BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4S5_LEIBR

TriTrypDb:

LbrM.06.1120 , LBRM2903_060018600

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H4S5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.605
CLV_C14_Caspase3-7	462	466	PF00656	0.577
CLV_C14_Caspase3-7	577	581	PF00656	0.535
CLV_MEL_PAP_1	324	330	PF00089	0.609
CLV_NRD_NRD_1	301	303	PF00675	0.736
CLV_NRD_NRD_1	349	351	PF00675	0.577
CLV_NRD_NRD_1	403	405	PF00675	0.570
CLV_NRD_NRD_1	470	472	PF00675	0.637
CLV_NRD_NRD_1	474	476	PF00675	0.631
CLV_NRD_NRD_1	489	491	PF00675	0.618
CLV_NRD_NRD_1	600	602	PF00675	0.566
CLV_NRD_NRD_1	614	616	PF00675	0.547
CLV_NRD_NRD_1	663	665	PF00675	0.436
CLV_NRD_NRD_1	760	762	PF00675	0.728
CLV_NRD_NRD_1	87	89	PF00675	0.653
CLV_PCSK_FUR_1	471	475	PF00082	0.648
CLV_PCSK_KEX2_1	301	303	PF00082	0.736
CLV_PCSK_KEX2_1	349	351	PF00082	0.577
CLV_PCSK_KEX2_1	403	405	PF00082	0.570
CLV_PCSK_KEX2_1	472	474	PF00082	0.683
CLV_PCSK_KEX2_1	489	491	PF00082	0.628
CLV_PCSK_KEX2_1	585	587	PF00082	0.427
CLV_PCSK_KEX2_1	600	602	PF00082	0.427
CLV_PCSK_KEX2_1	663	665	PF00082	0.436
CLV_PCSK_KEX2_1	709	711	PF00082	0.431
CLV_PCSK_KEX2_1	759	761	PF00082	0.732
CLV_PCSK_KEX2_1	766	768	PF00082	0.741
CLV_PCSK_KEX2_1	781	783	PF00082	0.854
CLV_PCSK_KEX2_1	87	89	PF00082	0.652
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.736
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.738
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.417
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.397
CLV_PCSK_PC1ET2_1	766	768	PF00082	0.604
CLV_PCSK_PC1ET2_1	781	783	PF00082	0.774
CLV_PCSK_PC7_1	297	303	PF00082	0.693
CLV_PCSK_PC7_1	468	474	PF00082	0.581
CLV_PCSK_SKI1_1	116	120	PF00082	0.515
CLV_PCSK_SKI1_1	141	145	PF00082	0.529
CLV_PCSK_SKI1_1	529	533	PF00082	0.632
CLV_PCSK_SKI1_1	559	563	PF00082	0.547
CLV_PCSK_SKI1_1	638	642	PF00082	0.665
CLV_PCSK_SKI1_1	651	655	PF00082	0.372
CLV_PCSK_SKI1_1	663	667	PF00082	0.580
CLV_PCSK_SKI1_1	723	727	PF00082	0.468
DEG_APCC_DBOX_1	233	241	PF00400	0.401
DEG_SPOP_SBC_1	187	191	PF00917	0.652
DEG_SPOP_SBC_1	66	70	PF00917	0.541
DOC_CYCLIN_RxL_1	583	593	PF00134	0.576
DOC_MAPK_gen_1	393	402	PF00069	0.576
DOC_MAPK_gen_1	543	552	PF00069	0.464
DOC_MAPK_gen_1	585	592	PF00069	0.561
DOC_MAPK_gen_1	709	716	PF00069	0.497
DOC_MAPK_MEF2A_6	585	592	PF00069	0.500
DOC_MAPK_NFAT4_5	585	593	PF00069	0.364
DOC_MAPK_RevD_3	290	304	PF00069	0.655
DOC_PP2B_LxvP_1	27	30	PF13499	0.497
DOC_PP2B_LxvP_1	588	591	PF13499	0.510
DOC_PP2B_LxvP_1	671	674	PF13499	0.466
DOC_PP4_FxxP_1	715	718	PF00568	0.540
DOC_SPAK_OSR1_1	633	637	PF12202	0.460
DOC_USP7_MATH_1	102	106	PF00917	0.452
DOC_USP7_MATH_1	143	147	PF00917	0.428
DOC_USP7_MATH_1	187	191	PF00917	0.714
DOC_USP7_MATH_1	201	205	PF00917	0.507
DOC_USP7_MATH_1	227	231	PF00917	0.651
DOC_USP7_MATH_1	233	237	PF00917	0.561
DOC_USP7_MATH_1	386	390	PF00917	0.717
DOC_USP7_MATH_1	452	456	PF00917	0.827
DOC_USP7_MATH_1	509	513	PF00917	0.652
DOC_USP7_MATH_1	696	700	PF00917	0.768
DOC_USP7_MATH_1	71	75	PF00917	0.671
DOC_USP7_MATH_1	749	753	PF00917	0.564
DOC_USP7_UBL2_3	616	620	PF12436	0.379
DOC_WW_Pin1_4	154	159	PF00397	0.508
DOC_WW_Pin1_4	257	262	PF00397	0.701
DOC_WW_Pin1_4	279	284	PF00397	0.611
DOC_WW_Pin1_4	438	443	PF00397	0.594
DOC_WW_Pin1_4	507	512	PF00397	0.685
DOC_WW_Pin1_4	638	643	PF00397	0.524
DOC_WW_Pin1_4	698	703	PF00397	0.588
DOC_WW_Pin1_4	745	750	PF00397	0.551
LIG_14-3-3_CanoR_1	116	121	PF00244	0.534
LIG_14-3-3_CanoR_1	154	158	PF00244	0.447
LIG_14-3-3_CanoR_1	173	180	PF00244	0.404
LIG_14-3-3_CanoR_1	208	216	PF00244	0.420
LIG_14-3-3_CanoR_1	246	252	PF00244	0.581
LIG_14-3-3_CanoR_1	371	381	PF00244	0.826
LIG_14-3-3_CanoR_1	403	411	PF00244	0.569
LIG_14-3-3_CanoR_1	615	619	PF00244	0.388
LIG_14-3-3_CanoR_1	695	705	PF00244	0.513
LIG_14-3-3_CanoR_1	729	738	PF00244	0.623
LIG_14-3-3_CanoR_1	740	749	PF00244	0.575
LIG_14-3-3_CanoR_1	767	777	PF00244	0.742
LIG_14-3-3_CanoR_1	87	92	PF00244	0.619
LIG_Actin_WH2_2	527	545	PF00022	0.514
LIG_Actin_WH2_2	599	617	PF00022	0.628
LIG_BIR_III_4	319	323	PF00653	0.668
LIG_Clathr_ClatBox_1	39	43	PF01394	0.504
LIG_CSL_BTD_1	158	161	PF09270	0.485
LIG_CtBP_PxDLS_1	36	40	PF00389	0.512
LIG_FHA_1	155	161	PF00498	0.607
LIG_FHA_1	197	203	PF00498	0.642
LIG_FHA_1	211	217	PF00498	0.311
LIG_FHA_1	24	30	PF00498	0.620
LIG_FHA_1	248	254	PF00498	0.585
LIG_FHA_1	267	273	PF00498	0.636
LIG_FHA_1	282	288	PF00498	0.483
LIG_FHA_1	3	9	PF00498	0.481
LIG_FHA_1	323	329	PF00498	0.521
LIG_FHA_1	405	411	PF00498	0.745
LIG_FHA_1	414	420	PF00498	0.770
LIG_FHA_1	458	464	PF00498	0.729
LIG_FHA_1	516	522	PF00498	0.356
LIG_FHA_1	585	591	PF00498	0.510
LIG_FHA_1	660	666	PF00498	0.513
LIG_FHA_1	733	739	PF00498	0.419
LIG_FHA_2	310	316	PF00498	0.689
LIG_FHA_2	419	425	PF00498	0.812
LIG_FHA_2	508	514	PF00498	0.623
LIG_FHA_2	528	534	PF00498	0.416
LIG_FHA_2	639	645	PF00498	0.544
LIG_FHA_2	67	73	PF00498	0.795
LIG_FHA_2	79	85	PF00498	0.573
LIG_FHA_2	88	94	PF00498	0.578
LIG_LIR_Gen_1	115	124	PF02991	0.497
LIG_LIR_Gen_1	15	24	PF02991	0.484
LIG_LIR_Gen_1	275	283	PF02991	0.617
LIG_LIR_Gen_1	93	102	PF02991	0.417
LIG_LIR_Nem_3	115	121	PF02991	0.508
LIG_LIR_Nem_3	15	21	PF02991	0.482
LIG_LIR_Nem_3	156	162	PF02991	0.597
LIG_LIR_Nem_3	275	279	PF02991	0.501
LIG_LIR_Nem_3	681	686	PF02991	0.579
LIG_LIR_Nem_3	719	725	PF02991	0.460
LIG_MYND_1	98	102	PF01753	0.621
LIG_RPA_C_Fungi	755	767	PF08784	0.580
LIG_SH2_CRK	162	166	PF00017	0.591
LIG_SH2_CRK	18	22	PF00017	0.488
LIG_SH2_CRK	547	551	PF00017	0.586
LIG_SH2_NCK_1	255	259	PF00017	0.397
LIG_SH2_STAP1	547	551	PF00017	0.586
LIG_SH2_STAT5	11	14	PF00017	0.477
LIG_SH2_STAT5	18	21	PF00017	0.469
LIG_SH2_STAT5	569	572	PF00017	0.579
LIG_SH3_3	155	161	PF00018	0.486
LIG_SH3_3	258	264	PF00018	0.714
LIG_SH3_3	339	345	PF00018	0.719
LIG_SH3_3	422	428	PF00018	0.558
LIG_SH3_3	439	445	PF00018	0.523
LIG_SH3_3	639	645	PF00018	0.580
LIG_SUMO_SIM_anti_2	669	674	PF11976	0.576
LIG_SUMO_SIM_par_1	426	432	PF11976	0.601
LIG_TRAF2_1	641	644	PF00917	0.694
LIG_TRAF2_1	81	84	PF00917	0.767
LIG_TYR_ITIM	16	21	PF00017	0.486
LIG_WRC_WIRS_1	220	225	PF05994	0.430
MOD_CDK_SPK_2	745	750	PF00069	0.551
MOD_CK1_1	146	152	PF00069	0.703
MOD_CK1_1	186	192	PF00069	0.655
MOD_CK1_1	195	201	PF00069	0.646
MOD_CK1_1	282	288	PF00069	0.465
MOD_CK1_1	309	315	PF00069	0.784
MOD_CK1_1	356	362	PF00069	0.749
MOD_CK1_1	372	378	PF00069	0.829
MOD_CK1_1	409	415	PF00069	0.624
MOD_CK1_1	423	429	PF00069	0.670
MOD_CK1_1	432	438	PF00069	0.742
MOD_CK1_1	476	482	PF00069	0.575
MOD_CK1_1	52	58	PF00069	0.761
MOD_CK1_1	60	66	PF00069	0.700
MOD_CK1_1	605	611	PF00069	0.609
MOD_CK1_1	732	738	PF00069	0.630
MOD_CK1_1	762	768	PF00069	0.784
MOD_CK1_1	775	781	PF00069	0.573
MOD_CK2_1	102	108	PF00069	0.479
MOD_CK2_1	432	438	PF00069	0.737
MOD_CK2_1	479	485	PF00069	0.583
MOD_CK2_1	507	513	PF00069	0.609
MOD_CK2_1	521	527	PF00069	0.459
MOD_CK2_1	638	644	PF00069	0.561
MOD_CK2_1	78	84	PF00069	0.713
MOD_CK2_1	87	93	PF00069	0.622
MOD_GlcNHglycan	108	112	PF01048	0.712
MOD_GlcNHglycan	146	149	PF01048	0.517
MOD_GlcNHglycan	185	188	PF01048	0.731
MOD_GlcNHglycan	190	193	PF01048	0.727
MOD_GlcNHglycan	194	197	PF01048	0.690
MOD_GlcNHglycan	308	311	PF01048	0.768
MOD_GlcNHglycan	371	374	PF01048	0.840
MOD_GlcNHglycan	431	434	PF01048	0.822
MOD_GlcNHglycan	481	484	PF01048	0.580
MOD_GlcNHglycan	5	8	PF01048	0.544
MOD_GlcNHglycan	59	62	PF01048	0.721
MOD_GlcNHglycan	638	641	PF01048	0.664
MOD_GlcNHglycan	656	659	PF01048	0.471
MOD_GlcNHglycan	731	734	PF01048	0.575
MOD_GlcNHglycan	751	754	PF01048	0.495
MOD_GlcNHglycan	756	759	PF01048	0.724
MOD_GSK3_1	146	153	PF00069	0.688
MOD_GSK3_1	165	172	PF00069	0.539
MOD_GSK3_1	182	189	PF00069	0.710
MOD_GSK3_1	192	199	PF00069	0.778
MOD_GSK3_1	262	269	PF00069	0.678
MOD_GSK3_1	279	286	PF00069	0.425
MOD_GSK3_1	348	355	PF00069	0.644
MOD_GSK3_1	358	365	PF00069	0.737
MOD_GSK3_1	405	412	PF00069	0.666
MOD_GSK3_1	475	482	PF00069	0.577
MOD_GSK3_1	66	73	PF00069	0.722
MOD_GSK3_1	697	704	PF00069	0.646
MOD_GSK3_1	741	748	PF00069	0.723
MOD_GSK3_1	762	769	PF00069	0.800
MOD_GSK3_1	771	778	PF00069	0.732
MOD_N-GLC_1	362	367	PF02516	0.649
MOD_NEK2_1	10	15	PF00069	0.560
MOD_NEK2_1	107	112	PF00069	0.697
MOD_NEK2_1	144	149	PF00069	0.459
MOD_NEK2_1	180	185	PF00069	0.662
MOD_NEK2_1	209	214	PF00069	0.591
MOD_NEK2_1	266	271	PF00069	0.702
MOD_NEK2_1	467	472	PF00069	0.642
MOD_NEK2_1	516	521	PF00069	0.508
MOD_NEK2_1	557	562	PF00069	0.485
MOD_NEK2_1	614	619	PF00069	0.481
MOD_NEK2_1	654	659	PF00069	0.361
MOD_NEK2_1	697	702	PF00069	0.671
MOD_NEK2_1	731	736	PF00069	0.514
MOD_NEK2_2	247	252	PF00069	0.601
MOD_NEK2_2	322	327	PF00069	0.600
MOD_PIKK_1	196	202	PF00454	0.501
MOD_PIKK_1	372	378	PF00454	0.829
MOD_PIKK_1	60	66	PF00454	0.733
MOD_PIKK_1	760	766	PF00454	0.728
MOD_PIKK_1	768	774	PF00454	0.740
MOD_PKA_1	303	309	PF00069	0.756
MOD_PKA_1	473	479	PF00069	0.616
MOD_PKA_1	759	765	PF00069	0.729
MOD_PKA_1	766	772	PF00069	0.739
MOD_PKA_1	87	93	PF00069	0.618
MOD_PKA_2	153	159	PF00069	0.400
MOD_PKA_2	172	178	PF00069	0.539
MOD_PKA_2	210	216	PF00069	0.397
MOD_PKA_2	233	239	PF00069	0.444
MOD_PKA_2	303	309	PF00069	0.756
MOD_PKA_2	348	354	PF00069	0.830
MOD_PKA_2	467	473	PF00069	0.808
MOD_PKA_2	474	480	PF00069	0.693
MOD_PKA_2	521	527	PF00069	0.522
MOD_PKA_2	614	620	PF00069	0.631
MOD_PKA_2	749	755	PF00069	0.647
MOD_PKA_2	759	765	PF00069	0.629
MOD_PKA_2	766	772	PF00069	0.825
MOD_PKA_2	87	93	PF00069	0.618
MOD_PKB_1	393	401	PF00069	0.576
MOD_PKB_1	471	479	PF00069	0.616
MOD_Plk_1	122	128	PF00069	0.428
MOD_Plk_1	413	419	PF00069	0.685
MOD_Plk_1	527	533	PF00069	0.628
MOD_Plk_1	71	77	PF00069	0.770
MOD_Plk_2-3	44	50	PF00069	0.789
MOD_Plk_2-3	527	533	PF00069	0.628
MOD_Plk_4	102	108	PF00069	0.406
MOD_Plk_4	165	171	PF00069	0.417
MOD_Plk_4	210	216	PF00069	0.460
MOD_Plk_4	283	289	PF00069	0.433
MOD_Plk_4	35	41	PF00069	0.513
MOD_Plk_4	395	401	PF00069	0.747
MOD_Plk_4	406	412	PF00069	0.695
MOD_Plk_4	533	539	PF00069	0.362
MOD_Plk_4	562	568	PF00069	0.398
MOD_Plk_4	574	580	PF00069	0.394
MOD_Plk_4	649	655	PF00069	0.526
MOD_Plk_4	701	707	PF00069	0.408
MOD_ProDKin_1	154	160	PF00069	0.500
MOD_ProDKin_1	257	263	PF00069	0.709
MOD_ProDKin_1	279	285	PF00069	0.605
MOD_ProDKin_1	438	444	PF00069	0.593
MOD_ProDKin_1	507	513	PF00069	0.672
MOD_ProDKin_1	638	644	PF00069	0.539
MOD_ProDKin_1	698	704	PF00069	0.576
MOD_ProDKin_1	745	751	PF00069	0.554
MOD_SUMO_for_1	497	500	PF00179	0.577
MOD_SUMO_rev_2	524	531	PF00179	0.512
MOD_SUMO_rev_2	644	653	PF00179	0.585
TRG_DiLeu_BaEn_1	533	538	PF01217	0.616
TRG_ENDOCYTIC_2	18	21	PF00928	0.489
TRG_ENDOCYTIC_2	547	550	PF00928	0.597
TRG_ER_diArg_1	348	350	PF00400	0.579
TRG_ER_diArg_1	402	404	PF00400	0.577
TRG_ER_diArg_1	471	474	PF00400	0.699
TRG_ER_diArg_1	600	602	PF00400	0.452
TRG_ER_diArg_1	625	628	PF00400	0.487
TRG_ER_diArg_1	663	665	PF00400	0.436
TRG_ER_diArg_1	759	761	PF00400	0.732
TRG_ER_diArg_1	86	88	PF00400	0.655
TRG_NLS_MonoCore_2	300	305	PF00514	0.700
TRG_NLS_MonoCore_2	470	475	PF00514	0.698
TRG_NLS_MonoExtC_3	470	475	PF00514	0.717
TRG_NLS_MonoExtN_4	301	306	PF00514	0.729
TRG_NLS_MonoExtN_4	468	475	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	549	554	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	664	669	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD2	Leptomonas seymouri	40%	100%
A0A3S5H5U2	Leishmania donovani	72%	100%
A4HT06	Leishmania infantum	72%	100%
E9AKZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	93%
Q4QIW2	Leishmania major	70%	100%