Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4S7_LEIBR

TriTrypDb:

LbrM.06.1140 , LBRM2903_060018800

Length:

1094

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.618
CLV_C14_Caspase3-7	724	728	PF00656	0.354
CLV_NRD_NRD_1	121	123	PF00675	0.615
CLV_NRD_NRD_1	27	29	PF00675	0.366
CLV_NRD_NRD_1	356	358	PF00675	0.594
CLV_NRD_NRD_1	48	50	PF00675	0.364
CLV_NRD_NRD_1	686	688	PF00675	0.378
CLV_NRD_NRD_1	81	83	PF00675	0.522
CLV_NRD_NRD_1	847	849	PF00675	0.461
CLV_PCSK_KEX2_1	1048	1050	PF00082	0.431
CLV_PCSK_KEX2_1	121	123	PF00082	0.615
CLV_PCSK_KEX2_1	27	29	PF00082	0.366
CLV_PCSK_KEX2_1	356	358	PF00082	0.594
CLV_PCSK_KEX2_1	686	688	PF00082	0.548
CLV_PCSK_KEX2_1	81	83	PF00082	0.522
CLV_PCSK_KEX2_1	846	848	PF00082	0.462
CLV_PCSK_PC1ET2_1	1048	1050	PF00082	0.431
CLV_PCSK_SKI1_1	1079	1083	PF00082	0.453
CLV_PCSK_SKI1_1	237	241	PF00082	0.514
CLV_PCSK_SKI1_1	27	31	PF00082	0.515
CLV_PCSK_SKI1_1	373	377	PF00082	0.629
CLV_PCSK_SKI1_1	395	399	PF00082	0.421
CLV_PCSK_SKI1_1	450	454	PF00082	0.513
CLV_PCSK_SKI1_1	554	558	PF00082	0.485
CLV_PCSK_SKI1_1	664	668	PF00082	0.549
CLV_PCSK_SKI1_1	686	690	PF00082	0.531
CLV_PCSK_SKI1_1	806	810	PF00082	0.507
CLV_PCSK_SKI1_1	866	870	PF00082	0.415
CLV_PCSK_SKI1_1	874	878	PF00082	0.406
CLV_Separin_Metazoa	692	696	PF03568	0.428
DEG_APCC_DBOX_1	372	380	PF00400	0.610
DEG_APCC_DBOX_1	638	646	PF00400	0.437
DEG_APCC_DBOX_1	663	671	PF00400	0.527
DEG_APCC_DBOX_1	686	694	PF00400	0.496
DEG_Nend_UBRbox_3	1	3	PF02207	0.471
DEG_SCF_FBW7_1	147	152	PF00400	0.539
DEG_SPOP_SBC_1	817	821	PF00917	0.500
DOC_CKS1_1	383	388	PF01111	0.614
DOC_CYCLIN_RxL_1	551	559	PF00134	0.352
DOC_CYCLIN_RxL_1	683	692	PF00134	0.528
DOC_CYCLIN_RxL_1	862	873	PF00134	0.372
DOC_MAPK_gen_1	49	56	PF00069	0.359
DOC_MAPK_gen_1	846	855	PF00069	0.397
DOC_MAPK_gen_1	863	871	PF00069	0.272
DOC_MAPK_MEF2A_6	13	21	PF00069	0.419
DOC_MAPK_MEF2A_6	373	381	PF00069	0.637
DOC_MAPK_MEF2A_6	446	455	PF00069	0.434
DOC_MAPK_MEF2A_6	897	904	PF00069	0.319
DOC_MAPK_MEF2A_6	988	995	PF00069	0.440
DOC_MAPK_NFAT4_5	988	996	PF00069	0.314
DOC_MAPK_RevD_3	342	357	PF00069	0.464
DOC_PP1_RVXF_1	114	121	PF00149	0.629
DOC_PP1_RVXF_1	393	399	PF00149	0.422
DOC_PP1_RVXF_1	47	54	PF00149	0.520
DOC_PP1_RVXF_1	685	692	PF00149	0.532
DOC_PP2B_LxvP_1	621	624	PF13499	0.481
DOC_PP2B_PxIxI_1	256	262	PF00149	0.537
DOC_PP4_FxxP_1	708	711	PF00568	0.506
DOC_PP4_FxxP_1	832	835	PF00568	0.534
DOC_SPAK_OSR1_1	897	901	PF12202	0.328
DOC_USP7_MATH_1	112	116	PF00917	0.625
DOC_USP7_MATH_1	192	196	PF00917	0.811
DOC_USP7_MATH_1	284	288	PF00917	0.504
DOC_USP7_MATH_1	297	301	PF00917	0.568
DOC_USP7_MATH_1	337	341	PF00917	0.527
DOC_USP7_MATH_1	346	350	PF00917	0.641
DOC_USP7_MATH_1	485	489	PF00917	0.465
DOC_USP7_MATH_1	552	556	PF00917	0.515
DOC_USP7_MATH_1	723	727	PF00917	0.536
DOC_USP7_MATH_1	745	749	PF00917	0.515
DOC_USP7_MATH_1	791	795	PF00917	0.683
DOC_USP7_MATH_1	817	821	PF00917	0.641
DOC_WW_Pin1_4	1062	1067	PF00397	0.493
DOC_WW_Pin1_4	145	150	PF00397	0.814
DOC_WW_Pin1_4	216	221	PF00397	0.490
DOC_WW_Pin1_4	382	387	PF00397	0.687
DOC_WW_Pin1_4	651	656	PF00397	0.535
DOC_WW_Pin1_4	675	680	PF00397	0.629
DOC_WW_Pin1_4	808	813	PF00397	0.618
LIG_14-3-3_CanoR_1	1014	1020	PF00244	0.538
LIG_14-3-3_CanoR_1	303	311	PF00244	0.607
LIG_14-3-3_CanoR_1	336	342	PF00244	0.645
LIG_14-3-3_CanoR_1	34	44	PF00244	0.590
LIG_14-3-3_CanoR_1	561	568	PF00244	0.515
LIG_14-3-3_CanoR_1	610	614	PF00244	0.486
LIG_14-3-3_CanoR_1	730	739	PF00244	0.351
LIG_14-3-3_CanoR_1	897	903	PF00244	0.487
LIG_14-3-3_CanoR_1	956	960	PF00244	0.416
LIG_Actin_WH2_2	12	29	PF00022	0.450
LIG_APCC_ABBAyCdc20_2	1079	1085	PF00400	0.370
LIG_BRCT_BRCA1_1	264	268	PF00533	0.481
LIG_BRCT_BRCA1_1	297	301	PF00533	0.554
LIG_BRCT_BRCA1_1	531	535	PF00533	0.459
LIG_BRCT_BRCA1_1	564	568	PF00533	0.511
LIG_CSL_BTD_1	832	835	PF09270	0.534
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.535
LIG_Dynein_DLC8_1	414	420	PF01221	0.401
LIG_eIF4E_1	14	20	PF01652	0.433
LIG_eIF4E_1	967	973	PF01652	0.316
LIG_FHA_1	1041	1047	PF00498	0.491
LIG_FHA_1	1063	1069	PF00498	0.478
LIG_FHA_1	256	262	PF00498	0.551
LIG_FHA_1	310	316	PF00498	0.409
LIG_FHA_1	348	354	PF00498	0.472
LIG_FHA_1	383	389	PF00498	0.699
LIG_FHA_1	416	422	PF00498	0.562
LIG_FHA_1	469	475	PF00498	0.451
LIG_FHA_1	639	645	PF00498	0.531
LIG_FHA_1	658	664	PF00498	0.421
LIG_FHA_1	819	825	PF00498	0.551
LIG_FHA_1	881	887	PF00498	0.445
LIG_FHA_1	924	930	PF00498	0.502
LIG_FHA_1	955	961	PF00498	0.542
LIG_FHA_1	963	969	PF00498	0.581
LIG_FHA_2	722	728	PF00498	0.520
LIG_GBD_Chelix_1	605	613	PF00786	0.502
LIG_LIR_Apic_2	706	711	PF02991	0.510
LIG_LIR_Apic_2	830	835	PF02991	0.446
LIG_LIR_Apic_2	872	878	PF02991	0.314
LIG_LIR_Apic_2	965	970	PF02991	0.297
LIG_LIR_Gen_1	134	141	PF02991	0.590
LIG_LIR_Gen_1	4	15	PF02991	0.374
LIG_LIR_Gen_1	780	789	PF02991	0.427
LIG_LIR_Gen_1	987	995	PF02991	0.450
LIG_LIR_Nem_3	134	139	PF02991	0.558
LIG_LIR_Nem_3	200	206	PF02991	0.453
LIG_LIR_Nem_3	4	10	PF02991	0.428
LIG_LIR_Nem_3	438	442	PF02991	0.524
LIG_LIR_Nem_3	627	633	PF02991	0.581
LIG_LIR_Nem_3	780	785	PF02991	0.426
LIG_LIR_Nem_3	987	993	PF02991	0.418
LIG_LYPXL_yS_3	917	920	PF13949	0.486
LIG_MYND_1	342	346	PF01753	0.466
LIG_NRBOX	392	398	PF00104	0.598
LIG_NRBOX	552	558	PF00104	0.340
LIG_NRBOX	662	668	PF00104	0.461
LIG_NRP_CendR_1	1091	1094	PF00754	0.482
LIG_PTAP_UEV_1	253	258	PF05743	0.435
LIG_Rb_pABgroove_1	262	270	PF01858	0.529
LIG_RPA_C_Fungi	441	453	PF08784	0.493
LIG_RPA_C_Insects	1027	1042	PF08784	0.417
LIG_SH2_CRK	1029	1033	PF00017	0.453
LIG_SH2_CRK	124	128	PF00017	0.616
LIG_SH2_CRK	649	653	PF00017	0.543
LIG_SH2_CRK	841	845	PF00017	0.535
LIG_SH2_CRK	875	879	PF00017	0.535
LIG_SH2_GRB2like	770	773	PF00017	0.375
LIG_SH2_NCK_1	841	845	PF00017	0.444
LIG_SH2_PTP2	14	17	PF00017	0.434
LIG_SH2_SRC	932	935	PF00017	0.321
LIG_SH2_SRC	967	970	PF00017	0.300
LIG_SH2_STAP1	432	436	PF00017	0.443
LIG_SH2_STAP1	44	48	PF00017	0.500
LIG_SH2_STAP1	470	474	PF00017	0.391
LIG_SH2_STAP1	7	11	PF00017	0.552
LIG_SH2_STAP1	964	968	PF00017	0.448
LIG_SH2_STAT5	14	17	PF00017	0.476
LIG_SH2_STAT5	436	439	PF00017	0.436
LIG_SH2_STAT5	470	473	PF00017	0.444
LIG_SH2_STAT5	763	766	PF00017	0.459
LIG_SH2_STAT5	770	773	PF00017	0.481
LIG_SH2_STAT5	774	777	PF00017	0.430
LIG_SH2_STAT5	964	967	PF00017	0.450
LIG_SH3_2	188	193	PF14604	0.540
LIG_SH3_3	168	174	PF00018	0.792
LIG_SH3_3	183	189	PF00018	0.554
LIG_SH3_3	251	257	PF00018	0.657
LIG_SH3_3	339	345	PF00018	0.660
LIG_SH3_3	649	655	PF00018	0.543
LIG_SH3_3	91	97	PF00018	0.528
LIG_SUMO_SIM_anti_2	248	255	PF11976	0.485
LIG_SUMO_SIM_anti_2	640	646	PF11976	0.442
LIG_SUMO_SIM_anti_2	989	995	PF11976	0.435
LIG_SUMO_SIM_par_1	653	660	PF11976	0.508
LIG_SUMO_SIM_par_1	867	873	PF11976	0.428
LIG_TRAF2_1	1073	1076	PF00917	0.489
LIG_TRAF2_1	1090	1093	PF00917	0.449
LIG_TRAF2_1	703	706	PF00917	0.506
LIG_TYR_ITIM	5	10	PF00017	0.421
LIG_TYR_ITIM	839	844	PF00017	0.556
LIG_TYR_ITIM	915	920	PF00017	0.496
LIG_WRC_WIRS_1	436	441	PF05994	0.535
LIG_WW_2	342	345	PF00397	0.470
MOD_CK1_1	111	117	PF00069	0.759
MOD_CK1_1	140	146	PF00069	0.519
MOD_CK1_1	155	161	PF00069	0.623
MOD_CK1_1	255	261	PF00069	0.497
MOD_CK1_1	438	444	PF00069	0.477
MOD_CK1_1	498	504	PF00069	0.605
MOD_CK1_1	555	561	PF00069	0.563
MOD_CK1_1	675	681	PF00069	0.615
MOD_CK1_1	712	718	PF00069	0.582
MOD_CK1_1	734	740	PF00069	0.487
MOD_CK1_1	820	826	PF00069	0.491
MOD_CK1_1	954	960	PF00069	0.325
MOD_CK2_1	1070	1076	PF00069	0.507
MOD_CK2_1	111	117	PF00069	0.624
MOD_CK2_1	238	244	PF00069	0.582
MOD_CK2_1	245	251	PF00069	0.545
MOD_CK2_1	916	922	PF00069	0.439
MOD_GlcNHglycan	1020	1023	PF01048	0.581
MOD_GlcNHglycan	1057	1060	PF01048	0.649
MOD_GlcNHglycan	1079	1082	PF01048	0.501
MOD_GlcNHglycan	110	113	PF01048	0.709
MOD_GlcNHglycan	157	160	PF01048	0.733
MOD_GlcNHglycan	194	197	PF01048	0.766
MOD_GlcNHglycan	240	243	PF01048	0.712
MOD_GlcNHglycan	247	250	PF01048	0.631
MOD_GlcNHglycan	254	257	PF01048	0.473
MOD_GlcNHglycan	274	280	PF01048	0.650
MOD_GlcNHglycan	297	300	PF01048	0.553
MOD_GlcNHglycan	339	342	PF01048	0.596
MOD_GlcNHglycan	370	373	PF01048	0.594
MOD_GlcNHglycan	426	429	PF01048	0.443
MOD_GlcNHglycan	500	503	PF01048	0.663
MOD_GlcNHglycan	504	507	PF01048	0.717
MOD_GlcNHglycan	523	526	PF01048	0.364
MOD_GlcNHglycan	564	567	PF01048	0.682
MOD_GlcNHglycan	579	582	PF01048	0.530
MOD_GlcNHglycan	717	720	PF01048	0.603
MOD_GlcNHglycan	733	736	PF01048	0.500
MOD_GlcNHglycan	745	748	PF01048	0.426
MOD_GlcNHglycan	764	767	PF01048	0.291
MOD_GlcNHglycan	793	796	PF01048	0.744
MOD_GlcNHglycan	934	937	PF01048	0.464
MOD_GlcNHglycan	978	981	PF01048	0.355
MOD_GSK3_1	108	115	PF00069	0.686
MOD_GSK3_1	145	152	PF00069	0.673
MOD_GSK3_1	155	162	PF00069	0.781
MOD_GSK3_1	192	199	PF00069	0.768
MOD_GSK3_1	377	384	PF00069	0.620
MOD_GSK3_1	411	418	PF00069	0.687
MOD_GSK3_1	498	505	PF00069	0.636
MOD_GSK3_1	515	522	PF00069	0.502
MOD_GSK3_1	552	559	PF00069	0.447
MOD_GSK3_1	601	608	PF00069	0.491
MOD_GSK3_1	67	74	PF00069	0.683
MOD_GSK3_1	671	678	PF00069	0.534
MOD_GSK3_1	717	724	PF00069	0.459
MOD_GSK3_1	816	823	PF00069	0.633
MOD_GSK3_1	923	930	PF00069	0.322
MOD_GSK3_1	951	958	PF00069	0.352
MOD_N-GLC_1	282	287	PF02516	0.557
MOD_N-GLC_1	498	503	PF02516	0.593
MOD_N-GLC_1	71	76	PF02516	0.516
MOD_NEK2_1	1028	1033	PF00069	0.384
MOD_NEK2_1	1077	1082	PF00069	0.484
MOD_NEK2_1	209	214	PF00069	0.549
MOD_NEK2_1	347	352	PF00069	0.509
MOD_NEK2_1	377	382	PF00069	0.555
MOD_NEK2_1	423	428	PF00069	0.451
MOD_NEK2_1	493	498	PF00069	0.540
MOD_NEK2_1	556	561	PF00069	0.375
MOD_NEK2_1	656	661	PF00069	0.642
MOD_NEK2_1	756	761	PF00069	0.420
MOD_NEK2_1	785	790	PF00069	0.329
MOD_NEK2_1	869	874	PF00069	0.446
MOD_NEK2_1	898	903	PF00069	0.493
MOD_NEK2_1	927	932	PF00069	0.362
MOD_NEK2_1	986	991	PF00069	0.463
MOD_NEK2_2	284	289	PF00069	0.534
MOD_NEK2_2	435	440	PF00069	0.540
MOD_OFUCOSY	1069	1074	PF10250	0.572
MOD_PIKK_1	160	166	PF00454	0.701
MOD_PIKK_1	302	308	PF00454	0.542
MOD_PIKK_1	379	385	PF00454	0.627
MOD_PIKK_1	415	421	PF00454	0.534
MOD_PIKK_1	951	957	PF00454	0.379
MOD_PKA_2	1013	1019	PF00069	0.594
MOD_PKA_2	192	198	PF00069	0.697
MOD_PKA_2	302	308	PF00069	0.475
MOD_PKA_2	415	421	PF00069	0.532
MOD_PKA_2	560	566	PF00069	0.573
MOD_PKA_2	609	615	PF00069	0.562
MOD_PKA_2	638	644	PF00069	0.440
MOD_PKA_2	896	902	PF00069	0.500
MOD_PKA_2	955	961	PF00069	0.454
MOD_Plk_1	100	106	PF00069	0.692
MOD_Plk_1	116	122	PF00069	0.576
MOD_Plk_1	152	158	PF00069	0.554
MOD_Plk_1	377	383	PF00069	0.643
MOD_Plk_4	310	316	PF00069	0.430
MOD_Plk_4	402	408	PF00069	0.634
MOD_Plk_4	417	423	PF00069	0.377
MOD_Plk_4	609	615	PF00069	0.410
MOD_Plk_4	638	644	PF00069	0.481
MOD_Plk_4	756	762	PF00069	0.458
MOD_Plk_4	955	961	PF00069	0.316
MOD_ProDKin_1	1062	1068	PF00069	0.488
MOD_ProDKin_1	145	151	PF00069	0.815
MOD_ProDKin_1	216	222	PF00069	0.485
MOD_ProDKin_1	382	388	PF00069	0.685
MOD_ProDKin_1	651	657	PF00069	0.535
MOD_ProDKin_1	675	681	PF00069	0.627
MOD_ProDKin_1	808	814	PF00069	0.619
MOD_SUMO_for_1	1090	1093	PF00179	0.466
MOD_SUMO_for_1	29	32	PF00179	0.519
MOD_SUMO_for_1	670	673	PF00179	0.577
TRG_DiLeu_BaEn_1	640	645	PF01217	0.540
TRG_DiLeu_BaLyEn_6	967	972	PF01217	0.440
TRG_ENDOCYTIC_2	1029	1032	PF00928	0.468
TRG_ENDOCYTIC_2	124	127	PF00928	0.617
TRG_ENDOCYTIC_2	14	17	PF00928	0.416
TRG_ENDOCYTIC_2	436	439	PF00928	0.448
TRG_ENDOCYTIC_2	649	652	PF00928	0.548
TRG_ENDOCYTIC_2	7	10	PF00928	0.509
TRG_ENDOCYTIC_2	841	844	PF00928	0.540
TRG_ENDOCYTIC_2	917	920	PF00928	0.486
TRG_ER_diArg_1	120	122	PF00400	0.623
TRG_ER_diArg_1	26	28	PF00400	0.362
TRG_ER_diArg_1	355	357	PF00400	0.562
TRG_ER_diArg_1	685	687	PF00400	0.393
TRG_ER_diArg_1	81	83	PF00400	0.546
TRG_ER_diArg_1	846	848	PF00400	0.466
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	664	668	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	687	692	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV03	Leptomonas seymouri	46%	100%
A0A3R7L2Z7	Trypanosoma rangeli	29%	100%
A0A3S5H5U4	Leishmania donovani	77%	100%
C9ZTP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AG70	Leishmania infantum	77%	100%
E9AKZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QIW0	Leishmania major	75%	100%