Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4H4T0_LEIBR

TriTrypDb:

LbrM.06.1170 , LBRM2903_060019100

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 3
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H4T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4T0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	4
GO:0003824	catalytic activity	1	6
GO:0016853	isomerase activity	2	6
GO:0016860	intramolecular oxidoreductase activity	3	4
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	89	93	PF00082	0.314
DEG_Nend_UBRbox_1	1	4	PF02207	0.525
DEG_SCF_FBW7_1	118	125	PF00400	0.200
DOC_CKS1_1	119	124	PF01111	0.371
DOC_MAPK_gen_1	67	75	PF00069	0.350
DOC_PP4_FxxP_1	119	122	PF00568	0.371
DOC_USP7_MATH_1	48	52	PF00917	0.319
DOC_WW_Pin1_4	1	6	PF00397	0.369
DOC_WW_Pin1_4	118	123	PF00397	0.330
LIG_14-3-3_CanoR_1	67	73	PF00244	0.281
LIG_14-3-3_CanoR_1	78	88	PF00244	0.352
LIG_BRCT_BRCA1_1	140	144	PF00533	0.257
LIG_FHA_1	123	129	PF00498	0.344
LIG_FHA_1	55	61	PF00498	0.323
LIG_FHA_2	29	35	PF00498	0.538
LIG_IRF3_LxIS_1	75	82	PF10401	0.275
LIG_LIR_Apic_2	116	122	PF02991	0.384
LIG_LIR_Apic_2	129	133	PF02991	0.427
LIG_LIR_Gen_1	53	63	PF02991	0.292
LIG_LIR_Nem_3	100	105	PF02991	0.333
LIG_LIR_Nem_3	53	59	PF02991	0.230
LIG_LYPXL_yS_3	102	105	PF13949	0.261
LIG_Pex14_2	142	146	PF04695	0.422
LIG_SH2_CRK	120	124	PF00017	0.307
LIG_SH2_CRK	130	134	PF00017	0.224
LIG_SH2_CRK	56	60	PF00017	0.250
LIG_SH2_SRC	96	99	PF00017	0.371
LIG_SH2_STAP1	56	60	PF00017	0.250
LIG_SH2_STAT5	120	123	PF00017	0.308
LIG_SH2_STAT5	137	140	PF00017	0.331
LIG_SH2_STAT5	56	59	PF00017	0.324
LIG_SH2_STAT5	61	64	PF00017	0.152
LIG_SH2_STAT5	96	99	PF00017	0.371
LIG_SUMO_SIM_par_1	36	42	PF11976	0.312
LIG_TYR_ITIM	118	123	PF00017	0.343
LIG_WRC_WIRS_1	139	144	PF05994	0.238
MOD_CK2_1	28	34	PF00069	0.513
MOD_CK2_1	81	87	PF00069	0.383
MOD_GlcNHglycan	50	53	PF01048	0.150
MOD_GSK3_1	118	125	PF00069	0.319
MOD_GSK3_1	50	57	PF00069	0.275
MOD_GSK3_1	77	84	PF00069	0.332
MOD_NEK2_1	138	143	PF00069	0.272
MOD_NEK2_1	79	84	PF00069	0.258
MOD_PIKK_1	79	85	PF00454	0.233
MOD_PKA_2	42	48	PF00069	0.341
MOD_PKA_2	77	83	PF00069	0.321
MOD_Plk_1	33	39	PF00069	0.411
MOD_Plk_4	10	16	PF00069	0.414
MOD_Plk_4	113	119	PF00069	0.284
MOD_Plk_4	138	144	PF00069	0.251
MOD_Plk_4	54	60	PF00069	0.275
MOD_Plk_4	68	74	PF00069	0.399
MOD_ProDKin_1	1	7	PF00069	0.366
MOD_ProDKin_1	118	124	PF00069	0.330
TRG_ENDOCYTIC_2	102	105	PF00928	0.331
TRG_ENDOCYTIC_2	120	123	PF00928	0.306
TRG_ENDOCYTIC_2	56	59	PF00928	0.304
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.150

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I216	Leptomonas seymouri	61%	100%
A0A0N1I5T9	Leptomonas seymouri	31%	100%
A0A0N1IJS7	Leptomonas seymouri	27%	90%
A0A0S4JA26	Bodo saltans	29%	89%
A0A1X0NGQ4	Trypanosomatidae	53%	99%
A0A3R7NHA8	Trypanosoma rangeli	35%	80%
A0A3S5H5U6	Leishmania donovani	83%	70%
A0A422NM49	Trypanosoma rangeli	46%	99%
A4H4R8	Leishmania braziliensis	28%	100%
A4HSZ7	Leishmania infantum	29%	100%
A4HT10	Leishmania infantum	83%	100%
C9ZTP4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AKY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AKZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q10N04	Oryza sativa subsp. japonica	29%	100%
Q4QIV7	Leishmania major	79%	100%
Q4QIX1	Leishmania major	29%	100%
Q8GYD1	Arabidopsis thaliana	31%	100%
Q8I7Z7	Leishmania donovani	29%	100%