Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nuclear Dbf2-related kinase

Species:

Leishmania braziliensis

UniProt:

A4H4S9_LEIBR

TriTrypDb:

LbrM.06.1160 , LBRM2903_060019000

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.410
CLV_C14_Caspase3-7	255	259	PF00656	0.325
CLV_C14_Caspase3-7	267	271	PF00656	0.155
CLV_NRD_NRD_1	104	106	PF00675	0.323
CLV_NRD_NRD_1	20	22	PF00675	0.678
CLV_NRD_NRD_1	298	300	PF00675	0.378
CLV_NRD_NRD_1	51	53	PF00675	0.564
CLV_PCSK_KEX2_1	102	104	PF00082	0.257
CLV_PCSK_KEX2_1	20	22	PF00082	0.688
CLV_PCSK_KEX2_1	221	223	PF00082	0.252
CLV_PCSK_KEX2_1	226	228	PF00082	0.252
CLV_PCSK_KEX2_1	361	363	PF00082	0.296
CLV_PCSK_KEX2_1	369	371	PF00082	0.296
CLV_PCSK_KEX2_1	51	53	PF00082	0.564
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.257
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.252
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.252
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.331
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.331
CLV_PCSK_PC7_1	222	228	PF00082	0.384
CLV_PCSK_SKI1_1	122	126	PF00082	0.310
CLV_PCSK_SKI1_1	167	171	PF00082	0.384
CLV_PCSK_SKI1_1	197	201	PF00082	0.252
CLV_PCSK_SKI1_1	279	283	PF00082	0.286
CLV_PCSK_SKI1_1	369	373	PF00082	0.376
CLV_PCSK_SKI1_1	79	83	PF00082	0.266
DEG_Nend_UBRbox_3	1	3	PF02207	0.734
DEG_SPOP_SBC_1	237	241	PF00917	0.389
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.460
DOC_MAPK_gen_1	102	111	PF00069	0.310
DOC_MAPK_gen_1	112	118	PF00069	0.287
DOC_MAPK_gen_1	197	206	PF00069	0.252
DOC_MAPK_gen_1	338	346	PF00069	0.357
DOC_PP1_RVXF_1	432	439	PF00149	0.428
DOC_PP2B_LxvP_1	393	396	PF13499	0.467
DOC_SPAK_OSR1_1	176	180	PF12202	0.258
DOC_USP7_MATH_1	128	132	PF00917	0.325
DOC_USP7_MATH_1	185	189	PF00917	0.269
DOC_USP7_MATH_1	237	241	PF00917	0.297
DOC_USP7_MATH_1	33	37	PF00917	0.432
DOC_USP7_MATH_2	260	266	PF00917	0.175
DOC_USP7_UBL2_3	102	106	PF12436	0.252
DOC_WW_Pin1_4	1	6	PF00397	0.635
DOC_WW_Pin1_4	285	290	PF00397	0.252
LIG_14-3-3_CanoR_1	103	111	PF00244	0.315
LIG_14-3-3_CanoR_1	299	303	PF00244	0.175
LIG_14-3-3_CanoR_1	370	374	PF00244	0.403
LIG_APCC_ABBAyCdc20_2	434	440	PF00400	0.430
LIG_BIR_III_2	258	262	PF00653	0.262
LIG_BRCT_BRCA1_1	173	177	PF00533	0.271
LIG_BRCT_BRCA1_1	219	223	PF00533	0.271
LIG_BRCT_BRCA1_1	35	39	PF00533	0.493
LIG_CtBP_PxDLS_1	261	265	PF00389	0.175
LIG_FHA_1	93	99	PF00498	0.359
LIG_FHA_2	22	28	PF00498	0.655
LIG_FHA_2	370	376	PF00498	0.384
LIG_LIR_Apic_2	288	294	PF02991	0.252
LIG_LIR_Apic_2	317	323	PF02991	0.252
LIG_LIR_Gen_1	144	155	PF02991	0.271
LIG_LIR_Gen_1	372	381	PF02991	0.277
LIG_LIR_Gen_1	41	49	PF02991	0.591
LIG_LIR_Gen_1	65	74	PF02991	0.362
LIG_LIR_Nem_3	307	311	PF02991	0.254
LIG_LIR_Nem_3	372	376	PF02991	0.252
LIG_LIR_Nem_3	407	413	PF02991	0.383
LIG_LIR_Nem_3	41	47	PF02991	0.532
LIG_LIR_Nem_3	65	71	PF02991	0.365
LIG_Pex14_2	82	86	PF04695	0.331
LIG_PTAP_UEV_1	415	420	PF05743	0.528
LIG_RPA_C_Fungi	47	59	PF08784	0.429
LIG_SH2_CRK	320	324	PF00017	0.252
LIG_SH2_CRK	44	48	PF00017	0.530
LIG_SH2_PTP2	291	294	PF00017	0.252
LIG_SH2_PTP2	397	400	PF00017	0.254
LIG_SH2_SRC	373	376	PF00017	0.325
LIG_SH2_SRC	397	400	PF00017	0.404
LIG_SH2_STAP1	316	320	PF00017	0.252
LIG_SH2_STAT3	233	236	PF00017	0.271
LIG_SH2_STAT5	147	150	PF00017	0.287
LIG_SH2_STAT5	178	181	PF00017	0.265
LIG_SH2_STAT5	291	294	PF00017	0.269
LIG_SH2_STAT5	397	400	PF00017	0.422
LIG_SH2_STAT5	409	412	PF00017	0.363
LIG_SH3_3	283	289	PF00018	0.252
LIG_SH3_3	393	399	PF00018	0.460
LIG_SH3_3	413	419	PF00018	0.327
LIG_TRAF2_1	372	375	PF00917	0.175
LIG_TYR_ITIM	314	319	PF00017	0.252
LIG_UBA3_1	160	167	PF00899	0.252
LIG_WRC_WIRS_1	139	144	PF05994	0.296
MOD_CK1_1	238	244	PF00069	0.371
MOD_CK1_1	265	271	PF00069	0.296
MOD_CK1_1	92	98	PF00069	0.325
MOD_CK2_1	238	244	PF00069	0.322
MOD_CK2_1	369	375	PF00069	0.325
MOD_GlcNHglycan	208	211	PF01048	0.391
MOD_GlcNHglycan	240	243	PF01048	0.315
MOD_GlcNHglycan	264	267	PF01048	0.359
MOD_GlcNHglycan	415	419	PF01048	0.615
MOD_GlcNHglycan	445	448	PF01048	0.524
MOD_GlcNHglycan	449	452	PF01048	0.563
MOD_GSK3_1	244	251	PF00069	0.300
MOD_GSK3_1	281	288	PF00069	0.282
MOD_GSK3_1	443	450	PF00069	0.468
MOD_N-GLC_1	1	6	PF02516	0.539
MOD_N-GLC_1	14	19	PF02516	0.587
MOD_N-GLC_1	330	335	PF02516	0.296
MOD_N-GLC_1	443	448	PF02516	0.555
MOD_NEK2_1	138	143	PF00069	0.252
MOD_NEK2_1	206	211	PF00069	0.357
MOD_NEK2_1	217	222	PF00069	0.257
MOD_NEK2_1	252	257	PF00069	0.349
MOD_NEK2_1	281	286	PF00069	0.287
MOD_NEK2_1	298	303	PF00069	0.281
MOD_NEK2_1	443	448	PF00069	0.441
MOD_NEK2_2	185	190	PF00069	0.252
MOD_NEK2_2	330	335	PF00069	0.263
MOD_PIKK_1	324	330	PF00454	0.384
MOD_PKA_1	369	375	PF00069	0.325
MOD_PKA_2	104	110	PF00069	0.271
MOD_PKA_2	298	304	PF00069	0.175
MOD_PKA_2	369	375	PF00069	0.403
MOD_Plk_1	172	178	PF00069	0.268
MOD_Plk_1	248	254	PF00069	0.324
MOD_Plk_2-3	244	250	PF00069	0.318
MOD_Plk_4	281	287	PF00069	0.269
MOD_Plk_4	43	49	PF00069	0.531
MOD_Plk_4	94	100	PF00069	0.325
MOD_ProDKin_1	1	7	PF00069	0.636
MOD_ProDKin_1	285	291	PF00069	0.252
MOD_SUMO_rev_2	402	410	PF00179	0.469
MOD_SUMO_rev_2	423	428	PF00179	0.492
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.331
TRG_ENDOCYTIC_2	139	142	PF00928	0.277
TRG_ENDOCYTIC_2	147	150	PF00928	0.228
TRG_ENDOCYTIC_2	316	319	PF00928	0.252
TRG_ENDOCYTIC_2	373	376	PF00928	0.384
TRG_ENDOCYTIC_2	397	400	PF00928	0.429
TRG_ENDOCYTIC_2	44	47	PF00928	0.460
TRG_NLS_MonoExtC_3	101	106	PF00514	0.252
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	26%	100%
A0A0N0P3Q8	Leptomonas seymouri	25%	100%
A0A0N0P4J7	Leptomonas seymouri	77%	100%
A0A0N0P787	Leptomonas seymouri	26%	100%
A0A0N0P8H5	Leptomonas seymouri	30%	100%
A0A0N0P953	Leptomonas seymouri	26%	95%
A0A0N1I1M7	Leptomonas seymouri	27%	71%
A0A0N1IM47	Leptomonas seymouri	22%	100%
A0A0N1IMD1	Leptomonas seymouri	27%	73%
A0A0N1PBE9	Leptomonas seymouri	24%	90%
A0A0N1PC31	Leptomonas seymouri	29%	100%
A0A0N1PDW7	Leptomonas seymouri	26%	100%
A0A0N1PEV2	Leptomonas seymouri	25%	84%
A0A0N1PEW4	Leptomonas seymouri	23%	74%
A0A0S4IQ75	Bodo saltans	24%	90%
A0A0S4IRZ7	Bodo saltans	24%	92%
A0A0S4ISS4	Bodo saltans	25%	100%
A0A0S4IX25	Bodo saltans	26%	70%
A0A0S4IX86	Bodo saltans	25%	100%
A0A0S4J4B3	Bodo saltans	27%	100%
A0A0S4J575	Bodo saltans	23%	73%
A0A0S4J6L4	Bodo saltans	30%	100%
A0A0S4J7K4	Bodo saltans	24%	94%
A0A0S4J7Q1	Bodo saltans	23%	76%
A0A0S4J804	Bodo saltans	25%	87%
A0A0S4J842	Bodo saltans	25%	85%
A0A0S4J9Q7	Bodo saltans	24%	100%
A0A0S4JA09	Bodo saltans	26%	100%
A0A0S4JBR3	Bodo saltans	26%	100%
A0A0S4JCG2	Bodo saltans	27%	100%
A0A0S4JCK1	Bodo saltans	51%	97%
A0A0S4JER5	Bodo saltans	29%	100%
A0A0S4JI45	Bodo saltans	25%	70%
A0A0S4JI67	Bodo saltans	39%	100%
A0A0S4JIY0	Bodo saltans	26%	70%
A0A0S4JN19	Bodo saltans	24%	74%
A0A0S4JPZ1	Bodo saltans	23%	100%
A0A0S4JPZ7	Bodo saltans	25%	100%
A0A0S4JQA2	Bodo saltans	26%	77%
A0A0S4JTJ8	Bodo saltans	27%	100%
A0A0S4JWD5	Bodo saltans	26%	100%
A0A0S4KFT7	Bodo saltans	29%	100%
A0A0S4KHR9	Bodo saltans	24%	100%
A0A0S4KMV7	Bodo saltans	23%	100%
A0A1X0NIX2	Trypanosomatidae	23%	100%
A0A1X0NJV4	Trypanosomatidae	26%	89%
A0A1X0NM94	Trypanosomatidae	25%	90%
A0A1X0NRF6	Trypanosomatidae	25%	83%
A0A1X0NTP1	Trypanosomatidae	28%	78%
A0A1X0NUQ4	Trypanosomatidae	26%	100%
A0A1X0NW24	Trypanosomatidae	24%	100%
A0A1X0NY93	Trypanosomatidae	27%	100%
A0A1X0NYK8	Trypanosomatidae	23%	100%
A0A1X0P020	Trypanosomatidae	24%	100%
A0A1X0P022	Trypanosomatidae	26%	71%
A0A1X0P0R3	Trypanosomatidae	26%	75%
A0A1X0P150	Trypanosomatidae	27%	73%
A0A1X0P1A2	Trypanosomatidae	26%	98%
A0A1X0P2H8	Trypanosomatidae	27%	100%
A0A1X0P2I7	Trypanosomatidae	25%	100%
A0A1X0P3J5	Trypanosomatidae	29%	99%
A0A1X0P484	Trypanosomatidae	24%	66%
A0A1X0P4Z7	Trypanosomatidae	25%	82%
A0A1X0P549	Trypanosomatidae	25%	96%
A0A1X0P5B1	Trypanosomatidae	28%	100%
A0A1X0P5F2	Trypanosomatidae	28%	100%
A0A1X0P6L8	Trypanosomatidae	26%	72%
A0A1X0P795	Trypanosomatidae	27%	67%
A0A1X0P7V0	Trypanosomatidae	30%	100%
A0A1X0P8F7	Trypanosomatidae	38%	100%
A0A1X0P919	Trypanosomatidae	25%	100%
A0A1X0PAW2	Trypanosomatidae	23%	100%
A0A3Q8IB30	Leishmania donovani	31%	100%
A0A3Q8IC87	Leishmania donovani	25%	100%
A0A3Q8IDK8	Leishmania donovani	25%	81%
A0A3Q8IE25	Leishmania donovani	25%	69%
A0A3Q8IFW0	Leishmania donovani	24%	100%
A0A3Q8IJM9	Leishmania donovani	25%	95%
A0A3Q8IND3	Leishmania donovani	22%	87%
A0A3Q8INQ4	Leishmania donovani	28%	100%
A0A3Q8IRT6	Leishmania donovani	28%	89%
A0A3Q8IU22	Leishmania donovani	27%	71%
A0A3R7K5P9	Trypanosoma rangeli	23%	100%
A0A3R7KMF0	Trypanosoma rangeli	21%	100%
A0A3R7KRP1	Trypanosoma rangeli	24%	96%
A0A3R7MHW5	Trypanosoma rangeli	26%	100%
A0A3R7MKG5	Trypanosoma rangeli	23%	100%
A0A3R7MKJ1	Trypanosoma rangeli	29%	84%
A0A3R7MPF2	Trypanosoma rangeli	27%	70%
A0A3R7N4D8	Trypanosoma rangeli	27%	100%
A0A3R7N5S4	Trypanosoma rangeli	26%	100%
A0A3R7RLL1	Trypanosoma rangeli	59%	100%
A0A3S5H5G0	Leishmania donovani	26%	100%
A0A3S5H5U5	Leishmania donovani	89%	100%
A0A3S7WTN9	Leishmania donovani	26%	100%
A0A3S7WV74	Leishmania donovani	27%	72%
A0A3S7X8Z8	Leishmania donovani	24%	93%
A0A3S7X9R4	Leishmania donovani	31%	100%
A0A3S7X9S2	Leishmania donovani	31%	100%
A0A422MYB4	Trypanosoma rangeli	29%	100%
A0A422N0Q9	Trypanosoma rangeli	25%	74%
A0A422N3Y6	Trypanosoma rangeli	24%	100%
A0A422NFN4	Trypanosoma rangeli	24%	90%
A0A422NT89	Trypanosoma rangeli	23%	69%
A0A422P0J2	Trypanosoma rangeli	31%	100%
A0A422P0N6	Trypanosoma rangeli	27%	100%
A0A422P1R5	Trypanosoma rangeli	23%	100%
A0A422P270	Trypanosoma rangeli	39%	100%
A0A422P3N8	Trypanosoma rangeli	25%	78%
A0A422P4V9	Trypanosoma rangeli	31%	99%
A0A422P4X7	Trypanosoma rangeli	25%	90%
A0A8I3S724	Canis lupus familiaris	26%	100%
A1Z9X0	Drosophila melanogaster	28%	75%
A2VDV2	Bos taurus	41%	98%
A2YBX5	Oryza sativa subsp. indica	26%	77%
A4H459	Leishmania braziliensis	27%	100%
A4H8C4	Leishmania braziliensis	25%	100%
A4H9L8	Leishmania braziliensis	31%	100%
A4H9X1	Leishmania braziliensis	26%	72%
A4HCD7	Leishmania braziliensis	26%	100%
A4HCE6	Leishmania braziliensis	22%	100%
A4HDU3	Leishmania braziliensis	26%	100%
A4HED7	Leishmania braziliensis	29%	100%
A4HFC9	Leishmania braziliensis	26%	69%
A4HFF3	Leishmania braziliensis	26%	91%
A4HG27	Leishmania braziliensis	23%	84%
A4HI35	Leishmania braziliensis	28%	89%
A4HJT5	Leishmania braziliensis	23%	100%
A4HJW2	Leishmania braziliensis	25%	100%
A4HLN2	Leishmania braziliensis	25%	71%
A4HN71	Leishmania braziliensis	31%	100%
A4HNI1	Leishmania braziliensis	26%	95%
A4HQG8	Leishmania braziliensis	23%	100%
A4HSE2	Leishmania infantum	26%	100%
A4HWP5	Leishmania infantum	26%	100%
A4HXY2	Leishmania infantum	31%	100%
A4HZV1	Leishmania infantum	26%	100%
A4I1T4	Leishmania infantum	28%	100%
A4I2K6	Leishmania infantum	25%	69%
A4I349	Leishmania infantum	25%	81%
A4I5B1	Leishmania infantum	28%	89%
A4I7C4	Leishmania infantum	24%	100%
A4I967	Leishmania infantum	27%	71%
A4IB02	Leishmania infantum	25%	93%
A4IBT4	Leishmania infantum	31%	100%
A4IBT9	Leishmania infantum	31%	100%
A4IC37	Leishmania infantum	25%	95%
A4IGM9	Xenopus tropicalis	26%	100%
A5A7I7	Solanum tuberosum	27%	82%
A5A7I8	Solanum tuberosum	27%	85%
A5GFW1	Sus scrofa	27%	100%
A7MB74	Bos taurus	31%	100%
A8KBH6	Xenopus tropicalis	31%	68%
A8WUG4	Caenorhabditis briggsae	27%	76%
A8X6H4	Caenorhabditis briggsae	29%	100%
A8XJL7	Caenorhabditis briggsae	38%	96%
A8XJQ6	Caenorhabditis briggsae	26%	100%
A8XNJ6	Caenorhabditis briggsae	30%	98%
A8XW88	Caenorhabditis briggsae	30%	100%
B6DTC0	Bodo saltans	24%	100%
C6K3W8	Leptomonas seymouri	28%	86%
C9ZIW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZLF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	72%
C9ZMH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZQL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	71%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZSU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	71%
C9ZTP2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	98%
C9ZUU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	69%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
D0A2R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A4H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	75%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E8NHS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ACW7	Leishmania major	24%	81%
E9ACY7	Leishmania major	24%	69%
E9AET0	Leishmania major	25%	100%
E9AFM1	Leishmania major	31%	100%
E9AFZ2	Leishmania major	25%	95%
E9AG71	Leishmania infantum	89%	100%
E9AGR6	Leishmania infantum	27%	72%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	73%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	87%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AYR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	69%
E9AZF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	83%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	89%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B408	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	71%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B745	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	95%
F1M7Y5	Rattus norvegicus	28%	76%
F1QGZ6	Danio rerio	26%	67%
F4I4F2	Arabidopsis thaliana	27%	91%
J9W0G9	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	32%	79%
O00141	Homo sapiens	31%	100%
O01427	Caenorhabditis elegans	27%	100%
O13310	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	97%
O14965	Homo sapiens	26%	100%
O15530	Homo sapiens	30%	82%
O19111	Oryctolagus cuniculus	30%	77%
O22932	Arabidopsis thaliana	28%	100%
O22971	Arabidopsis thaliana	27%	91%
O42626	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	73%
O55099	Rattus norvegicus	26%	100%
O55173	Rattus norvegicus	30%	81%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O61267	Drosophila melanogaster	26%	96%
O64682	Arabidopsis thaliana	29%	100%
O70126	Mus musculus	26%	100%
O70150	Rattus norvegicus	26%	100%
O94487	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	73%
P00517	Bos taurus	28%	100%
P04409	Bos taurus	30%	68%
P05126	Bos taurus	29%	68%
P05128	Bos taurus	28%	67%
P05130	Drosophila melanogaster	29%	67%
P05131	Bos taurus	28%	100%
P05132	Mus musculus	28%	100%
P05383	Sus scrofa	28%	100%
P05696	Rattus norvegicus	30%	68%
P05771	Homo sapiens	29%	68%
P05772	Oryctolagus cuniculus	29%	68%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P08414	Mus musculus	28%	97%
P09215	Rattus norvegicus	28%	68%
P09217	Rattus norvegicus	30%	77%
P10102	Oryctolagus cuniculus	30%	68%
P10666	Xenopus laevis	31%	72%
P12370	Drosophila melanogaster	30%	100%
P12688	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	67%
P13234	Rattus norvegicus	27%	96%
P15792	Phaseolus vulgaris	28%	75%
P16911	Drosophila melanogaster	28%	100%
P16912	Drosophila melanogaster	27%	78%
P17252	Homo sapiens	30%	68%
P17612	Homo sapiens	28%	100%
P18961	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	67%
P20444	Mus musculus	29%	68%
P21137	Caenorhabditis elegans	30%	100%
P21901	Aplysia californica	25%	100%
P22204	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	80%
P22612	Homo sapiens	28%	100%
P22694	Homo sapiens	28%	100%
P23298	Mus musculus	30%	67%
P23443	Homo sapiens	30%	87%
P24723	Homo sapiens	30%	67%
P25321	Cricetulus griseus	28%	100%
P26818	Bos taurus	27%	66%
P27791	Rattus norvegicus	28%	100%
P28178	Dictyostelium discoideum	32%	95%
P28583	Glycine max	26%	90%
P28867	Mus musculus	27%	68%
P31748	AKT8 murine leukemia virus	29%	91%
P31749	Homo sapiens	29%	95%
P31750	Mus musculus	29%	95%
P31751	Homo sapiens	30%	95%
P32328	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	81%
P34099	Dictyostelium discoideum	27%	70%
P34947	Homo sapiens	27%	77%
P35626	Homo sapiens	27%	66%
P36887	Sus scrofa	28%	100%
P38070	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	87%
P38679	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	42%	76%
P41743	Homo sapiens	28%	76%
P42818	Arabidopsis thaliana	29%	98%
P43249	Bos taurus	27%	77%
P43291	Arabidopsis thaliana	28%	100%
P45894	Caenorhabditis elegans	26%	77%
P47196	Rattus norvegicus	29%	95%
P47197	Rattus norvegicus	30%	95%
P49673	Ascaris suum	25%	100%
P51817	Homo sapiens	31%	100%
P53681	Daucus carota	29%	76%
P53682	Oryza sativa subsp. japonica	26%	85%
P54265	Mus musculus	36%	72%
P54644	Dictyostelium discoideum	31%	100%
P59241	Rattus norvegicus	26%	100%
P67998	Oryctolagus cuniculus	30%	87%
P67999	Rattus norvegicus	30%	87%
P68180	Cricetulus griseus	28%	100%
P68181	Mus musculus	28%	100%
P68182	Rattus norvegicus	28%	100%
P68403	Rattus norvegicus	29%	68%
P68404	Mus musculus	29%	68%
P83099	Drosophila melanogaster	31%	68%
P90980	Caenorhabditis elegans	29%	67%
P93759	Arabidopsis thaliana	25%	86%
P97477	Mus musculus	26%	100%
Q01314	Bos taurus	29%	95%
Q02956	Mus musculus	30%	77%
Q05513	Homo sapiens	30%	77%
Q05655	Homo sapiens	29%	67%
Q05999	Arabidopsis thaliana	29%	79%
Q06226	Rattus norvegicus	32%	100%
Q09013	Homo sapiens	35%	72%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	80%
Q09898	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	75%
Q0DCT8	Oryza sativa subsp. japonica	26%	77%
Q0DYK7	Oryza sativa subsp. japonica	26%	83%
Q10SC8	Oryza sativa subsp. japonica	26%	100%
Q12701	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	77%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q14012	Homo sapiens	28%	100%
Q15208	Homo sapiens	41%	98%
Q16974	Aplysia californica	30%	70%
Q17941	Caenorhabditis elegans	29%	84%
Q19266	Caenorhabditis elegans	27%	76%
Q1PFB9	Arabidopsis thaliana	29%	82%
Q25378	Lytechinus pictus	29%	69%
Q27687	Leishmania major	31%	92%
Q2L6W9	Caenorhabditis elegans	36%	96%
Q2LZZ7	Drosophila pseudoobscura pseudoobscura	42%	99%
Q2PJ68	Caenorhabditis elegans	31%	98%
Q2QM77	Oryza sativa subsp. japonica	30%	94%
Q2QQR2	Oryza sativa subsp. japonica	27%	74%
Q2QY53	Oryza sativa subsp. japonica	28%	100%
Q2RAX3	Oryza sativa subsp. japonica	28%	100%
Q2TA06	Bos taurus	27%	100%
Q2V452	Arabidopsis thaliana	26%	100%
Q38869	Arabidopsis thaliana	28%	91%
Q38870	Arabidopsis thaliana	27%	70%
Q38871	Arabidopsis thaliana	26%	82%
Q38872	Arabidopsis thaliana	26%	84%
Q38873	Arabidopsis thaliana	26%	85%
Q39016	Arabidopsis thaliana	28%	92%
Q39030	Arabidopsis thaliana	30%	97%
Q39183	Arabidopsis thaliana	26%	78%
Q42396	Arabidopsis thaliana	26%	93%
Q42438	Arabidopsis thaliana	26%	85%
Q4Q0B0	Leishmania major	23%	100%
Q4Q1Z0	Leishmania major	22%	89%
Q4Q416	Leishmania major	26%	71%
Q4Q5T9	Leishmania major	25%	100%
Q4Q5W2	Leishmania major	24%	100%
Q4Q7M5	Leishmania major	27%	89%
Q4Q9K2	Leishmania major	29%	100%
Q4QBR6	Leishmania major	26%	100%
Q4QDK7	Leishmania major	27%	72%
Q4QF23	Leishmania major	26%	100%
Q4QIV8	Leishmania major	89%	100%
Q4QJJ0	Leishmania major	27%	100%
Q4R633	Macaca fascicularis	32%	100%
Q4V3C8	Arabidopsis thaliana	30%	94%
Q54C18	Dictyostelium discoideum	27%	88%
Q54IF2	Dictyostelium discoideum	29%	71%
Q54IH8	Dictyostelium discoideum	40%	84%
Q54L81	Dictyostelium discoideum	31%	98%
Q54PB4	Dictyostelium discoideum	28%	95%
Q54UZ1	Dictyostelium discoideum	25%	100%
Q54WX4	Dictyostelium discoideum	26%	100%
Q54Y26	Dictyostelium discoideum	43%	86%
Q59S66	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	86%
Q5BKK4	Xenopus tropicalis	28%	100%
Q5JLS2	Oryza sativa subsp. japonica	28%	84%
Q5PU49	Canis lupus familiaris	27%	68%
Q5Q0U5	Fundulus heteroclitus	31%	100%
Q5QNM6	Oryza sativa subsp. japonica	28%	89%
Q5R4K9	Pongo abelii	28%	76%
Q5R7A7	Pongo abelii	28%	92%
Q5R7G9	Pongo abelii	25%	72%
Q5R8M1	Pongo abelii	41%	98%
Q5VQQ5	Oryza sativa subsp. japonica	28%	88%
Q60823	Mus musculus	29%	95%
Q62074	Mus musculus	28%	76%
Q62833	Rattus norvegicus	26%	77%
Q63450	Rattus norvegicus	29%	100%
Q63484	Rattus norvegicus	30%	95%
Q64617	Rattus norvegicus	30%	67%
Q64FQ2	Arabidopsis thaliana	29%	87%
Q66HE5	Rattus norvegicus	25%	72%
Q6A1A2	Homo sapiens	30%	100%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	100%
Q6CFS5	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	77%
Q6DE08	Xenopus laevis	26%	100%
Q6ERS4	Oryza sativa subsp. japonica	26%	100%
Q6GLY8	Xenopus laevis	29%	100%
Q6GPL3	Xenopus laevis	27%	100%
Q6GPN6	Xenopus laevis	28%	100%
Q6IP76	Xenopus laevis	29%	94%
Q6NW76	Danio rerio	27%	100%
Q6P2M8	Homo sapiens	27%	100%
Q6TGC6	Pneumocystis carinii	43%	90%
Q6TJY3	Bos taurus	30%	86%
Q6U1I9	Gallus gallus	30%	100%
Q75GK4	Oryza sativa subsp. japonica	27%	100%
Q75H77	Oryza sativa subsp. japonica	27%	100%
Q75L42	Oryza sativa subsp. japonica	27%	100%
Q7JP68	Caenorhabditis elegans	27%	100%
Q7LZQ8	Xenopus laevis	30%	68%
Q7SY24	Danio rerio	29%	68%
Q7TNJ7	Rattus norvegicus	28%	96%
Q7TSE6	Mus musculus	39%	98%
Q7XIM0	Oryza sativa subsp. japonica	27%	80%
Q7XSQ5	Oryza sativa subsp. japonica	26%	85%
Q7YRC6	Bos taurus	27%	100%
Q7ZTW4	Danio rerio	30%	100%
Q7ZX15	Xenopus laevis	29%	94%
Q84SL0	Oryza sativa subsp. japonica	25%	83%
Q852N6	Oryza sativa subsp. japonica	27%	79%
Q869W6	Dictyostelium discoideum	30%	100%
Q8BGW6	Mus musculus	26%	100%
Q8BSK8	Mus musculus	30%	87%
Q8BW96	Mus musculus	29%	100%
Q8BZN4	Mus musculus	26%	71%
Q8INB9	Drosophila melanogaster	30%	74%
Q8IU85	Homo sapiens	28%	100%
Q8LPZ7	Oryza sativa subsp. japonica	26%	83%
Q8MJ44	Canis lupus familiaris	28%	100%
Q8MYF1	Dictyostelium discoideum	30%	100%
Q8R4U9	Rattus norvegicus	28%	100%
Q8R4V0	Rattus norvegicus	28%	92%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	27%	100%
Q8VEB1	Mus musculus	27%	77%
Q8W1D5	Arabidopsis thaliana	27%	93%
Q8W490	Arabidopsis thaliana	27%	97%
Q8W4I7	Arabidopsis thaliana	25%	86%
Q8WTQ7	Homo sapiens	27%	82%
Q8WU08	Homo sapiens	25%	100%
Q90XF2	Danio rerio	28%	77%
Q91819	Xenopus laevis	24%	100%
Q91820	Xenopus laevis	25%	100%
Q91VB2	Mus musculus	28%	95%
Q91VJ4	Mus musculus	41%	98%
Q91YS8	Mus musculus	29%	100%
Q922R0	Mus musculus	30%	100%
Q924X7	Mus musculus	26%	93%
Q93VD3	Arabidopsis thaliana	24%	94%
Q940H6	Arabidopsis thaliana	29%	100%
Q965G5	Caenorhabditis elegans	28%	100%
Q96BR1	Homo sapiens	28%	92%
Q96NX5	Homo sapiens	28%	96%
Q98TY9	Xenopus laevis	29%	95%
Q9BYT3	Homo sapiens	25%	89%
Q9C098	Homo sapiens	26%	70%
Q9C6P3	Arabidopsis thaliana	25%	87%
Q9C8M5	Arabidopsis thaliana	28%	96%
Q9ERE3	Mus musculus	28%	92%
Q9FG74	Arabidopsis thaliana	26%	91%
Q9FJ55	Arabidopsis thaliana	26%	94%
Q9FX86	Arabidopsis thaliana	29%	75%
Q9FXQ3	Oryza sativa subsp. japonica	25%	83%
Q9GNR4	Leishmania major	31%	100%
Q9H093	Homo sapiens	25%	72%
Q9HBY8	Homo sapiens	29%	100%
Q9JJX8	Mus musculus	29%	100%
Q9LEU7	Arabidopsis thaliana	27%	100%
Q9LGV5	Oryza sativa subsp. japonica	28%	99%
Q9LJL9	Arabidopsis thaliana	29%	76%
Q9LP51	Arabidopsis thaliana	28%	88%
Q9LSF1	Arabidopsis thaliana	32%	100%
Q9LT38	Arabidopsis thaliana	28%	100%
Q9LTW5	Arabidopsis thaliana	30%	79%
Q9LUL2	Arabidopsis thaliana	29%	95%
Q9M101	Arabidopsis thaliana	26%	88%
Q9MZD9	Ovis aries	28%	100%
Q9N0X0	Sus scrofa	26%	100%
Q9NAH6	Caenorhabditis elegans	30%	83%
Q9NBK5	Drosophila melanogaster	42%	98%
Q9P7I2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9P7J8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	80%
Q9QYK9	Mus musculus	26%	100%
Q9QZS5	Mus musculus	28%	100%
Q9SCS2	Arabidopsis thaliana	29%	76%
Q9SEZ7	Arabidopsis thaliana	27%	97%
Q9SJ61	Arabidopsis thaliana	26%	88%
Q9SMQ4	Arabidopsis thaliana	27%	100%
Q9SN43	Arabidopsis thaliana	28%	93%
Q9SUA3	Arabidopsis thaliana	26%	90%
Q9SYB9	Arabidopsis thaliana	28%	100%
Q9SZM3	Arabidopsis thaliana	27%	94%
Q9TXJ0	Caenorhabditis elegans	29%	100%
Q9UBS0	Homo sapiens	30%	94%
Q9UQB9	Homo sapiens	26%	100%
Q9USX7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	87%
Q9WUA6	Mus musculus	30%	95%
Q9WVC6	Mus musculus	31%	100%
Q9XF67	Arabidopsis thaliana	29%	93%
Q9XT18	Oryctolagus cuniculus	31%	100%
Q9XTG7	Caenorhabditis elegans	29%	86%
Q9Y1J3	Caenorhabditis elegans	29%	72%
Q9Y243	Homo sapiens	30%	95%
Q9Y2H1	Homo sapiens	40%	98%
Q9Y7J6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	83%
Q9Y899	Emericella nidulans	26%	100%
Q9Z1M4	Mus musculus	30%	94%
Q9Z2A0	Mus musculus	30%	81%
Q9Z2G7	Ictidomys tridecemlineatus	28%	83%
Q9ZV15	Arabidopsis thaliana	28%	78%
V5B871	Trypanosoma cruzi	26%	100%
V5BAZ8	Trypanosoma cruzi	27%	100%
V5BC28	Trypanosoma cruzi	23%	91%
V5BCH2	Trypanosoma cruzi	28%	100%
V5BEK5	Trypanosoma cruzi	30%	100%
V5BFI8	Trypanosoma cruzi	24%	100%
V5BG98	Trypanosoma cruzi	24%	100%
V5BH88	Trypanosoma cruzi	28%	83%
V5BHW8	Trypanosoma cruzi	24%	72%
V5BI43	Trypanosoma cruzi	23%	91%
V5BKJ3	Trypanosoma cruzi	23%	100%
V5BL06	Trypanosoma cruzi	27%	70%
V5BP88	Trypanosoma cruzi	26%	98%
V5BPK4	Trypanosoma cruzi	31%	75%
V5BQH6	Trypanosoma cruzi	39%	100%
V5BSA6	Trypanosoma cruzi	26%	69%
V5BU83	Trypanosoma cruzi	25%	89%
V5D179	Trypanosoma cruzi	27%	75%
V5DAY8	Trypanosoma cruzi	29%	100%
V5DC40	Trypanosoma cruzi	26%	83%
V5DCD4	Trypanosoma cruzi	24%	78%
V5DI55	Trypanosoma cruzi	27%	100%
V5DMJ4	Trypanosoma cruzi	25%	100%
V5DPP5	Trypanosoma cruzi	59%	100%
V5DQT5	Trypanosoma cruzi	30%	99%
V5DUH0	Trypanosoma cruzi	24%	83%
W0LYS5	Macrobrachium nipponense	28%	100%