Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4S4_LEIBR

TriTrypDb:

LbrM.06.1110 , LBRM2903_060018500

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A4H4S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.588
CLV_NRD_NRD_1	160	162	PF00675	0.446
CLV_PCSK_KEX2_1	160	162	PF00082	0.480
CLV_PCSK_SKI1_1	161	165	PF00082	0.505
CLV_PCSK_SKI1_1	3	7	PF00082	0.359
DEG_SCF_FBW7_2	5	10	PF00400	0.591
DOC_CKS1_1	322	327	PF01111	0.315
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.390
DOC_MAPK_gen_1	160	168	PF00069	0.452
DOC_MAPK_MEF2A_6	120	127	PF00069	0.540
DOC_PP1_RVXF_1	316	322	PF00149	0.256
DOC_PP2B_LxvP_1	11	14	PF13499	0.300
DOC_PP2B_LxvP_1	151	154	PF13499	0.425
DOC_PP2B_LxvP_1	198	201	PF13499	0.581
DOC_PP4_FxxP_1	322	325	PF00568	0.536
DOC_USP7_MATH_1	126	130	PF00917	0.464
DOC_USP7_MATH_1	134	138	PF00917	0.377
DOC_USP7_MATH_1	145	149	PF00917	0.606
DOC_USP7_MATH_1	159	163	PF00917	0.566
DOC_USP7_MATH_1	36	40	PF00917	0.494
DOC_WW_Pin1_4	3	8	PF00397	0.601
DOC_WW_Pin1_4	321	326	PF00397	0.293
DOC_WW_Pin1_4	51	56	PF00397	0.532
LIG_14-3-3_CanoR_1	138	142	PF00244	0.517
LIG_14-3-3_CanoR_1	160	168	PF00244	0.446
LIG_14-3-3_CanoR_1	249	255	PF00244	0.449
LIG_14-3-3_CanoR_1	320	325	PF00244	0.402
LIG_14-3-3_CanoR_1	45	53	PF00244	0.547
LIG_APCC_ABBA_1	5	10	PF00400	0.494
LIG_BIR_II_1	1	5	PF00653	0.358
LIG_EVH1_1	13	17	PF00568	0.289
LIG_FHA_1	150	156	PF00498	0.666
LIG_FHA_1	195	201	PF00498	0.605
LIG_FHA_1	204	210	PF00498	0.562
LIG_FHA_1	46	52	PF00498	0.317
LIG_FHA_1	95	101	PF00498	0.495
LIG_FHA_2	162	168	PF00498	0.505
LIG_LIR_Nem_3	29	35	PF02991	0.343
LIG_LIR_Nem_3	6	11	PF02991	0.338
LIG_NRP_CendR_1	327	329	PF00754	0.674
LIG_SH2_CRK	21	25	PF00017	0.386
LIG_SH2_NCK_1	256	260	PF00017	0.405
LIG_SH2_STAT3	139	142	PF00017	0.417
LIG_SH2_STAT5	139	142	PF00017	0.392
LIG_SH2_STAT5	32	35	PF00017	0.415
LIG_SH2_STAT5	42	45	PF00017	0.420
LIG_SH3_3	11	17	PF00018	0.452
LIG_SUMO_SIM_anti_2	84	91	PF11976	0.325
LIG_SUMO_SIM_par_1	122	131	PF11976	0.445
LIG_SUMO_SIM_par_1	78	85	PF11976	0.389
LIG_TYR_ITIM	19	24	PF00017	0.395
MOD_CDC14_SPxK_1	54	57	PF00782	0.302
MOD_CDK_SPxK_1	3	9	PF00069	0.347
MOD_CDK_SPxK_1	321	327	PF00069	0.305
MOD_CDK_SPxK_1	51	57	PF00069	0.300
MOD_CK1_1	137	143	PF00069	0.508
MOD_CK1_1	181	187	PF00069	0.511
MOD_CK2_1	172	178	PF00069	0.628
MOD_CK2_1	262	268	PF00069	0.482
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.347
MOD_GlcNHglycan	180	183	PF01048	0.425
MOD_GlcNHglycan	236	239	PF01048	0.478
MOD_GlcNHglycan	256	259	PF01048	0.150
MOD_GlcNHglycan	264	267	PF01048	0.258
MOD_GlcNHglycan	278	281	PF01048	0.473
MOD_GlcNHglycan	28	31	PF01048	0.545
MOD_GlcNHglycan	288	291	PF01048	0.543
MOD_GlcNHglycan	38	41	PF01048	0.496
MOD_GSK3_1	145	152	PF00069	0.618
MOD_GSK3_1	203	210	PF00069	0.509
MOD_GSK3_1	250	257	PF00069	0.460
MOD_GSK3_1	276	283	PF00069	0.516
MOD_GSK3_1	36	43	PF00069	0.487
MOD_NEK2_1	254	259	PF00069	0.509
MOD_NEK2_1	26	31	PF00069	0.452
MOD_NEK2_2	40	45	PF00069	0.509
MOD_PIKK_1	172	178	PF00454	0.376
MOD_PKA_2	137	143	PF00069	0.518
MOD_PKA_2	159	165	PF00069	0.432
MOD_PKA_2	44	50	PF00069	0.538
MOD_Plk_1	149	155	PF00069	0.422
MOD_Plk_1	172	178	PF00069	0.453
MOD_Plk_4	250	256	PF00069	0.481
MOD_Plk_4	270	276	PF00069	0.350
MOD_Plk_4	28	34	PF00069	0.411
MOD_ProDKin_1	3	9	PF00069	0.599
MOD_ProDKin_1	321	327	PF00069	0.305
MOD_ProDKin_1	51	57	PF00069	0.537
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.387
TRG_ENDOCYTIC_2	21	24	PF00928	0.385
TRG_ENDOCYTIC_2	8	11	PF00928	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR4	Leptomonas seymouri	47%	100%
A0A1X0NGN1	Trypanosomatidae	25%	99%
A0A3S5H5U1	Leishmania donovani	74%	100%
A0A422NM50	Trypanosoma rangeli	28%	99%
A4HT05	Leishmania infantum	74%	100%
C9ZTN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	82%
E9AKZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QIW3	Leishmania major	72%	100%
V5BT69	Trypanosoma cruzi	26%	99%