Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H4T3_LEIBR

TriTrypDb:

LbrM.06.1200 , LBRM2903_060019400

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4T3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.437
CLV_C14_Caspase3-7	408	412	PF00656	0.467
CLV_C14_Caspase3-7	546	550	PF00656	0.625
CLV_NRD_NRD_1	125	127	PF00675	0.576
CLV_NRD_NRD_1	238	240	PF00675	0.482
CLV_NRD_NRD_1	387	389	PF00675	0.657
CLV_NRD_NRD_1	457	459	PF00675	0.471
CLV_NRD_NRD_1	502	504	PF00675	0.466
CLV_PCSK_FUR_1	500	504	PF00082	0.468
CLV_PCSK_KEX2_1	125	127	PF00082	0.576
CLV_PCSK_KEX2_1	238	240	PF00082	0.482
CLV_PCSK_KEX2_1	260	262	PF00082	0.340
CLV_PCSK_KEX2_1	387	389	PF00082	0.633
CLV_PCSK_KEX2_1	457	459	PF00082	0.558
CLV_PCSK_KEX2_1	502	504	PF00082	0.466
CLV_PCSK_KEX2_1	568	570	PF00082	0.598
CLV_PCSK_KEX2_1	572	574	PF00082	0.640
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.340
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.603
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.603
CLV_PCSK_SKI1_1	217	221	PF00082	0.345
CLV_PCSK_SKI1_1	390	394	PF00082	0.627
CLV_PCSK_SKI1_1	451	455	PF00082	0.532
CLV_PCSK_SKI1_1	541	545	PF00082	0.639
CLV_PCSK_SKI1_1	569	573	PF00082	0.602
CLV_PCSK_SKI1_1	74	78	PF00082	0.612
DEG_Nend_UBRbox_4	1	3	PF02207	0.486
DEG_SCF_FBW7_1	165	171	PF00400	0.436
DEG_SPOP_SBC_1	37	41	PF00917	0.656
DEG_SPOP_SBC_1	81	85	PF00917	0.482
DOC_CDC14_PxL_1	560	568	PF14671	0.607
DOC_CKS1_1	110	115	PF01111	0.583
DOC_CKS1_1	165	170	PF01111	0.439
DOC_CKS1_1	346	351	PF01111	0.630
DOC_MAPK_gen_1	238	246	PF00069	0.546
DOC_MAPK_gen_1	260	267	PF00069	0.336
DOC_MAPK_gen_1	500	507	PF00069	0.550
DOC_MAPK_MEF2A_6	238	246	PF00069	0.546
DOC_PP1_RVXF_1	55	61	PF00149	0.630
DOC_PP2B_LxvP_1	397	400	PF13499	0.422
DOC_PP2B_LxvP_1	505	508	PF13499	0.470
DOC_USP7_MATH_1	168	172	PF00917	0.460
DOC_USP7_MATH_1	288	292	PF00917	0.573
DOC_USP7_MATH_1	342	346	PF00917	0.633
DOC_USP7_MATH_1	37	41	PF00917	0.592
DOC_USP7_MATH_1	423	427	PF00917	0.604
DOC_USP7_MATH_1	98	102	PF00917	0.537
DOC_USP7_UBL2_3	376	380	PF12436	0.414
DOC_USP7_UBL2_3	568	572	PF12436	0.522
DOC_WW_Pin1_4	109	114	PF00397	0.659
DOC_WW_Pin1_4	164	169	PF00397	0.527
DOC_WW_Pin1_4	279	284	PF00397	0.510
DOC_WW_Pin1_4	345	350	PF00397	0.569
DOC_WW_Pin1_4	82	87	PF00397	0.504
LIG_14-3-3_CanoR_1	172	176	PF00244	0.383
LIG_14-3-3_CanoR_1	238	246	PF00244	0.397
LIG_14-3-3_CanoR_1	295	301	PF00244	0.553
LIG_14-3-3_CanoR_1	404	414	PF00244	0.644
LIG_14-3-3_CanoR_1	466	472	PF00244	0.642
LIG_14-3-3_CanoR_1	516	523	PF00244	0.544
LIG_14-3-3_CanoR_1	57	65	PF00244	0.630
LIG_14-3-3_CanoR_1	578	582	PF00244	0.675
LIG_APCC_ABBA_1	155	160	PF00400	0.443
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.509
LIG_APCC_ABBAyCdc20_2	323	329	PF00400	0.548
LIG_BIR_III_4	317	321	PF00653	0.464
LIG_BRCT_BRCA1_1	361	365	PF00533	0.542
LIG_BRCT_BRCA1_1	533	537	PF00533	0.675
LIG_Clathr_ClatBox_1	105	109	PF01394	0.667
LIG_FAT_LD_1	332	340	PF03623	0.475
LIG_FHA_1	28	34	PF00498	0.585
LIG_FHA_1	300	306	PF00498	0.608
LIG_FHA_1	369	375	PF00498	0.650
LIG_FHA_1	413	419	PF00498	0.486
LIG_FHA_1	42	48	PF00498	0.590
LIG_FHA_1	431	437	PF00498	0.541
LIG_FHA_1	549	555	PF00498	0.728
LIG_FHA_1	565	571	PF00498	0.502
LIG_FHA_1	82	88	PF00498	0.639
LIG_FHA_2	346	352	PF00498	0.505
LIG_FHA_2	44	50	PF00498	0.499
LIG_FHA_2	524	530	PF00498	0.541
LIG_LIR_Apic_2	144	150	PF02991	0.583
LIG_LIR_Gen_1	173	183	PF02991	0.352
LIG_LIR_Gen_1	308	319	PF02991	0.395
LIG_LIR_Gen_1	534	545	PF02991	0.667
LIG_LIR_LC3C_4	272	277	PF02991	0.423
LIG_LIR_Nem_3	173	179	PF02991	0.552
LIG_LIR_Nem_3	218	223	PF02991	0.492
LIG_LIR_Nem_3	308	314	PF02991	0.367
LIG_LIR_Nem_3	534	540	PF02991	0.670
LIG_LIR_Nem_3	557	563	PF02991	0.608
LIG_LYPXL_yS_3	563	566	PF13949	0.608
LIG_MLH1_MIPbox_1	361	365	PF16413	0.542
LIG_NRBOX	331	337	PF00104	0.474
LIG_PCNA_yPIPBox_3	145	155	PF02747	0.415
LIG_PCNA_yPIPBox_3	387	396	PF02747	0.582
LIG_Pex14_2	203	207	PF04695	0.523
LIG_SH2_CRK	147	151	PF00017	0.586
LIG_SH2_NCK_1	327	331	PF00017	0.510
LIG_SH2_SRC	327	330	PF00017	0.515
LIG_SH2_STAP1	215	219	PF00017	0.505
LIG_SH2_STAP1	327	331	PF00017	0.510
LIG_SH2_STAT3	107	110	PF00017	0.608
LIG_SH2_STAT3	26	29	PF00017	0.519
LIG_SH2_STAT5	107	110	PF00017	0.668
LIG_SH2_STAT5	223	226	PF00017	0.518
LIG_SH2_STAT5	258	261	PF00017	0.480
LIG_SH2_STAT5	278	281	PF00017	0.296
LIG_SH2_STAT5	59	62	PF00017	0.559
LIG_SH2_STAT5	75	78	PF00017	0.632
LIG_SH3_1	280	286	PF00018	0.379
LIG_SH3_3	162	168	PF00018	0.465
LIG_SH3_3	280	286	PF00018	0.379
LIG_SH3_3	466	472	PF00018	0.666
LIG_SH3_3	92	98	PF00018	0.581
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.468
LIG_SUMO_SIM_par_1	14	21	PF11976	0.468
LIG_UBA3_1	536	544	PF00899	0.644
LIG_WRC_WIRS_1	204	209	PF05994	0.553
LIG_WRC_WIRS_1	540	545	PF05994	0.506
LIG_WW_3	471	475	PF00397	0.541
MOD_CDC14_SPxK_1	117	120	PF00782	0.528
MOD_CDK_SPK_2	279	284	PF00069	0.356
MOD_CDK_SPxK_1	114	120	PF00069	0.529
MOD_CDK_SPxxK_3	82	89	PF00069	0.486
MOD_CK1_1	114	120	PF00069	0.636
MOD_CK1_1	171	177	PF00069	0.557
MOD_CK1_1	282	288	PF00069	0.548
MOD_CK1_1	345	351	PF00069	0.697
MOD_CK1_1	36	42	PF00069	0.665
MOD_CK1_1	403	409	PF00069	0.700
MOD_CK1_1	493	499	PF00069	0.563
MOD_CK1_1	518	524	PF00069	0.644
MOD_CK1_1	539	545	PF00069	0.574
MOD_CK1_1	577	583	PF00069	0.647
MOD_CK2_1	345	351	PF00069	0.519
MOD_CK2_1	523	529	PF00069	0.565
MOD_GlcNHglycan	113	116	PF01048	0.552
MOD_GlcNHglycan	133	136	PF01048	0.632
MOD_GlcNHglycan	162	165	PF01048	0.518
MOD_GlcNHglycan	210	214	PF01048	0.543
MOD_GlcNHglycan	239	242	PF01048	0.445
MOD_GlcNHglycan	296	299	PF01048	0.577
MOD_GlcNHglycan	35	38	PF01048	0.700
MOD_GlcNHglycan	361	364	PF01048	0.553
MOD_GlcNHglycan	407	410	PF01048	0.618
MOD_GlcNHglycan	420	424	PF01048	0.503
MOD_GlcNHglycan	469	472	PF01048	0.650
MOD_GlcNHglycan	484	487	PF01048	0.506
MOD_GlcNHglycan	492	495	PF01048	0.567
MOD_GlcNHglycan	533	536	PF01048	0.589
MOD_GSK3_1	131	138	PF00069	0.662
MOD_GSK3_1	160	167	PF00069	0.609
MOD_GSK3_1	209	216	PF00069	0.494
MOD_GSK3_1	29	36	PF00069	0.662
MOD_GSK3_1	37	44	PF00069	0.623
MOD_GSK3_1	400	407	PF00069	0.587
MOD_GSK3_1	419	426	PF00069	0.460
MOD_GSK3_1	478	485	PF00069	0.566
MOD_GSK3_1	515	522	PF00069	0.650
MOD_GSK3_1	544	551	PF00069	0.632
MOD_LATS_1	402	408	PF00433	0.480
MOD_N-GLC_1	523	528	PF02516	0.549
MOD_NEK2_1	178	183	PF00069	0.474
MOD_NEK2_1	18	23	PF00069	0.478
MOD_NEK2_1	294	299	PF00069	0.569
MOD_NEK2_1	305	310	PF00069	0.404
MOD_NEK2_1	370	375	PF00069	0.548
MOD_NEK2_1	405	410	PF00069	0.630
MOD_NEK2_1	419	424	PF00069	0.477
MOD_NEK2_1	442	447	PF00069	0.604
MOD_NEK2_1	523	528	PF00069	0.640
MOD_NEK2_1	531	536	PF00069	0.589
MOD_NEK2_1	548	553	PF00069	0.520
MOD_NEK2_2	98	103	PF00069	0.489
MOD_PIKK_1	523	529	PF00454	0.620
MOD_PKA_2	171	177	PF00069	0.393
MOD_PKA_2	237	243	PF00069	0.434
MOD_PKA_2	294	300	PF00069	0.592
MOD_PKA_2	403	409	PF00069	0.645
MOD_PKA_2	515	521	PF00069	0.578
MOD_PKA_2	577	583	PF00069	0.644
MOD_Plk_1	209	215	PF00069	0.444
MOD_Plk_1	337	343	PF00069	0.494
MOD_Plk_2-3	549	555	PF00069	0.516
MOD_Plk_4	171	177	PF00069	0.463
MOD_Plk_4	178	184	PF00069	0.422
MOD_Plk_4	381	387	PF00069	0.479
MOD_Plk_4	493	499	PF00069	0.473
MOD_Plk_4	549	555	PF00069	0.597
MOD_ProDKin_1	109	115	PF00069	0.661
MOD_ProDKin_1	164	170	PF00069	0.519
MOD_ProDKin_1	279	285	PF00069	0.519
MOD_ProDKin_1	345	351	PF00069	0.568
MOD_ProDKin_1	82	88	PF00069	0.502
MOD_SUMO_for_1	76	79	PF00179	0.601
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.641
TRG_ENDOCYTIC_2	563	566	PF00928	0.608
TRG_ENDOCYTIC_2	75	78	PF00928	0.674
TRG_ER_diArg_1	386	388	PF00400	0.723
TRG_ER_diArg_1	457	460	PF00400	0.470
TRG_ER_diArg_1	500	503	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.604
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.730

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF5	Leptomonas seymouri	34%	100%
A0A3S7WPN2	Leishmania donovani	69%	99%
A4HT12	Leishmania infantum	69%	99%
E9AL00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QIV5	Leishmania major	66%	100%