1	453	463	PF00069	0.625
DOC_MAPK_MEF2A_6	105	113	PF00069	0.538
DOC_MAPK_MEF2A_6	227	236	PF00069	0.502
DOC_MAPK_MEF2A_6	427	436	PF00069	0.573
DOC_MAPK_MEF2A_6	636	645	PF00069	0.523
DOC_PP1_RVXF_1	748	754	PF00149	0.679
DOC_PP2B_LxvP_1	367	370	PF13499	0.558
DOC_PP4_FxxP_1	390	393	PF00568	0.623
DOC_PP4_FxxP_1	517	520	PF00568	0.798
DOC_USP7_MATH_1	145	149	PF00917	0.562
DOC_USP7_MATH_1	36	40	PF00917	0.546
DOC_USP7_MATH_1	462	466	PF00917	0.731
DOC_USP7_MATH_1	485	489	PF00917	0.752
DOC_USP7_MATH_1	555	559	PF00917	0.723
DOC_USP7_MATH_1	658	662	PF00917	0.702
DOC_USP7_MATH_1	733	737	PF00917	0.754
DOC_USP7_MATH_1	746	750	PF00917	0.533
DOC_USP7_UBL2_3	703	707	PF12436	0.715
DOC_WW_Pin1_4	103	108	PF00397	0.617
DOC_WW_Pin1_4	186	191	PF00397	0.593
DOC_WW_Pin1_4	256	261	PF00397	0.473
DOC_WW_Pin1_4	291	296	PF00397	0.692
DOC_WW_Pin1_4	369	374	PF00397	0.579
DOC_WW_Pin1_4	385	390	PF00397	0.728
DOC_WW_Pin1_4	393	398	PF00397	0.787
DOC_WW_Pin1_4	511	516	PF00397	0.674
DOC_WW_Pin1_4	524	529	PF00397	0.737
DOC_WW_Pin1_4	531	536	PF00397	0.787
DOC_WW_Pin1_4	553	558	PF00397	0.704
DOC_WW_Pin1_4	615	620	PF00397	0.682
LIG_14-3-3_CanoR_1	142	150	PF00244	0.384
LIG_14-3-3_CanoR_1	163	172	PF00244	0.329
LIG_14-3-3_CanoR_1	2	11	PF00244	0.579
LIG_14-3-3_CanoR_1	219	229	PF00244	0.585
LIG_14-3-3_CanoR_1	290	295	PF00244	0.577
LIG_14-3-3_CanoR_1	316	320	PF00244	0.651
LIG_14-3-3_CanoR_1	35	43	PF00244	0.662
LIG_14-3-3_CanoR_1	377	381	PF00244	0.721
LIG_14-3-3_CanoR_1	384	389	PF00244	0.532
LIG_14-3-3_CanoR_1	44	51	PF00244	0.556
LIG_14-3-3_CanoR_1	477	485	PF00244	0.554
LIG_14-3-3_CanoR_1	518	528	PF00244	0.675
LIG_14-3-3_CanoR_1	559	566	PF00244	0.755
LIG_14-3-3_CanoR_1	590	600	PF00244	0.820
LIG_14-3-3_CanoR_1	611	620	PF00244	0.583
LIG_14-3-3_CanoR_1	630	638	PF00244	0.754
LIG_14-3-3_CanoR_1	650	658	PF00244	0.630
LIG_14-3-3_CanoR_1	740	748	PF00244	0.582
LIG_Actin_WH2_2	206	221	PF00022	0.351
LIG_APCC_ABBA_1	170	175	PF00400	0.571
LIG_BIR_III_2	394	398	PF00653	0.595
LIG_BRCT_BRCA1_1	622	626	PF00533	0.560
LIG_BRCT_BRCA1_1	748	752	PF00533	0.527
LIG_Clathr_ClatBox_1	171	175	PF01394	0.504
LIG_FHA_1	159	165	PF00498	0.647
LIG_FHA_1	166	172	PF00498	0.464
LIG_FHA_1	20	26	PF00498	0.682
LIG_FHA_1	206	212	PF00498	0.348
LIG_FHA_1	291	297	PF00498	0.549
LIG_FHA_1	545	551	PF00498	0.605
LIG_FHA_1	566	572	PF00498	0.770
LIG_FHA_1	578	584	PF00498	0.583
LIG_FHA_1	665	671	PF00498	0.592
LIG_FHA_2	142	148	PF00498	0.652
LIG_FHA_2	175	181	PF00498	0.543
LIG_FHA_2	201	207	PF00498	0.626
LIG_FHA_2	4	10	PF00498	0.635
LIG_FHA_2	536	542	PF00498	0.572
LIG_GBD_Chelix_1	150	158	PF00786	0.586
LIG_LIR_Apic_2	387	393	PF02991	0.623
LIG_LIR_Apic_2	514	520	PF02991	0.594
LIG_LIR_Gen_1	144	154	PF02991	0.509
LIG_LIR_Gen_1	208	218	PF02991	0.344
LIG_LIR_Gen_1	249	260	PF02991	0.516
LIG_LIR_Nem_3	144	149	PF02991	0.530
LIG_LIR_Nem_3	249	255	PF02991	0.498
LIG_LIR_Nem_3	302	308	PF02991	0.611
LIG_LIR_Nem_3	567	572	PF02991	0.552
LIG_LIR_Nem_3	623	629	PF02991	0.558
LIG_LIR_Nem_3	668	674	PF02991	0.665
LIG_LYPXL_S_1	670	674	PF13949	0.662
LIG_LYPXL_yS_3	671	674	PF13949	0.663
LIG_MYND_1	369	373	PF01753	0.574
LIG_NRBOX	153	159	PF00104	0.599
LIG_SH2_CRK	146	150	PF00017	0.591
LIG_SH2_CRK	266	270	PF00017	0.477
LIG_SH2_CRK	512	516	PF00017	0.590
LIG_SH2_NCK_1	512	516	PF00017	0.590
LIG_SH2_STAP1	146	150	PF00017	0.489
LIG_SH2_STAT5	324	327	PF00017	0.710
LIG_SH3_1	505	511	PF00018	0.565
LIG_SH3_1	76	82	PF00018	0.674
LIG_SH3_2	422	427	PF14604	0.581
LIG_SH3_3	101	107	PF00018	0.694
LIG_SH3_3	121	127	PF00018	0.708
LIG_SH3_3	184	190	PF00018	0.703
LIG_SH3_3	223	229	PF00018	0.557
LIG_SH3_3	363	369	PF00018	0.662
LIG_SH3_3	419	425	PF00018	0.728
LIG_SH3_3	500	506	PF00018	0.804
LIG_SH3_3	616	622	PF00018	0.551
LIG_SH3_3	76	82	PF00018	0.547
LIG_SUMO_SIM_anti_2	642	647	PF11976	0.511
LIG_SUMO_SIM_par_1	108	116	PF11976	0.539
LIG_SUMO_SIM_par_1	499	504	PF11976	0.544
LIG_TRAF2_1	373	376	PF00917	0.803
MOD_CDC14_SPxK_1	556	559	PF00782	0.677
MOD_CDK_SPK_2	393	398	PF00069	0.686
MOD_CDK_SPxK_1	186	192	PF00069	0.462
MOD_CDK_SPxK_1	385	391	PF00069	0.756
MOD_CDK_SPxK_1	553	559	PF00069	0.682
MOD_CDK_SPxxK_3	291	298	PF00069	0.613
MOD_CDK_SPxxK_3	511	518	PF00069	0.590
MOD_CK1_1	112	118	PF00069	0.705
MOD_CK1_1	13	19	PF00069	0.695
MOD_CK1_1	137	143	PF00069	0.607
MOD_CK1_1	245	251	PF00069	0.542
MOD_CK1_1	259	265	PF00069	0.443
MOD_CK1_1	294	300	PF00069	0.623
MOD_CK1_1	315	321	PF00069	0.683
MOD_CK1_1	527	533	PF00069	0.769
MOD_CK1_1	615	621	PF00069	0.705
MOD_CK1_1	736	742	PF00069	0.569
MOD_CK2_1	218	224	PF00069	0.636
MOD_CK2_1	3	9	PF00069	0.599
MOD_CK2_1	334	340	PF00069	0.706
MOD_CK2_1	461	467	PF00069	0.778
MOD_CK2_1	501	507	PF00069	0.772
MOD_CK2_1	604	610	PF00069	0.629
MOD_CK2_1	636	642	PF00069	0.648
MOD_CK2_1	693	699	PF00069	0.655
MOD_Cter_Amidation	409	412	PF01082	0.593
MOD_GlcNHglycan	115	118	PF01048	0.580
MOD_GlcNHglycan	15	18	PF01048	0.528
MOD_GlcNHglycan	158	161	PF01048	0.631
MOD_GlcNHglycan	194	197	PF01048	0.529
MOD_GlcNHglycan	256	259	PF01048	0.587
MOD_GlcNHglycan	298	301	PF01048	0.604
MOD_GlcNHglycan	335	339	PF01048	0.571
MOD_GlcNHglycan	38	41	PF01048	0.557
MOD_GlcNHglycan	46	49	PF01048	0.659
MOD_GlcNHglycan	464	467	PF01048	0.636
MOD_GlcNHglycan	480	483	PF01048	0.576
MOD_GlcNHglycan	561	564	PF01048	0.567
MOD_GlcNHglycan	593	596	PF01048	0.681
MOD_GlcNHglycan	614	617	PF01048	0.780
MOD_GlcNHglycan	633	636	PF01048	0.636
MOD_GlcNHglycan	638	641	PF01048	0.691
MOD_GlcNHglycan	709	712	PF01048	0.530
MOD_GlcNHglycan	742	745	PF01048	0.751
MOD_GSK3_1	105	112	PF00069	0.776
MOD_GSK3_1	116	123	PF00069	0.606
MOD_GSK3_1	13	20	PF00069	0.677
MOD_GSK3_1	137	144	PF00069	0.601
MOD_GSK3_1	214	221	PF00069	0.527
MOD_GSK3_1	242	249	PF00069	0.510
MOD_GSK3_1	290	297	PF00069	0.685
MOD_GSK3_1	308	315	PF00069	0.536
MOD_GSK3_1	527	534	PF00069	0.842
MOD_GSK3_1	536	543	PF00069	0.731
MOD_GSK3_1	549	556	PF00069	0.749
MOD_GSK3_1	572	579	PF00069	0.717
MOD_GSK3_1	614	621	PF00069	0.634
MOD_GSK3_1	65	72	PF00069	0.452
MOD_GSK3_1	736	743	PF00069	0.602
MOD_N-GLC_1	11	16	PF02516	0.716
MOD_N-GLC_1	44	49	PF02516	0.730
MOD_NEK2_1	11	16	PF00069	0.609
MOD_NEK2_1	113	118	PF00069	0.698
MOD_NEK2_1	213	218	PF00069	0.559
MOD_NEK2_1	296	301	PF00069	0.651
MOD_NEK2_1	3	8	PF00069	0.619
MOD_NEK2_1	308	313	PF00069	0.537
MOD_NEK2_1	334	339	PF00069	0.704
MOD_NEK2_1	461	466	PF00069	0.527
MOD_NEK2_1	540	545	PF00069	0.755
MOD_NEK2_1	614	619	PF00069	0.544
MOD_NEK2_1	693	698	PF00069	0.758
MOD_NEK2_1	725	730	PF00069	0.591
MOD_NEK2_1	90	95	PF00069	0.449
MOD_NEK2_2	214	219	PF00069	0.601
MOD_PIKK_1	371	377	PF00454	0.592
MOD_PIKK_1	65	71	PF00454	0.576
MOD_PIKK_1	650	656	PF00454	0.671
MOD_PKA_1	219	225	PF00069	0.388
MOD_PKA_2	141	147	PF00069	0.555
MOD_PKA_2	218	224	PF00069	0.500
MOD_PKA_2	315	321	PF00069	0.683
MOD_PKA_2	376	382	PF00069	0.732
MOD_PKA_2	383	389	PF00069	0.565
MOD_PKA_2	544	550	PF00069	0.692
MOD_PKA_2	602	608	PF00069	0.671
MOD_PKB_1	648	656	PF00069	0.561
MOD_Plk_1	17	23	PF00069	0.533
MOD_Plk_1	214	220	PF00069	0.609
MOD_Plk_1	535	541	PF00069	0.571
MOD_Plk_2-3	536	542	PF00069	0.572
MOD_Plk_4	145	151	PF00069	0.496
MOD_Plk_4	246	252	PF00069	0.509
MOD_Plk_4	315	321	PF00069	0.544
MOD_Plk_4	348	354	PF00069	0.706
MOD_Plk_4	527	533	PF00069	0.581
MOD_ProDKin_1	103	109	PF00069	0.612
MOD_ProDKin_1	186	192	PF00069	0.598
MOD_ProDKin_1	256	262	PF00069	0.472
MOD_ProDKin_1	291	297	PF00069	0.691
MOD_ProDKin_1	369	375	PF00069	0.580
MOD_ProDKin_1	385	391	PF00069	0.731
MOD_ProDKin_1	393	399	PF00069	0.787
MOD_ProDKin_1	511	517	PF00069	0.675
MOD_ProDKin_1	524	530	PF00069	0.738
MOD_ProDKin_1	531	537	PF00069	0.787
MOD_ProDKin_1	553	559	PF00069	0.705
MOD_ProDKin_1	615	621	PF00069	0.683
MOD_SUMO_for_1	452	455	PF00179	0.502
TRG_DiLeu_BaEn_1	683	688	PF01217	0.751
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.788
TRG_ENDOCYTIC_2	146	149	PF00928	0.495
TRG_ENDOCYTIC_2	266	269	PF00928	0.518
TRG_ENDOCYTIC_2	671	674	PF00928	0.663
TRG_ER_diArg_1	218	220	PF00400	0.380
TRG_ER_diArg_1	269	272	PF00400	0.699
TRG_ER_diArg_1	442	445	PF00400	0.565
TRG_ER_diArg_1	524	526	PF00400	0.592
TRG_ER_diArg_1	544	546	PF00400	0.824
TRG_ER_diArg_1	648	651	PF00400	0.688
TRG_ER_diArg_1	694	697	PF00400	0.680
TRG_NES_CRM1_1	273	285	PF08389	0.511
TRG_NES_CRM1_1	668	683	PF08389	0.753
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWN9	Leptomonas seymouri	32%	97%
A0A3S7WPP9	Leishmania donovani	57%	95%
A4HT13	Leishmania infantum	57%	95%
E9AL01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	95%
Q4QIV4	Leishmania major	58%	100%