DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania braziliensis

UniProt:

A4H4S6_LEIBR

TriTrypDb:

LbrM.06.1130 , LBRM2903_060018700

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H4S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.556
CLV_C14_Caspase3-7	513	517	PF00656	0.381
CLV_NRD_NRD_1	14	16	PF00675	0.670
CLV_NRD_NRD_1	309	311	PF00675	0.548
CLV_NRD_NRD_1	324	326	PF00675	0.505
CLV_NRD_NRD_1	486	488	PF00675	0.493
CLV_NRD_NRD_1	91	93	PF00675	0.431
CLV_PCSK_FUR_1	483	487	PF00082	0.508
CLV_PCSK_KEX2_1	14	16	PF00082	0.670
CLV_PCSK_KEX2_1	309	311	PF00082	0.531
CLV_PCSK_KEX2_1	324	326	PF00082	0.423
CLV_PCSK_KEX2_1	485	487	PF00082	0.514
CLV_PCSK_KEX2_1	91	93	PF00082	0.436
CLV_PCSK_SKI1_1	324	328	PF00082	0.282
CLV_PCSK_SKI1_1	389	393	PF00082	0.274
CLV_PCSK_SKI1_1	416	420	PF00082	0.361
CLV_PCSK_SKI1_1	456	460	PF00082	0.409
DEG_APCC_DBOX_1	411	419	PF00400	0.425
DEG_APCC_DBOX_1	79	87	PF00400	0.291
DEG_SPOP_SBC_1	237	241	PF00917	0.326
DOC_CYCLIN_RxL_1	485	498	PF00134	0.542
DOC_MAPK_gen_1	387	396	PF00069	0.445
DOC_MAPK_gen_1	412	420	PF00069	0.417
DOC_MAPK_gen_1	485	495	PF00069	0.542
DOC_MAPK_MEF2A_6	14	23	PF00069	0.558
DOC_MAPK_MEF2A_6	387	396	PF00069	0.378
DOC_MAPK_NFAT4_5	389	397	PF00069	0.377
DOC_PP1_RVXF_1	242	248	PF00149	0.388
DOC_PP2B_LxvP_1	56	59	PF13499	0.481
DOC_USP7_MATH_1	149	153	PF00917	0.340
DOC_USP7_MATH_1	191	195	PF00917	0.770
DOC_USP7_MATH_1	317	321	PF00917	0.523
DOC_USP7_MATH_1	382	386	PF00917	0.390
DOC_USP7_MATH_1	452	456	PF00917	0.434
DOC_WW_Pin1_4	126	131	PF00397	0.367
DOC_WW_Pin1_4	251	256	PF00397	0.407
DOC_WW_Pin1_4	285	290	PF00397	0.768
DOC_WW_Pin1_4	319	324	PF00397	0.509
DOC_WW_Pin1_4	67	72	PF00397	0.566
LIG_14-3-3_CanoR_1	139	147	PF00244	0.391
LIG_14-3-3_CanoR_1	273	280	PF00244	0.507
LIG_14-3-3_CanoR_1	346	351	PF00244	0.418
LIG_14-3-3_CanoR_1	359	367	PF00244	0.257
LIG_14-3-3_CanoR_1	387	392	PF00244	0.424
LIG_14-3-3_CanoR_1	416	421	PF00244	0.330
LIG_14-3-3_CanoR_1	442	448	PF00244	0.332
LIG_14-3-3_CanoR_1	504	512	PF00244	0.589
LIG_14-3-3_CanoR_1	51	57	PF00244	0.714
LIG_14-3-3_CanoR_1	63	71	PF00244	0.561
LIG_Actin_WH2_2	403	418	PF00022	0.517
LIG_APCC_ABBA_1	339	344	PF00400	0.482
LIG_APCC_ABBA_1	418	423	PF00400	0.358
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BIR_III_2	209	213	PF00653	0.460
LIG_BRCT_BRCA1_1	361	365	PF00533	0.326
LIG_BRCT_BRCA1_1	454	458	PF00533	0.483
LIG_CtBP_PxDLS_1	123	127	PF00389	0.343
LIG_DLG_GKlike_1	387	394	PF00625	0.460
LIG_FHA_1	28	34	PF00498	0.652
LIG_FHA_1	295	301	PF00498	0.596
LIG_FHA_1	329	335	PF00498	0.465
LIG_FHA_1	51	57	PF00498	0.633
LIG_FHA_2	108	114	PF00498	0.684
LIG_FHA_2	286	292	PF00498	0.585
LIG_FHA_2	417	423	PF00498	0.344
LIG_FHA_2	506	512	PF00498	0.560
LIG_IRF3_LxIS_1	19	24	PF10401	0.472
LIG_LIR_Nem_3	131	137	PF02991	0.205
LIG_LIR_Nem_3	209	214	PF02991	0.391
LIG_LIR_Nem_3	432	437	PF02991	0.454
LIG_LYPXL_S_1	133	137	PF13949	0.193
LIG_LYPXL_yS_3	134	137	PF13949	0.193
LIG_LYPXL_yS_3	211	214	PF13949	0.368
LIG_NRBOX	390	396	PF00104	0.260
LIG_PTAP_UEV_1	197	202	PF05743	0.487
LIG_RPA_C_Fungi	46	58	PF08784	0.664
LIG_SH2_PTP2	417	420	PF00017	0.471
LIG_SH2_STAP1	267	271	PF00017	0.498
LIG_SH2_STAP1	367	371	PF00017	0.390
LIG_SH2_STAT5	417	420	PF00017	0.471
LIG_SH3_2	75	80	PF14604	0.332
LIG_SH3_3	176	182	PF00018	0.719
LIG_SH3_3	195	201	PF00018	0.680
LIG_SH3_3	277	283	PF00018	0.721
LIG_SH3_3	299	305	PF00018	0.377
LIG_SH3_3	394	400	PF00018	0.525
LIG_SH3_3	4	10	PF00018	0.529
LIG_SH3_3	72	78	PF00018	0.377
LIG_SUMO_SIM_par_1	122	127	PF11976	0.356
LIG_SUMO_SIM_par_1	329	336	PF11976	0.383
LIG_TYR_ITIM	415	420	PF00017	0.484
LIG_TYR_ITSM	130	137	PF00017	0.193
MOD_CDC14_SPxK_1	322	325	PF00782	0.469
MOD_CDK_SPK_2	319	324	PF00069	0.502
MOD_CDK_SPxK_1	319	325	PF00069	0.495
MOD_CK1_1	145	151	PF00069	0.406
MOD_CK1_1	240	246	PF00069	0.421
MOD_CK1_1	259	265	PF00069	0.355
MOD_CK1_1	275	281	PF00069	0.624
MOD_CK1_1	349	355	PF00069	0.432
MOD_CK1_1	385	391	PF00069	0.451
MOD_CK1_1	50	56	PF00069	0.721
MOD_CK1_1	67	73	PF00069	0.620
MOD_CK2_1	505	511	PF00069	0.559
MOD_GlcNHglycan	119	122	PF01048	0.701
MOD_GlcNHglycan	147	150	PF01048	0.304
MOD_GlcNHglycan	16	19	PF01048	0.506
MOD_GlcNHglycan	240	243	PF01048	0.372
MOD_GlcNHglycan	274	277	PF01048	0.405
MOD_GlcNHglycan	319	322	PF01048	0.449
MOD_GlcNHglycan	384	387	PF01048	0.447
MOD_GlcNHglycan	480	483	PF01048	0.529
MOD_GlcNHglycan	71	74	PF01048	0.613
MOD_GSK3_1	107	114	PF00069	0.605
MOD_GSK3_1	124	131	PF00069	0.395
MOD_GSK3_1	138	145	PF00069	0.404
MOD_GSK3_1	192	199	PF00069	0.753
MOD_GSK3_1	23	30	PF00069	0.733
MOD_GSK3_1	232	239	PF00069	0.390
MOD_GSK3_1	348	355	PF00069	0.298
MOD_GSK3_1	404	411	PF00069	0.451
MOD_GSK3_1	43	50	PF00069	0.569
MOD_GSK3_1	459	466	PF00069	0.544
MOD_LATS_1	105	111	PF00433	0.411
MOD_N-GLC_1	116	121	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.479
MOD_NEK2_1	124	129	PF00069	0.328
MOD_NEK2_1	21	26	PF00069	0.714
MOD_NEK2_1	42	47	PF00069	0.640
MOD_NEK2_1	458	463	PF00069	0.482
MOD_NEK2_1	493	498	PF00069	0.576
MOD_NEK2_1	505	510	PF00069	0.574
MOD_PIKK_1	138	144	PF00454	0.323
MOD_PIKK_1	192	198	PF00454	0.526
MOD_PIKK_1	225	231	PF00454	0.348
MOD_PIKK_1	459	465	PF00454	0.418
MOD_PKA_1	14	20	PF00069	0.474
MOD_PKA_2	138	144	PF00069	0.351
MOD_PKA_2	14	20	PF00069	0.731
MOD_PKA_2	149	155	PF00069	0.304
MOD_PKA_2	196	202	PF00069	0.730
MOD_PKA_2	272	278	PF00069	0.634
MOD_PKA_2	35	41	PF00069	0.574
MOD_PKA_2	437	443	PF00069	0.419
MOD_PKA_2	50	56	PF00069	0.729
MOD_PKB_1	109	117	PF00069	0.473
MOD_PKB_1	414	422	PF00069	0.419
MOD_Plk_1	124	130	PF00069	0.217
MOD_Plk_1	328	334	PF00069	0.460
MOD_Plk_1	352	358	PF00069	0.217
MOD_Plk_1	424	430	PF00069	0.256
MOD_Plk_4	129	135	PF00069	0.251
MOD_Plk_4	328	334	PF00069	0.272
MOD_Plk_4	387	393	PF00069	0.387
MOD_Plk_4	424	430	PF00069	0.256
MOD_ProDKin_1	126	132	PF00069	0.367
MOD_ProDKin_1	251	257	PF00069	0.407
MOD_ProDKin_1	285	291	PF00069	0.767
MOD_ProDKin_1	319	325	PF00069	0.502
MOD_ProDKin_1	67	73	PF00069	0.563
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.457
TRG_ENDOCYTIC_2	134	137	PF00928	0.193
TRG_ENDOCYTIC_2	211	214	PF00928	0.368
TRG_ENDOCYTIC_2	417	420	PF00928	0.471
TRG_ER_diArg_1	106	109	PF00400	0.348
TRG_ER_diArg_1	13	15	PF00400	0.738
TRG_ER_diArg_1	323	325	PF00400	0.548
TRG_ER_diArg_1	412	415	PF00400	0.542
TRG_ER_diArg_1	483	486	PF00400	0.551
TRG_ER_diArg_1	488	491	PF00400	0.547
TRG_ER_diArg_1	90	92	PF00400	0.434
TRG_NES_CRM1_1	84	97	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ62	Leptomonas seymouri	60%	100%
A0A0S4KFW8	Bodo saltans	28%	100%
A0A1X0NIH3	Trypanosomatidae	33%	100%
A0A3R7NRE8	Trypanosoma rangeli	36%	100%
A0A3S5H5U3	Leishmania donovani	74%	100%
A4HT07	Leishmania infantum	74%	100%
C9ZTN9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
E9AKZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QIW1	Leishmania major	75%	100%
V5BNK9	Trypanosoma cruzi	37%	100%